Table Of ContentRepRoductive Medicine RepRoductive Medicine & Assisted
RM&ART
RepRoductive techniques seRies
IVF in the Medically Complicated Patient
A Guide to Management, Second Edition
E dited by
Nick S Macklon, MB ChB, MD, FRCOG, Professor of Obstetrics and
Gynaecology, Academic Unit of Human Development and Health/Faculty
of Medicine, University of Southampton, and Director, Complete Fertility
Centre Southampton, Princess Anne Hospital, Southampton, UK
Each patient seeking assisted reproduction has a unique set of circumstances
that affects the outcome of treatment. Particularly challenging are those
patients with pre-existing medical conditions or those receiving medical
therapies that may impact the safety and success of their IVF treatments.
Prior identification and preparation of the patient at increased risk of com-
plications will enable the clinician to avoid problems in advance, anticipate
the necessary management, and optimize outcomes. This new expanded
edition of a prize-winning text provides a readily accessible, authoritative,
and didactic source of information to aid clinicians in this important field.
From reviews of the first edition:
“This is a very apt and concise book on the subject … but also provides
evidence-based discussion of other complex situations such as managing
hydrosalpinges and fibroids … This book should be read by every specialist
dealing with large numbers of patients undergoing IVF as they will encounter
these patients and will benefit from up-to-date and accurate data
presented here.”
—Highly Commended, Obstetrics & Gynaecology Category, 2006 BMA
Medical Book Competition
“This book attempts to highlight an important but neglected area of
practice. It is highly original and a much-needed resource for clinicians
working in IVF and infertility units.”
—The Society of Authors and the Royal Society of Medicine Book Awards 2006
Markets: Reproductive Medicine, Gynaecology
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K21521 tio
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ISBN-13: 978-1-4822-0669-2 nd
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9 781482 206692
K21521_Cover_mech.indd All Pages 5/8/14 10:29 AM
IVF in the
Medically
Complicated
Patient
REPRODUCTIVE MEDICINE AND ASSISTED REPRODUCTIVE
TECHNIQUES SERIES
David Gardner
University of Melbourne, Australia
Zeev Shoham
Kaplan Hospital, Rehovot, Israel
Kay Elder, Jacques Cohen
Human Preimplantation Embryo Selection, ISBN: 9780415399739
Michael Tucker, Juergen Liebermann
Vitrification in Assisted Reproduction, ISBN: 9780415408820
John D Aplin, Asgerally T Fazleabas, Stanley R Glasser, Linda C Giudice
The Endometrium, Second Edition, ISBN: 9780415385831
Nick Macklon, Ian Greer, Eric Steegers
Textbook of Periconceptional Medicine, ISBN: 9780415458924
Andrea Borini, Giovanni Coticchio
Preservation of Human Oocytes, ISBN: 9780415476799
Steven R Bayer, Michael M Alper, Alan S Penzias
The Boston IVF Handbook of Infertility, Third Edition, ISBN: 9781841848105
Ben Cohlen, Willem Ombelet
Intra-Uterine Insemination: Evidence-Based Guidelines for Daily Practice,
ISBN: 9781841849881
Adam H. Balen
Infertility in Practice, Fourth Edition, ISBN: 9781841848495
Nick Macklon
IVF in the Medically Complicated Patient, Second Edition:
A Guide to Management, ISBN: 9781482206692
IVF in the
Medically
Complicated
Patient
Second Edition
A Guide to
Management
Edited by
Nick S Macklon, MB ChB, MD, FRCOG
Professor of Obstetrics and Gynaecology, Academic Unit of Human
Development and Health / Faculty of Medicine, University of Southampton,
and Director, Complete Fertility Centre Southampton, Princess Anne
Hospital, Southampton, UK
Boca Raton London New York
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© 2014 by Taylor & Francis Group, LLC
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No claim to original U.S. Government works
Version Date: 20140304
International Standard Book Number-13: 978-1-4822-0671-5 (eBook - PDF)
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Contents
Contributors ...............................................................................................................vii
1. The Patient with Cystic Fibrosis .......................................................................1
GCML Page-Christiaens, AJ Goverde, and F Teding van Berkhout
2. The Patient at Risk from Thrombosis ............................................................21
NS Macklon
3. The Patient with Hyperprolactinaemia ..........................................................31
AN Andersen, MP Lauritsen, and M Krog
4. The Patient with Autoimmune Disease ..........................................................39
D Galliano, A Pellicer, and J Bellver
5. The Patient with Epilepsy ................................................................................47
E Campbell and J Craig
6. The Patient with Inflammatory Bowel Disease .............................................59
SV Kane and JG Al Hashash
7. The Patient with Hypertension .......................................................................69
BB van Rijn and MA Coleman
8. The Patient with Obesity .................................................................................79
T Hardy and W Ledger
9. The Patient with Polycystic Ovary Syndrome ...............................................91
SMC De Sousa and RJ Norman
10. The Patient with Hydrosalpinx .....................................................................103
A Strandell
11. The Patient with Endometriosis ....................................................................119
Y Cheong
12. The Patient with Fibroids ..............................................................................129
Y Khalaf and SK Sunkara
13. The Patient with Congenital Uterine Abnormalities ..................................137
PK Heinonen
v
vi Contents
14. The Patient with Malignant Disease ............................................................147
RA Anderson
15. The Girl with Cancer .....................................................................................157
KT Schmidt
16. The Patient with Turner’s Syndrome ...........................................................163
O Hovatta and B Borgström
17. The Couple Testing Positive for Hepatitis B and C .....................................171
JG Lemmen, A Loft, and S Ziebe
18. The Couple Testing Positive for Human Immunodeficiency Virus ...........183
MV Sauer
19. The Couple with Sexual Dysfunction ...........................................................193
WL Gianotten
20. The IVF Patient, International Travel and Vaccinations ..........................205
H Tijani and NS Macklon
Contributors
JG Al Hashash Y Cheong
Division of Gastroenterology, Academic Unit of Human Development
Hepatology and Nutrition and Health
University of Pittsburgh Medical Faculty of Medicine
Center University of Southampton
Pittsburgh, Pennsylvania, United Complete Fertility Centre
States Southampton
Princess Anne Hospital
AN Andersen Southampton, United Kingdom
The Fertility Clinic
Copenhagen University Hospital MA Coleman
Rigshospitalet, Copenhagen, Denmark University Hospitals
Southampton NHS Foundation Trust
RA Anderson Southampton, United Kingdom
MRC Centre for Reproductive Health
University of Edinburgh
J Craig
Queens Medical Research Institute
Department of Neurosciences
Edinburgh, United Kingdom
Belfast Health and Social Care Trust
Belfast, United Kingdom
J Bellver
Department of Obstetrics and
SMC De Sousa
Gynecology
Royal Adelaide Hospital
Faculty of Medicine
Adelaide, South Australia, Australia
University of Valencia and Instituto
Valenciano de Infertilidad
D Galliano
Valencia, Spain
Department of Reproduction
Instituto Valenciano de Infertilidad
B Borgström
Barcelona, Spain
Department of Clinical
Science, Intervention and
Technology WL Gianotten
Karolinska Institutet Department of Medical Sexology
Karolinska University Hospital University Medical Center
Huddinge Utrecht, the Netherlands
Stockholm, Sweden
AJ Goverde
E Campbell Department of Obstetrics and
Department of Neurosciences Gynaecology
Belfast Health and Social Care Trust University Medical Center
Belfast, United Kingdom Utrecht, the Netherlands
vii
viii Contributors
T Hardy JG Lemmen
Royal Hospital for Women Fertility Clinic Rigshospitalet
Randwick, New South Wales, Australia Copenhagen, Denmark
PK Heinonen A Loft
School of Medicine Fertility Clinic Rigshospitalet
University of Tampere and Copenhagen, Denmark
Department of Obstetrics and
Gynecology NS Macklon
Tampere University Hospital Academic Unit of Human Development
Tampere, Finland and Health
Faculty of Medicine
O Hovatta University of Southampton
Department of Clinical Science, Complete Fertility Centre Southampton
Intervention and Technology Princess Anne Hospital
Karolinska Institutet Southampton, United Kingdom
Karolinska University Hospital
Huddinge RJ Norman
Stockholm, Sweden The Robinson Institute
School of Pediatrics and Reproductive
SV Kane Health
Department of Gastroenterology University of Adelaide
Mayo Clinic Adelaide, South Australia, Australia
Rochester, Minnesota, United States
GCML Page-Christiaens
Y Khalaf Department Obstetrics and Gynaecology
The Assisted Conception Unit University Medical Center
Guy’s Hospital Utrecht, the Netherlands
London, United Kingdom
A Pellicer
M Krog Department of Obstetrics and
The Fertility Clinic Gynecology
Copenhagen University Hospital Faculty of Medicine
Rigshospitalet University of Valencia and Instituto
Copenhagen, Denmark Valenciano de Infertilidad
Valencia, Spain
MP Lauritsen
The Fertility Clinic MV Sauer
Copenhagen University Hospital Department of Obstetrics and
Rigshospitalet Gynecology
Copenhagen, Denmark Columbia University
New York, New York, United States
W Ledger
Department of Obstetrics and KT Schmidt
Gynaecology Fertility Clinic
School of Women’s and Children’s Health University Hospital of Copenhagen
University of New South Wales Rigshospitalet
Sydney, New South Wales, Australia Copenhagen, Denmark
