Hepatology at a Glance

128 Pages·2015·35.3 MB·English

by  Deepak Joshi

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Hepatology
at a Glance
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Hepatology
at a Glance
Deepak Joshi
Consultant Hepatologist
King’s College Hospital
London, UK
Geri Keane
Clinical Research Fellow
Institute for Liver and Digestive Health
University College London
London, UK
Alison Brind
Consultant Gastroenterologist with interest in
Hepatology
University Hospital of North Midlands,
Stoke on Trent, UK
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Library of Congress Cataloging‐in‐Publication Data
Joshi, Deepak, author.
Hepatology at a glance / Deepak Joshi, Geri Keane, Alison Brind.
p. ; cm.
Includes index.
ISBN 978-1-118-75939-4 (pbk.)
I. Keane, Margaret G. (Margaret Geraldine), author. II. Brind, Alison, author. III. Title.
[DNLM: 1. Liver Diseases. WI 700]
RC845
616.3′62–dc23
2014040281
A catalogue record for this book is available from the British Library.
Wiley also publishes its books in a variety of electronic formats. Some content that appears in print
may not be available in electronic books.
Cover image: iStock/ © Eraxion
Set in 9.5/11.5pt Minion by SPi Publisher Services, Pondicherry, India
1 2015
Contents
Preface vii
Acknowledgements viii
List of abbreviations ix
How to use your revision guide xii
Part 1 Basics 1
1 Liver and biliary anatomy and structure 2
2 Liver metabolism and function 4
3 Coagulation in liver disease 6
4 Liver fibrosis 8
Part 2 Evaluation of liver disease 11
5 Clinical history 12
6 Liver examination 14
7 Liver function tests 16
8 Radiology in liver disease 18
9 Liver biopsy 20
10 Non‐invasive markers of fibrosis 22
Part 3 Clinical scenarios 25
11 Asymptomatic abnormal LFTs 26
12 Jaundice 28
13 Portal hypertension 30
14 Variceal bleeding 32
15 Ascites 34
16 Management of complications of ascites 36
17 Renal dysfunction in cirrhosis 38
18 Cardiopulmonary complications 40
19 Hepatic encephalopathy 42
20 Acute liver failure 44
21 Liver disease in pregnancy 46
22 Indications for liver transplantation 48
23 Drug‐induced liver injury 50
24 Focal liver lesions 52
Part 4 Diseases 55
25 Alcohol‐related liver disease 56
26 Management of alcohol misuse 58
27 Fatty liver disease 60
28 Hepatitis A and hepatitis E viruses 62
29 Hepatitis B virus and delta hepatitis 64
v
30 Hepatitis C virus 67
31 Autoimmune hepatitis 70
32 Primary biliary cirrhosis 72
33 Sclerosing cholangiopathies 74
34 Overlap syndromes 76
35 Haemochromatosis and iron overload 78
36 Wilson’s disease 80
37 Metabolic disorders 82
38 Multisystemic diseases 84
39 Vascular disorders 86
40 Hepatocellular carcinoma 88
41 Cholangiocarcinoma 90
42 Surgical procedures 92
43 Biliary disorders 94
44 Pancreatic disorders 96
45 Post‐liver transplantation: general considerations 98
46 Post‐liver transplantation: disease recurrence 100
47 Tropical liver disease: parenchymal 102
48 Tropical liver disease: hepatobiliary 104
49 Nutrition and liver disease 106
Further reading 108
Index 109
vi
Preface
Hepatology is a rapidly growing specialty with increasing self‐assessment MCQs are designed as a single best response in keep­
emphasis within the medical curriculum requiring an ‘at a ing with the specialty certificate examination in gastroenterology.
Glance’ of its own. We have integrated core principles of basic The publishers of ‘at Glance’ approached the education com­
science, pathophysiology, treatments and management algorithms mittee of the British Society of Gastroenterology (BSG) who
into a single easy‐to‐use text. As such, it can be used by medical selected the authors. We should like to thank the BSG for their
students throughout their training, junior doctors entering the support and the opportunity to contribute to the literature with
field of hepatology and also by allied health care professionals with this innovative publication. In addition, we would like to thank all
an interest in hepatology. our colleagues who took the time to review each chapter and
As with other at a Glance publications, Hepatology at a Glance ensure the content was of the highest standard. We also thank the
is based around a two‐page spread for each main topic, with colour staff at Wiley Blackwell, without whom we would not have been
figures and text complementing each other to give an overview of able to produce this new and exciting first edition.
a topic. Case studies based on some of the most commonly encoun­
tered presentations in hepatology are included. The book covers Deepak Joshi
all the core elements of hepatology and its major diseases; fur­ Geri Keane
ther reading suggestions are included for more in‐depth study. The Alison Brind
vii
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