Table Of ContentSandor L. Erda
(Ed.)
GABA
eNS
Outside the
With 73 Figures
Springer-Verlag
Berlin Heidelberg New York
London Paris Tokyo
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Budapest
Sandor L.Erdo, Ph.D.
Department of Anatomy
University of Gottingen
Kreuzbergring 36
W-3400 Gottingen, FRG
Proceedings of the International Symposium
on Peripheral GABAergic Mechanisms, Rome, July 19 - 21, 1990
ISBN-13: 978-3-642-76917-7 e-ISBN-13: 978-3-642-76915-3
DOl: 10.1007/978-3-642-76915-3
Library of Congress Cataloging-in-Publication Data. International Symposium on Peripheral GABAergic Me
chanisms (1990: Rome, Italy). GABA outside the CNS 1 Sandor L. Erda (ed.). p. em. "Proceedings ofthe In
ternational Symposium on Peripheral GABAergic Mechanisms, Rome, July 19-21, 1990" -T.p. verso. Includes
bibliographical references and index.
ISBN-13: 978-3-642-76917-7
1. GABA-Physiological effect-Congresses. 2. GABA-Receptors-Congresses. 3. Nerves, Peripheral-Congtesses.
1. Erda, Sandor L. II. Title. QP364.7.1595 1990 599'.019245-dc20 91-38963 CIP
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Acknowledgements
I am grateful for financial support from the following pharmaceutical and
chemical companies: Schering-Plough Ltd., Bloomfield, NJ, USA;
Ciba-Geigy, AG Basel, Switzerland; Bayer AG, Frankfurt, Germany; and
Research Biochemicals Inc., Natick, MA, USA. Without their generous
help it would have been impossible to hold this symposium. The excellent
secretarial assistance of Louise Muller is ~reatly appreciated.
Preface
The first comprehensive review of the possible role of y-aminobutyric acid
(GABA) outside the mammalian brain appeared 5 years ago!. Since that
time, a large body of new evidence has accumulated to suggest that GABA
may have a functional significance outside the central nervous system. The
recent important findings obtained using biochemical, pharmacological,
histochemical, physiological and other approaches made it necessary to
update, summarize, and resynthesize the knowledge of peripheral GABA
ergic mechanisms. These were the major goals of the International Sym
posium on Peripheral GABAergic Mechanisms held in Rome in July 1990.
Although this was a satellite symposium of the European Society for
Neurochemistry meeting, the participants, and thus the contributors to this
book, were also invited from overseas, from countries such as Australia,
Canada, Japan and the United States. The meeting thus took on an in
ternational, or even intercontinental, character.
This book will provide the reader with state-of-the-art knowledge of the
role of GABA in the mammalian periphery. Moreover, my hope is that the
volume will serve not only as a comprehensive source of timely informa
tion for the GABA specialist, but also as thought-provoking reading for
other life scientists with an interest in the biochemistry, physiology,
pharmacology, or even morphology of the neuronal and nonneuronal tissues
of mammals.
Now read on ... The Editor, 1991
I Erda SL, Bowery NG (eds) (1986) GABAergic Mechanisms in the Mammalian Periphery.
Raven, New York.
Contents
GADA in the Peripheral Nervous System
The Role of GABA in the Peripheral NelVous System
C. Tanaka and K. Taniyama .........•................... 3
GABAergic Neurons in the Myenteric Plexus
K.R. Jessen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
GABA and Gut Motility
D.I.B. Kerr and J. Ong ................................. 29
The GABAergic InnelVation of Paravertebral Sympathetic Ganglia
1.R. Wolff, P. Kasa, E. DoM, A Piirducz, and F. 106 ........... 45
L-Glutamate Decarboxylase Immunoreactivity
in the Sympathoadrenal System
O. HappaUi, T. Karhula, H. Paivarinta, S. Soinila,
J.-Y. Wu, and M. Ahonen ............................... 65
GABAergic Action on Cholinergic Axon Terminals
in the Superior Cervical Ganglion
P. Kasa, E. DoM, and J.R. Wolff ......................... 83
GADA in Non-Neural Tissues
Non-Neuronal GABA Systems: An Overview
S.L. Erda .......................................... 97
GABA and Endocrine Cells of the Gastro-entero-pancreatic System:
A Review
P. Gilon and C. Remacle .............................. 111
GABA and Diamine Oxidase Activity in the
Gastrointestinal Mucosa: Possible links
W.A. Fogel and S.L. Erda ............................. 133
GABA and the liver: The First 40 Years
G.Y. Minuk ....................................... 143
VIII Contents
GABA-Immunoreactive Structures in Rat Kidney
E. Dob6, A Parducz, J.R. Wolff, and S.L. Erda .............. 155
GABAergic Mechanisms in Bovine Adrenal Chromaffin Cells:
Their Role in the Regulation of Catecholamine Secretion
M.J. Oset-Gasque, E. Castro, and M.P. Gonzalez ............. 167
The GABAergic System in Human Female Genital Organs
A Laszl6, G.L. Nadasy, E. Monos, B. Zsolnai, and S.L. Erda .... 183
Neurotransmitter Amino Acids as Modulators
of Biological Processes of Spermatozoa
H.K. Boldizsar, L. Wekerle, E. V~n, P. Sarl6s, and J. Barna ...... 199
Pharmacology and GADA Receptors
GABA Receptors Inside and Outside the Brain
N.G. Bowery ....................................... 215
Autoradiographic Localization of Peripheral GABA Receptors
A
W.L. Collier, M. Carlesimo, P. Napoleone, and F. Amenta ....... 233
The GABAs Receptor Profile of a Series of Phosphinic Acids:
Agonist and Antagonist Activity in a Range of Peripheral Tissues
J.M. Hills and W. Howson ..... 249
0 •••••• 0 •••• 0 •• 0000. 0 •••
GABAergic Mechanisms and Cardiovascular Function
K. Taniyama, N. Saito, S. Matsuyama, K. Takeda, and C. Tanaka .. 261
GABAergic Mechanisms in the Pulmonary System
R.W. Chapman, JoA. Hey, D.C. Bolser, C.A. Rizzo, R.W. Egan,
and W. Kreutner ................. 269
0 ••• 0 •••••• 0 •••••••
GABAergic Mechanisms and Modulation
of the Anaphylactic Response
L. Zilletti, M. Ciuffi, S. Franchi-Micheli, and G. Gentilini ...... 277
0
Subject Index . 295
0 •••• 0 0 ••• 0 0 0 •• 0 ••• 0 ••••••• 0 0 ••• 0 ••• 0
list of Contributors
M. Ahonen
Department of Anatomy and Neurobiological Research Unit,
University of Helsinki, Helsinki, Finland
F. Amenta
Dipartimento Di Scienze Neurologiche, Universita "La Sapienza",
Via A. Borelli 50, 1-00161 Rome, Italy
J. Barna
Research Centre for Animal HuSbandry, H-2053 Herceghalom, Hungary
H.K. Boldizsar
Department of Physiology and Biochemistry, University of Veterinary
Science, P. O. Box 2, H-14oo Budapest, Hungary
D.C. Bolser
Department of Allergy and Immunology, Schering-Plough Research
60 Orange Street, Bloomfield, NJ 07003, USA
N.G. Bowery
Department of PharmaCOlogy, School of Pharmacy, University of London,
29/39 Brunswick Square, London WC1N lAX, UK
M. Broekman
Smith Kline Beecham Pharmaceuticals, The Fry the, Welwyn, AL6 9AR, UK
E. Castro
Instituto de Bioquimica, Centro mixto c.S.I.C.-U.C.M.,
Facultad de Farmacia, Ciudad Universitaria, E-28040 Madrid, Spain
M. Carlesimo
Dipartimento Di Scienze Neurologiche, Universita "La Sapienza",
Via A. Borelli 50, 1-00161 Rome, Italy
R.W. Chapman
Department of Allergy and Immunology, Schering-Plough Research,
60 Orange Street, Bloomfield, NJ 07003, USA
X List of Contri butors
M. Ciuffi
Department of Preclinical and Qinical Pharmacology, "Mario Aiazzi
Mancini", University of Florence, Viale G.B. Morgagni 65, 1-50134
Florence, Italy
W.L. Collier
Dipartimento Di Scienze Neurologiche, Universita "La Sapienza",
Via A. Borelli 50, 1-00161 Rome, Italy
E. Dob6
Central Research Laboratory, Albert-Szentgyorgyi University,
H-6720 Szeged, Hungary
R.W. Egan
Department of Allergy and Immunology, SChering-Plough Research,
60 Orange Street, Bloomfield, NJ 07003, USA
S.L. Erdo
Department of Anatomy, Georg-August-University, Kreuzbergring 36,
W-3400 Gottingen, FRG
W.A. Fogel
Department of Biogenic Amines, Polish Academy of Sciences, Tylna 3,
P.O. Box 225, PL-90-950 Lodz 1, Poland
S. Franchi-Micheli
Department of Preclinical and Clinical Pharmacology, "Mario Aiazzi
Mancini", University of Florence, Viale G.B. Morgagni 65, 1-50134
Florence, Italy
G. Gentilini
Department of Preclinical and Clinical Phramacology, "Mario Aiazzi
Mancini", University of Florence, Viale G.B. Morgagni 65, 1-50134
Florence, Italy
P. Gilon
Laboratory de Biologie Cellulaire, Batiment Claude Bernard, Place Croix
du Sud 5, B-1348 Louvain-Ia-Neuve, Belgium
Present address: Laboratoire de Diabetologie et Nutrition, Tour Claude
Bernard, UCL 54.74, Avenue Hippocrate 54, B-1200 Brussels, Belgium
List of Contributors XI
M.P. Gonzalez
Instituto de Bioquimica, Centro mixto C.S.I.C.-U.C.M.,
Facultad de Farmacia, Ciudad Universitaria, E-28040 Madrid, Spain
O. Happala
Department of Anatomy and Neurobiological Research Unit,
University of Helsinki, Helsinki, Finland
J.A Hey
Department of Allergy and Immunology, Schering-Plough Research,
60 Orange Street, Bloomfield, NJ 07003, USA
J.M. Hills
SmithKline Beecham Pharmaceuticals, The Fry the, Welwyn, AL6 9AR, UK
W. Howson
Smith Kline Beecham Pharmaceuticals, The Fry the, Welwyn, AL6 9AR, UK
K. Jessen
Department of Anatomy, University College London, Gower Street, London
WCIE6BT, UK
F. J06
Institute of Biphysics, Biological Research Centre, Hungarian Academy of
Sciences, Sz~ged, Hungary
T. Karhula
Department of Anatomy and Neurobiological Research Unit,
University of Helsinki, Helsinki, Finland
P. Kasa
Central Research Laboratory, Albert-Szentgyorgyi University,
H-6720 Szeged, Hungary
D.I.B. Kerr
Department of Anaesthesia and Intensive Care, The University of Adelaide,
South Australia 5000, Australia
W. Kreutner
Department of Allergy and Immunology, Schering-Plough Research,
60 Orange Street, Bloomfield, NJ 07003, USA
