DTIC ADA436017: Studies in the Formation of Ethyl Methylphosphonofluoridate From Rat and Human Serum Exposed to VX and in the Presence of Fluoride Ion

6 Pages·0.03 MB·English

by  Defense Technical Information Center

SEIDUTS NI EHT NOITAMROF E TFAODIROULF OMLNOYORHHFTPESOHPLYHTEM
TAR DNA NAMUH MURES DESOPXE OT XV DNA NI EHT ECNESERP FO EDIROULFNOI

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TCARTSBA

s itah tdool bn irekramoi btneg aevre nX Vaf osisylan aeh tro fdepoleve dnee bsa hdohte mA
dn anamu hdekip sn idetcete dsa wX V.evitcele sdn aevitisne syrev s t finooitaren eeg h ytabr ets ar
Ggnidnopserroc XV (etadiroulfonohpsoh- plyhte mlyht e,evitavire dseires - 8 1saCezili tduoht esmi h.T)G
dilos ema lrafeht ihet ihwpargotamor hsc agagni snuoi-tacifitna u yqdbewoll o)fEP Sn(oitcart xeesahp
ete dcirtemotohp roCtGc( - CrGe(temortc e sp)r ssDoaaPmF - .)SXMV -mor fdevlose ryletelpmo csa wG
f oseire sX Veh tn istneg aevre nreht oevlose ro tlaitneto peh tsa hdohte meh tdn a)BG (niras
ulo cn otneg af og p5.0 1sa wtimi lnoitcete ddohte meh T.srotibihn iesaretsenilohc .nm

NOITCUDORTNI

ylemertx es ierusopx ef oeerge deh tenimrete do tdn aerusopx etneg aevre nyfire vo tytilib aehT
gnihsilbat s nedonep esddoht enmoitacifir etvnerr u.Csnosa elracitil odp n,alacitc a,tlacid erm otfnatropmi
n inoisserpe dtnacifingi sarehtie .setilobate mtneg aevre nf oecneser peh tro/dn aytivitc aesaretseniloh c
nihti wnev edn anoitalupo panihti wyltnacifingi setautcul fo tnwon ks iytivitc aesaretsenilohC
px ef oytireve sdn anoisserpe desaretseniloh cneewte bnoitalerro celpmi sA.slaudividni t o sneiruso
elbavresb oylisa eto ner asetanohpsohplyhtemlykl aeh ts ahcu ssetilobate mtneg aevre N.tnediv esyawla
w orl onfoitazitavir eedriuq eyrltnerr udcna eh to tytixelpmo cd-n aemi tsdd ahcih wsisylan aC Glevel
ost alwa org u.Oemeh cssisyla nealpmas X Vgniyfitnau qf oelbapa csdohte mlacitylan apoleve dr odnif
erutaret i.Alnoitatnemurts neilbalia vgani seuuss idt ndaoo l sbhac ussecirt almacigolo i nbeirusopxe
s adevre shcih wdohte metadidna cgnisimor pyre ven odecudor psdohte mtneg aevre nro fhcraes a gnitrats
elpma selpmi sylevitale ry bdool beh tn iseti sdnuo bmor fdetarenege rsa wB G,dohte msih tn I.tniop
dilo sy bdewollo f) 4H pt aediroul ff onoitidda (noitalupina mxirtam -.noitcart xeegdirtr aecsahp 1 s ihT
sgolan aX Vhti wdes unee breve nsa hdohtem . serusop x XeyVdu t oslto o satlaufe seuvo ryp a tmdi na
lyhte me byleki ldluo wtcudor peh T.yass aeh tf osnoitidno ceh tredn umor fmrofe rto ndluo wflest iXV
.etadiroulfonohpsohplyhte
1
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1. REPORT DATE 2. REPORT TYPE 3. DATES COVERED
00 JAN 2002 N/A -
4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER
Studies In The Formation Of Ethyl Methylphosphonofluoridate From
5b. GRANT NUMBER
Rat And Human Serum Exposed To Vx And In The Presence Of Fluoride
Ion 5c. PROGRAM ELEMENT NUMBER
6. AUTHOR(S) 5d. PROJECT NUMBER
5e. TASK NUMBER
5f. WORK UNIT NUMBER
7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION
EAI Corporation, 1308 Continental Dr, Suite J, Abingdon, MD 21009; REPORT NUMBER
Research and Technology Directorate, U.S. Army ECBC, APG-EA,
Edgewood, MD 21010
9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S)
11. SPONSOR/MONITOR’S REPORT
NUMBER(S)
12. DISTRIBUTION/AVAILABILITY STATEMENT
Approved for public release, distribution unlimited
13. SUPPLEMENTARY NOTES
This article is from ADA409494 Proceedings of the 2001 ECBC Scientific Conference on Chemical and
Biological Defense Research, 6-8 March , Marriott’s Hunt Valley Inn, Hunt Valley, MD.
14. ABSTRACT
15. SUBJECT TERMS
16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF 18. NUMBER 19a. NAME OF
ABSTRACT OF PAGES RESPONSIBLE PERSON

a. REPORT b. ABSTRACT c. THIS PAGE UU 5
unclassified unclassified unclassified
Standard Form 298 (Rev. 8-98)
Prescribed by ANSI Std Z39-18
LATNEMIREPXE

SLAIRE TDSANLMAACIMEHC

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ocsi W,eekuawliM (ynapmo Clacimeh Chcirdl Amor fedarg s a)w5 .H 3pr(eff uebtate csauo e.u )qnAisn
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NOIT AERLAPPMEARSP

namuH and rat s n2 i X(eVtul ihdt idweki pss a)w O,MsiuoL. t,Samgi Sa(re - )lo nt3aa.p7o4r1p
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ne hst amwur ensam udheki pgsnitlus eer h,tyas sdaradna tes hr.t osFisyla nra odfev ads neataflus
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.d aepdirou lrfevl ies hhtguorht

LATNEMURTSNI

ttelwe Harehti en odezylan aere wselpmaS - drakcaP 0985CG - ttel w rDeaoPHF - drakcaP 0986
GC -e l. p) ,mEkaDrSaw e DN3S(7M95 xan e yTsb atwel ni (cid:210) tneg Aaer AtopeD (ebu ttnebro sdilo s
,c nmIrehtany D0( 0M9E C nAgani s)u A,Pdrof x,Oc nmIrehtan y:Deb u)tSMAA Dm(ets ygSnirotinoM
tt uab invmul o CceG h otdtecafret nriebros e)d A,PdrofxO - 5 0mx2sa3 anwmul o Cc eG. hrTotcennoc
xmm BsDsenkci h mt5u.0 - margo reprutarepm e0t 0M9E CeA h.T) A,Celadno v,Acifitnei cWS& J S(5M
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160 o C at 15 o 0 6op2tm a,retunim/C o C at 40 eh tn ideos usa wDS Me h .Tsetuni m3ro fdle hdn aetunim/C
sa welpma seh tret f .A2 8dn a,9 9,11 1z/ mt agnirotino mno idetcele shti wedo mnoitazino inortcele
tn odebrosed wol fnim/L m00 1gnis ugnihsulfkca by bdenoitidnoce rsa webu ttnebro seh tnmulo cC Geh
0 8 t2naegort iyn rfdo - 300 mor fecnerefretn itnio pgnilo io bhgi heh tesaerce do tsetuni mthgi eo tevi fro fC
stneve repb uttnebr oes h ftgonihsulfkc a.Bselpm amsur eesht nmulo cdn atnemurtsn ieh tf onoitadarged
.xirt aemlpm aes h fteorut axnelpm oec hettips eedniles aeblba tgasnicudorp
oLtm/ g6n6. 7m1o rsfdradna t XseVv igfnitcej nyillaitneuq e ysdbehsilbat sse aewvr udcradna tAs
. hdT aepdirou lrfevl i nasLom/ g6n.671 xan e oaTdtetcenn osc adw aepdirou lrfevl ies (cid:210) eb uStMA AD
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X Veh tmor fdevlose rylrael csa wB Gdohte msih tgnis U.ecnerefretn ilaitneto ptnatropmi - dluo wdn aG
.dohte meh thti werefretn iton
revli seh tf oes ueh ts alle ws adessess aere wnoitacifidic adn ano iediroul ff oecnatropm iehT
red nduerape rmpur edseki p fssotlus esrisfyla nea hstts ie1ll b. asTelpm amsur edseki p nsdo aepdiroul
e hdtedulc nsiisyla nda nnaoitarape replpm a fssonoitair a.Vn oeidirou ldf nraeff u fbsonoitidn oscuoirav
itin ieh tf osisylan a) 1:stnemtaer tgniwollof gC0m 0l5a hguor hgtnitcej n yitbneu lreetl iefgdirtr aEc PS
81
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deretl ief h otdted dsatnega elr lra oefnil a fsnooitutitsb u )s,3pe tEs PrSehtona y bdewollo fmure sdekip s
o)t FoK ne(nil ads nraeff u fbnooitid d )a,4d aepdirou lrfevl ihasguor hntoitcej ndi npae tEs PrSehtona
deretli feh to t)F Kon (enila sdn areffu bf onoitidd a) 5,pet sEP Srehton ay bdewollo fmure sderetli feht
y bdewollo fmures d n Fa fKnooitid d )a,6d aepdirou lrfevl ihasguor hgtnitcej ndi npae tEs PrSehtona
o ne(nil ads n Fa fKnooitid d )a,7pe tEs PrSehto n yadbewoll omfur edseretl ief h ot)treff uob ne(nilas
neh tdn apet sEP Srehton ay bdewollo fmure sderetli feh to t)reffub ,d aepdirou lrfevl ihasguor hgtnitcejni
. pe tEs PrSehto n yadbewoll omfur edseretl ief h otrteff udb n Fa fKnooitid d )ad8na
o Htep httsuj d oarteff u fbnooitid dea htta hdtetacid nniev eds nxa isstnemtae r ,te1lb a oTgtnidroccA
s arwu oyfletamixorppa X Vemo secudor po tyrassece nyletulosb aton - egr a nltinese rsp aewdirou l ffGi
XhVc u sm%a 5d8 n%a 7y4letamixorp pya l. neOcnadnuba - eh tn itnemtsujd aH ptuohti wdemro fsa wG
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n oXV enilaS e+nilaS e+nilaS r+effuB e+nilaS + KF+ reffuB
retliF ylno Pad reffuB Pad KF Pad + KF
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.da pediroul frevli shguorh tdetcejn i,Lm/g n6.67 1=leve le k *i p S
.da pediroul frevli shguorh tdetcejn i,Lm/g n3.74 1=leve leki p *S*
dezylan ato nmure sta R***

amwur ensam ueh h fttocart xee hnte hswtlus eerhT e hhtguor hdtetcej nti u FbhKt idwetae rtt osn
X fVtonuo mlaaitnatsb udasetacid ndi aFpgA ediroul fsuo-euq af oecneser peh ttuohti wdemro fsa wG
froosruce r,apd aepdirou lrfevl ies h ytdbedivo rsp aswes aecse h nteidirou l ffeocru oes hetc n. inSoi
XV - G ra XonVe eebv adhlu orcosruce r ep. htTcart xeetate clayh tee h nttinese rnpe eebv aths um
XeVtaren e ogdt aepdirou lrfevl ies h ntgonitca e freolbap alcli tss atwa h Xt fVtocudo rnpwodkaerb - G.
etgdirtr aE cP8 S1g0 gCm0an5i sduetcart xs eaXswVsecxE . mur ets aer hhtt idwe ssu a sweam aesh
erofere hmtur ets aer h fttoa hnta hsts esl amwur ensam ueh h fteos aec h ntdieki ptsnuo mea h,trevoeroM
derevoc esr a XwsVsec xses eylletanoitrop o. rdPedeec xte oynlek isl aewgdirtr aEc PeS h ftyoticap aecht
morf s a XweV htta hdtetacid nhici hmwur ets aer hnta hmtur ensam uhht iewgdirtr aEc PlSaiti neiht
s a XwtVa h rteogdirtr aEc PeS hhtguor hdteirr agcni edb nmaur ensam ueh h ntsiet i osgtnidn irbehtie
pnoitadarge deh t,revew o .Hmure snamu hn iretsa fgnidarged XgVnimr o ffeolbap alcli tss atwcudor - G
yn a,yroeh tn .Isno iediroul fsuoeuq aro/dn ada pediroul frevli seh thti wtcatno cn iema ct inehw
lOaren eeg hstniat etra h Xt fVtocudo rnpwodkaerb ecudo rnp aecr-utcur testaoihtonohpso hlpyht elmyhte
XV - x ee. hGT f oselpma sn inwoh snee beva hnoisrevno csih tf oelbapa cstcudor pnoitadarge df oecnetsi
. XdVerots 3
Ghto bro fezylan ao tdedee ne bdluo wdohte ma,erusopx etneg aevre nelbisso paf otnev eeh tnI -
Vdn astnega g- itenemta e. rsTecirt almacigolo i nbsitnega n odes uylsuoiver pdohte mao tralimi ssa wth
. B oGetrusop xneam umhrifn o ocstelpm amsur edsevihcra 1 namu hdekip sX Vf oesa ctneser peh tn I
X Vgnidnopserro ceh tdecudor pdohte msih tmures na cdohte -msih tgnitacidn istnuom aelbarusae mn iG
te do tdes ueb rehgi hylthgil sdecudor posl athgi etnemtae r .Tstneg aevre nf oseire sVdn aGeh thto btce
X Vf ostnuoma ndoednep ehdci hrwu otfne-mtae r otdterapm o sc)aLm/ g5n9. 3m(ur ets a nrGi
.)Lm/g n92.3 (sleve lediroul fsuonegodne
i wmure snamu hdekip sX VgnitaerT revli seh thguorh tetatec alyht eeh tgnitcejn idn aF Kht
X Vf ostnuom atsehgi heh tdedlei yda pediroulf - yalbabo r sphici h)wLm/ g7n. 2,1nev etsnemtaer tG(
X Veer ff onoitanibmoc -X Vdnuo bemyzn edn asrosrucer pG - t dotincdar t mx.ue rr toeassRruc eGrp
dorp .da peh thguorh tnoitcejn inop utceff eema seh tecu
XeVe ref hetsaerc e odstraep p ,a H4 opetlpm aes hsteifidi chaci h,wreff u fbnooitiddA - G
elbiss o ep. nLOm/ g5n0 . o43t6 .m5o rpfo red h ytdbetartsul l simaur ensam u fheos aec h ntriosrucerp
itanalpxe X faVnooitazin oei h stpio rsdi hrt onfo - e Chr toyftinif fs atsiness erlosruce rGp SPE
81
4
H7 tpnaa h H4t tptanet xreetae r oagdtezin o eidblu o Xw nVpiuo regni mea h,telpma x re. oeFgdirtrac
lu otwa hstelucel odmegra h fceogatnecr erpegr agalnitaerc e h .Taide mEP Seh to tdni bo tyleki lsse le bd
Claitin ieh tsevivru selucelo mdetale rylesol cemo sr oX Vwo hf onoitseuq feos aec h nteigdirtr aEcPS
81
si hettadicu l oedteriuq e srnioitagitsev nlianoitid d.Arae ltc o snmiur ets atr odn nmaur ensamuh
ehp .nonemon
sG Xa fVLom/ g4n.5 6d1edle i XyLVm/ g6n.6 7 t1daeki pmsur etsaR - feotartl ief h ntgiolana
ssec x redonuob nsutneserp edr nda aepdirou lrfevl ies h ntdoetcej nsi aewtartl isf i. heTgdirtr aEc PeSht
ft Lo5m2 . f0sotouq i. lmAur ees h otdted dXaV detaer tgnie bretf adezylan aneh tere wmure sderetli feh
sG Xa fVLom/ g5n9 .y3letamixorp pdaecudo rspelpm aess e. hsTtnega ehrtiw - stneserp e sr.i ghoTlana
ssa melbanosae rasevi gX Vdnuo bdn adnuobn uhto bf omu se h .Ttneg aevre neh tf omro fdnuo beht
ba edirou lef h ftnooissi mtoa hdtet osn a. twtIne gea h ft%o9. 5r9 osftnuoc chaci hLwm/ g4n.9 6 f1eocnal
XgVnitlus eer httcef fyellacitsa rtd osne omdur ets aer h ftnooitarape rep h nttinegaer - mo rnfoitcudo rGp
9n2. 3e1(lb a nTnie e sssaelpm adseki pesht .)edirou lhft iLwm/ g5n9 .s3usr eevdirou ltfuoht iLwm/g
f osleve lsuonegodn eda hmure sta rdeto ntah tstrope rreilra ehti wtnemeerg an is inoitavresb osihT
.reff uebtate c fanooitid d na)oD Gn(am oeStareneg e orttneiciff uesdiroulf 5,4

SNOISULCNOC

ohte mA ro fdepoleve dsa wrekramoi btneg aevre naf onoitacifitnau qdn anoitacifire veh tro fd
sGdaeifir e evnb aecrusop x Xe.VXV gni skuci udq nea-lpm i sssiisyla nsai h.Tselpm amsur e nsgiolana
gnirotin orm ida nsaeirotarob adlle i nfeilbalia vnaoitatnemurtsni oGetlbacilp p s atidi nsaeitilicaf - seires
Vdna si htt unbwo ntk o snpiuo rggniva ellanigi reo htta h stei-gatnavdas irdoj aem h.Tstne geavr esneires
.setilobat etmne gea h fteos aec h nteiu rots lsai

REFERENCES

.1 pohcsneB.P .,HgrebnegnaL.P .,JsjiuhloP.M ,.locamr a.hlP p.plAoci x,oT 146 , 156 - 161, (1997).
.2 ,.rgo t h a,t.,m riEro.Jm.e rJSJl.hwKCo.FW 478 , 51 - 61, (1989).
.3 ,.rgotamo r,.hiJCnitne s,.itJVsov o.r RP,.oLnitsog A.’AD.P 407 , 221 - 232, (1987).
.4 ..locamra h.Pmehco i,Bkj inD a .V,Cgn oeJD.A.P.L 33 , 663 - 6 69, (1984).
.5 ,pohcsneB.P.H ,dlevejiB.C.E ,ottO.F.M ,tdrahnegeD.M.A.E.C naV.M.P.H ,nedleH eD.A.P.L, gnoJ
,.mehcoi BlacitylanA 151 , 242 - 253, (1985).
5