Inflammation and Retinal Disease: Complement Biology and Pathology

176 Pages·2010·4.73 MB·English

by  Natalia Karagianni

Advances in Experimental Medicine and Biology
Volume 703
Editorial Board:
IRUN R. COHEN, The Weizmann Institute of Science
ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research
JOHN D. LAMBRIS, University of Pennsylvania
RODOLFO PAOLETTI, University of Milan
For other titles published in this series, go to
www.springer.com/series/5584

John D. Lambris Anthony P. Adamis
●
Editors
Inflammation and Retinal
Disease: Complement
Biology and Pathology
Editors
John D. Lambris Anthony P. Adamis
Department of Pathology Department of Ophthalmology
Laboratory of Medicine and Visual Sciences
University of Pennsylvania University of Illinois at Chicago
Pennsylvania Illinois
USA USA
ISSN 0065-2598
ISBN 978-1-4419-5634-7 e-ISBN 978-1-4419-5635-4
DOI 10.1007/978-1-4419-5635-4
Springer New York Dordrecht Heidelberg London
Library of Congress Control Number: 2010931838
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Preface
Numerous studies have pointed to the key role of complement in the pathogenesis of
retinal disease, particularly age-related macular degeneration (AMD). Reports about
new gene associations and links to other physiological pathways are emerging almost
on a weekly base. Several promising clinical candidates covering a wide area of
potential treatment applications are in the pipelines of both industrial and academic
groups. This indicates an increasing interest in complement as a therapeutic target. In
view of these exciting discoveries, scientists from around the world convened at the
First Aegean Conferences Conference on Inflammation and Retinal Disease:
Complement Biology and Pathology (June 10–17, 2007) in Crete, Greece, to discuss
recent advances in this rapidly-evolving field. This volume represents a collection of
topics on the functions of complement in eye diseases, pathophysiology, protein
structures, and complement therapeutics discussed during the conference.
Our sincere thanks to the contributing authors for the time and effort they have
devoted to writing what I consider exceptionally informative chapters in a book that
will have a significant impact on the complement field. We would also like to
express my thanks to Rodanthi Lambris for her assistance in collating the chapters
and preparing the documents for publication and I gratefully acknowledge the
generous help provided by Dimitrios Lambris in managing the organization of this
meeting. Finally, I also thank Andrea Macaluso of Springer Publishers for her
supervision in this book’s production.
John D. Lambris
Anthony P. Adamis
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Contents
1 The Case for Complement and Inflammation
in AMD: Open Questions ....................................................................... 1
Natalia Karagianni and Anthony P. Adamis
2 The Role of Complement in AMD ......................................................... 9
Peter F. Zipfel, Nadine Lauer, and Christine Skerka
3 Multiple Interactions of Complement Factor H
with Its Ligands in Solution: A Progress Report ................................. 25
Stephen J. Perkins, Ruodan Nan, Azubuike I. Okemefuna,
Keying Li, Sanaullah Khan, and Ami Miller
4 Genetic Control of Complement Activation
in Humans and Age Related Macular Degeneration ........................... 49
Laura A. Hecker and Albert O. Edwards
5 Bisretinoids of RPE Lipofuscin: Trigger for Complement
Activation in Age-Related Macular Degeneration ............................... 63
Janet R. Sparrow
6 The Role of the Classical Complement Cascade in Synapse
Loss During Development and Glaucoma ............................................ 75
Allison M. Rosen and Beth Stevens
7 A Role for Complement in Glaucoma? ................................................. 95
Lizhen Ren and John Danias
8 The ATP-Binding Cassette Transporter ABCA4: Structural and
Functional Properties and Role in Retinal Disease .............................. 105
Yaroslav Tsybovsky, Robert S. Molday, and Krzysztof Palczewski
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9 Suppression of Drusen Formation by Compstatin, a Peptide
Inhibitor of Complement C3 activation, on Cynomolgus
Monkey with Early-Onset Macular Degeneration ............................... 127
Zai-Long Chi, Tsunehiko Yoshida, John D. Lambris,
and Takeshi Iwata
10 A Targeted Inhibitor of the Complement Alternative Pathway
Reduces RPE Injury and Angiogenesis in Models of Age-Related
Macular Degeneration ............................................................................ 137
Bärbel Rohrer, Qin Long, Beth Coughlin, Brandon Renner,
Yuxiang Huang, Kannan Kunchithapautham, Viviana P. Ferreira,
Michael K. Pangburn, Gary S. Gilkeson, Joshua M. Thurman,
Stephen Tomlinson, and V. Michael Holers
11 Complement Depletion with Humanized Cobra
Venom Factor in a Mouse Model of Age-Related
Macular Degeneration ............................................................................ 151
David C. Fritzinger, Robin Dean, Carol Meschter,
Katina Wong, Roman Halter, Jürgen Borlak, William D. St. John,
and Carl-Wilhelm Vogel
Index ................................................................................................................. 163
Contributors
Anthony P. Adamis
Department of Ophthalmology and Visual Sciences
University of Illinois at Chicago, Illinois, USA
Jürgen Borlak
Center for Biomedical and Biotechnology, Fraunhofer Institute for Toxicology
and Experimental Medicine, 30625, Hannover, Germany
Zai-Long Chi
Division of Molecular & Cellular Biology, National Institute of Sensory Organs,
National Hospital Organization Tokyo Medical Center, Tokyo, Japan
[email protected]
Beth Coughlin
Department of Neuroscience, Medical University of South Carolina,
Charleston SC, USA
[email protected]
John Danias
Departments of Cell Biology and Ophthalmology, SUNY Downstate
Medical center NY, 450 Clarkson Ave, Box #5, Brooklyn, NY 11203, USA
[email protected]
Robin Dean
Comparative Biosciences Inc, Sunnyvale CA, 94085, USA
Albert O. Edwards
Institute for Molecular Biology, University of Oregon, Eugene OR, 97403, USA
[email protected]
Viviana P. Ferreira
Department of Biochemistry, University of Texas Health Sciences Center,
Tyler TX, USA
[email protected]
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