Table Of ContentProgress in Inflammation Research
Series Editor
Prof. Dr. Michael J. Parnham
Senior Scientific Advisor
PLiVA dd
Prilaz baruna Filipovica 25
HR-10000 Zagreb
Croatia
Advisory Board
G. Z. Feuerstein (Merck Research Laboratories, West Point, PA, USA
M. Pairet (Boehringer Ingelheim Pharma KG, Biberach a. d. Riss, Germany)
W. van Eden (Universiteit Utrecht, Utrecht, The Netherlands)
Forthcoming titles:
Pharmacotherapy of Gastrointestinallnflammation, A. Guglietta (Editor), 2003
Arachidonate Remodeling and Inflammation, A.N. Fonteh, R.L. Wykle (Editor), 2003
Inflammatory Processes and Cancer,
D.W. Morgan, M. Nakada, U. Forssmann (Editors), 2003
Recent Advances in Pathophysiology of COPD, T.T. Hansel, P.J. Barnes (Editors), 2003
Anti-Inflammatory or Anti-Rheumatic Drugs,
R.O. Day, D.E. Furst, P.L.C.M. van Riel (Editors), 2004
Cytokines and Joint Injury, P. Miossec, W.B. van den Berg (Editors), 2004
Antibiotics as Immunomodulatory Agents, B. Rubin, J. Tamaoki (Editors), 2004
(Already published titles see last page.)
Heat Shock Proteins and Inflammation
w.
van Eden
Editor
Springer Basel AG
Editor
Willem van Eden
Division of Immunology
Department of Infectious Diseases and Immunology
Faculty of Veterinary Medicine
University of Utrecht
Yalelaan 1
3584CL Utrecht
The Netherlands
Library of Congress Cataloging-in-Publication Data
Heat shock proteins and inflammation / W. van Eden, editor.
p. cm. --(progress in inflammation research)
Includes bibliographical references and index.
ISBN 978-3-0348-9410-4 ISBN 978-3-0348-8028-2 (eBook)
DOI 10.1007/978-3-0348-8028-2
1. Heat shock proteins. 2. Inflammation--Mediators. 1. Eden, Willem van, 1953-II. PIR (Series)
QP552.H43H4272003
616' .0473--dc22 2003052375
Bibliographic information published by Die Deutsche Bibliothek
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The use of registered names, trademarks etc. in this publication, even if not identified as such, does not imply that
they are exempt from the relevant protective laws and regulations or free for general use.
ISBN 978-3-0348-9410-4
This work is subject to copyright. AII rights are reserved, whether the whole or part of the material is concerned,
specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on micro
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be obtained.
© 2003 Springer Basel AG
Originally published by Birkhăuser Verlag in 2003
Softcover reprint of the hardcover 1s t edilion 2003
Printed on acid-free paper produced from chlorine-free pulp. TCF =
Cover design: Markus Etterich, Basel
Cover illuslralion: Expression of HSP60 in a rejected human allograft with cytoplasmic immunoreactivity in the tubular
epithelium, glomerulas and blood vessels (see page 225.)
ISBN 978-3-0348-9410-4
987654321 www.birkhăuser-science.com
Contents
List of contributors vii
Preface xiii
Irun R. Cohen, Francisco 1. Quintana, Gabriel Nussbaum,
Michal Cohen, Alexandra lanin-lhorov and Ofer Lider
HSP60 and the regulation of inflammation: Physiological and pathological 1
Willem van Eden, Liesbeth Paul and Ruurd van der lee
Heat shock proteins and suppression of inflammation 15
Sreyashi Basu and Pramod Srivastava
Heat shock proteins in immune response 33
Clarissa U. I. Prazeres da Costa, Hermann Wagner
and Thomas C. Miethke
Heat shock protein-mediated activation of innate immune cells 43
Arne von Bonin, Minka Breloer and Solveig H. More
Eukaryotic HSP60: A "danger signal" for T- and natural killer cells. 55
Rebecca 1. Brownlie and Stephen 1. Thompson
Heat shock proteins and experimental arthritis 69
1. S. Hill Gaston, Richard C. Dugg/eby, Jane C. Goodall,
Roberto Raggiaschi and Mark S. Lillicrap
Heat shock proteins and reactive arthritis ............ . 83
Isme M. de Kleer, Berent P. Prakken, Salvatore Albani and Wietse Kuis
The development of immune therapy with HSP60 for juvenile
idiopathic arthritis 97
Contents
Gabriel S. Panayi and Valerie M. Corrigall
Heat shock proteins and rheumatoid arthritis 109
Gisella L. Puga Yung, Tho D. Le, Sarah Roord, Berent P. Prakken
and Salvatore Albani
Heat shock proteins for immunotherapy of rheumatoid arthritis 139
Michael Knoflach, Bruno Mayrl, Mahavir Singh and Georg Wick
Immunity to heat shock proteins and atherosclerosis 159
Brian Henderson
Chaperonins: Chameleon proteins that influence myeloid cells 175
Thomas Lehner, Yufei Wang and Charles Kelly
Heat shock protein receptors, functions and their effect
on monocytes and dendritic cells 193
Klemens Trieb
Heat shock protein expression in transplanted kidney 217
Ad P. Koets
Mycobacterial heat shock proteins and the bovine immune system 233
Johannes M. van Noort
Microbial infection generates pro-inflammatory autoimmunity against
the small heat shock protein alpha B-crystallin and provides the fuel
for the development of multiple sclerosis . . . . . . . . . . . . . . . . .2 . 4. 5 . . .
Kalle Soderstrom
HSP60-peptide interference with CD94/NKG2 receptors ........... . 257
Index 273
vi
List of contributors
Salvatore Albani, Departments of Medicine and Pediatrics, University of California
San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0663, USA; e-mail:
[email protected]; Androclus Therapeutics, 4204 Sorrento Valley Blvd., Ste A-C,
San Diego, CA 92121, USA; and IACOPO Institute for Translational Medicine,
9500 Gilman Drive, La Jolla, CA 92093-0663, USA
Sreyashi Basu, Center for Immunotherapy of Cancer and Infectious Diseases, Uni
versity of Connecticut School of Medicine, MC1601, Farmington, CT 06030-1601,
USA; e-mail: [email protected]
Minka Breloer, Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht
str. 74, D-20359 Hamburg, Germany; e-mail: [email protected]
Rebecca J. Brownlie, Department of Life Sciences, King's College London, Franklin
Wilkins Building, 150 Stamford Street, London SEI 9NN, UK;
e-mail: [email protected]. uk
Irun R. Cohen, Department of Immunology, The Weizmann Institute of Science,
Rehovot, 76100; Israel; e-mail: [email protected]
Michal Cohen, Department of Immunology, The Weizmann Institute of Science,
Rehovot, 76100; Israel; e-mail: [email protected]
Valerie M. Corrigall, Department of Rheumatology, GKT School of Medicine,
King's College London, Guy's Hospital, London SEI 9RT, UK;
e-mail: [email protected]
Clarissa U.I. Prazeres da Costa, Institute for Medical Microbiology, Immunology
and Hygiene, Technical University of Munich, Trogerstr. 9, D-81675 Munich, Ger
many; e-mail: [email protected]
vii
List of contributors
Isme M. de Kleer, University Medical Center Utrecht, Wilhelmina Children's Hos
pital, Department of Pediatric Immunology, P.O. Box 85090, NL-3508 AB Utrecht,
The Netherlands; e-mail: [email protected]
Richard C. Duggleby, Department of Medicine, University of Cambridge School of
Clinical Medicine, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge CB2
2QQ, UK; e-mail: [email protected]
].S. Hill Gaston, Department of Medicine, University of Cambridge School of Clin
ical Medicine, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge CB2
2QQ, UK; e-mail: [email protected]
Jane C. Goodall, Department of Medicine, University of Cambridge School of Clin
ical Medicine, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge CB2
2QQ, UK; e-mail: [email protected]
Brian Henderson, Cellular Microbiology Research Group, Eastman Dental Institute,
University College London, 256 Gray's Inn Road, London WC1X 8LD, UK;
e-mail: [email protected]. uk
Charles Kelly, Department of Oral Medicine and Pathology; Guy's, King's & St.
Thomas' Medical Schools, King's College, London SEl 9RT, UK;
e-mail: [email protected]
Michael Knoflach, Institute of Pathophysiology, University of Innsbruck, Medical
School, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria;
e-mail: [email protected]
Ad P. Koets, Department of Farm Animal Health and Division of Immunology,
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medi
cine, Utrecht University, P.O. Box 80.165, NL-3508 TD Utrecht, The Netherlands;
e-mail: [email protected]
Wietse Kuis, University Medical Center Utrecht, Wilhelmina Children's Hospital,
Department of Pediatric Immunology, P.O. Box 85090, NL-3508 AB Utrecht, The
Netherlands; e-mail: [email protected]
Tho D. Le, Departments of Medicine and Pediatrics, University of California San
Diego, 9500 Gilman Drive, La Jolla, CA 92093-0663, USA;
e-mail: [email protected]
viii
List of contributors
Thomas Lehner, Department of Immunobiology; Guy's, King's & St. Thomas' Med
ical Schools, King's College, London SEl 9RT, UK; e-mail: [email protected]
Ofer Lider, Department of Immunology, The Weizmann Institute of Science,
Rehovot, 76100, Israel; e-mail: [email protected]
Mark S. Lillicrap, Department of Medicine, University of Cambridge School of
Clinical Medicine, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge CB2
2QQ, UK
Bruno Mayrl, Institute of Pathophysiology, University of Innsbruck, Medical
School, Fritz-Pregl-Str. 3, A-6020 Innsbruck, Austria
Thomas C. Miethke, Institute for Medical Microbiology, Immunology and Hygiene,
Technical University of Munich, Trogerstr. 9, D-81675 Munich, Germany;
e-mail: [email protected]
Solveig H. More, Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht
str. 74, D-20359 Hamburg, Germany; e-mail: [email protected]
Gabriel Nussbaum, Department of Immunology, The Weizmann Institute of Science,
Rehovot, 76100, Israel; e-mail: [email protected]
Gabriel S. Panayi, Department of Rheumatology, GKT School of Medicine, King's
College London, Guy's Hospital, London SEl 9RT, UK;
e-mail: [email protected]
Liesbeth Paul, Biomedical Primate Centre, Lange Kleiweg 139, NL-2288 GJ
Rijswijk, The Netherlands; e-mail: [email protected]
Berent P. Prakken, University Medical Center Utrecht, Wilhelmina Children's Hos
pital, Department of Pediatric Immunology, P.O. Box 85090, 3508 AB Utrecht, The
Netherlands; e-mail: [email protected]
Gisella L. Puga Yung, Departments of Medicine and Pediatrics, University of Cali
fornia San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0663, USA; e-mail: gpu
[email protected]; and Instituto de Ciencias Biomedicas (ICBM), Facultad de Med
icina Norte, Universidad de Chile, Av. Independencia 1027, Casilla 13898, Santia
go 653499, Chile
Francisco J. Quintana, Department of Immunology, The Weizmann Institute of Sci
ence, Rehovot, 76100, Israel; e-mail: [email protected]
ix
List of contributors
Roberto Raggiaschi, Department of Medicine, University of Cambridge School of
Clinical Medicine, Box 157, Addenbrooke's Hospital, Hills Road, Cambridge CB2
2QQ, UK
Sarah Roord, University Medical Center Utrecht, Wilhelmina Children's Hospital,
P.O. Box 85090, NL-3508 AB Utrecht, The Netherlands;
e-mail: [email protected]
Mahavir Singh, Lionex Diagnostics and Therapeutics GmbH, Mascheroder Weg IB,
D-38124 Braunschweig, Germany; e-mail: [email protected]
Kalle Soderstrom, In Silico R&D, Entelos Inc., 110 Marsh Drive, Foster City, CA
94404, USA; [email protected]
Pramod Srivastava, Center for Immunotherapy of Cancer and Infectious Diseases,
University of Connecticut School of Medicine, MC1601, Farmington, CT 06030-
1601, USA; e-mail: [email protected]
Stephen J. Thompson, Department of Life Sciences, King's College London,
Franklin-Wilkins Building, 150 Stamford Street, London SEI 9NN;
e-mail: [email protected]. uk
Klemens Trieb, Department of Orthopedics, University of Vienna, Wahringergurtel
18-20, A-I090 Vienna, Austria; e-mail: [email protected]
Ruurd van der Zee, Division of Immunology, Department of Infectious Diseases and
Immunology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 1,
3584CL Utrecht, The Netherlands; e-mail: [email protected]
Willem van Eden, Division of Immunology, Department of Infectious Diseases and
Immunology, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 1,
3584CL Utrecht, The Netherlands; e-mail: [email protected]
Johannes M. van Noort, Division of Immunological and Infectious Diseases, TNO
Prevention and Health, P.O. Box 2215, NL-2301 CE Leiden, The Netherlands;
e-mail: [email protected]
Arne von Bonin, Bernhard-Nocht-Institute for Tropical Medicine, Bernhard-Nocht
str. 74, D-20359 Hamburg, Germany; e-mail: [email protected]
x
