Functional Gastrointestinal Disorders(FGIDs)

48 Pages·2016·1.78 MB·English

Functional Gastrointestinal
Disorders(FGIDs) in Children:
A Developing Country
Insight.

Eyad Altamimi, MD
Pediatric Gastroenterologist
Associate Professor of Pediatrics
Mu’tah University
Functional Gastrointestinal Disorders (FGIDs)
include a variable combination of age-
dependent, chronic or recurrent
gastrointestinal symptoms not otherwise
explained by structural or biochemical
abnormalities
Gastroenterology,2006
The term functional emphasizes that many
of the symptoms may accompany normal
development (eg, infant regurgitation) or
may be a response to otherwise normal
internal or external cues (eg, constipation
following painful stooling)
Gastroenterology,2006
Etiology & Pathophysiology
Despite the availability of isolated findings
and hypothesis the etiology of most of
FGIDs still need to be determined
J Pediatr Gastroenterol Nutr,2013
J Pediatr, 2015
The pathophysiology
of FGID is thought to
involve
abnormalities in the

relationship
between the enteric
and central nervous
systems
In Adult Gut:
100 million neurons located along the gut
-
which produce various neurotransmitters,
regulating mood and satiety
N Engl J Med,1996
95% of the body`s total serotonin is
-
located in the gut
ACS Chem Neurosci,2013
There is a high prevalence of psychiatric

disorders in FGID patients(anxiety and
depression)
Patients with internalizing psychiatric

disorders are found to have a higher
prevalence of pain predominant FGID
Diagnosis:
Physician’s lack of understanding

or appreciation of the illness

Absence of reliable biologic

markers and specific diagnostic
tests
Curr Pediatr Rep ,2013
Approach of FGID symptoms