Function and Structure of the Immune System

801 Pages·1979·24.71 MB·English

by  Karl Lennert (auth.)

FUNCTION AND
STRUCTURE OF THE
IMMUNE SYSTEM
ADV ANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
Nathan Back State Univerllity of New York at Buffalo
N. R. Di Luzio Tulane Univerllity School of Medicine
Bernard Halpern College de France and Inlltitute of Immuno-Biology
Ephraim Katchalski The Wei;r;mann Inlltitute of Science
David Kritchevsky Willtar lrutitute
Abel Lajtha New York State Rellearch lrutitute for Neurochemilltry and Drug Addiction
RodoIro Paoletti Univerllity of Milan
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FUNCTION AND
STRUCTURE OF THE
IMMUNE SYSTEM
Edited by
Wolfgang Muller-Ruchholtz
and
Hans Konrad Muller-Hermelink
University of Kiel
Kiel, Germany
PLENUM PRESS • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
International Conference on Lymphatic Tissue and Germinal Centers in Immune
Reactions, 6th, Damp/Kiel, 1978.
Function and structure of the immune system.
(Advances in experimental medicine and biology; v. 114)
"Proceedings. "
Includes index.
1. Immunology - Congresses. 2. Immunocompetent cells - Congresses. 3. Can
cer - Immunological aspects - Congresses. I. Miiller-Ruchholtz, Wolfgang.
II. Miiller-Hermelink, Hans Konrad. III. Title. IV. Series. [DNLM: 1. Immunity,
Cellular - Congresses. 2. Lymphocytes - Immunology - Congresses. WI AD559
v. 114 / QW568 159 1978f]
QR180.3.153 1978 616.07'9 79-4272
Proceedings of the Sixth International Conference on Lymphatic Tissues and
Germinal Centers in Immune Reactions held in Damp/Kiei, Germany, June
11-16,1978
© 1979 Plenum Press, New York
Softcover reprint of the hardcover 1s t edition 1979
A Division of Plenum Publishing Corporation
227 West 17th Street. New York, N.Y. 10011
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted,
in any form or by any means, electronic, mechanical, photocopying, microfJIming,
recording, or otherwise, without written permission from the Publisher
ISBN 978-1-4615-9103-0 ISBN 978-1-4615-9101-6 (eBook)
DOl 10.1007/978-1-4615-9101-6
Preface
This volume represents the Proceedings of the VI. International
Conference on Lymphatic Tissues and Germinal Centers in Immune
Reactions. The Meeting took place in Damp, a small resort with
great facilities on the shores of the Baltic Sea near Kiel on
June 11 - 16, 1978. Both, the Genius loci and the God of Weathers
were charming enough to stimulate the many participants from all
continents and also to facilitate the establishment and/or
maintenance of close contacts outside the sessions.
The organizers of this Conference have tried to remind the
scientific community of the necessity to (re-) consider sufficiently
the role of morphological studies for a thorough understanding of
immune reactions. Furthermore, they have been anxious to emphasize
a closer connection between analytical work and biological relevance
of the phenomena observed. Thus, three main trends were formulated:
(1) connections and correlations between function and structure,
(2) in-vivo relevance of in-vitro models and (3) clinical relevance
of experimental models.
The programme, induced by these outlines and reflected by the
contents of this volume, covers a remarkably broad field of
interests and activities. It is set in order under nine session
chapters. Each of them may allow the reader to answer for himself
the question how far the above trends have been recognized,
especially when considering the variety of new methodological
approaches reported.
Although the usefulness of publishing proceedings such as these
has sometimes been challenged, it is believed that the present
v
PREFACE
volume provides a variety of stimuli for future experimental and
clinical work on the function and structure of the immune system.
Considering that scientific progress depends on both the generation
of falsifiable hypotheses and the dissemination and experimental
analysis of these, it is hoped that these proceedings will make a
worthwhile contribution to these objectives.
W. Mliller-Ruchholtz
H.K. Mliller-Hermelink
Contents
INTRODUCTORY REMARKS Karl Lennert . . . . . . . • . . • . 1
SESSION A I
LYMPHOID CELL DIFFERENTIATION AND TRAFFIC
Chairpersons: Maria de Sousa and J.L. Gowans
Introduction: On the 20th Anniversary of a Scientific
Discovery . . . . . . • . • • • • . •• 13
Maria de Sousa
Ontogenetic Differentiation of Epithelial and Non-
Epithelial Cells in the Human Thymus 19
B. von Gaudecker and H.K. Mliller-Hermelink
Antigenic Changes Associated with Chicken B Lymphocyte
Development • • . . .. ...• 25
R.L. Boyd and H.A. Ward
Evidence for Surface Antigen(s) Specific for a Sub-
population of Peripheral Band T Lymphocytes
in the Chicken . . . . . . . . . . . • . . • 31
K. Schauenstein, R. Pfeilschifter and G. Wick
Separation of Germinal Centres from Chicken Spleen 37
A.M. Smithyman, K. Carr, D. Forman and R.G. White
Germinal Centres and the B-Cell System: A Search for the
Germinal Centre Precursor Cell in the Rat . 43
Nicolette A. Gastkemper, Auk S. Wubbena and
Paul Nieuwenhuis
Migratory Patterns of the Ly Subsets of T Lymphocytes
in the Mouse •..•.. • • . . 51
M. de Sousa, A. Freitas, B. Huber, H. Cantor
and E.A. Boyse
vii
viii CONTENTS
Correlation of Innnunogenetic and Histological Changes
in Innnunodeficient Mutant hr/hr Mice • • . 55
Angelika B. Reske-Kunz, Margrit P. Scheid,
Maria de Sousa and Edward A. Boyse
Morphology of the Extrafollicular Zone and Pseudo
Follicles of the Rat Lymph Node, and Their
Role in Lymphocyte Traffic • • • • • • . 59
G. Sainte-Marie and F.-S. Peng
Lymphocyte-High Endothelial Venule Interactions:
Examination of Species Specificity . . . . . • . . 65
Eugene Butcher, Roland Scollay and Irving Weissman
Basic Mechanisms of Lymphocyte Recirculation in Lewis Rats 73
Arthur o. Anderson, N.D. Anderson and J.D. White
The Effect of Cytoskeletal Inhibitors on the Migration
of Lymphocytes across Vascular Endothelium . • • 85
M.E. Smith and W.L. Ford
New Evidence on Control Mechanisms in Lymphocyte Traffic 93
A.S.G. Curtis, M. Davies and P.C. Wilkinson
Separation of Earthworm Coelomocytes by Velocity
Sedimentation . • • • • . • • . . . • • 101
E.L. Cooper, H.R. MacDonald and B. Sordat
Two Subpopulations of Cortisone-Resistant Lymphoid Cells
in the Rabbit Thymus • • • . • • • . 107
W. Leene, P.J.M. Roholl, K.A. Hoeben and
T.M. Hogenes
Development of an Isotope Dilution Assay to Determine
the T-Cell Mass in Guinea Pigs • • . . . • • . 113
J.M. Dwyer, M. Wade and M. Thakur
Lymphocyte Production and Organ Distribution of Newly
Formed Lymphocytes after Selective 3H-Deoxycytidine
Labelling of Mesenteric Lymph Nodes ..•..• 119
R. Pabst and F. Trepel
Germinal Centers and the B-Cell System: B Cell Differen-
tiation in Rabbit Appendix Germinal Centers 125
Davine Opste1ten, Dieuwertje van der Heijden,
Rita Stikker and Paul Nieuwenhuis
The Influence of the Thymus upon the Number and Class
Distribution of Innnunoglobulin Containing Cells
in the Bone Marrow and Other Lymphoid Organs of
the Mouse 133
R. Benner, A. van Oudenaren, J.J. Haaijman, J.
Slinger1and-Teunissen, Th.H. van der Kwast and
E.A.J. Wolters
Sunnning-up . . • • . 139
J.L. Gowans
CONTENTS ix
SESSION A 2
IMMUNOLOGICAL FUNCTION OF CELL SURFACE STRUCTURES
Chairpersons: J.J. Marchalonis and R.M.E. Parkhouse
Introduction: The Immunoglobulin-like T Cell Receptor
Problem . . • . . . • . • • • . • . • . • . • 145
John J. Marchalonis and Jane M. Moseley
Isolation and Partial Identification of Immunoglobulin
from T Cells • • • . . . • . • . . . 157
Aleksander Szenberg
Codistribution of Antigen and Fab Determinants on
Thymic Antigen-Binding Cells •••. • . 165
D. DeLuca, G.W. Warr and J.J. Marchalonis
Ontogeny of Spontaneous Rosette Forming Cells in Mice • •• 173
E.J. Steele
Multiple Ig Classes on Rabbit B Lymphocytes . 181
Bert J.E.G. Bast, Ria Manten-Slingerland,
Rudy E. Ballieux and David Catty
C3 Receptors and Membrane Complement Components on
Lymphocytes jointly Cause Binding of EAC 187
M.P. Dierich and B. Landen
C3 and C5 Compete for the Same Binding Site on
Complement Receptor Cells • • • . • 189
M.P. Dierich and B. Landen
Inhibition of C3b and C3d Receptor Activity by
Xenoantisera Prepared by Immunization with
Cell-Bound C3 Receptor Protein ••..•• 191
J. Gerdes, U. Klatt, H. Stein and H. Herrmann
Modulation of the Immune Response by Pretreatment of
Antigen with Complement • 195
W. Opferkuch, W. Horn, F. Falkenberg and
S.H.E. Kaufmann
Characterization of an IgG-Fc Receptor Protein Isolated
from Human B-Prolymphocytic and B-Chronic
Lymphocytic Leukemia Cells .• • . • . • • 199
J. Thones and H. Stein
Antisera Cause Alterations in Morphology and Enzyme
Activity in the Plasma Membrane of Rat
Thymocytes . . • . • • • • . . • . . 207
U. Hurtenbach, V. Speth, E. Ferber and H.C. Bauer
x CONTENTS
Modulation of Cell Membrane Antigens During
Differentiation of Rat T-Lymphocytes 213
R. Arndt, Rosemarie Stark and H.-G. Thiele
Interactions Between Neuraminidase-Treated
Lymphocytes and Liver Cells . • • • . • • • 219
Hubert Kolb, Amelie Kriese and Hans-Albert Kolb
Immunological Characteristics of Neo-Antigens on the
Cell Surface After Neuraminidase Treatment • 223
R. Johannsen, H.H. Sedlacek and F.R. Seiler
Carbohydrate Incorporation into Glycoconjugates of
Mouse Thymocytes During Con A Stimulation -
Involvement of Two Subpopulations 229
R.V.W. van Eijk and P.F. Muhlradt
Are Endogenous C-Type Viruses Physiologically
Required for the Regulation of the Humoral
Immune Response? • • . . . . . • . . • • • 233
G. Schumann, R.H. Gisler, A.F. Brownbill
and Ch. Moroni
Plating Inhibition Assay (PIA): A New Test for
Cell Mediated Cytotoxicity • . . • 239
K. Ulrichs, K.-M. Kuhlencordt and
W. Muller-Ruchholtz
Summing-Up: Lymphocyte Receptors 243
R.M.E. Parkhouse
SESSION A 3
IMMUNOLOGICAL TOLERANCE (SUPPRESSION/DELETION)
Chairpersons: J.R. Batchelor and W. Muller-Ruchholtz
Introduction . . . • . . • • • 247
W. Muller-Ruchholtz
Differentiation of B Cells and the Clonal Abortion
Theory • • • . . ••• 253
G.J.V. Nossal
Permanent Abolition of Reactivity to Major Histo
compatibility Antigens Requires Elimination
of Pre thymic Precursors • • . • . . 259
H.K. Muller-Hermelink, H.-U. Wottge and
W. Muller-Ruchholtz