Design, synthesis and biological evaluation of N,N-substituted amine derivatives as cholesteryl ...

45 Pages·2017·3.45 MB·English

Design, synthesis and biological evaluation of N,N-substituted amine
derivatives as cholesteryl ester transfer protein inhibitors

Xinran Wang 1, Lijuan Hao 1, Xuanqi Xu 2, Wei Li 1, Chunchi Liu 1, Dongmei Zhao 1,* and
Maosheng Cheng 1
1 Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang
Pharmaceutical University, shenyang 110016, China; [email protected]
2 Department of Chemistry, University of Wisconsin- Madison, Madison, WI, USA; [email protected]
* Correspondence: [email protected]; Tel.: [phone]

Content: 1H NMR, 13C NMR, HRMS for all target compounds reported in this study.
O
N N
NH
N N
F C CF
3 3
Compound 12

O
N N
N
N N O
O
F C CF
3 3
Compound 13

O
N N
N
N N
O
O
F C CF
3 3
Compound 14

O
N N
N
N N NH2
F C CF
3 3
Compound 15

O
N N
O
N
N N S
O
F C CF
3 3
Compound 16