Drugs for the Management of Rheumatoid Arthritis: Clinical Evaluation

587 Pages·2017·5.34 MB·English

(as supplied by the authors)
APPENDIX 1: LITERATURE SEARCH STRATEGY
OVERVIEW
Interface: Ovid
Databases: EBM Reviews - Cochrane Central Register of Controlled Trials <April
2016>
Embase
Ovid MEDLINE
Ovid MEDLINE In-Process & Other Non-Indexed Citations
Note: Subject headings have been customized for each database.
Duplicates between databases were removed in Ovid.
Date of May 3, 2016
Search:
Alerts: Monthly search updates began May 4 and ran until March 1, 2017.
Study Types: randomized controlled trials; controlled clinical trials
Limits: Publication years: see multi-database strategie
Humans
SYNTAX GUIDE
/ At the end of a phrase, searches the phrase as a subject heading
MeSH Medical Subject Heading
exp Explode a subject heading
* Before a word, indicates that the marked subject heading is a primary topic;
or, after a word, a truncation symbol (wildcard) to retrieve plurals or varying
endings
ADJ Requires words are adjacent to each other (in any order)
ADJ# Adjacency within # number of words (in any order)
.ti Title
.ab Abstract
.hw Heading Word; usually includes subject headings and controlled vocabulary
.kf Author keyword heading word (MEDLINE)
.kw Author keyword (Embase)
.pt Publication type

1
(as supplied by the authors)

MULTI-DATABASE STRATEGIES

biologic DMARDs – 2015 to present

# Searches
1 Adalimumab/
2 Certolizumab Pegol/
3 Etanercept/
4 golimumab/ use oemezd
5 Infliximab/
6 tocilizumab/ use oemezd
7 Abatacept/
8 Rituximab/
9 (adalimumab or Humira or Trudexa or certolizumab pegol or Cimzia or Perstymab
or etanercept or Enbrel or golimumab or Simponi or infliximab or Inflectra or
Remicade or Remsima or Reemsima or Remmicade or Remykeyd or Revellex or
anakinra or Kineret or Antril or tocilizumab or Actemra or Aktemra or RoActemra or
atlizumab or abatacept or Orencia or Belatacept or Nulojix or rituximab or Rituxan
or Mabtera or Mabthera or Reditux or Relito or Rituxim).ti,ab,kw,kf.
10 or/1-9
11 exp Arthritis, Rheumatoid/ use pmez
12 exp rheumatoid arthritis/ use oemezd
13 (rheumatic* or rheumatoid* or rheumatis*).ti,ab,kf,kw.
14 ((Caplan* or Felty* or Sjogren* or Sicca*) adj3 syndrome*).ti,ab,kf,kw.
15 Still* Disease*.ti,ab,kf,kw.
16 or/11-15
2
(as supplied by the authors)
17 10 and 16
18 (Randomized Controlled Trial or Controlled Clinical Trial or Pragmatic Clinical
Trial).pt.
19 Randomized Controlled Trial/
20 exp Randomized Controlled Trials as Topic/
21 "Randomized Controlled Trial (topic)"/
22 Controlled Clinical Trial/
23 exp Controlled Clinical Trials as Topic/
24 "Controlled Clinical Trial (topic)"/
25 Randomization/
26 Random Allocation/
27 Double-Blind Method/
28 Double Blind Procedure/
29 Double-Blind Studies/
30 Single-Blind Method/
31 Single Blind Procedure/
32 Single-Blind Studies/
33 Placebos/
34 Placebo/
35 Control Groups/
36 Control Group/
37 (random* or sham or placebo*).ti,ab,hw,kf,kw.
38 ((singl* or doubl*) adj (blind* or dumm* or mask*)).ti,ab,hw,kf,kw.
39 ((tripl* or trebl*) adj (blind* or dumm* or mask*)).ti,ab,hw,kf,kw.
40 (control* adj3 (study or studies or trial*)).ti,ab,kf,kw.
3
(as supplied by the authors)
41 (Nonrandom* or non random* or non-random* or quasi-random* or
quasirandom*).ti,ab,hw,kf,kw.
42 allocated.ti,ab,hw.
43 ((open label or open-label) adj5 (study or studies or trial*)).ti,ab,hw,kf,kw.
44 or/18-43
45 17 and 44
46 exp animals/
47 exp animal experimentation/ or exp animal experiment/
48 exp models animal/
49 nonhuman/
50 exp vertebrate/ or exp vertebrates/
51 or/46-50
52 exp humans/
53 exp human experimentation/ or exp human experiment/
54 or/52-53
55 51 not 54
56 45 not 55
57 56 not conference abstract.pt.
58 limit 57 to english language
59 limit 58 to yr="2015 -Current"
60 remove duplicates from 59

Methotrexate – 2014 to present

# Searches
4
(as supplied by the authors)
1 Methotrexate/
2 (abitrexate or amethopterin* or amethpterin* or ametopterin* or antifolan or Artrait
or Atrexal or Bertanel or Biotrexate or brimexate or canceren or cytotrex or ebetrex
or ebetrexat* or emtexate or emthexat* or Emthrxate or emtrexate or enthexate or
farmitrexat* or farmotrex or Hytas or Imutrex or ifamet or imeth or fermitrexat* or
fauldexato or folex or hdmtx or lantarel or ledertrexate or lumexon or maxtrex or
medsatrexate or Meisusheng or merox or metatrexan or metex or Metrex or
Methoblastin or methohexate or methotrate or Methox or meticil or Metodik or
methotrexat* or Methylaminopterin* or methrotrexate or methopterin* or
methpterin* or metopterin* or Metotressato or Metotrexato or Metotreksat or
metoject or Metrotex or mexate or MTX or Novatrex or Otrexup or Rasuvo or
Rheumatrex or texate or tremetex or trexeron or Trexall or trixilem or Midu or Mtrex
or Neotrexat* or Onkomet or Otaxem or Pterin or Quinux or Reumatrex or
Sanotrexat* or Texorate or Trexan or Trexate or Trexol or Trexonate or Trexxol or
Unitrexates or Viztreksat or Xantromid or Zexate).ti,ab,kw,kf.
3 1 or 2
4 exp Arthritis, Rheumatoid/ use pmez
5 exp rheumatoid arthritis/ use oemezd
6 (rheumatic* or rheumatoid* or rheumatis*).ti,ab,kf,kw.
7 ((Caplan* or Felty* or Sjogren* or Sicca*) adj3 syndrome*).ti,ab,kf,kw.
8 Still* Disease*.ti,ab,kf,kw.
9 or/4-8
10 3 and 9
11 (Randomized Controlled Trial or Controlled Clinical Trial or Pragmatic Clinical
Trial).pt.
12 Randomized Controlled Trial/
13 exp Randomized Controlled Trials as Topic/
14 "Randomized Controlled Trial (topic)"/
15 Controlled Clinical Trial/
16 exp Controlled Clinical Trials as Topic/
17 "Controlled Clinical Trial (topic)"/
5
(as supplied by the authors)
18 Randomization/
19 Random Allocation/
20 Double-Blind Method/
21 Double Blind Procedure/
22 Double-Blind Studies/
23 Single-Blind Method/
24 Single Blind Procedure/
25 Single-Blind Studies/
26 Placebos/
27 Placebo/
28 Control Groups/
29 Control Group/
30 (random* or sham or placebo*).ti,ab,hw,kf,kw.
31 ((singl* or doubl*) adj (blind* or dumm* or mask*)).ti,ab,hw,kf,kw.
32 ((tripl* or trebl*) adj (blind* or dumm* or mask*)).ti,ab,hw,kf,kw.
33 (control* adj3 (study or studies or trial*)).ti,ab,kf,kw.
34 (Nonrandom* or non random* or non-random* or quasi-random* or
quasirandom*).ti,ab,hw,kf,kw.
35 allocated.ti,ab,hw.
36 ((open label or open-label) adj5 (study or studies or trial*)).ti,ab,hw,kf,kw.
37 or/11-36
38 10 and 37
39 exp animals/
40 exp animal experimentation/ or exp animal experiment/
41 exp models animal/
6
(as supplied by the authors)
42 nonhuman/
43 exp vertebrate/ or exp vertebrates/
44 or/39-43
45 exp humans/
46 exp human experimentation/ or exp human experiment/
47 or/45-46
48 44 not 47
49 38 not 48
50 49 not conference abstract.pt.
51 limit 50 to english language
52 limit 51 to yr="2014 -Current"
53 remove duplicates from 52

Subsequent Entry Biologics (SEBs), products under development, small molecules,
traditional DMARDs (hydroxychloroquine, sulfasalazine, leflunomide) – no date limit

# Searches
1 exp Arthritis, Rheumatoid/ use pmez
2 exp rheumatoid arthritis/ use oemezd
3 (rheumatic* or rheumatoid* or rheumatis*).ti,ab,kf,kw.
4 ((Caplan* or Felty* or Sjogren* or Sicca*) adj3 syndrome*).ti,ab,kf,kw.
5 Still* Disease*.ti,ab,kf,kw.
6 or/1-5
7 Infliximab/ or Adalimumab/ or Etanercept/
8 (adalimumab or Humira or Trudexa or infliximab or Inflectra or Remicade or
Remsima or Reemsima or Remmicade or Remykeyd or Revellex or etanercept or
7
(as supplied by the authors)
Enbrel).ti,ab,kw,kf.
9 7 or 8
10 (reference or innovator or originator or generic or generics or biosimilar or bio-
similar or biosimilars or bio-similars or follow-on or subsequent-entry or SEB or
SEBs or biobetter or biobetters or bio-better or bio-betters or biosuperior or
biosuperiors or bio-superior or bio-superiors or next generation or second-
generation or third-generation or next-gen).ti,ab.
11 (biologic* or biological*).ti,kw,kf.
12 exp *Biological Products/ use pmez
13 exp *biological product/ use oemezd
14 or/10-13
15 9 and 14
16 Hydroxychloroquine/
17 (Hydroxychloroquin* or Oxychlorochin* or Oxychloroquin* or Hydroxychlorochin* or
Plaquenil or Idrossiclorochina or Oxichlorochinum or Hydroxyquine or Advaquenil
or Arthroquin or Axokine or Chloguin or Diclor or Dimard or Dolquine or Duloc or
Duroc or Ercoquin or Evoquin or Fen Le or Geniquin or Haloxin or HCQS or
Hydroquin or Hydroquine or Hyquin or Ilinol or Immard or Metirel or Oxcq or
Oxiklorin or Plakvenil or Plaquinol or Quensyl or Quinoric or Reconil or Reuquinol
or Roquin or Supretic or Winflam or Yuma or Zyq or chloroquinol).ti,ab,kf,kw.
18 Sulfasalazine/ use pmez
19 salazosulfapyridine/ use oemezd
20 (Salicylazosulfapyridin* or salazosulfpyridin* or salazopyrin* or salazopyridin* or
Sulphasalazin* or Salazosulfapyridin* or Pleon or azopyrin* or azosulfidin* or
benzosulfa or colopleon or Ulcol or Ucine or Azulfidin* or azlufidin* or Azulfadin* or
pyralin or Asulfidine or Azulfin or azulfid* or Bomecon or Disalazin or Falazine or
Gastropyrin or Lazafin or Lazo or rorasul or Rosulfant or SAAZ or Salazex or
Salazine or Salazo or Salazodin or Salivon or salisulf or Salopyr or Salopyrine or
Saridin* or Sazo or Sulcolon or Sulfasalazin or Sulfasalizin* or sulfosalazin* or
Sulfitis or Sulzin or Zopyrin).ti,ab,kw,kf.
21 leflunomide/
22 (leflunomid* or arava or Airuohua or Arabloc or Arastad or Aravida or Arheuma or
Arolef or Arresto* or Artrilab or Cartina or Imaxetil or Inflaxen or Kinetos or Lara or
8
(as supplied by the authors)
Leflu or Lefluar or Lefluartil or Leflyutab or Lefno or Lefora or Lefra-20 or Motoral or
Movelef or Nodia or Repso or Rheufact or Rheumide or Rualba or Synomid or
Youtong).ti,ab,kw,kf.
23 tofacitinib/
24 (Tofacitinib* or tasocitinib* or Xeljanz* or Kselyanz*).ti,ab,kw,kf.
25 baricitinib/
26 (Baricitinib* or ISP4442I3Y or LY3009104 or INCB028050 or ISP 4442I3Y or LY
3009104 or INCB 28050 or "INCB 028050").ti,ab,kf,kw.
27 sarilumab/
28 (Sarilumab* or NU90V55F8I or SAR153191 or REGN88 or SAR 153191 or REGN
88).ti,ab,kw,kf.
29 sirukumab/
30 (sirukumab* or 640443FU93 or CNTO136 or CNTO 136).ti,ab,kw,kf.
31 or/16-30
32 6 and (15 or 31)
33 (Randomized Controlled Trial or Controlled Clinical Trial or Pragmatic Clinical
Trial).pt.
34 Randomized Controlled Trial/
35 exp Randomized Controlled Trials as Topic/
36 "Randomized Controlled Trial (topic)"/
37 Controlled Clinical Trial/
38 exp Controlled Clinical Trials as Topic/
39 "Controlled Clinical Trial (topic)"/
40 Randomization/
41 Random Allocation/
42 Double-Blind Method/
43 Double Blind Procedure/
9
(as supplied by the authors)
44 Double-Blind Studies/
45 Single-Blind Method/
46 Single Blind Procedure/
47 Single-Blind Studies/
48 Placebos/
49 Placebo/
50 Control Groups/
51 Control Group/
52 (random* or sham or placebo*).ti,ab,hw,kf,kw.
53 ((singl* or doubl*) adj (blind* or dumm* or mask*)).ti,ab,hw,kf,kw.
54 ((tripl* or trebl*) adj (blind* or dumm* or mask*)).ti,ab,hw,kf,kw.
55 (control* adj3 (study or studies or trial*)).ti,ab,kf,kw.
56 (Nonrandom* or non random* or non-random* or quasi-random* or
quasirandom*).ti,ab,hw,kf,kw.
57 allocated.ti,ab,hw.
58 ((open label or open-label) adj5 (study or studies or trial*)).ti,ab,hw,kf,kw.
59 or/33-58
60 32 and 59
61 exp animals/
62 exp animal experimentation/ or exp animal experiment/
63 exp models animal/
64 nonhuman/
65 exp vertebrate/ or exp vertebrates/
66 or/61-65
67 exp humans/
10