Table Of ContentImmunology
Lecture Notes
Immunology
Lecture Notes
Ian Todd
MA, PhD, FHEA
Associate Professor and Reader in Cellular Immunopathology
University of Nottingham
School of Life Sciences
Queen’s Medical Centre
Nottingham
Gavin Spickett
MA, LLM DPhil, BM BCh, FRCPath, FRCP, FRCPE
Consultant and Senior Lecturer in Clinical Immunology
Royal Victoria Infirmary
Newcastle upon Tyne
Lucy Fairclough
BSc, MSc, PhD
Assistant Professor in Immunology
University of Nottingham
School of Life Sciences
Queen’s Medical Centre
Nottingham
Seventh Edition
This edition first published 2010 © 2015 by John Wiley & Sons, Ltd
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1 2015
Contents
Preface to the seventh edition, vii
From the preface to the first edition, viii
Key to symbols used in this edition, ix
Overview of the immune system, x
Part 1 Immunity and the Immune System
1 The nature of immunity, 3
2 Immune recognition, 14
3 Lymphocyte development and activation, 34
4 Lymphocyte interactions, cytokines and the lymphoid system, 45
5 Immunoglobulins, 63
6 Complement, 79
7 Phagocytes, 87
8 Mast cells, basophils and eosinophils, 94
9 Killer cells, 101
Part 2 Immunopathology
10 Immunity and infection, 111
11 Primary and secondary immunodeficiency
disorders, 126
12 The generation of tissue‐damaging responses, 148
13 Mechanisms of immunological tissue damage, 167
14 Lymphoproliferative disease, 179
15 Transplantation, 191
16 Immunological therapy, 203
Part 3 Self-assessment: answers
Self-assessment: answers, 215
Index, 221
Preface to the seventh
edition
The first edition of Lecture Notes: Immunology that New features of this seventh edition have been intro-
was published in 1987 was conceived and written by duced to help maximize the reader’s acquisition of
Professor Gordon Reeves to provide an introduction knowledge and understanding from the text. Clinical
to immunology and show its relevance to students of Case Scenarios have been introduced throughout to
medicine and biology in a straightforward and com- give clinical contextualisation of important immuno-
prehensible way, avoiding unnecessary detail and logical principles and to illustrate the scientific basis of
jargon. These principles have been maintained in clinical understanding and reasoning. The introduc-
successive editions, whilst updating the text to take tory chapter has been substantially revised and the
account of advances that clarify understanding of the sections on clinically relevant immunological methods
immune system and the application of this knowl- in Chapters 4 and 5 have been completely updated.
edge to medicine. These criteria have also been The content has been revised throughout to incorpo-
applied in formulating this seventh edition of Lecture rate important new knowledge and concepts that aid
Notes: Immunology. basic understanding of the immune system and immu-
This is the first edition of Lecture Notes: Immunology nopathology. More detail has been added to many of
to be published with full colour illustrations. We have the answers to the self‐assessment questions so that
taken advantage of this by including photographs of readers can more fully appreciate why their own
important clinical features of a number of immuno- answers are right (or wrong!). We hope that all of these
pathological conditions. We have also incorporated new features will make the reading of this book both
high quality molecular graphic images of key mole- more informative and more enjoyable.
cules of the immune system (antibodies, T‐cell recep-
tors and HLA proteins); we are especially grateful Ian Todd
to our colleague, Dr Paddy Tighe (University of Gavin Spickett
Nottingham) for producing these molecular images. Lucy Fairclough
From the preface to the
first edition
The undergraduate student meeting immunology This text is based on the teaching modules developed
during a busy medical or biological sciences curricu- in the Nottingham Medical School which have been
lum or the qualified doctor attempting to get to grips designed to provide sufficient grounding to enable
with the subject for specialist training is often students to comprehend and utilize developments in
daunted by what appears to be an opaque wall of immunology in their practice of medicine. Students
mystifying jargon surrounding a mass of intricate often feel more comfortable with the detail when they
information. The aim of Lecture Notes on Immunology have glimpsed the whole and for this reason the initial
is to provide a concise statement covering the basic chapter outlines the salient features of immunity. These
facts and concepts that are essential for a first under- are also summarized in an ‘overview of the immune
standing of the subject and its relevance to medicine system’ presented as the frontispiece. Many of these
and allied disciplines. Nomenclature has been thoughts have been stimulated by the, often penetrating,
simplified and appropriately defined and the major questions of first‐year students as well as the more clini-
principles introduced in a biological setting. Figures cally informed enquiries of medical graduates and I
and tables are used to summarize or highlight impor- hope that this text will assist the questioning process.
tant information, and key words are emphasized in
the text in bold type. Gordon Reeves
