Table Of ContentHypothalamus and
Endocrine Functions
CURRENT TOPICS IN MOLECULAR ENDOCRINOLOGY
Series Editors: Bert W. O'Malley and Anthony R. Means
Department of Cell Biology
Baylor College of Medicine
Houston, Texas
Volume 1: Hormone Binding and Target Cell Activation in the Testis
Edited by Maria L. Dufau and Anthony R. Means
Volume 2: Hormonal Regulation of Spermatogenesis
Edited by Frank S. French, Vidar Hansson,
E. Martin Ritzen, and Shihadeh N. Nayfeh
Volume 3: Hypothalamus and Endocrine Functions
Edited by Fernand Labrie, Joseph Meites,
and Georges Pelletier
A Continuation Order Plan is available for this series. A continuation order will bring
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Hypothalamus and
Endocrine Functions
Edited by
Fernand Labrie
Centre Hospitalier de l'Universite Laval
Quebec, Canada
Joseph Meites
Michigan State University
East Lansing, Michigan
and
Georges Pelletier
Centre Hospitalier de l'Universite Laval
Quebec, Canada
PLENUM PRESS, NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
International Symposium on Hypothalamus and Endocrine Functions, Quebec, 1975.
Hypothalamus and endocrine functions.
(Current topics in molecular endocrinology; v. 3)
Includes bibliographies and index.
I. Hypothalamic hormones-Congresses. I. Labrie, Fernard, 1937- II. Meites,
Joseph, 1913- III. Pelletier, Georges, 1939- IV. Title V. Series. [DNLM:
1. Hypothalamus-Physiology-Congresses. 2. Pituitary hormone releasing factors
Congresses. WI CU82M v. 3/WL312 I594h 1975]
QP572.H9I58 1975 599'.01 '927 76-13912
ISBN-I 3 : 978-1-4684-2600-7 e-ISBN-13: 978-1-4684-2598-7
DOl: 10.1007/978-1-4684-2598-7
Proceedings of the International Symposium on Hypothalamus and
Endocrine Functions held in Quebec City, September 21-24, 1975
© 1976 Plenum Press, New York
Softcover reprint of the hardcover 1st edition 1976
A Division of Plenum Publishing Corporation
227 West 17th Street, New York, N.Y. 10011
United Kingdom edition published by Plenum Press, London
A Division of Plenum Publishing Company, Ltd.
Davis House (4th Floor), 8 Scrubs Lane, Hariesden, London, NWI0 6SE, England
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted,
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Preface
Although physiological and anatomical evidence had
clearly indicated for many years that the secretion of
anterior pituitary hormones is under control by the
central nervous system, it is only recently that the
isolation and determination of structure of three hypo
thalamic hypophysiotropic hormones have been accomplished.
This has brought the concept of neurohormonal control
of adenohypophyseal function into precise biochemical
and chemical terms. The relative ease of synthesis of
TRH (thyrotropin-releasing hormone), LH-RH (luteinizing
hormone-releasing hormone), somatostatin and their
analogues has opened a new era in the field of endocri
nology and has led to a rapid expansion of our knowled-
ge of the control of anterior pituitary function.
The rapid evolution of fundamental and clinical
research on hypothalamic hormones and the many potential
clinical applications indicate the importance of inte
grating the knowledge gained in recent years. This is
well illustrated in the Proceedings of the International
Symposium on Hypothalamus and Endocrine Functions held
in Quebec City on September 21-24th, 1975, which indi
cates that impressive progress has been made in large
variety of aspects of hypothalamic hormone research. In
fact, attempts were made to review the recent achieve
ments in the localization of hypothalamic hormones using
immunohistochemical methods, chemistry and assays of hy
pothalamic hormones, control of hypothalamic hormone se
cretion by neurotransmitters, prostaglandins and cyclic
nucleotides, mechanisms of action of hypothalamic hormo
nes, clinical studies with TRH, LH-RH and somatostatin,
effect of somatostatin on glucagon and insulin secre
tion, control of growth hormone and prolactin secretion,
and mechanisms of steroid feedback on gonadotropin se
cretion in laboratory animal and man.
v
PREFACE
Although many important aspects of the current re
search in neuroendocrinology were not discussed at this
Symposium, the text of the main lectures as well as the
abstracts of poster sessions contained in this book should
offer a useful and stimulating review of the current
trends of investigation in this fast-moving field.
Fernand Labrie
Joseph Meites
Georges Pelletier
Preface ....•...••••...•.......•...•.......•...........•.. 1
F. Labrie, J. Meites and G. Pelletier
CONTROL OF HYPOTHALAMIC HORMONE SECRETION
Relation of the Hypothalamo-Pituitary-Gonadal System to
Decline of Reproductive Functions in Aging Female
Rats ..•.•.•...•..................•..•......•....... 3
J. Meites, H.H. Huang and G.D. Riegle
Role of Prostaglandins (PGs) in the Control of Adenohy
pophyseal Hormone Secretion .•.••.•....•.....•.•..•• 21
S.M. McCann, S.R. Ojeda, P.G. Harms, J.E. Wheaton,
D.K. Sundberg and G.P. Fawcett
Adrenergic and Cholinergic Inputs to the Amygdala: Role
ln Gonadotropin Secretion ...............•....••.... 37
J. Borrell, F. Piva and L. Martini
Neurotransmitters and Control of Pituitary Function •..•. 51
C. Kordon, M. Hery and A. Enjalbert
viii CONTENTS
CLINICAL APPLICATIONS OF LH-RH and TRH
Studies on the Diagnostic Use of LH-RH •••..•....•.••..•.
J.G. Rochefort, A. Chapdelaine, G. Tolis and J.
Van Campenhout
Diagnostic and Therapeutic Use of LH-RH in the Infertile
Man .••.•...••..••.••..••..•.•..••••......•.•••.•... 73
L. Schwarzstein
Therapeutic Use of Luteinizing Hormone-Releasing Hormone
in the Human Female ..•••.....••.•.••..••...•...•.•• 93
S.J. Ni11ius
SOMATOSTATIN
Clinical Implications of Growth Hormone Release-Inhibit-
ing Hormone (GH-RIH) ......•...••••...••..•••....•. 115
G.M. Besser
Somatostatin and the Endocrine Pancreas................. 127
J.E. Gerich
MECHANISM OF ACTION OF HYPOTHALAMIC HORMONES
AND STEROID FEEDBACK
New Aspects of the Mechanism of Action of Hypothalamic
Regulatory Hormones................................ 147
F. Labrie, A. De Lean, N. Barden, L. Ferland, J.
Drouin, P. Borgeat, M. Beaulieu and O. Morin
CONTENTS ix
Steroid Binding In the Hypothalamus and Pituitary....... 171
J.-P. Raynaud, M.-M. Bouton, D. Philibert and
B. Vannier
Role of Sex Steroids on LH and FSH secretion In the Rat. • 191
L. Ferland, J. Drouin and F. Labrie
The Role of Estradiol in Modulating LH and FSH Response 211
to Gonadotropin Releasing Hormone ................. .
R.B. Jaffe, W.R. Keye, Jr. and J.R. Young
CONTROL OF PRL AND GH SECRETION AND ACTION
Control of Prolactin Secretion in Man.................... 257
H.G. Bohnet and H.G. Friesen
Neuropharmacological Aspects of the Neural Control of 283
Prolactin Secretion ........... .......•.............
J.A. Clemens
Episodic GH Secretion: Evidence for a Hypothalamic Dopa- 303
minergic Mechanism .......................•.........
J.O. Willoughby and J.B. Martin
Hormonal Control of Liver Prolactin Receptors.. .......... 321
P.A. Kelly, L. Ferland, F. Labrie and A. De Lean
x CONTENTS
CHEMISTRY AND ASSAY OF HYPOTHALAMIC HORMONES
Suppression of Gonadotropin Release and Ovulation in
Animals by Inhibitory Analogs of Luteinizing
Hormone-Releasing Hormone ••••.•..•...••.....•..... 339
D.H. Coy, E.J. Coy, J.A. Vilchez-Martinez, A. de
la Cruz, A. Arimura and A.V. Schally
Isolation and Characterization of Hypothalamic Peptide
Hormones •.••.••......•...•••..••....••..•...••••• 355
R. Burgus, M. Amoss, P. Brazeau, M. Brown,
N. Ling, C. Rivier, J. Rivier, W. Vale
and J. Villarreal
Analogs of Somatostatin Part A. Chemistry and In vi-
tro Results ...••..•.......••.•.•.••.•......••.•.. 373
H. Immer, N.A. Abraham, V. Nelson, K. Sestanj, M.
G8tz, P. Brazeau and J.B. Martin
Part B. In Vivo Activities:
Prolongation of Action with Protamine Zinc ..... . 379
P. Brazeau and J.B. Martin
In Vivo Methods for Studying the Action of Hypothalamic
Hormones with Special Reference to their Antisera
as Tools for Investigation ...••..••.....••.••..••.
A. Arimura
Applications of Adenohypophyseal Cell Cultures to Neuro-
endocrine Studies.................................. 397
W. Vale, C. Rivier, M. Brown, L. Chan, N. Ling and
J. Rivier
