Macro Roles for MicroRNAs in the Life and Death of Neurons

127 Pages·2010·1.53 MB·English

by  Kenneth S. Kosik

Research and Perspectives in Neurosciences
Forfurther volumes:
http://www.Springer.com/series/2357
Bart de Strooper Yves Christen
l
Editors
Macro Roles for MicroRNAs
in the Life and Death of
Neurons
Editors
Dr.BartdeStrooper Dr.YvesChristen
KULeuvenandVIB FondationIPSENpourla
CenterHumanGenetics RechercheTherapeutique
Lab.NeuronalCellBiology 65quaiGeorgeGorse
Herestraat49 92650BoulogneBillancourt
3000Leuven Cedex
CampusGasthuisberg6 France
Belgium [email protected]
[email protected]
ISSN:0945-6082
ISBN:978-3-642-04297-3 e-ISBN:978-3-642-04298-0
DOI10.1007/978-3-642-04298-0
SpringerHeidelbergDordrechtLondonNewYork
LibraryofCongressControlNumber:2009939121
#Springer-VerlagBerlinHeidelberg2010
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Foreword
ThediscoveryofmicroRNAshasrevealedanunexpectedandspectacularadditional
level of fine tuning of the genome and how genes are used again and again in
different combinations to generate the complexity that underlies for instance the
brain. Sincethe initial studies performedinC.elegans, wegave goneafar wayto
begin to understand how microRNA pathways can have an impact on health and
disease in human. Although microRNAs are abundantly expressed in the brain,
relativelylittleisknownaboutthemultiplefunctionsoftheseRNAmoleculesinthe
nervous system. Nevertheless, we know already that microRNA pathways play
majorrolesintheproliferation,differentiation,functionandmaintenanceofneuro-
nalcells.SeveralintriguingstudieshavelinkedmicroRNAsasmajorregulatorsof
theneuronalphenotype,andhaveimplicatedspecificmicroRNAsintheregulation
of synapse formation and plasticity. Dysfunction of microRNA pathways is also
slowlyemergingasapotential important contributortothepathogenesisofmajor
neurodegenerativedisorderssuchasAlzheimer’sdiseaseandParkinson’sdisease.
Thesenovelinsightsappeartobeparticularpromisingfortheunderstandingofthe
veryfrequentandbadlyunderstoodsporadicformsofthesediseasesascomparedto
thegeneticforms. Thus,thebetterunderstandingoftheimplicationsofthisnovel
field ofmolecular biology is crucial for the broad area ofneurosciences,from the
fundamental aspects to the clinic, and from novel diagnostic to potentially thera-
peutic applications for severe neurological and maybe psychiatric diseases. The
presentvolumegatherscontributionstotheColloqueMe´decineetRechercheonthe
implications of microRNAs in neuroscience organized by the Fondation Ipsen, in
Paris,onApril20,2009.Ithadasobjectivetobringtogetherneuroscientistsfrom
differentareasofresearchtodiscusstheircurrentinsightsintothewonderfulworld
ofmicroRNAs,andtohearanddiscusstheirresearchandviewsaboutmicroRNA
biologyinneuronalprocessesandinbraindisorders.
BartdeStrooper
YvesChristen
v
Acknowledgments
The editors wish to thank Jacqueline Mervaillie and Sonia Le Cornec for the
organizationofthemeetingandMaryLynnGagefortheeditingofthebook.
vii
Contents
ProfilingthemicroRNAs ...................................................... 1
KennethS.Kosik,ThalesPapagiannakopoulos,NaXu,
KawtherAbu-Elneel,TsunglinLiu,andMinJeongKye
TheWideVarietyofmiRNAExpressionProfiles
intheDevelopingandMatureCNS .......................................... 9
MarikaKapsimali
InteractionsbetweenmicroRNAsandTranscription
FactorsintheDevelopmentandFunction
oftheNervousSystem ........................................................ 19
DavidJ.Simon
AmicroRNAFeedbackCircuitinMidbrainDopamineNeurons ......... 27
AsaAbeliovich
Fine-tuningmRNATranslationatSynapseswithmicroRNAs ............ 35
GerhardM.Schratt
NeuronalP-bodiesandTransportofmicroRNA-Repressed
mRNAs ......................................................................... 45
FlorenceRage
CrosstalkbetweenmicroRNAandEpigeneticRegulation
inStemCells ................................................................... 57
KeithSzulwach,ShuangChang,andPengJin
microRNAsinCNSDevelopmentandNeurodegeneration:
InsightsfromDrosophilaGenetics ........................................... 69
StephenM.Cohen
ix
x Contents
DrosophilaasaModelforNeurodegenerativeDisease:
RolesofRNAPathwaysinPathogenesis .................................... 79
NancyM.Bonini
microRNAsinSporadicAlzheimer’sDiseaseandRelated
Dementias ...................................................................... 91
Se´bastienS.He´bert,WimMandemakers,AikateriniS.Papadopoulou,
andBartDeStrooper
microRNADysregulationinPsychiatricDisorders ........................ 99
BinXu,JosephA.Gogos,andMariaKarayiorgou
Index ........................................................................... 119
Contributors
Abeliovich Asa Columbia University Medical Center, 630 West 168th Street,
Room15-405,NewYork,NY10032,USA,[email protected]
Abu-ElneelKawther NeuroscienceResearchInstitute,DepartmentofMolecular
CellularandDevelopmentalBiology,UniversityofCaliforniaSantaBarbara,USA
Bonini Nancy M. University of Pennsylvania, 306 Leidy Laboratories, Depart-
mentofBiology,Philadelphia,PA19104,USA,[email protected]
Chang Shuang Department of Human Genetics, Emory University School of
Medicine,Atlanta,GA30322,USA
CohenStephenM. TemasekLifeSciencesLaboratoryLimited,1ResearchLink
National University of Singapore, 117604 Singapore, SINGAPORE, steve@
tll.org.sg
De Strooper Bart Center for human genetics, K.U. Leuven and Department of
molecularanddevelopmentalgenetics,VIBLeuven,BELGIUM
Gogos Joseph A. Department of Physiology & Cellular Biophysics and Depart-
mentofNeuroscience,ColumbiaUniversity,NewYork,USA
He´bert Se´bastien S. Centre de Recherche du CHUQ (CHUL), Axe Neuros-
ciences,Universite´ Laval,De´partementdeBiologieme´dicale,2705Boul.Laurier,
LocalRC-9800,Que´bec,Qc,Canada,[email protected]
JinPeng DepartmentofHuman Genetics andGraduatePrograminGeneticsand
Molecular Biology, Emory University School of Medicine, Atlanta, GA 30322,
USA,[email protected]
Kapsimali Marika INSERM U784, Ge´ne´tique Mole´culaire du De´veloppement,
Ecole Normale Supe´rieure, 46 rue d´Ulm, 75230 PARIS Cedex 05 FRANCE,
[email protected]
xi
xii Contributors
Karayiorgou Maria Columbia University, Department of Psychiatry, 1051
RiversideDrive,Unit#28,NewYorkNY10032,USA,[email protected]
Kosik Kenneth S. Neuroscience Research Institute, Department of Molecular
Cellular and Developmental Biology, University of California Santa Barbara,
BiologyII,Room6139A,SantaBarbara,CA93106,USA,[email protected]
Kye Min Jeong Neuroscience Research Institute, Department of Molecular
CellularandDevelopmentalBiology,UniversityofCaliforniaSantaBarbara,USA
LiuTsunglin NeuroscienceResearchInstitute,DepartmentofMolecularCellular
andDevelopmentalBiology,UniversityofCaliforniaSantaBarbara,USA
MandemakersWim Centerforhumangenetics,K.U.LeuvenandDepartmentof
molecularanddevelopmentalgenetics,VIBLeuven,BELGIUM
Papadopoulou Aikaterini S. Center for human genetics, K.U. Leuven and
Departmentofmolecularanddevelopmentalgenetics,VIBLeuven,BELGIUM
Papagiannakopoulos Thales Neuroscience Research Institute, Department of
Molecular Cellular and Developmental Biology, University of California Santa
Barbara,USA
Rage Florence Institut de Ge´ne´tique mole´culaire de Montpellier, UMR 5535,
1919 route de Mende 34293 Montpellier Cedex 05, FRANCE, florence.
[email protected]
Schratt Gerhard M. University of Heidelberg, Interdisciplinary Center for
Neurosciences (IZN), SFB488 Junior Group, Im Neuenheimer Feld 345, 1.OG,
69120Heidelberg,GERMANY,[email protected]
Simon David J. Department of Molecular Biology, Massachusetts General
Hospital, 185 Cambridge Street, Simches 7, Boston, MA 02114, USA, david.
[email protected]
Szulwach Keith Department of Human Genetics and Graduate Program in
Genetics and Molecular Biology, Emory University School of Medicine, Atlanta,
GA30322,USA
Xu Bin Department of Physiology & Cellular Biophysics and Department of
PsychiatryColumbiaUniversity,NewYork,USA
Na Xu Neuroscience Research Institute, Departement of Molecular Cellular and
DevelopmentalBiology,UniversityofCaliforniaSantaBarbara,USA