Table Of ContentGASTROINTESTINAL
AND LIVER PATHOLOGY
GASTROINTESTINAL
AND LIVER PATHOLOGY
A Volume in the Series
FOUNDATIONS IN DIAGNOSTIC PATHOLOGY
SECOND EDITION
ED I T E D BY
Christine A. Iacobuzio-Donahue, MD, PhD
Associate Professor of Pathology, Oncology, and Surgery
Johns Hopkins Medical Institutions
Department of Pathology
Division of Gastrointestinal and Liver Pathology
Baltimore, Maryland
Elizabeth Montgomery, MD
Professor of Pathology, Oncology, and Orthopedic Surgery
Johns Hopkins Medical Institutions
Department of Pathology
Division of Gastrointestinal and Liver Pathology
Baltimore, Maryland
S E R I E S E D I TO R
John R. Goldblum, MD, FCAP, FASCP, FACG
Chairman, Department of Anatomic Pathology
The Cleveland Clinic Foundation
Cleveland Clinic Lerner College of Medicine
Case Western Reserve University
Cleveland, Ohio
1600 John F. Kennedy Blvd.
Ste 1800
Philadelphia, PA 19103-2899
GASTROINTESTINAL AND LIVER PATHOLOGY, SECOND EDITION ISBN: 978-1-4377-0925-4
(A Volume in the Series Foundations in Diagnostic Pathology
Series edited by John R. Goldblum, MD)
Copyright 2012, 2005 by Saunders, an imprint of Elsevier Inc.
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ISBN: 978-1-4377-0925-4
Executive Publisher: William Schmitt
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Printed in China
Last digit is the print number: 9 8 7 6 5 4 3 2 1
To Tim—my husband, my best friend, my constant supporter,
and the most decent person I have ever known
—CID
To Sasha, Peter Alex, Sean, and Jonathan
—EM
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Contributors
Carol Adair, MD H. Parry Dilworth, MD
Pathology Residency Program Director Abbott Northwestern Laboratories
Baylor University Medical Center Minneapolis, Minnesota
Dallas, Texas Epithelial Neoplasms of the Stomach, Neoplasms of
Pathology of the Anus the Small Intestine, Gastrointestinal Lymphoma
Syed Z. Ali, MD Theresa S. Emory, MD
Professor, Departments of Pathology and Radiology Clinical Associate Professor
Johns Hopkins University School of Medicine Department of Pathology
Attending, Department of Pathology East Tennessee State University
Johns Hopkins Hospital Quillen College of Medicine
Baltimore, Maryland Johnson City, Tennessee
Non-Neoplastic and Neoplastic Pathology of the Highlands Pathology Consultants
Pancreas Bristol, Tennessee
Idiopathic Infammatory Bowel Disease
Pedram Argani, MD
Department of Pathology James R. Eshleman, MD, PhD
Johns Hopkins University School of Medicine Department of Pathology
Staff Pathologist Department of Oncology
Johns Hopkins Hospital Associate Director
Baltimore, Maryland Molecular Diagnostics Laboratory
Pathology of the Gallbladder and Extrahepatic Bile Johns Hopkins Medical Institutions
Ducts Baltimore, Maryland
Molecular Diagnostics in Gastrointestinal Pathology
David Baewer, MD, PhD
Department of Pathology Hubert H. Fenton, MD
Johns Hopkins Medical Institutions Mercy Hospital
Baltimore, Maryland Baltimore, Maryland
Pathology of the Anus Epithelial Neoplasms of the Stomach, Gastrointestinal
Lymphoma
Baishali Bhattacharya, MD, MPH
Surgical and Gastroenterology Pathologist Cyril Fisher, MD, DSc, FRCPath
Caris Life Sciences Professor of Tumor Pathology
Phoenix, Arizona Department of Histopathology
Non-Neoplastic Disorders of the Stomach Consultant Pathologist
Institute of Cancer Research
Toby C. Cornish, MD, PhD
Royal Marsden Hospital
Johns Hopkins Hospital
London, United Kingdom
Department of Surgical Pathology
Gastrointestinal Mesenchymal Tumors
Baltimore, Maryland
Neoplasms of the Small Intestine Baojin Fu, MD
Department of Pathology
Johns Hopkins Medical Institutions
Baltimore, Maryland
Non-Neoplastic Disorders of the Esophagus
vii
viii CONTRIBUTORS
Christopher D. Gocke, MD Marc R. Lewin, MD
Associate Professor of Pathology and Oncology Propath Dermatology
Director of Hematology Molecular Diagnostics Dallas, Texas
Johns Hopkins University School of Medicine Epithelial Neoplasms of the Stomach,
Baltimore, Maryland Gastrointestinal Lymphoma
Gastrointestinal Lymphoma
Elizabeth Montgomery, MD
Joel K. Greenson, MD Professor of Pathology, Oncology, and Orthopedic
Professor, Department of Pathology Surgery
University of Michigan Medical School Johns Hopkins Medical Institutions
Director, Surgical Pathology Fellowship Program Department of Pathology
Department of Pathology Division of Gastrointestinal and Liver Pathology
University of Michigan Health System Baltimore, Maryland
Ann Arbor, Michigan Tumors of the Esophagus, Non-Neoplastic and
Infammatory/Descriptive/Iatrogenic Colitides Infammatory Disorders of the Small Bowel,
Gastrointestinal Mesenchymal Tumors,
Ralph H. Hruban, MD
Non-Neoplastic and Neoplastic Disorders of the
Professor, Departments of Pathology and Oncology
Appendix
Johns Hopkins University School of Medicine
Pathologist, Department of Pathology Roger Klein Moreira, MD
Johns Hopkins Hospital Assistant Professor
Baltimore, Maryland Department of Pathology and Cell Biology
Non-Neoplastic and Neoplastic Pathology of the Columbia University College of Physicians
Pancreas and Surgeons
New York, New York
Christine A. Iacobuzio-Donahue, MD, PhD
Metabolic and Toxic Conditions of the Liver,
Associate Professor of Pathology, Oncology,
Infammatory and Infectious Diseases of the Liver,
and Surgery
Liver Neoplasms
Johns Hopkins Medical Institutions
Department of Pathology Shiyama Mudali, MD
Division of Gastrointestinal and Liver Pathology Department of Pathology
Baltimore, Maryland Johns Hopkins Medical Institutions
Non-Neoplastic and Infammatory Disorders of the Baltimore, Maryland
Small Bowel, Gastrointestinal Polyposis Syndromes, Gastrointestinal Lymphoma
Epithelial Neoplasms of the Colorectum
Thong Nguyen, DO
Dora M. Lam-Himlin, MD Associate Pathologist
Assistant Professor of Laboratory Medicine and Alegent Health System
Anatomic Pathology Omaha, Nebraska
Mayo Medical School Gastrointestinal Mesenchymal Tumors
Senior Associate Consultant in Gastrointestinal
Jason Y. Park, MD, PhD, FCAP
Pathology
Assistant Professor, Department of Pathology
Mayo Clinic Arizona
University of Texas Southwestern Medical Center
Scottsdale, Arizona
Associate Director
Non-Neoplastic and Neoplastic Disorders of the
Advanced Diagnostics Laboratory
Appendix
Children’s Medical Center
Laura W. Lamps, MD Dallas, Texas
Associate Professor of Pathology Epithelial Neoplasms of the Stomach
Director of Surgical Pathology
Department of Pathology
University of Arkansas for Medical Sciences
Little Rock, Arkansas
Infectious Diseases of the Colon
CONTRIBUTORS ix
M. Eugenia Rueda-Pedraza, MD, Col. USMC Michael Torbenson, MD
Clinical Assistant Professor Associate Professor of Pathology
Department of Pathology Department of Pathology
Uniformed Services University of the Health Sciences Johns Hopkins University School of Medicine
Bethesda, Maryland Baltimore, Maryland
Chief, Department of Pathology Non-Neoplastic and Neoplastic Disorders of the
Heidelberg Military Hospital Appendix
Heidelberg, Germany
Athanasios C. Tsiatis, MD
Non-Neoplastic Disorders of the Esophagus
Department of Pathology
Chanjuan Shi, MD, PhD Johns Hopkins Medical Institutions
Assistant Professor Baltimore, Maryland
Vanderbilt University Molecular Diagnostics in Gastrointestinal Pathology
Department of Pathology
Kay Washington, MD, PhD
Nashville, Tennessee
Professor, Department of Pathology
Non-Neoplastic and Infammatory Disorders of the
Vanderbilt University Medical Center
Small Bowel
Nashville, Tennessee
Leslie H. Sobin, MD Metabolic and Toxic Conditions of the Liver,
Department of Hepatic and Gastrointestinal Pathology Infammatory and Infectious Diseases of the Liver,
Armed Forces Institute of Pathology Liver Neoplasms
Washington, DC
Idiopathic Infammatory Bowel Disease
