Fibrinogen in Neurological Diseases

38 Pages·2017·4.5 MB·English

Fibrinogen in
Neurological Diseases:
Mechanisms, Imaging,
Therapeutics
Katerina Akassoglou, PhD

Senior Investigator
Gladstone Institutes

Professor of Neurology
University of California, San Francisco
Disclosures:

Named Inventor: US 8980836, 8877195, 7807644, 8569242
Brain
Vasculature

3D-
Immuno-
labeling
in Cleared
Brain

Pamela Rios

Victoria Rafalski
Blood-Brain Barrier Disruption
Multiple Blood Vessels
Sclerosis
Animal
Model
Blood Leakage
Merge
Pamela Rios,
Maya Ellisman
CONFIDENTIAL
Peripheral Triggers?
Molecular Determinants?

CONFIDENTIAL
Blood coagulation factors
Fibrinogen
CONFIDENTIAL
Eduard Rindfleisch (1836-1908)

"If one looks carefully at freshly
altered parts of the white matter ...
one perceives already with the
naked eye a red point or line in the
middle of each individual focus,..
the lumen of a small vessel
engorged with blood ... All this
leads us to search for the primary
cause of the disease in an
alteration of individual vessels and
their ramifications; All vessels
running inside the foci, but also
those which traverse the
immediately surrounding but still
intact parenchyma are in a state
characteristic of chronic
inflammation."
Fibrinogen is abundantly deposited in
neurological diseases
Human Brain
Multiple sclerosis (MS), Traumatic brain injury (TBI)
Alzheimers disease (AD)

MS TBI AD

fibrinogen fibrinogen fibrinogen
Fibrinogen is abundantly deposited in
neurological diseases
Control - Human Human Active MS lesion
Fibrinogen
Mark Petersen
Fibrinogen is abundantly deposited in
neurological diseases
Control Active MS lesion Chronic Inactive MS
Fibrinogen
Mark Petersen