Davis’s Drug Guide for Nurses

1492 Pages·2016·13.189 MB·English

by  April Hazard Vallerand, Cynthia A. Sanoski, Judith Hopfer Deglin

CARRY AWAY TABERS
TODAY!
#1 MEDICAL DICTIONARY
for Nursing & Health Professions
§ Lists of major signs and symptoms alert
you to what to look for or anticipate.
§ Patient Care information describes
assessment, treatment, and patient
teaching for each step in the process.
§ Caution/Safety Alerts highlight
information critical to safe patient care.
VERY GOOD BOOK FOR NURSES GREAT RESOURCE FOR
OR THOSE IN THE MEDICAL FIELD. NURSING STUDENTS!
“A very good reference book for “The Bible for Nurses creating
medical terms and meanings. care plans! Has everything you will
Explains what things are and need; disease definition, symptoms,
how they work, and where things NANDA’s, interventions. A must-have
are in the body” for students!“
~ Carol A. Miller ~ Dora Duran
ORDER YOUR COPY TODAY!
1. Available in your health science bookstore.
2. Call 800.323.3555 (US) | 800.665.1148 (CAN)
3. Visit www.FADavis.com.
DDG15E_House Ad_2015.indd 1 1/14/16 4:46 PM
Name /bks_53148_deglins_dg/53148_t 03/19/2D014 07:45AMH O PlatWe # 0- CTomOp osi teUpg 1S222E # 1YOUR
rug guiDe
Name /bks_53148_deglins_dg/53148_w 02/26/2014 01:45PM Plate # 0-Compositepg 1273 # 1
1222 traZODone
butorphanol,calciumgluconate,carboplatin, REMS
carmustine,cefazolin,ceftazidime,ceftriaxone, Risk Evaluation and
cefuroxime,ciprofloxacin,cisplatin,cyclophos- traZODone (traz-oh-done) Mitigation Strategies (REMS) Icon
phamide,cytarabine,dactinomycin,daunorubi- Desyrel, Oleptro, Trazorel
cinhydrochloride,dexamethasone,digoxin,di- NNNNNNaaaaaammmmmmeeeeee //////bbbbbbkkkkkkssssss______555555333333111111444444888888______ddddddeeeeeegggggglllllliiiiiinnnnnnssssss______ddddddgggggg//////555555333333111111444444888888______wwwwww 000000222222//////222222666666//////222222000000111111444444 000000111111::::::444444555555PPPPPPMMMMMM PPPPPPllllllaaaaaatttttteeeeee ###### 000000------CCCCCCoooooommmmmmppppppoooooossssssiiiiiitttttteeeeeeppppppgggggg 111111222222777777333333 ###### 111111
phenhydramine,dobutamine,docetaxel, Classification Active and Discontinued
dopamine,doxorubicin,doxorubicinliposome, Therapeutic: antidepressants Drug Trade Names
doxycycline,droperidol,enalaprilat,etoposide Pregnancy Category C warfarin 1273
phosphate,famotidine,fentanyl,filgrastim,flox-
uridine,fluconazole,fluorouracil,ganciclovir, Indications HIGH ALwwwwwwEaaaaaaRrrrrrrffffffaaaaaarrrrrrTiiiiiinnnnnn 111111222222777777333333 safelybutmayrequiremorefrequentPT/INRassess-
gemcitabine,gentamicin,gransietron,haloperi-
dol,heparin,hydrocortisone,hydromorphone, cMhRarjoEonrDidc etppaarbiens fssoyionrnd .HrUoimngehlas ,bineclleuddiUngsedi:aIbnestoicmnneiua,ropa- HHHHHHIIIIIIGGGGGGHHHHHH AAAAAALLLLLLEEEEEERRRRRRTTTTTT smsmsmsmsmsmaaaaaaeeeeeeffffffeeeeeennnnnnllllllttttttyyyyyyssssss;;;;;;bbbbbbGGGGGGuuuuuutttttteeeeeerrrrrrmmmmmmiiiiii::::::aaaaaaDDDDDDyyyyyyuuuuuurrrrrreeeeeeeeeeeeqqqqqqttttttuuuuuuooooooiiiiiiggggggrrrrrreeeeeerrrrrreeeeeemmmmmmaaaaaattttttooooooeeeeeerrrrrrrrrrrreeeeeetttttthhhhhhffffffrrrrrraaaaaaeeeeeennnnnnqqqqqqeeeeeeuuuuuuxxxxxxeeeeeeppppppnnnnnneeeeeettttttccccccPPPPPPttttttTTTTTTeeeeee//////ddddddIIIIIINNNNNNaaaaaannnnnnRRRRRRttttttiiiiiiaaaaaaccccccssssssoooooossssssaaaaaaeeeeeeggggggssssssuuuuuussssss------------ ments;Geri:Duetogreaterthanexpectedanticoagu-
ifosfamide,imipenem/cilastatin,leucovorin,lor- tAhyl,earntd manexdieitcy.ations CCCCCCoooooowwwwwwwuuuuuummmmmmaaaaaaaaaaaarrrrrrddddddaffffffaaaaaaiiiiiinnnnnnrrrrrr,,,,,,riiiiiiJJJJJJnnnnnnaaaaaafnnnnnna((((((ttttttoooooowwwwwwvvvvvvaaaaaareeeeeerrrrrrnnnnnn------iffffffaaaaaan------rrrrrriiiiiinnnnnn))))))(war-fallllll-aaaaaannnnnnrttttttrrrrrreeeeeeissssssnppppppoooooonnnnnn)sssssseeeeee,,,,,,iiiiiinnnnnniiiiiittttttiiiiiiaaaaaatttttteeeeeeaaaaaannnnnnddddddmmmmmmaaaaaaiiiiiinnnnnnttttttaaaaaaiiiiiinnnnnnaaaaaattttttlllllloooooowwwwwweeeeeerrrrrrddddddoooooosssssseeeeeessssss...... lantresponse,initiateandmaintainatlowerdoses.
adzineep,amme,smnaag,nmeestihuomtrseuxlafatete,,mmeathnynliptorel,dmniespoelorin-e, Action CCTCTCTCTCTCTohhhhhhllllllaaaaaaeeeeeessssssrrrrrrussssssaaaaaappppppiiiiiififififififieeeeeemccccccuuuuuuaaaaaattttttttttttiiiiiicccccciiiiiioooooo::::::annnnnnaaaaaannnnnndttttttiiiiiiccccccioooooonaaaaaagggggguuuuuu,llllllaaaaaannnnnnJttttttssssssantoven AGAGAGAGAGAGIIIIIIdddddd::::::vvvvvvcccccceeeeeerrrrrraaaaaarrrrrrmmmmmmsssssseeeeeeppppppssssssRRRRRR,,,,,,nnnnnneeeeeeaaaaaaaaaaaauuuuuusssssscccccceeeeeettttttaaaaaaiiiiii......ooooooDDDDDDnnnnnneeeeeessssssrrrrrr//////SSSSSSmmmmmmiiiiii::::::ddddddddddddeeeeeeeeeeeerrrrrrEEEEEEmmmmmmffffffaaaaaaffffffeeeeeellllllnnnnnncccccceeeeeettttttccccccssssssrrrrrroooooossssssiiiiiissssss......HHHHHHeeeeee------
metoclopramide,metronidazole,mitomycin,mi- AlterstheeffectsofserotonininthePPPPPPChhhhhhaaaaaaNrrrrrrmmmmmmS.aaaaaaccccccToooooollllllhooooooggggggeiiiiiiccccccr::::::accccccoooooopuuuuuuemmmmmmuaaaaaarrrrrr-iiiiiinnnnnnssssss mmmmmmaaaaaatttttt::::::BBBBBBLLLLLLEEEEEEEEEEEEDDDDDDIIIIIINNNNNNGGGGGG......MMMMMMiiiiiisssssscccccc::::::ffffffeeeeeevvvvvveeeeeerrrrrr...... AdverseReactions/SideEffects
tctccsoiuhaadxlrrlifaobcnanrioemlitl,ndriernaoetet/n,hemcpeo,l,riaxtfeopvaenuczanohilctpaalllneooint,arsailipvtx,deaees,enrlat,,acortpzoghbiemrnernaaoeytmm,pcapimhoynrycsi,oltidlivnmimiin,nnee,tebrt,s,hliotampahsdozeitiiotitunanhtmseeeos,p,pibravurai,imin-nmti-i--/ ptvtPAihieobchlanosaE.rpormforfmenpalcatycticsoooo:vngeAkcI:ercnoiWsnonteindoeenvtleemlt eprfiaarocnbilecsrtsswo searebnketsda.catfitoeCTPPIPmtrcIPmtrcIPmtrcIPmtrcIPmtrcIPmtrcniiiiiirnnnnnniiiiiirrrrrroooooorrrrrrssssssooooooheeeeeePPPPPP,oooooolhrddddddnnnnnnkkkkkkoaaaaaannnnnnpppppprrrrrr......waeiiiiiissssssooooooeeeeeeaaaaaaehhhhhhrMMMMMMacccccceeeeeerrrrrrffffffggggggyyyyyyhassssssaaaaaasyyyyyygddddddaaaaaallllllnnnnnnrraaaaaalrrrrrrinnnnnneeeeeetttttteeeeeeaaaaaaxxxxxxiiiiiicsaiiiiiimmmmmmmaaaaaaaaaaaassssssnannnnnniiiiiioooooottttttggggggkkkkkksssssshhhhhhhccccccbbbbbbdpieeeeeennnnnnaaaaaayyyyyyaoooooo,,,,,,oooooommmmmmfimnnnnnnssssssmDDDDDDafffffflllllleiiiiiiddddddeeeeeeCCCCCCffffffssssssneeeeeeuuuuuucnnnnnnicmmmmmmaccccccaaaaaattttttuttttttnrrrrrrttttttuuuuuurrrrrrttttttyc,,,,,,eeeeeeaoooooooeeeeeeeeeeeerrrrrriaaaaaaAAAAAAtaaaaaaffffffseeeeeeggggggdttttttyttttttssssssmmmmmmtimmmmmmtoooooorrrrrrltttttteeeeeeerhhhhhhciiiiiioirrrrrraaaaaayyyyyysssssseeeeeeyyyyyyrrrrrra-oooooollllllonnnnnnoooooorrrrrr:cccccc-fifififififigttttttiiiiiiCmmmmmmXXXXXXssssssaaaaaabbbbbboooooonkkkkkkrrrrrrbbbbbbrrrrrrffffffidddddd::::::aiiiiiiaooooooooooooclllllliiiiiiVVVVVVllllllffffffeeeeeeaaaaaaaaaaaaeeeeeenmmmmmmsssssstllllll:ttttttnnnnnnuuuuuuiiiiiiiiiiiieoooooobbbbbbnnnnnnoooooobbbbbbtnnnnnnffffffoooooouuuuuussssssaaaaaaigclllllleeeeeesssssswwwwwwrrrrrriiiiiicqqqqqqccccccccccccttttttiiiiiiohhhhhhuuuuuuotttttttttttteeeeeeoiiiiiihhhhhhrrrrrreeeeeeoooooovvvvvvoooooonnnnnnueeeeeeeeeeeennnnnnrmmmmmmattttttnnnnnnmmmmmm::::::yMMMMMMttttttDDDDDDmbbbbbbssssssbbbbbbg......ooooooeeeeeeIIIIIIoooooo,,,,,,PPPPPPccccccsssssslllllluDDDDDDiiiiiiiiiiiirrrrrrrrrrrrsssssszzzzzzaXeeeeeeeeeeeeeeeeee,,,,,,aaaaaaaaaaaavvvvvvl------------PPPPPPreeeeeessssssauuuuuueeeeeennnnnnillllllssssss------------nntssbbbbbbIDIDIDIDIDIDddddddctvctvctvctvctvctvddddddhhhhhhnnnnnnoaoaoaoaoaoaiiiiiiiiiiiiiiiiiirrrrrrnnnnnnssssssrrrrrrnnnnnnllllllttttttnnnnnnuuuuuuppppppuuuuuuooooooeeeeeeeeeeeeeeeeeeaaaaaarrrrrrggggggllllllmmmmmm,,,,,,,,,,,,rrrrrrzzzzzzfifififififiooooooaaaaaa------ccccccssssssoooooobbbbbbrrrrrraaaaaaDDDDDDeeeeeeuuuuuuccccccllllllaaaaaaoooooottttttfffffflllllleeeeeerrrrrrtttttteeeeeeoooooommmmmmffffffllllll,,,,,,iiiiiioooooouuuuuussssssyyyyyyttttttoooooommmmmm,,,,,,eeeeee,,,,,,ttttttnnnnnnggggggiiiiiinnnnnnflflflflflflaaaaaattttttaaaaaacccccc::::::eeeeeeaaaaaannnnnnuuuuuussssssssssssmmmmmmttttttAAAAAAnnnnnnddddddrrrrrr,,,,,,ccccccbbbbbb,,,,,,ooooooiiiiiieeeeeeooooooaaaaaaddddddccccccccccccnnnnnnppppppnnnnnnsssssshhhhhhiiiiiieeeeeettttttiiiiiippppppxxxxxxaaaaaasssssslllllliiiiiiddddddiiiiiiiiiiiizzzzzzoooooofifififififi,,,,,,mmmmmmaaaaaarrrrrroooooorrrrrrqqqqqqbbbbbbiiiiiizzzzzzaaaaaannnnnnllllllaaaaaauuuuuuaaaaaaooooooeeeeeemmmmmmbbbbbbttttttiiiiiimmmmmmllllll,,,,,,iiiiiinnnnnn,,,,,,eeeeeeddddddppppppflflflflflfliiiiiiaaaaaaaaaaaaeeeeee((((((hhhhhhuuuuuuddddddyyyyyynnnnnniiiiiiqqqqqq,,,,,,eeeeeeooooooiiiiiinnnnnnddddddnnnnnnttttttnnnnnnrrrrrrcccccciiiiiirrrrrreeeeeettttttrrrrrroooooolllllliiiiiihhhhhhoooooouuuuuucccccc,,,,,,ooooooqqqqqqeeeeeeddddddooooooggggggqqqqqqfifififififiuuuuuuiiiiiieeeeeerrrrrrlllllluuuuuunnnnnnbbbbbb,,,,,,iiiiiieeeeeennnnnniiiiiinnnnnnggggggaaaaaaccccccssssssnnnnnnssssssppppppoooooollllllnnnnnnvvvvvv,,,,,,iiiiiiooooooooooooaaaaaallllllnnnnnn,,,,,,ccccccppppppooooooggggggnnnnnnttttttaaaaaaeeeeeeiiiiiiiiiiiiiiiiiinnnnnnssssssnnnnnnpppppp,,,,,,ccccccddddddeeeeeeeeeeeeaaaaaaNNNNNNlllllleeeeeeoooooooooooottttttssssssllllllccccccooooooSSSSSSgggggg,,,,,,uuuuuuppppppiiiiiiAAAAAArrrrrriiiiiittttttwwwwwwssssssiiiiiittttttaaaaaaIIIIIIeeeeeeeeeeee------rrrrrraaaaaaDDDDDD------))))))llllllaaaaaarrrrrr,,,,,,,,,,,,ssssss------------,,,,,, GImnIat:etc:rrBaaLmcEtEpiDso,INnnGas.uMseias.cD:efervmer:.dermalnecrosis.He-
cristine,vinorelbine,zidovudine. Distribution:Widelydistributetptptptptptpdiiiiiiororororororoooooo.nnnnnnssssssooooootttttthhhhhhffffffeeeeeetttttttttttthhhhhhiiiiiiccccccrrrrrroooooovvvvvvmmmmmmaaaaaallllllbbbbbbvvvvvveeeeeeuuuuuussssssppppppffffffllllllooooooaaaaaaccccccrrrrrrmmmmmmeeeeeemmmmmmaaaaaatttttteeeeeeiiiiiinnnnnnoooooottttttnnnnnn......aaaaaannnnnnddddddeeeeeemmmmmmbbbbbboooooolllllliiiiiizzzzzzaaaaaattttttiiiiiioooooonnnnnnaaaaaafffffftttttteeeeeerrrrrr fmfmfmfmfmfmaaaaaarrrrrriiiiiiiiiiiinnnnnnnnnnnnooooooaaaaaappppppnnnnnnhhhhhhddddddeeeeeeqqqqqqnnnnnnttttttmmmmmmhhhhhheeeeeeaaaaaayyyyyyrrrrrrqqqqqqiiiiiisssssskkkkkktttttthhhhhhooooooeeeeeeffffffbbbbbbrrrrrriiiiiillllllsssssseeeeeekkkkkkeeeeeeddddddooooooiiiiiiffffffnnnnnnbbbbbbggggggllllll......eeeeeeCCCCCCeeeeeehhhhhhddddddrrrrrriiiiiioooooonnnnnnnnnnnngggggg......iiiiiiccccccCCCCCCuuuuuuhhhhhhssssssrrrrrreeeeeeoooooonnnnnnooooooiiiiiiffffffccccccaaaaaaaaaaaacccccclllllleeeeeeccccccttttttooooooaaaaaa------------ Drug-Drug:Abciximab,androgens,capecita-
● Yam-SpihteotIenrcicoinmBpactoilbloiliditayl:,aalzdtreesolenuakmin,,caemfoipkearcai-n, siPMdreeLo tietafeeffbi-onetlchBitsrisemn aidnati ennRngdE:iEnD8xg9,c –r9e5t%ioI.nn:AIAIAIAIAIAIdnnnnnnEcccccctttttteeeeeexttttttirrrrrriiiiiitffffffooooooceeeeeeerrrrrrnnnnnnneeeeeeassssssswwwwwwivtiiiiiittttttehhhhhhilhhhhhhyoeeeeeemppppppaaaaaantttttteiiiiiicccccctsassssssyyyyyybnnnnnnttttttohhhhhheeeeee-ssssssiiiiiissssssooooooffffffvvvvvviiiiiittttttaaaaaammmmmmiiiiiinnnnnnKKKKKK------ddddddeeeeeeppppppeeeeeennnnnn------ hahahahahahallllllooooooccccccllllllooooooiiiiiihhhhhhnnnnnnooooooggggggeeeeeellllllssssssaaaaaattttttiiiiiibbbbbboooooouuuuuunnnnnnsssssseeeeeemmmmmmrrrrrraaaaaaeeeeeeyyyyyyssssssppppppuuuuuullllllttttttaaaaaasssssscccccciiiiiittttttnnnnnniiiiiioooooossssssnnnnnniiiiiiggggggoooooonnnnnnffffffiiiiiififififififiwwwwwwccccccaaaaaaaaaaaarrrrrrnnnnnnffffffaaaaaattttttrrrrrrlllllliiiiiiiiiiiinnnnnnvvvvvveeeeee;;;;;;rrrrrriiiiiiffffffddddddccccccaaaaaahhhhhhmmmmmmrrrrrrooooooaaaaaannnnnnggggggiiiiiieeeeeecccccc,,,,,,aaaaaacccccc------ bine,cefotetan,chloramphenicol,clopidogrel,
zone,cefotaxime,cefotetan,cefoxitin,chlor- CAlizPedITbAyLthIeZElivDer le(CttYePr3sA4enzyPmreoddddddttttttiiiiiiseeeeeeccccccpnnnnnnyEEEEEEttttttshccccccfffffftllllllffffffeooooooeeeeeeymttttttccccccttttttiiiiiilttttttnnnnnnssssss)agggggg::::::;ffffffxPPPPPPaaaaaamrrrrrrccccccieeeeeettttttoooooovvvvvvsieeeeeerrrrrrnssssssnnnnnniatttttt((((((miiiiiiIIIIIIooooooIIIIIInnnnnnn,,,,,,aVVVVVVoooooodlIIIIIIffffffIIIIIItttttt,,,,,,hhhhhhIIIIIItrrrrrrXXXXXXoooooor,,,,,,mmmmmmaaaaaaennnnnnbbbbbbddddddaooooooeeeeeeXXXXXXtmmmmmm))))))m......bbbbbbTTTTTToooooohhhhhhlllllleiiiiiicccccceeeeeerrrrrrneeeeeeaaaaaavvvvvveeeeeepppppptnnnnnneeeeeettttttossssssuuuuuu......------f:Vttttttttttttiiiiiieiiiiiinnnnnnooooooggggggnnnnnnnffffffooooooaaaaaaoffffffccccccwwwwwwttttttoooooouaaaaaarrrrrrrrrrrr......ffffffsAAAAAAaaaaaarrrrrrcccccciiiiiiuuuuuutnnnnnnttttttheeeeeemmmmmmaaaaaaaaaaaarllllllyyyyyyccccccobbbbbbooooooeeeeeehhhhhhmqqqqqqoooooollllllddddddiiiiiibuuuuuunnnnnneeeeeeggggggoeeeeeettttttoooooossssssttttttppppppsiiiiiiooooooinnnnnnppppppsrrrrrrmmmmmmoooooo,aaaaaaddddddyyyyyyuuuuuuPqqqqqqccccccttttttiiiiiiuaaaaaaooooooccccccnnnnnnttttttliiiiiioooooooooooo-ffffffnnnnnnccccccoooooolllllloooooofffffftttttt------ disulfiram,fluconazole,fluoroquinolones,itra-
promazine,clindamycin,cyclosporine,fludara- excretionofunchangeddrugbmytohPPPPPPenhhhhhhaaaaaakarrrrrrimmmmmmdrnyaaaaaaecccccceyooooooskkkkkkm.iiiiiinnnnnneeeeeebttttttiiiiiioccccccsssssslism,Atrialfibrillawwwwwwaaaaaannnnnnaaaaaatddddddrrrrrriffffffhhhhhhaaaaaaorrrrrrooooooiiiiiinnnnnnrrrrrrnmmmmmm......BBBBBBooooooaaaaaawnnnnnnrrrrrraaaaaabbbbbbilllllliiiiiitttttttccccccuuuuuuoooooohrrrrrrnnnnnnaaaaaattttttttttttrrrrrreeeeeeeaaaaaassssssccccccm,,,,,,eeeeeeccccccppppppaaaaaattttttrrrrrrbiiiiiibbbbbbvvvvvvaaaaaaeeeeeeommmmmmsssssslccccccaaaaaaooooooizzzzzzznnnnnneeeeeettttttppppppaaaaaaaiiiiiiiiiiiinnnnnn-nnnnnneeeeeeiiiiii,,,,,,nnnnnnrrrrrrggggggiiiiiiffffffeeeeeeaaaaaassssssmmmmmmttttttrrrrrrppppppooooooiiiiii------nnnnnn,,,,,, conazole,metronidazole(includingvaginaluse),
bine,furosemide,idarubicin,irinotecan, Half-life:5–9hr(immediate-reAAAAAAlbbbbbbessssssaoooooosrrrrrrepppppp)ttttttiiiiii.oooooonnnnnn::::::WWWWWWeeeeeellllllllllllaaaaaabbbbbbssssssoooooorrrrrrbbbbbbeeeeeeddddddffffffrrrrrroooooommmmmmtttttthhhhhheeeeeeGGGGGGIIIIIIttttttrrrrrraaaaaaccccccttttttaaaaaafffffftttttteeeeeerrrrrr ggggggeeeeeennnnnnmmmmmmaaaaaayyyyyypppppptttttthhhhhheeeeeeaaaaaannnnnnttttttiiiiiiccccccooooooaaaaaagggggguuuuuullllllaaaaaannnnnnttttttrrrrrreeeeeessssssppppppoooooonnnnnnsssssseeeeeettttttoooooowwwwwwaaaaaarrrrrrffffffaaaaaarrrrrriiiiiinnnnnn......
levofloxacin,levorphanol,morphine,nalbu- tiooooooonrrrrrraaaaaa.llllllaaaaaaMddddddmmmmmmiiiiiiannnnnniiiiiissssssnttttttrrrrrraaaaaaattttttiiiiiioooooognnnnnne......mentofmyocardiaMMMMMMlaaaaaannnnnniyyyyyynooooooftttttthhhhhhaeeeeeerrrrrrrddddddcrrrrrrtuuuuuuiggggggossssssmmmmmmnaaaaaayyyyyy:aaaaaaffffffDffffffeeeeeeccccccetttttttttttthhhhhhceeeeeeraaaaaaccccccettttttiiiiiivvvvvvaiiiiiittttttyyyyyysooooooeffffffwwwwwwsaaaaaarrrrrrffffffaaaaaarrrrrriiiiiinnnnnn...... thrombolytics,eptifibatide,tirofiban,ticlopi-
phine,ondansetron,piperacillin/tazobactam, TIDMrEu/gA-CdTrIuOgN, dPRruOgF-ILE (arnistittttttDDDDDDkdeeeeeerrrrrriiiiiiessssssbbbbbbottttttprrrrrrrrrrrreeeeeeiiiiiirfaaaaaabbbbbbessssssuuuuuuttttttdsmmmmmmttttttsiiiiiieiiiiiioooooollllllakkkkkknnnnnnan......::::::ttCCCCCChrrrrrrooooooessssss,ssssssfeeeeeefDssssssettttttchhhhhheeeeeeet)ppppppcllllllaaaaaarcccccceeeeeeennnnnnttttttaaaaaaabbbbbbsuuuuuuettttttddddddsooooooeeeeeerssssssnnnnnnioooooosttttttkeeeeeennnnnn------ofDDDDDDffffffeeeeeesccccccrrrrrrttttttuuuuuuu......qqqqqqggggggb------bbbbbbNNNNNNllllllseeeeeeaaaaaaeeeeeettttttedddddduuuuuuiiiiiiqnnnnnnrrrrrraaaaaaggggggullllllrrrrrriiiiiiPPPPPPssssssekkkkkkrrrrrroooooowwwwwwnddddddiiiiiitttttttuuuuuuhhhhhhccccccaaaaaaMttttttnnnnnnssssssiiiiii::::::ssssssISSSSSSeeeeeetttttt,,,,,,,......aaaaaaJJJJJJrrrrrrDoooooonnnnnnhhhhhhiiiiiinnnnnncccccceaaaaaa’’’’’’ssssss,,,,,,-ccccccwwwwwwhhhhhhooooooaaaaaarrrrrrmmmmmmttttttppppppoooooommmmmmeeeeeeffffffiiiiii------lllllleeeeee,,,,,, dine,sulfonamides,quinidine,quinine,NSAIDs,
● sAzutdrmedpaitbtiovwzeoitIchninoc,rotamodppdoatttoeicbsaoinlliu.ttyio:nDsocnoonttadiinluintegtdreaxstturo-se. RPOOUnfoTaEotudr, aaln O1pd–Nr2S odEwdTrkuugct- P2E–ctA4iKrowekllllllPMHPMHPMHPMHPMHPMHniiiiiivvvvvvarrrrrraaaaaaeeeeeeeeeeeeoooooollllllrrrrrrttttttsoffffff......ttttttaaaaaa------eeeeeeebbbbbbllllllfiiiiiiiiiiiioooooonnnnnnffffffseeeeeetllllllBBBBBBiiiiii::::::Dwhssssssriiiiii444444mmmmmmnnnnnnkU222222riddddddssRhhhhhhoaaaaaaiiiiiirrrrrrnnnnnnkAnnnnnn......mggggggddddddT::::::IoEEEEEE999999Obxxxxxx999999fcccccc%%%%%%Nurrrrrr......feeeeeeusttttttiiiiiiooooootfnnnnnnuo::::::rMMMMMMreeeeeeemttttttaaaaaabbbbbbtooooooahlllllliiiiiitzzzzzzreeeeeeiddddddoobbbbbbmnyyyyyytttttthhhhhheeeeeebanodeccccccDDDDDDggggggoooooollllllmiiiiiittttttoooooohhhhhhrrrrrrnnnnnneuuuuuueeeeeevvvvvvggggggrrrrrreeeeeeggggggmeeeeeebssssss,,,,,,rrrrrr------......dddddd,,,,,,FFFFFFoggggggoooooooooooobiiiiiinnnnnnoooooonnnnnnlggggggoiddddddkkkkkkcqqqqqqgggggg::::::luuuuuuooooooIIIIIIinnnnnnaaaaaa,,,,,,ezggggggPPPPPPiiiiiieeeeee,,,,,,aaaaaaavssssssffffffnnnnnntttttteeeeeeiiiiiietoooooonnnnnnaaaaaainnnnnnxxxxxxuuuuuunoggggggooooooggggggrrrrrrfffffftiiiiiinnnnnnneeeeeellllllsaaaaaaeeeeeessssssrrrrrr.eeeeeekkkkkkggggggannnnnn,,,,,,eeeeeePffffffggggggfqqqqqqeeeeee,,,,,,tuuuuuuvvvvvvrlllllleaaaaaaeeeeeeiiiiiiccccccennnnnnrrrrrrroooooottttttffffffiiiiiieeeeeevrrrrrrttttttiiiiiiwwwwwwiiiiiieeeeeeeccccccssssss,,,,,,eeeeeeggggggoooooon,,,,,,aaaaaaffffffaaaaaaffffffrrrrrrnnnnnn-oooooollllllddddddiiiiiiooooooccccccdddddd,,,,,,ssssss fvaarlipnraonadtqest,haenrdisaksopfirbilneemdianygq.Cthhreorneiscpuosneseoftoacweatra--
Donotmixordilutewithotherdrugs. interactions TTTTTTIIIIIIMMMMMMEEEEEE//////AAAAAACCCCCCTTTTTTIIIIIIOOOOOONNNNNN PPPPPPRRRRRROOOOOOFFFFFFIIIIIILLLLLLEEEEEE ((((((eeeeeeffffffffffffeeeeeeccccccttttttssssssoooooonnnnnn hhhhhhiiiiiigggggghhhhhhiiiiiinnnnnnvvvvvviiiiiittttttaaaaaammmmmmiiiiiinnnnnnKKKKKKccccccoooooonnnnnntttttteeeeeennnnnntttttt((((((sssssseeeeeeeeeeeelllllliiiiiissssssttttttiiiiiinnnnnnAAAAAAppppppppppppeeeeeennnnnnddddddiiiiiixxxxxxMMMMMM))))))
Contraindications/Precparuocccccctooooooisaaaaaaoggggggtuuuuuuhnllllllaaaaaaesttttttiiiiiiooooootnnnnnnictttttteeeeeessssssvttttttssssssa))))))lveplacement. mmmmmmaaaaaayyyyyyaaaaaannnnnnttttttaaaaaaggggggoooooonnnnnniiiiiizzzzzzeeeeeetttttthhhhhheeeeeeaaaaaannnnnnttttttiiiiiiccccccooooooaaaaaagggggguuuuuullllllaaaaaannnnnntttttteeeeeeffffffffffffeeeeeeccccccttttttooooooffffffwwwwwwaaaaaarrrrrrffffffaaaaaarrrrrriiiiiinnnnnn...... minophenmayqtheriskofbleeding.Chronicalco-
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Patient/FamilyTeaching CrioodnatrftaerinMdIi;cCaotnecdurirne:ntHeylpeecrAtrsoeccnRPRPRPRPRPRPosOOOOOOOOOOOOti,,,,,,nUUUUUUtiIIIIIIVVVVVVTTTTTTivvoEEEEEEuitlysn;ivReO3O3O3O3O3O3e666666NNNNNNt––––––chSSSSSS777777EEEEEEoe222222TTTTTTvrhhhhhherrrrrrarpyyp;PPPPPP555555eEEEEEE––––––-AAAAAA777777KKKKKKddddddaaaaaayyyyyyssssss†††††† DDDDDD222222––––––UUUUUU555555RRRRRRAAAAAAddddddaaaaaaTTTTTTyyyyyyIIIIIIssssssOOOOOO‡‡‡‡‡‡NNNNNN RRRRRRooooooPPPPPPuuuuuuOOOOOOtttttt,,,,,,eeeeeeIIIIII//////VVVVVVDDDDDD((((((ooooooAAAAAAssssssddddddaaaaaauuuuuugggggglllllltttttteeeeeessssss))))))::::::222222––––––555555mmmmmmgggggg//////ddddddaaaaaayyyyyyffffffoooooorrrrrr222222––––––444444ddddddaaaaaayyyyyyssssss;;;;;;tttttthhhhhheeeeeennnnnn holingestionmaypactionofwarfarin;ifchronic
● Ipbnrrseotamrtuhpc,ttlcypoaiuftignehen,wtstwoonenslloeinttiogfyrohwfetoahrletsheancnaiknrlgeessp/hlreoogrfsetn,ssseiwsosenolalfilng CdoruAngcdsuu(drrlloiten ns&etazuo gpsleieedsod,of irwaMmtiArteOihtchi ynlheinbeitIdbonlreustn†‡C†‡C†‡C†‡C†‡C†‡Ceeo)ooooooAAAAAAAAAAAAtrrtftftftftftf.nnnnnnttttttaaaaaaeeeeeefcttttttorrrrrrccccccrrrrrreddddddooooooraaaaaaliiiiiinnnnnnssssssroiiiiiissssssMccccccnnnnnnttttttooooooeaaaaaatddddddnnnnnnnnnnnnAtttttttsttttttiiiiiiiiiiiiccccccnnnnnniddddddOuuuuuuoooooonaaaaaawaaaaaa-sssssstttttteeeeeettttttliiiiiiiiiiiigiooooooooooooiknnnnnnnnnnnntefhssssssa//////PPPPPPchrrrrrreeeeeeteoccccccaaaaaapruuuuuusattttttiiiiiioooooot(innnnnncIssssssIs,yVnItIh,eIsXi,alACalACalACalACalACalACsooooooddddddssssssYYYYYYawwwwwwiiiiiijjjjjjPPPPPPaaaaaauuuuuuoeeeeee222222nnnnnnnssssssrrrrrrCCCCCCttttttppppppfdddddd999999dddddddaaaaaaoooooo******aaaaaattttttvssssss333333iiiiiiiiiiiieeeeeelllllleeeeeeyyyyyyiXnnnnnnaaaaaasssssstddddddllllllttttttiiiiiillllllssssssaoooooonnnnnneeeeee)oooooollllllsssssseeeeeeggggggeeeeeemrrrrrr.sssssseeeeeettttttbbbbbbrrrrrroooooohhhhhhTiiiiiiyyyyyyaaaaaarrrrrrooooooirrrrrrttttttssssssVVVVVVrrrrrrneeeeeeeeeeeehiiiiiiKKKKKKssssssccccccwwwwwwuuuuuuOOOOOOoooooolllllliiiiiiKRRRRRRettttttttttttrrrrrrsssssshhhhhhCCCCCCddddddoooooo-111111CCCCCCreeeeeeffffffdYYYYYYbbbbbbAAAAAAIIIIIIPPPPPPaNNNNNNiiiiiiAAAAAAlllllle222222iiiiiiRRRRRRggggggttttttCCCCCCaaaaaap......eeeeeep999999ttttttIIIIIInnnnnneeeeeennnnnn******ddddddooooooee222222iiiiiittttttttttttppppppyyyyyyiiiiiiaaaaaaaaaaaanppppppaaaaaaunnnnnntttttteeeeeetttttteeeeeeiiiiiidddddd......-eeeeeetttttt//////nnnnnnhhhhhh-ooooootttttteeeeeerrrrrrssssssrrrrrraaaaaaoooooopppppprrrrrryyyyyyiiiiiinnnnnnwwwwwwiiiiiitttttthhhhhh atilocnoohfowlaarbfaursienrmesauyltbseiqnsdiguneifitocpanptrliovderucdtaiomnaogef,caloct--
opfotuhnedfsacine,2p4ahlpoiutartsio,dnisz,zwineeisgshtogralionssofomfcoornestchioanus5- pcUhisdaearlcCmboaeahnuacttvieoioongurte;s,Mn lwyaoyhimqne:irncCis akrdoifosvtuaiisccciCCCCCCwnwnwnwnwnwnudaaaaaaoooooooooooolllllllEeuuuuuunnnnnnaccccccnnnnnnoooooottttttraddddddrrrrrrfrrrrrrtssssssaaaaaadddddddtf;;;;;;eiiiiiiiiiiiiAAAAAAinnnnnnennnnnnsmccccccjjjjjjddddddettttttuuuuuuiiiiiiciiiiiivvvvvvrrrrrrpacccccceeeeeeyyyyyysaaaaaattoooooouuuuuu/ettttttrrrrrrllllllsieeeeeecccccc;dssssssddddddeeeeeeuuuuuuS:rrrrrrerrrrrriiiiiiuddddddaggggggnnnnnnPiiiiiieeeeeeitssssss::::::rrrrrr-ieeeeeeyyyyyyUUUUUUoraaaaaa;;;;;;nnnnnnssssssnSSSSSSeeeeeeecccccceeeeee;;;;;;oooooovvvvvvvRRRRRRnnnnnneeeeeeeeeeeettttttrrrrrrerrrrrreeeeeeccccccooooooeeeeeenlllllllllllliiiiiinnnnnnllllllvvvvvveeeeeetttttteeeeeetddddddbbbbbbrrrrrrirrrrrrbbbbbboooooooaaaaaallllllrrrrrreeeeeeiiiiiinnnnnneeeeeekkkkkkn,,,,,,ddddddiiiiiiddddddeeeeeeiiiiiinnnnnnyyyyyynnnnnnoeeeeeeggggggeeeeee,,,,,,;;;;;;yyyyyyooooooOOOOOOfddddddrrrrrrppppppiiiiiitsssssssssssseeeeee------pppppphnnnnnniiiiii------roPPPPPP0a0a0a0a0a0addddddm......OOOOOO222222jjjjjjuuuuuu,,,,,,mmmmmmssssssIIIIIIbttttttVVVVVVggggggdddddd//////((((((kkkkkkoaaaaaaCCCCCCiiiiiiggggggllllllhhhhhhyyyyyye((((((iiiiiiddddddmmmmmmllllllmooooooddddddaaaaaassssssrrrrrrxxxxxxeeeeeeeeeeeeiiiiiimmmmmmbbbbbbbnnnnnnyyyyyyuuuuuu(cid:30)(cid:30)(cid:30)(cid:30)(cid:30)(cid:30)orrrrrrmmmmmmeeeeee111111ssssssldddddduuuuuummmmmmioooooollllllcttttttssssssoooooosssssseeeeee))))))oooooo::::::::::::e111111ffffffIIIIIIIIIIII000000nnnnnnNNNNNNviiiiiimmmmmmRRRRRRtttttteiiiiii,,,,,,ggggggaaaaaauuuuuu))))))nllllllssssssfffffflllllleeeeeeooooooooooootrrrrrraaaaaa000000sdddddd222222......111111iiiiii.––––––nnnnnnmmmmmm444444ggggggggggggdddddddddddd//////ooooookkkkkkaaaaaayyyyyyssssssggggggsssssseeeeeeiiiiii——————fffffftttttthhhhhheeeeeennnnnn tingfactor.Acutealcoholingestionmayqactionof
nessoccur.Cautionpatienttoavoidcrowdsand especiallydauprpinlgiceaarblyletreatmentoeeeeeeaaaaaarsssssseeeeeed;;;;;;oUUUUUUnnnnnnscccccceoooooonnnnnnattttttrrrrrrdoooooojllllllllllllueeeeeeddddddsthhhhhhmyyyyyyppppppeeeeeeerrrrrrntttttteeeeeetnnnnnn;ssssssiiiiiioooooonnnnnn;;;;;;OOOOOOBBBBBB::::::CCCCCCrrrrrroooooosssssssssssseeeeeessssssppppppllllllaaaaaacccccceeeeeennnnnnttttttaaaaaa lllllliiiiiivvvvvveeeeeerrrrrrddddddyyyyyyssssssffffffuuuuuunnnnnnccccccttttttiiiiiioooooonnnnnniiiiiisssssspppppprrrrrreeeeeesssssseeeeeennnnnntttttt......MMMMMMaaaaaaiiiiiinnnnnntttttteeeeeennnnnnaaaaaannnnnncccccceeeeeeddddddoooooosssssseeeeee warfarin.Barbiturates,carbamazepine,rifampin,
personswithknowninfections. SeverehepaticorrenaldiseaseP(hdacacacacacaconanananananaauuuuuuddddddsssssssemmmmmmeeeeeeprccccccaaaaaaooooooyyyyyymnnnnnnccccccrggggggaaaaaaeeeeeeeuuuuuunnnnnncssssssaeeeeeeiiiiiiottttttaaaaaaffffffaaaaaamllllllcttttttmmmmmmaaaaaa-llllllaaaaaaohhhhhhllllllffffffeeeeeeoooooommmmmmkrrrrrrmmmmmmoooooorrrrrriaaaaaarrrrrrttttttiiiiiihhhhhhnooooooaaaaaannnnnngggggg......eeeeeeeiiiiiinnnnnnttttttthhhhhhieeeeeecffffffeeeeeettttttsuuuuuussssss......MMMMMMaaaaaayyyyyyaaaaaallllllssssssoooooo rrrrrraaaaaannnnnnggggggeeeeee——————000000......000000555555––––––000000......333333444444mmmmmmgggggg//////kkkkkkgggggg//////ddddddaaaaaayyyyyy...... andhormonalcontraceptivescontainingestro-
● Mcinoganyctrcoaamcuepspeletittoeionrandtoougfreitnhngeicraaenpfdfyefacontrsd.aCttoaleuaatvisootin6dpmbartoeieafnosttlltoowu-se mPleesedcnie:dnSetuds;i)cs;iadLfaeecrutiasstekionmno:atDyeibsstecaobgnlrietsiahnoAteuederrb;aidtatatatatataUUUUUUttttttGooooooiiiiiinnnnnnneeeeeesssssssrlrrrrrrccccccnnnnnneyyyyyyeeeeeeuceeeeeettttttorassssssoooooo;;;;;;ghCCCCCCiffffffooooooWWWWWW:daaaaaaiuuuuuurrrrrrroooooooluuuuuullllllIttttttdccccccmmmmmmmhhhhhhrnttttttpeeeeeeiiiiiirooooooeeeeeerrrrrrioooooobssssssennnnnntooooooeeeeeeuuuuuutiionrrrrrrwwwwwwawwwwwwnssssssitlllllliiiiiillllllliiiiiithhhhhhttttttavvvvvvyyyyyyohhhhhhlioooooodeeeeeenesiiiiiiccccccrrrrrrcccccconnnnnndhhhhhhnddddddaaaaaaftiiiiii::::::serrrrrriiiiiillllllrssssssaddddddrrrrrrMMMMMMeeeeeeee:yyyyyybbbbbbapdaaaaaaaaaaaadtttttteeeeeesssssshhhhhhllllllotaaaaaaiiiiiiWeeeeee;eeeeeeggggggrrrrrri;;;;;;-nnnnnniiiiiiCCCCCCoHHHHHHnnnnnnaaaaaaYYYYYYggggggiiiiiiennnnnnssssssPPPPPPnccccccpppppptttttt222222oooooolyyyyyyooooooCCCCCC;;;;;;rrrrrr.lttttttyyyyyy999999eeeeeePPPPPPnnnnnn******aoooaaaoaoaoa222222ttttttttttttffffffiiiiiiiiiiiiaaaaaaeeeeeebppppppaaaaaallllllnnnnnnoooooollllll;;;;;;llllllttttttooooooseeeeeessssssrrrrrrllllllwwwwwweeeeeeoAAAAAAcccccciiiiiiaaaaaassssssoooooottttttrhhhhhhnnnnnniiiiiimmmmmmaaaaaaddddddnnnnnnbhhhhhhpppppp//////iiiiiiooooooppppppllllllssssssiiiiiierrrrrr------aaaaaa------------dfAT7AT7AT7AT7AT7AT7222222r......aaaaaavvvvvvmmmmmm555555obbbbbbaaaaaammmmmmgggggglllllliiiiiieeeeeem$$$$$$ggggggllllllttttttaaaaaa111111,,,,,,ssssss111111000000::::::bbbbbb000000......111111888888iiiiiitllllllmmmmmm333333mmmmmmhiiiiii//////ttttttgggggggggggg111111yyyyyye......,,,,,,000000CCCCCC222222((((((000000ggggggoooooo,,,,,,mmmmmmGssssss222222eeeeeeggggggtttttt......nnnnnn::::::555555,,,,,,IGGGGGGeeeeee222222mmmmmm......eeeeeerrrrrrt555555ggggggnnnnnniiiiiirccccccmmmmmmeeeeee$$$$$$arrrrrr111111aaaaaaggggggiiiiii000000,,,,,,ccccccvvvvvvc......333333——————888888aaaaaat333333mmmmmmiiiiii//////llllll111111gggggg111111aaaaaaa,,,,,,000000mmmmmmbbbbbb444444f000000ggggggllllllt,,,,,,mmmmmmeeeeee333333$$$$$$egggggg))))))111111mmmmmm,,,,,,r000000555555gggggg......888888mmmmmm$$$$$$333333111111//////gggggg111111000000,,,,,,000000......666666888888000000333333mmmmmm,,,,,,//////gggggg,,,,,, Mgeannmyoaytphetrhedraungticsomagauylaafnfetcrtetshpeoancsteivtiotywoafrwfaarrifna.rin.
feeding. recommended;useextended-rDeleit(t(t(t(t(t(aqqqqqqhhhhhhsseeeeeerrrrrrteCCCCCCiiiiiissssssYYYYYYrtkkkkkkPPPPPPa222222ooooooibCCCCCCffffffb999999bbbbbble******lllllleeeeee333333tueeeeeesddddddaaaaaalllllliiiiiiwlllllltnnnnnneeeeeegggggglllllliieeeeeetwwwwww,,,,,,ohiiiiiiooooootttttthhhhhhrrrrrrcnwwwwwwssssssattttttiiiiiiaaaaaattttttu:hhhhhhnnnnnn-ddddddtttttthhhhhhaaaaaaCeeeeeerrrrrrddddddrVVVVVVddddddKKKKKKoooooooOOOOOOssssssRRRRRRsiiiiiinnnnnnCCCCCCsgggggg111111;;;;;;eAAAAAAllllllooooooAAAAAAswwwwwwggggggeeeeeeeeeeeerrrrrrtnnnnnniiiiiihoooooonnnnnnttttttiiiiiiyyyyyytttttteppppppiiiiiiaaaaaaeeeeeellllllpla111111111111000000000000c000000000000,,,,,,,,,,,,e474747474747......nmmmmmm555555mmmmmmggggggt$$$$$$agggggg111111$$$$$$000000111111b......8888880000003.3.3.3.3.3.u888888//////333333111111t//////000000111111000000000000d,,,,,,000000555555,,,,,,ommmmmm111111000000eggggggmmmmmm$$$$$$s888888gggggg......5$5$5$5$5$5$n212121212121/0/0/0/0/0/0o111111......888888000000t333333000000//////,,,,,,111111e666666000000mmmmmm000000n......ggggggPPPPPP-$$$$$$oooooo111111wwwwww000000dddddd......666666eeeeee444444rrrrrr////// Drug-NaturalProducts:St.John’swortpef-
● Aoduvtiasdevpicaetieonfthneoaltthtocraerceepivreoafensysivoancacli.nationswith- tAiodnv.erseReactions/SidteerEddddddfoooooobfsssssseeeeeeersssssscssssssehhhhhhtooooooasuuuuuusllllllddddddtbbbbbbeeeeeemccccccoooooonnnnnnissssssliiiiiiddddddkeeeeee(cid:31)(cid:31)(cid:31)(cid:31)(cid:31)(cid:31)rrrrrr.eeeeeeCCCCCCddddddaaaaaannnnnn))))))aaaaaa;;;;;;ddddddPPPPPPiiiiiiaaaaaaeeeeeennnnnnddddddiiiiiidddddd::::::rrrrrrHHHHHHuuuuuuggggggaaaaaassssssnnnnnnaaaaaabbbbbbmmmmmmeeeeeeeeeeeeeeeeee......nnnnnnuuuuuussssss(cid:31)(cid:31)(cid:31)(cid:31)(cid:31)(cid:31)eeeeeeddddddGGGGGGeeeeeennnnnneeeeeettttttiiiiiicccccciiiiiimmmmmmffffffppppppoooooolllllliiiiiirrrrrrccccccaaaaaaiiiiiittttttiiiiiinnnnnnoooooonnnnnnjjjjjjeeeeee......ccccccSSSSSSttttttttttttrrrrrriiiiiiiiiiiiooooookkkkkkeeeeeennnnnntttttthhhhhh::::::rrrrrr555555oooooouuuuuummmmmmgggggghhhhhhgggggg(cid:31)(cid:31)(cid:31)(cid:31)(cid:31)(cid:31)//////vvvvvviiiiiiDDDDDDaaaaaaiiiiiillllllssssss......ccccccoooooonnnnnnttttttiiiiiinnnnnnuuuuuueeeeeedddddd...... fect.qbleedingriskwithanise,arnica,chamomile,
CNS:SUICIDALTHOUGHTS,droPwsrinoestse,cionnfuBsioinn,dd******iCCCCCCziAAAAAA-PPPPPPnIIIIIITTTTTTAAAAAALLLLLLgSSSSSSiiiiii:nnnnnnddddddiiiiiicccccc9aaaaaatttttteeeeee9ssssssllllll%iiiiiiffffffeeeeee------tttttthhhhhh.rrrrrreeeeeeaaaaaatttttteeeeeennnnnniiiiiinnnnnngggggg;;;;;;uuuuuunnnnnnddddddeeeeeerrrrrrlllllliiiiiinnnnnneeeeeessssssiiiiiinnnnnnddddddiiiiiiccccccaaaaaatttttteeeeeemmmmmmoooooossssssttttttffffffrrrrrreeeeeeqqqqqquuuuuueeeeeennnnnntttttt...... clove,dongquai,fenugreek,feverfew,garlic,
Evaluation/DesiredOutcomes ziness,fatigue,hallucinations,Mheaedtacahbe,oinlsoimsnmia,andExcretion:Metabolizedbythe ginger,ginkgo,Panaxginseng,licorice,and
● Regressionofbreast,gastric,orgastroesophageal nightmares,slurredspeech,sylnivcoepre.,weakness. others.
cancerandmetastases. EENT:blurredvision,tinnitus.CV:hypotension,ar-
rhythmias,chestpain,hyperteHnsiaonl,fp-allpiiftaeti:on4s,2QhTr. Drug-Food:Ingestionoflargequantitiesoffoods
intervalprolongation,tachycardia.GI:drymouth,al- highinvitaminKcontent(seelistinAppendixM)
teredtaste,constipation,diarrTheIaM,exEc/esAsCsaTlivIaOtioNn, PROFILE (effects on
mayantagonizetheanticoagulanteffectofwarfarin.
coagulation tests)
W
ROUTE ONSET PEAK DURATION Route/Dosage
PO,IV 36–72hr 5–7days† 2–5days‡ PO,IV(Adults):2–5mg/dayfor2–4days;then
adjustdailydosebyresultsofINR.Initiatetherapywith
†Ataconstantdose
lowerdosesingeriatricordebilitatedpatientsorin
‡Afterdiscontinuation
AsianpatientsorthosewithCYP2C9*2and/or
Contraindications/Precautions CYP2C9*3allelesorVKORC1AAgenotype.
Contraindicatedin:Uncontrolledbleeding;Open PO,IV(Children(cid:30)1mo):Initialloadingdose—
wounds;Activeulcerdisease;Recentbrain,eye,orspi- 0.2mg/kg(maximumdose:10mg)for2–4daysthen
nalcordinjuryorsurgery;Severeliverorkidneydis- adjustdailydosebyresultsofINR,use0.1mg/kgif
ease;Uncontrolledhypertension;OB:Crossesplacenta liverdysfunctionispresent.Maintenancedose
andmaycausefatalhemorrhageinthefetus.Mayalso range—0.05–0.34mg/kg/day.
causecongenitalmalformation.
UseCautiouslyin:Malignancy;Patientswithhis- Availability(genericavailable)
toryofulcerorliverdisease;Historyofpoorcompli- Tablets:1mg,2mg,2.5mg,3mg,4mg,5mg,6mg,
ance;Womenwithchildbearingpotential; Asianpa- 7.5mg,10mg.Cost:Generic—1mg$10.83/100,
tientsorthosewhocarrytheCYP2C9*2alleleand/or 2mg$10.83/100,2.5mg$10.83/100,3mg$10.83/
theCYP2C9*3allele,orwiththeVKORC1AAgenotype 100,4mg$10.83/100,5mg$8.52/100,6mg$10.64/
(qriskofbleedingwithstandarddosing;lowerinitial 100,7.5mg$10.83/100,10mg$10.83/100.Powder
dosesshouldbeconsidered);Pedi:Hasbeenused forinjection:5mg/vial.
(cid:31)Canadian drug name. (cid:31)Genetic implication. Strikethrough(cid:31)Discontinued.
*CAPITALS indicates life-threatening; underlines indicate most frequent.
New Heading
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Name /bks_53148_deglins_dg/53148_w 02/26/2014 01:45PM Plate # 0-Compositepg 1273 # 1
drugs in males and females of reproductive age
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NNNNNNNNUUUUUUUURRRRRRRRSSSSSSSSIIIIIIIINNNNNNNNGGGGGGGG IIIIIIIIMMMMMMMMPPPPPPPPLLLLLLLLIIIIIIIICCCCCCCCAAAAAAAATTTTTTTTIIIIIIIIOOOOOOOONNNNNNNNSSSSSSSS tttttttteeeeeeeerrrrrrrriiiiiiiinnnnnnnngggggggg,,,,,,,,eeeeeeeevvvvvvvvaaaaaaaalllllllluuuuuuuuaaaaaaaatttttttteeeeeeeerrrrrrrreeeeeeeecccccccceeeeeeeennnnnnnnttttttttIIIIIIIINNNNNNNNRRRRRRRRoooooooorrrrrrrrPPPPPPPPTTTTTTTTwrrrrrrrreeeeeeeeassssssssuuuuuuuurllllllllfttttttttassssssssraaaaaaaainnnnnnnnnddddddddhhhhhhhhaaaaaaaa1vvvvvvvveeeeeeee273
sssssssseeeeeeeeccccccccoooooooonnnnnnnnddddddddpppppppprrrrrrrraaaaaaaaccccccccttttttttiiiiiiiittttttttiiiiiiiioooooooonnnnnnnneeeeeeeerrrrrrrriiiiiiiinnnnnnnnddddddddeeeeeeeeppppppppeeeeeeeennnnnnnnddddddddeeeeeeeennnnnnnnttttttttllllllllyyyyyyyycccccccchhhhhhhheeeeeeeecccccccckkkkkkkkoooooooorrrrrrrriiiiiiiiggggggggiiiiiiiinnnnnnnnaaaaaaaallllllll All 5 steps of the
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●●●●●●●●A(A(A(A(A(A(A(A(wbbbbbbbbsssssssssssssssslllllllleeeeeeeeeeeeeeeeaeeeeeeeessssssssssssssssddddddddriiiiiiiiffffffffnnnnnnnnfooooooooggggggggarrrrrrrrggggggggssssssssriiiiiiiiuuuuuuuuggggggggimmmmmmmmnnnnnnnnnssssssssssssssss;;;;;;;;oooooooonnnnnnnn(ffffffffoooooooowbbbbbbbbsssssssslllllllleeeeeeeeeeeeeeeeaeeeeeeeebbbbbbbbrddddddddlllllllleeeeeeee-iiiiiiiinnnnnnnneeeeeeeefddddddddgggggggga;;;;;;;;aaaaaaaa-uuuuuuuunnnnnnnnrnnnnnnnnddddddddiuuuuuuuunhhhhhhhhssssssss)uuuuuuuueeeeeeeemmmmmmmmaaaaaaaalllllllloooooooobbbbbbbbrrrrrrrrrrrrrrrrrrrrrrrruuuuuuuuhhhhhhhhiiiiiiiiaaaaaaaassssssssiiiiiiiiggggggggnnnnnnnneeeeeeeegggggggg;;;;;;;;ttttttttaaaaaaaarrrrrrrrrrrrrrrryyyyyyyy,,,,,,,, ●●●●●●●●mlaneD(D(D(D(D(D(D(D(tnrrrrrrrroooooooorooooooootsessssssssnnnnnnnn;siiiiiiiiooooooooggggggggGpttttttttlllllllloeiiiiiiiiccccccccttttttttrnaaaaaaaaooooooooizzzzzzzzs:nnnnnnnnooooooooeDffffffff,nnnnnnnnuuuuuuuuuieeeeeeeessssssssne))))))))eeeeeeeeittooooooooCCCCCCCCioarrrrrrrrooooooootguuuuuuuuCCCCCCCCermmmmmmmmaaaaaaaaearrrrrrrraaaaaaaaanddddddddddddddddtduuuuuuuueiiiiiiiirrrrrrrrrnnnnnnnnmaaaaaaaat((((((((ha((((((((wwwwwwwwiaddddddddnaaaaaaaanooooooootrrrrrrrraxxxxxxxxeffffffffiaaaaaaaaaaaaaaaaxnrrrrrrrrzzzzzzzzpiiiiiiiiooooooooannnnnnnnesssssssst))))))))ciiiiiiiilnnnnnnnntowwwwwwwwe))))))))wdiiiiiiii........ttttttttehhhhhhhhDDDDDDDDarnooooooooAAAAAAAAdtvvvvvvvvnnnnnnnnioaaaaaaaacoooooooonnnnnnnnsotttttttteddddddddasiiiiiiiigaaaaaaaa.u- nursing process
Cobbbbbbbblllllllluaaaaaaaamcccccccckkkkkkkkassssssssttttttttdooooooooioooooooonllllllllssssssss,;;;;;;;;Jhhhhhhhhaeeeeeeeemmmmmmmmntaaaaaaaaottttttttuuuuuuuuvrrrrrrrreiiiiiiiiaaaaaaaan;;;;;;;;ffffffffaaaaaaaalllllllllllllllliiiiiiiinnnnnnnnhhhhhhhheeeeeeeemmmmmmmmaaaaaaaattttttttooooooooccccccccrrrrrrrriiiiiiiittttttttoooooooorrrrrrrrBBBBBBBBPPPPPPPP;;;;;;;; ccccccccoooooooonnnnnnnnffffffffuuuuuuuusssssssseeeeeeeeJJJJJJJJaaaaaaaannnnnnnnttttttttoooooooovvvvvvvveeeeeeeennnnnnnn((((((((wwwwwwwwaaaaaaaarrrrrrrrffffffffaaaaaaaarrrrrrrriiiiiiiinnnnnnnn))))))))wwwwwwwwiiiiiiiitttttttthhhhhhhhJJJJJJJJaaaaaaaannnnnnnnuuuuuuuummmmmmmmeeeeeeeetttttttt((((((((ssssssssiiiiiiiittttttttaaaaaaaagggggggglllllllliiiiiiiipppppppp--------
●●●●●●●●CTPhlhgrAtgrAtgrAtgrAtgrAtgrAtgrAtgrAtaehhhhhhhhaaaaaaaaauuuuuuuusssssssssrrrrrrrrrrttttttttssssssssaaaaaaaaeeeeeeeesaoooooooomeeeeeeeeiiiiiiii))))))))piaaaaaaaammmmmmmmssssssssfi........assssssssccccccccecbbbbbbbbc--------uffffffffppppppppaoooooooooooooooootoooooooosssssssstirrrrrrrrlcoiiiiiiiiissssssssoeeeeeeeessssssss:iiiiiiiig........ttttttttvvvvvvvvniiiiiiiiiiiiiiiiiSSSSSSSSavvvvvvvvcddddddddyyyyyyyyeeeeeeeen:eeeeeeeemmmmmmmmtssssssssnnnnnnnnicttttttttppppppppcccccccccooooooooottttttttoeeeeeeeeoooooooooooooooouaoooooooollllllllmmmmmmmmmssssssssgffffffff,,,,,,,,ssssssssuaaaaaaaaauuuuuuuuddddddddlddddddddrrrrrrrrraiddddddddeeeeeeeeiiiiiiiinnnnnnnnnnppppppppiiiiiiiitttttttttseeeeeeeeeeeeeeeeiiiiiiiis,,,,,,,,oooooooonnnnnnnnoooooooonnnnnnnnddddddddrrrrrrrraaaaaaaaoooooooollllllllnnnnnnnnnnnnnnnnooooooooaaaaaaaarrrrrrrrssssssssaaaaaaaaooooooooiiiiiiiirrrrrrrrnnnnnnnnggggggggeeeeeeeeccccccccaaaaaaaaaaaaaaaarrrrrrrrssssssssooooooooeeeeeeeettttttttrrrrrrrrffffffffaaaaaaaaiiiiiiiissssssssiiiiiiiiccccccccnnnnnnnneeeeeeeeaaaaaaaavvvvvvvvddddddddoooooooossssssssppppppppllllllllvvvvvvvviiiiiiiieeeeeeee---------------- ●●●●●●●●AGmIdtBbftBbftBbftBbftBbftBbftBbftBbfa:iuiuiuiuiuiuiuiuvnlnlnlnlnlnlnlnleeeeeeeetelelelelelelelelc:////////ccccccccemmmmmmmmrmmmmmmmmooooooooaaaaaaaaBaruuuuuuuuffffffffooooooooLeeeeeeeemsssssssssssssssssEnnnnnnnnttttttttefeifeifeifeifeifeifeifeiEpiiiiiiiiogogogogogogogogttttttttDsoooooooonnnnnnnnoooooooorrrrrrrrR,mmmmmmmmIffffffffiiiiiiiirrrrrrrrNfifififififififiniiiiiiiittttttttennnnnnnnhhhhhhhhiiiiiiiiGccccccccannnnnnnnggggggggaaaaaaaaaeeeeeeee.u))))))))nnnnnnnnMiiiiiiiiscllllllllssssssssooooooooaaaaaaaattttttttelllllllltrrrrrrrrrrrrrrrryyyyyyyyiarrrrrrrriggggggggseeeeeeee.oJJJJJJJJaaaaaaaaeeeeeeeeccccccccaaaaaaaacDllllllllnttttttttoooooooonnnnnnnnnnnnnnnn:eeeeeeeeemmmmmmmmuuuuuuuusuuuuuuuurrrrrrrrfervvvvvvvviiiiiiiimmmmmmmm/mmmmmmmmnnnnnnnnviiiiiiiiSmaaaaaaaaeggggggggbbbbbbbbeeeeeeeeir((((((((eeeeeeeennnnnnnnwwwwwwww:d.ssssssssrrrrrrrrdddddddddaaaaaaaaiiiiiiiiettttttttooooooooeeeeeeeerrrrrrrreaaaaaaaaddddddddffffffffffffffffrggggggggaaaaaaaaEmmmmmmmmmllllllllrrrrrrrrwwwwwwwwiiiiiiiifiiiiiiiippppppppeeeeeeeeannnnnnnnfhhhhhhhhttttttttddddddddel’’’’’’’’eeeeeeeeiiiiiiiissssssssnnnnnnnniiiiiiiinnnnnnnnnccccccccc))))))))eeeeeeeeeaaaaaaaatnnnnnnnn........ffffffffcttttttttsffffffffeeeeeeeeiiiiiiiieeeeeeeeroooooooowwwwwwwwoccccccccnnnnnnnnttttttttsssssssssssssssssaaaaaaaai,,,,,,,,sggggggggcccccccccccccccc.eeeeeeeeaaaaaaaaaaaaaaaaHnnnnnnnnpppppppprrrrrrrrttttttttaaaaaaaaeeeeeeeesssssssse-----------------
Prmmmmmmmmegeeeeeeeennnnnnnnntttttttta........ncyCategoryX Inaaaaaaaatrrrrrrrreeeeeeeeerssssssssattttttttaaaaaaaacrrrrrrrrttttttttteeeeeeeeioddddddddnoooooooorrrrrrrrsooooooootttttttthhhhhhhheeeeeeeerrrrrrrraaaaaaaaggggggggeeeeeeeennnnnnnnttttttttssssssssaaaaaaaarrrrrrrreeeeeeeeddddddddiiiiiiiissssssssccccccccoooooooonnnnnnnnttttttttiiiiiiiinnnnnnnnuuuuuuuueeeeeeeedddddddd........IIIIIIIInnnnnnnntttttttteeeeeeeerrrrrrrr--------
●●●●●●●●GGGGGGGGeeeeeeeerrrrrrrriiiiiiii::::::::PPPPPPPPaaaaaaaattttttttiiiiiiiieeeeeeeennnnnnnnttttttttssssssssoooooooovvvvvvvveeeeeeeerrrrrrrr6666666600000000yyyyyyyyrrrrrrrreeeeeeeexxxxxxxxhhhhhhhhiiiiiiiibbbbbbbbiiiiiiiittttttttggggggggrrrrrrrreeeeeeeeaaaaaaaatttttttteeeeeeeerrrrrrrrtttttttthhhhhhhhaaaaaaaannnnnnnneeeeeeeexxxxxxxx-------- Draaaaaaaauccccccccttttttttgiiiiiiiivvvvvvvv-eeeeeeeeDpppppppprooooooooutttttttteeeeeeeegnnnnnnnn:ttttttttiiiiiiiiAaaaaaaaallllllllbsssssssschhhhhhhhiooooooooxuuuuuuuuimllllllllddddddddabbbbbbbbbeeeeeeee,eeeeeeeeavvvvvvvvaaaaaaaanllllllllduuuuuuuuraaaaaaaattttttttoeeeeeeeegddddddddeffffffffnoooooooorrrrrrrrs,aaaaaaaacllllllllllllllllannnnnnnnpeeeeeeeeewwwwwwwwcita-
IndippppppppceeeeeeeeccccccccattttttttteeeeeeeeiddddddddoPPPPPPPPnTTTTTTTTs////////IIIIIIIINNNNNNNNRRRRRRRRrrrrrrrreeeeeeeessssssssppppppppoooooooonnnnnnnnsssssssseeeeeeee........MMMMMMMMoooooooonnnnnnnniiiiiiiittttttttoooooooorrrrrrrrffffffffoooooooorrrrrrrrssssssssiiiiiiiiddddddddeeeeeeeeeeeeeeeeffffffffffffffffeeeeeeeeccccccccttttttttssssssssaaaaaaaatttttttt bimmmmmmmmneeeeeeeee,ddddddddciiiiiiiicccccccceaaaaaaaafttttttttoiiiiiiiiooooooootennnnnnnntssssssssa((((((((nRRRRRRRR,xxxxxxxxc,,,,,,,,hOOOOOOOOlTTTTTTTToCCCCCCCCr,,,,,,,,aaaaaaaaamnnnnnnnnddddddddphnnnnnnnnaaaaaaaaettttttttnuuuuuuuurrrrrrrricaaaaaaaaollllllllppppppppl,rrrrrrrrooooooooclddddddddouuuuuuuupccccccccttttttttissssssssd))))))))o........grel,
Proplllllllloooooooohwwwwwwwwyleeeeeeeearrrrrrrrxittttttttshhhhhhhheeeeeeeearrrrrrrrnaaaaaaaadppppppppteeeeeeeeruuuuuuuuettttttttaiiiiiiiicccccccctmrrrrrrrraaaaaaaaennnnnnnnnggggggggteeeeeeeeossssssssf........:Venousthrombosis,Pul- ●●●●●●●●diPPPPPPPPsuOOOOOOOOl::::::::fiAAAAAAAArddddddddammmmmmmmmiiiiiiii,nnnnnnnnfliiiiiiiissssssssutttttttteeeeeeeecrrrrrrrrommmmmmmmneeeeeeeeaddddddddziiiiiiiioccccccccaaaaaaaaltttttttteiiiiiiiioooooooo,nnnnnnnnfluaaaaaaaattttttttossssssssraaaaaaaaommmmmmmmqeeeeeeeeuttttttttiiiiiiiiinmmmmmmmmoeeeeeeeeleeeeeeeeoaaaaaaaanccccccccehhhhhhhhsdddddddd,aaaaaaaaiyyyyyyyytr........a-
mtrctiiiroo●●●●●●●●●●●●●●●●soenknan.PrALoTPrALoTPrALoTPrALoTPrALoTPrALoTPrALoTPrALoTsooaMaaaaaaaaehhhhhhhhesatesatesatesatesatesatesatesatrffhhhhhhhhnnnnnnnnsssssssssddddddddyeeeeeeeebbbbbbbbdtaeeeeeeeeeeeeeeeegggggggghiriririririririrrnee:sr:sr:sr:sr:sr:sr:sr:sreeeeeeeeaaaaaaaaTTTTTTTTrimssssssssaaAAAAAAAAsssssssssppppppppocccccccceeeeeeeetgkPPPPPPPPcccccccclllllllleeeeeeeehmmmmmmmmmbssssssssooooooooehhhhhhhhTTTTTTTTuuuuuuuuo,ottttttttmttttttttaaaaaaaabiiiiiiii////////ttttttttttttttttDfeeeeeeeeliiiiiiiiCCCCCCCCIiIiIiIiIiIiIiIiyyyyyyyyuiccccccccnnnnnnnnevvvvvvvvNNNNNNNNfseooooooooubbbbbbbbsiiiiiiiinggggggggmPPPPPPPPRRRRRRRRcnnnnnnnnteeeeeeeennnnnnnntfurTTTTTTTTffffffffggggggggo,aaaaaaaallllllllossssssssemmmmmmmmreeeeeeeerArrrrrrrraaaaaaaacccccccciiiiiiiiafevvvvvvvvmaaaaaaaaoooooooonnnnnnnnttttttttddddddddtsmeeeeeeeeoooooooornnnnnnnntrrrrrrrrddddddddeeeeeeeeellllllllahirrrrrrrreeeeeeeeggggggggssssssssaystrrrrrrrrssssssssrmmmmmmmmeeeeeeeeoilmmmmmmmmddddddddaaaaaaaaoroffffffffsssssssscfiaaaaaaaarrrrrrrriiiiiiiiimttttttttnsooooooooffffffffa11111111eeeeeeeebiiiiiiiiiiiiiiiififififififififiknnnnnnnnrrrrrrrrrqqqqqqqq........oooooooobarcccccccc33333333eeeeeeeedttttttttuuuuuuuuinooaaaaaaaannnnnnnnuuuuuuuul––––––––iffffffffeeeeeeeeliiiiiiiidfeallllllllrrrrrrrrssssssssannnnnnnnttttttttnnnnnnnnm11111111seeeeeeeel::::::::tiiiiiiiieiiiiiiiittttttttuiqqqqqqqqnnnnnnnn........innnnnnnnllllllllMMMMMMMMom55555555bnyyyyyyyybuuuuuuuuggggggggnppppppppfooooooooosddddddddttttttttbeeeeeeeeattttttttiiiiiiiieeeeeeeelehhhhhhhhnnnnnnnnnnnnnnnnwuuuuuuuummmmmmmmoriddddddddqceeeeeeeeiiiiiiiicttttttttrrrrrrrrlittttttttlllllllleeeeeeeeiiiiiiiiiuiiiiiirrrrrriirrttooooooooyyyyyyyyaaaaaaaaeznnnnnnnnihssssssssaaaaaaaa........eorrrrrrrrttttttttavggggggggpppppppprrrrrrrrggggggggnetenPPPPPPPPiiiiiiiiieeeeeeeerrrrrrrrtttttttttccccccccnmo:hhhhhhhhTTTTTTTTeeeeeeeeuuuuuuuuMtDnppppppppeeeeeeee,,,,,,,,aaaaaaaattttttttsbiiiiiiiirrrrrrrrttttttttaaaaaaaaIIIIIIII.eIccccccccoaeeeeeeeeNNNNNNNNaaaaaaaa,ttttttttPcfiiiiiirrrrrriirrlppppppPPPPPPppPPRRRRRRRRDteeeeeeeeirrezttttttttyyyyyyTTTTTTyyTTennnnnnnnehhhhhhhhear........aaaaaaaa////////avtttttttt-aaaaaaaa-IIIIIIIIssssssssnnnnnnnnesNNNNNNNNnnnnnnnn........ddddddddenRRRRRRRRs- ●●●●●●●●fctvdahoairMlaDeMlaDeMlaDeMlaDeMlaDeMlaDeMlaDeMlaDernlnieeeeeeeeprqrqrqrqrqrqrqrqnoeoooooooovvvvvvvvaeeeeeeeeiiiiiiiiuuuuuuuurmenenenenenenenen,addddddddznnnnnnnnoiiiiiiiillllllll........snvvvvvvvviiiiiiiissssssssooooooooobccccccccauaaaaaaaa;;;;;;;;dlttttttttaaaaaaaaolllllllltuuuuuuuuqleeeeeeeeetitititititititiefiiiiiiiilnnnnnnnnssssssss,nnnnnnnnooooooooosyuuuuuuuuttttttttmttttttttt,nenenenenenenenetn........aaaaaaaahirrrrrrrrallllllllaceerrrrrrrrccccccccllllllllnyyyyyyyyeeeeeeeesmthhhhhhhhrdqqqqqqqqr,bbbbbbbbaaaaaaaaioisuuuuuuuueeeeeeeeennnnnnnnadkiiiiiiiinpggggggggggggggggsrrrrrrrreuuuuuuuueeeeeeeeoteeeeeeeeipsidnnnnnnnnssssssssfibbbbbbbbfi,arb33333333wwwwwwwwrrrrrrrrqbizaaaaaaaal––––––––nhhhhhhhheuannnnnnnnoeiiiiiiii55555555tiddddddddllllllllmlidneeeeeeeeessssssssdddddddddiia;;;;;;;;ppppppppnaaaaaaaae(dyppppppppaaaaaaaayyyyyyyygiq,ioooooooonsssssssstttttttt.ntiiiiiiiittttttttceeeeeeeeCitttttttteeeeeeeeeooooooootrnnnnnnnnlhhnnnnnnnnu,ottttttttrrrrrrrrrccccccccedqiiiiiiiifieeeeeeeeoiiiiiiiissssssssireeeeeeeeuaaaaaaaannbessssssssssssssssccccccccigiattttttttshhhhhhhhcnmmmmmmmmiiiiiiiipnllllllllvillllllllueeeeeeeeoaaaaaaaaan,ooooooooffffffffsgyyyyyyyynfffffffftennnnnnnneeeeeeeeeiisnnnnnnnnn,ccccccccceohhhhhhhhooooooooaNttttttttliiiiiiiifeeeeeeeeotttttttttlvvvvvvvvoSppppppppabbbbbbbbeeeeeeeeupA--------ceeeeeeeewsieIe-aDt)ra,s--, Saudbmhineaisdtr faotiro InV
prosccccccccthooooooooennnnnnnntttttttttirrrrrrrrcoooooooovllllllll;;;;;;;;ahhhhhhhhlvooooooooewwwwwwwwpeeeeeeeelvvvvvvvvaeeeeeeeecrrrrrrrre,,,,,,,,mtttttttthhhhhhhheeeeeeeeenIIIIIIIItNNNNNNNN.RRRRRRRR,,,,,,,,aaaaaaaassssssssttttttttaaaaaaaannnnnnnnddddddddaaaaaaaarrrrrrrrddddddddiiiiiiiizzzzzzzzeeeeeeeeddddddddssssssssyyyyyyyysssssssstttttttteeeeeeeemmmmmmmm mIIIIIIIIiVVVVVVVVnoAAAAAAAApddddddddmmmmmmmmheiiiiiiiinnnnnnnnniiiiiiiimssssssssttttttttarrrrrrrryaaaaaaaaqttttttttiiiiiiiioooooooothnnnnnnnneriskofbleeding.Chronicalco- in the Nursing
Actitttttttthhhhhhhhoaaaaaaaanttttttttpppppppprrrrrrrroooooooovvvvvvvviiiiiiiiddddddddeeeeeeeessssssssaaaaaaaaccccccccoooooooommmmmmmmmmmmmmmmoooooooonnnnnnnnbbbbbbbbaaaaaaaassssssssiiiiiiiissssssssffffffffoooooooorrrrrrrrccccccccoooooooommmmmmmmmmmmmmmmuuuuuuuunnnnnnnniiiiiiiiccccccccaaaaaaaattttttttiiiiiiiinnnnnnnngggggggg ●●●●●●●●hoDDDDDDDDliiiiiiiiirrrrrrrrneeeeeeeegccccccccettttttttstIIIIIIIIiVVVVVVVVo::::::::nRRRRRRRRmeeeeeeeeccccccccaooooooooypnnnnnnnnssssssssttttttttaiiiiiiiittttttttcuuuuuuuutttttttttieeeeeeeeoneeeeeeeeaaaaaaaaoccccccccfhhhhhhhhw55555555a--------rmmmmmmmmfaggggggggrvvvvvvvviniiiiiiiiaaaaaaaa;lllllllliwwwwwwwwfciiiiiiiitttttttthhhhhhhhhr22222222o........n77777777icmmmmmmmmLLLLLLLL
InteraaaaaaaafnnnnnnnneddddddddreiiiiiiiisnnnnnnnnttttttttweeeeeeeeirrrrrrrrtpppppppphrrrrrrrrheeeeeeeetttttttteiiiiiiiinnnnnnnnpggggggggatPPPPPPPPicTTTTTTTTsrrrrrrrryeeeeeeeensssssssstuuuuuuuuhllllllllettttttttsssssssss,,,,,,,,isiiiiiiiissssssssouuuuuuuufssssssssvuuuuuuuuitaaaaaaaaallllllllllllllllmyyyyyyyyirrrrrrrrneeeeeeeeffffffffKeeeeeeee-rrrrrrrrdeeeeeeeennnnnnnnepcccccccceeeeeeeeeddddddddn........- alcoooooooooffffffffhssssssssttttttttoeeeeeeeerrrrrrrrliiiiiiiillllllllaeeeeeeeebwwwwwwwwusaaaaaaaaetttttttteeeeeeeerrrrrrrrreffffffffsoooooooourrrrrrrrltiiiiiiiisnnnnnnnnjjjjjjjjieeeeeeeenccccccccsttttttttiiiiiiiiioooooooognnnnnnnnn........ifiRRRRRRRRceeeeeeeeaccccccccnooooooootnnnnnnnnlssssssssittttttttviiiiiiiiettttttttuuuuuuuurttttttttdeeeeeeeeddddddddamssssssssooooooooallllllllguuuuuuuuettttttttiiiiiiii,ooooooooannnnnnnnc- Implications
dentNNNNNNNNcoooooooolorrrrrrrrmmmmmmmmttiaaaaaaaanllllllllgIIIIIIIINNNNNNNNfaRRRRRRRRct((((((((onnnnnnnnroooooooostttttttt(ooooooooInnnnnnnnI,aaaaaaaaVnnnnnnnnIttttttttIiiiiiiii,ccccccccIooooooooXaaaaaaaa,ggggggggauuuuuuuunllllllllaaaaaaaadnnnnnnnnXttttttttssssssss))))))))).iiiiiiiiTssssssssh00000000e........88888888r––––––––a11111111p........e22222222........uAAAAAAAA-nnnnnnnn tioiiiiiiiinssssssssssssssssottttttttfaaaaaaaawbbbbbbbbllllllllaeeeeeeeerfffffffffooooooooarrrrrrrrri44444444nhhhhhhhhmrrrrrrrraaaaaaaaayttttttttbrrrrrrrrooooooooeqoooooooommmmmmmmdttttttttueeeeeeeeemmmmmmmmtppppppppoeeeeeeeeprrrrrrrraaaaaaaapttttttttuuuuuuuurrrrrrrrroeeeeeeeed........uDDDDDDDDciiiiiiiitlllllllliouuuuuuuuneeeeeeeennnnnnnnoftttttttt::::::::clot-
ticEIIIIIIIINNNNNNNNffRRRRRRRReoooooooocffffffffts22222222:........55555555P––––––––re33333333v........e55555555niiiiiiiitssssssssiorrrrrrrreeeeeeeenccccccccooooooooofmmmmmmmmthmmmmmmmmreeeeeeeeonnnnnnnnmddddddddbeeeeeeeeddddddddoeffffffffoooooooomrrrrrrrrbppppppppoaaaaaaaalttttttttiiiiiiiiiceeeeeeeennnnnnnnettttttttvsssssssseaaaaaaaantttttttttsvvvvvvvv.eeeeeeeerrrrrrrryyyyyyyy tinNNNNNNNNgoooooooofaffffffffcuuuuuuuutrrrrrrrrotttttttthhhhhhhhr.eeeeeeeeArrrrrrrrcdddddddduiiiiiiiilllllllltuuuuuuuuettttttttiiiiiiiiaoooooooolnnnnnnnnconnnnnnnnheeeeeeeeeeeeeeeeoddddddddleeeeeeeeiddddddddngbbbbbbbbeeeeeeeeesffffffffooooooootirrrrrrrroeeeeeeeenaaaaaaaamddddddddmmmmmmmmayiiiiiiiiqnnnnnnnniiiiiiiissssssssattttttttrrrrrrrrcaaaaaaaatttttttttiiiiiiiiiooooooooonnnnnnnnn........of section, as well
Phahwhwhwhwhwhwhwhwriiiiiiiiiiiiiiiiggggggggmtttttttthhhhhhhhhhhhhhhhammmmmmmmrrrrrrrriiiiiiiicssssssssiiiiiiiittttttttkkkkkkkkorrrrrrrraaaaaaaaooooooookllllllllffffffffivvvvvvvveeeeeeeenaaaaaaaammmmmmmmllllllllevvvvvvvvbbbbbbbbeeeeeeeetooooooooirrrrrrrrclllllllleeeeeeeeiiiiiiiizzzzzzzzppppppppsaaaaaaaallllllllaaaaaaaattttttttiiiiiiiiccccccccooooooooeeeeeeeennnnnnnnmmmmmmmm((((((((eeeeeeeeffffffffoooooooonnnnnnnnrrrrrrrrttttttttaaaaaaaaeeeeeeeennnnnnnnxxxxxxxxddddddddaaaaaaaammmmmmmmvvvvvvvveeeeeeeeppppppppnnnnnnnnlllllllleeeeeeeettttttttrrrrrrrr,,,,,,,,iiiiiiiippppppppccccccccuuuuuuuuaaaaaaaattttttttlllllllliiiiiiiiaaaaaaaaeeeeeeeerrrrrrrrnnnnnnnnhhhhhhhhttttttttssssssssyyyyyyyy-------- wanaC1C1C1C1C1C1C1C1droooooooo––––––––fhannnnnnnn22222222roiccccccccnrmmmmmmmmeeeeeeeem.nnnnnnnniiiiiiiiBnnnnnnnnotttttttt........arrrrrrrrnraaaaaaaaabttttttttliiiiiiiiitoooooooocuonnnnnnnnrn::::::::at22222222tremmmmmmmmasc,ggggggggec////////mmmmmmmmpatrLLLLLLLLib........vRRRRRRRRaemsaaaaaaaattttttttcaeeeeeeeeoz::::::::neAAAAAAAAtpddddddddaimmmmmmmminniiiiiiiiennnnnnnni,niiiiiiiissssssssrgttttttttieeeeeeeeferrrrrrrrasoooooooomtvvvvvvvvreeeeeeeeporrrrrrrri-n, as subheads
Absppppppppoeeeeeeeerrrrrrrrrpttttttttrrrrrrrrtooooooooippppppppohhhhhhhhnyyyyyyyy)))))))):........WLLLLLLLLooooooooewwwwwwwwlleeeeeeeearrrrrrrrbllllllllseeeeeeeeovvvvvvvvreeeeeeeebllllllllsssssssseaaaaaaaadrrrrrrrrfeeeeeeeeroaaaaaaaaccccccccmcccccccceeeeeeeethpppppppptttttttteaaaaaaaaGbbbbbbbbllllllllIeeeeeeeetrwwwwwwwwahhhhhhhhceeeeeeeetnnnnnnnnafrrrrrrrrtiiiiiiiiessssssssrkkkkkkkk ●●●●●●●●geYYYYYYYYn--------mSSSSSSSSiiiiiiiiattttttttyeeeeeeeepCCCCCCCCoooooooothmmmmmmmmeppppppppanaaaaaaaatttttttttiiiiiiiiicbbbbbbbboiiiiiiiiallllllllgiiiiiiiittttttttuyyyyyyyyl::::::::anaaaaaaaatmmmmmmmmriiiiiiiiekkkkkkkksaaaaaaaapccccccccoiiiiiiiinnnnnnnnns,,,,,,,,eaaaaaaaasssssssstoccccccccoooooooowrrrrrrrrabbbbbbbbriiiiiiiifccccccccaraaaaaaaaiccccccccniiiiiiii.dddddddd,,,,,,,, for Diluent,
oraliiiiiiiiassssssssdlllllllloooooooomwwwwwwwwineeeeeeeerrrrrrrris........tHHHHHHHHraeeeeeeeetppppppppioaaaaaaaanrrrrrrrriiiiiiii.nnnnnnnnmmmmmmmmaaaaaaaayyyyyyyyaaaaaaaaffffffffffffffffeeeeeeeecccccccctttttttttttttttthhhhhhhheeeeeeeePPPPPPPPTTTTTTTT////////IIIIIIIINNNNNNNNRRRRRRRR;;;;;;;;ddddddddrrrrrrrraaaaaaaawwwwwwww Mabbbbbbbbniiiiiiiivvvvvvvvyaaaaaaaallllllllorrrrrrrrtuuuuuuuuhddddddddeiiiiiiiinnnnnnnnr,,,,,,,,dccccccccreeeeeeeeuffffffffaaaaaaaagzzzzzzzzsoooooooomlllllllliiiiiiiinnnnnnnna,,,,,,,,yccccccccaeeeeeeeeffffffffffettttttttrrrrrrrrciiiiiiiitaaaaaaaatxxxxxxxxhooooooooennnnnnnnaeeeeeeeec,,,,,,,,tddddddddivooooooooitppppppppyaaaaaaaaommmmmmmmfiiiiiiiiwnnnnnnnnaeeeeeeeer,,,,,,,,feeeeeeeeappppppppri--------n.
DistbbbbbbbbrllllllllooooooooibooooooooddddddddutffffffffooooooooiorrrrrrrrPPPPPPPPnTTTTTTTT:////////CIIIIIIIINNNNNNNNroRRRRRRRRsiiiiiiiisnnnnnnnnesppppppppaaaaaaaathttttttttiiiiiiiieeeeeeeeennnnnnnnpttttttttlssssssssarrrrrrrrceeeeeeeeeccccccccneeeeeeeetiiiiiiiiavvvvvvvviiiiiiiibnnnnnnnnuggggggggtbbbbbbbbdooooooooottttttttehhhhhhhhshhhhhhhhneeeeeeeeopppppppptaaaaaaaaerrrrrrrriiiiiiiinnnnnnnnn- Driiiiiiiinnnnnnnnueeeeeeeegpppppppp-hhhhhhhhNrrrrrrrraiiiiiiiinnnnnnnnteeeeeeeeu,,,,,,,,rhhhhhhhhaeeeeeeeelppppppppPaaaaaaaarrrrrrrrriiiiiiiionnnnnnnn,,,,,,,,dlllllllluiiiiiiiiddddddddcooooooootccccccccsaaaaaaaa:iiiiiiiinnnnnnnnSteeeeeeee.,,,,,,,,Jmmmmmmmmooooooooohrrrrrrrrnpppppppp’hhhhhhhhsiiiiiiiiwnnnnnnnneeeeeeeeo,,,,,,,,rnnnnnnnntpiiiiiiiittttttttrrrrrrrrooooooooe--------f- Concentration,
terbaaaaaaaarnnnnnnnneddddddddaswwwwwwwwtaaaaaaaamrrrrrrrrffffffffiaaaaaaaalkrrrrrrrr.iiiiiiiinnnnnnnnaaaaaaaattttttttlllllllleeeeeeeeaaaaaaaasssssssstttttttt55555555hhhhhhhhrrrrrrrraaaaaaaafffffffftttttttteeeeeeeerrrrrrrrtttttttthhhhhhhheeeeeeeeIIIIIIIIVVVVVVVVbbbbbbbboooooooolllllllluuuuuuuussssssssddddddddoooooooosssssssseeeeeeee,,,,,,,, fecggggggggtllllllll.qyyyyyyyycccccccceeeeeeeebrrrrrrrrliiiiiiiiennnnnnnne,,,,,,,,dooooooooinxxxxxxxxyyyyyyyygttttttttooooooooriccccccccsiiiiiiiiknnnnnnnn,,,,,,,,wppppppppitoooooooohttttttttaaaaaaaaassssssssnssssssssiiiiiiiiisuuuuuuuuemmmmmmmm,accccccccrhhhhhhhhnllllllllooooooooicrrrrrrrriiiiiiiiadddddddd,eeeeeeeec,,,,,,,,hrrrrrrrraaaaaaaaamnnnnnnnniiiiiiiittttttttoiiiiiiii--------mile,
Pro44444444tehhhhhhhhirrrrrrrrnaaaaaaaaffffffffBtttttttteeeeeeeeirrrrrrrrnccccccccdeeeeeeeeissssssssnssssssssaaaaaaaagttttttttiiiiiiii:oooooooo9nnnnnnnn9oooooooo%ffffffffIIIIIIII.VVVVVVVViiiiiiiinnnnnnnnffffffffuuuuuuuussssssssiiiiiiiioooooooonnnnnnnn,,,,,,,,oooooooorrrrrrrr2222222244444444hhhhhhhhrrrrrrrraaaaaaaafffffffftttttttteeeeeeeerrrrrrrr cloddddddddviiiiiiiinnnnnnnneeeeeeeee,........dongquai,fenugreek,feverfew,garlic, and Rate
MetssssssssauuuuuuuubbbbbbbbboccccccccuuuuuuuulttttttttishhhhhhhhmeeeeeeeeppppppppaaaaaaaaarrrrrrrrniiiiiiiinnnnnnnndiiiiiiiinnnnnnnnEjjjjjjjjeeeeeeeexcccccccccttttttttiiiiiiiirooooooooennnnnnnnt........ionAAAAAAAAssssssss:iiiiiiiiaaaaaaaaMnnnnnnnnepppppppptaaaaaaaaabttttttttiiiiiiiioeeeeeeeelnnnnnnnnizttttttttssssssssedaaaaaaaannnnnnnnbddddddddythe ●●●●●●●●ginYYYYYYYYg--------SSSSSSSSeiiiiiiiirtttttttt,eeeeeeeegIIIIIIIIinnnnnnnnncccccccckoooooooogmmmmmmmmopppppppp,Paaaaaaaattttttttaiiiiiiiinbbbbbbbbaiiiiiiiillllllllxiiiiiiiittttttttgyyyyyyyy::::::::inaaaaaaaammmmmmmmseiiiiiiiinnnnnnnnnoooooooogpppppppp,hhhhhhhhliyyyyyyyyclllllllllllllllloiiiiiiiinnnnnnnnreeeeeeeeic,,,,,,,,ecccccccceeeeeeee,ffffffffattttttttaaaaaaaanzzzzzzzzdiiiiiiii--------
livertttttttt.hhhhhhhhoooooooosssssssseeeeeeeewwwwwwwwhhhhhhhhooooooooccccccccaaaaaaaarrrrrrrrrrrrrrrryyyyyyyytttttttthhhhhhhheeeeeeeeCCCCCCCCYYYYYYYYPPPPPPPP22222222CCCCCCCC99999999********22222222aaaaaaaalllllllllllllllleeeeeeeelllllllleeeeeeeeaaaaaaaannnnnnnndddddddd////////oooooooorrrrrrrrtttttttthhhhhhhheeeeeeee othddddddddeiiiiiiiimmmmmmmmrseeeeeeee.,,,,,,,,cccccccciiiiiiiipppppppprrrrrrrrooooooooflflflflflflflflooooooooxxxxxxxxaaaaaaaacccccccciiiiiiiinnnnnnnn,,,,,,,,ddddddddoooooooobbbbbbbbuuuuuuuuttttttttaaaaaaaammmmmmmmiiiiiiiinnnnnnnneeeeeeee,,,,,,,,eeeeeeeessssssssmmmmmmmmoooooooolllllllloooooooollllllll,,,,,,,,ggggggggeeeeeeeennnnnnnnttttttttaaaaaaaa--------
HalCtCtCtCtCtCtCtCtfyyyyyyyy-YYYYYYYYpppppppplPPPPPPPPeeeeeeeei22222222fmmmmmmmmeCCCCCCCC:99999999aaaaaaaayyyyyyyy********4333333332rrrrrrrreeeeeeeeaaaaaaaahqqqqqqqqllllllllrlllllllluuuuuuuueeeeeeee.iiiiiiiillllllllrrrrrrrreeeeeeeeeeeeeeee,,,,,,,,mmmmmmmmoooooooorrrrrrrroooooooottttttttrrrrrrrrhhhhhhhheeeeeeeeooooooooffffffffssssssssrrrrrrrreeeeeeeeeeeeeeeeqqqqqqqqwwwwwwwwuuuuuuuuiiiiiiiitttttttteeeeeeeehhhhhhhhnnnnnnnnVVVVVVVVttttttttmmmmmmmmKKKKKKKKOOOOOOOOooooooooRRRRRRRRnnnnnnnnCCCCCCCCiiiiiiiitttttttt11111111oooooooorrrrrrrrAAAAAAAAiiiiiiiinnnnnnnnAAAAAAAAggggggggggggggggaaaaaaaaeeeeeeeennnnnnnnnnnnnnnnddddddddoooooooo-------- Drmmmmmmmmuiiiiiiiigcccccccciiiiiiii-nnnnnnnnF,,,,,,,,ollllllllaaaaaaaaobbbbbbbbdeeeeeeeetttttttt:aaaaaaaallllllllIoooooooonllllllllg,,,,,,,,eppppppppsrrrrrrrrtooooooooiommmmmmmmnaaaaaaaaozzzzzzzziiiiiiiifnnnnnnnnleeeeeeeea........rgequantitiesoffoods
TIMllllllllEoooooooo/wwwwwwwwAeeeeeeeeCrrrrrrrrTddddddddIooooooooOsssssssseeeeeeeeNssssssss........PROFILE (effects on PPPPPPPPhaaaaaaaaigtttttttthiiiiiiiieeeeeeeeinnnnnnnnnttttttttv////////FFFFFFFFitaaaaaaaaammmmmmmmmiiiiiiiiinllllllllyyyyyyyyKTTTTTTTTceeeeeeeeoaaaaaaaancccccccctehhhhhhhhniiiiiiiitnnnnnnnn(ggggggggseelistinAppendixM)
co●●●●●●●●agMMMMMMMMuoooooooolannnnnnnntiiiiiiiittttttttiooooooooorrrrrrrrnhhhhhhhheeeeeeeetppppppppeaaaaaaaastttttttttiiiiiiiiscccccccc)ffffffffuuuuuuuunnnnnnnnccccccccttttttttiiiiiiiioooooooonnnnnnnnaaaaaaaannnnnnnnddddddddCCCCCCCCBBBBBBBBCCCCCCCCbbbbbbbbeeeeeeeeffffffffoooooooorrrrrrrreeeeeeeeaaaaaaaannnnnnnnddddddddppppppppeeeeeeeerrrrrrrriiiiiiii-------- ●●●●●●●●maIIIIIIIInnnnnnnnyssssssssattttttttnrrrrrrrruuuuuuuutaccccccccgttttttttoppppppppnaaaaaaaaittttttttziiiiiiiieeeeeeeeennnnnnnnttttttttthtttttttteooooooooattttttttaaaaaaaankkkkkkkktieeeeeeeecommmmmmmmaeeeeeeeegdddddddduiiiiiiiilccccccccaaaaaaaaanttttttttiiiiiiiitooooooooennnnnnnnffaaaaaaaaessssssssctddddddddoiiiiiiiirrrrrrrrfeeeeeeeewccccccccttttttttaeeeeeeeerddddddddfa........rin.
ooooooooddddddddiiiiiiiiccccccccaaaaaaaallllllllllllllllyyyyyyyytttttttthhhhhhhhrrrrrrrroooooooouuuuuuuugggggggghhhhhhhhoooooooouuuuuuuutttttttttttttttthhhhhhhheeeeeeeerrrrrrrraaaaaaaappppppppyyyyyyyy........ TTTTTTTTaaaaaaaakkkkkkkkeeeeeeeemmmmmmmmiiiiiiiisssssssssssssssseeeeeeeeddddddddddddddddoooooooosssssssseeeeeeeessssssssaaaaaaaassssssssssssssssoooooooooooooooonnnnnnnnaaaaaaaassssssssrrrrrrrreeeeeeeemmmmmmmmeeeeeeeemmmmmmmmbbbbbbbbeeeeeeeerrrrrrrreeeeeeeeddddddddtttttttthhhhhhhhaaaaaaaatttttttt W
RO●●●●●●●●UMMMMMMMMTEoooooooonnnnnnnniiiiiiiittttttttoooooooorrrrrrrrssssssssOttttttttooooooooNooooooooSllllllllEaaaaaaaaTnnnnnnnndddddddduuuuuuuurrrrrrrriiiiiiiinnnnnnnneeeeeeeePffffffffooooooooErrrrrrrrAKooooooooccccccccccccccccuuuuuuuullllllllttttttttbbbbbbbbllllllllooooooooDooooooooddddddddURbbbbbbbbAeeeeeeeeffffffffTooooooooIrrrrrrrrOeeeeeeeeNaaaaaaaannnnnnnndddddddd Roddddddddaaaaaaaauyyyyyyyyt;;;;;;;;edddddddd/ooooooooDnnnnnnnnooooooooottttttttsddddddddaooooooooguuuuuuuuebbbbbbbblllllllleeeeeeeeddddddddoooooooosssssssseeeeeeeessssssss........IIIIIIIInnnnnnnnffffffffoooooooorrrrrrrrmmmmmmmmhhhhhhhheeeeeeeeaaaaaaaalllllllltttttttthhhhhhhhccccccccaaaaaaaarrrrrrrreeeeeeeepppppppprrrrrrrroooooooo--------
PO,IppppppppVeeeeeeeerrrrrrrriiiiiiiiooooooooddddddddiiiiiiiiccccccccaaaaaaaa3llllllll6llllllllyyyyyyyy–dddddddd7uuuuuuuu2rrrrrrrrhiiiiiiiinnnnnnnnrggggggggtttttttthhhhhhhheeeeeeeerrrrrrrraaaaaaaa5pppppppp–yyyyyyyy7........days† 2–5days‡ ffffffffPeeeeeeeeOssssssssssssssss,iiiiiiiiooooooooInnnnnnnnVaaaaaaaallllllll(Aooooooooffffffffdmmmmmmmmuiiiiiiiilsssssssstssssssssseeeeeeee)dddddddd:2ddddddddoooooooo–ssssssss5eeeeeeeessssssssmaaaaaaaagtttttttt/ttttttttdiiiiiiiimmmmmmmmayeeeeeeeefoooooooooffffffffrcccccccc2hhhhhhhheeeeeeee–cccccccc4kkkkkkkkuuuuuuuudppppppppayoooooooosrrrrrrrr;lllllllltaaaaaaaahbbbbbbbben
†‡●●●●●●●●AAtftaTdcTdcTdcTdcTdcTdcTdcTdcereeeeeeeeoooooooooooooooocssssssssdssssssssoxxxxxxxxsssssssseeeeeeeeiniiiiiiiiiiiiiiiisssssssssvvvvvvvvsccccccccceeeeeeeetoooooooooiiiiiiiiallllllllttttttttffffffffyyyyyyyynnyyyyyyyywwwwwwwwtteeeeeeeeindllllllllaaaaaaaaaaaaaaaaeeeeeeeeuorrrrrrrrnnnnnnnnvvvvvvvvffffffffasaaaaaaaaaaaaaaaaddddddddetttttttttirrrrrrrreeeeeeeeoiiiiiiiiOOOOOOOOnnnnnnnnddddddddnvvvvvvvviiiiiiiioooooooosssssssseeeeeeeerrrrrrrrrrrrrrrruuuuuuuuiiiiiiiiddddddddssssssssffffffffuuuuuuuuoooooooommmmmmmmaaaaaaaassssssssiiiiiiiilllllllleeeeeeeennnnnnnnllllllllyyyyyyyy::::::::oooooooossssssssWWWWWWWWrrrrrrrruuuuuuuubbbbbbbbiiiiiiiiffffffffttttttttfifififififififillllllllhhhhhhhheeeeeeeecccccccchhhhhhhheeeeeeeeiiiiiiiieeeeeeeeddddddddoooooooonnnnnnnniiiiiiiillllllllnnnnnnnnddddddddttttttttggggggggiiiiiiiiiiiiiiiinnnnnnnnffffffffooooooooggggggggIIIIIIIIccccccccNNNNNNNN11111111ccccccccRRRRRRRRuuuuuuuuoooooooorrrrrrrriiiiiiiirrrrrrrrssssssssssssssssmmmmmmmm........eeeeeeeeIIIIIIIIxxxxxxxxooooooooffffffff--------rrrrrrrreeeeeeee alAodswitpvtpvtpvtpvtpvtpvtpvtpvjaeeeeeeeeuiiiiiiiieeeeeeeeessssssssssssssssnsrrrrrrrrreeeeeeeetttttttttsssssssssssssssspdpppppppp.i.i.i.i.i.i.i.idssssssssaoIIIIIIIIaaaaaaaaatttttttttnnnnnnnnttttttttsiiffffffffiiiiiiiielffffffffeooooooooeeeeeeeeyoooooooonsrrrrrrrrnnnnnnnnrrrrrrrrdtttttttttimmmmmmmm22222222sontttttttt––––––––ooooooooosppppppppger55555555rrrrrrrreaaaaaaaaeeeeeeeetbrttttttttddddddddhiiiiiiiiaaaaaaaaiyeeeeeeeeaaaaaaaaaoddddddddnnnnnnnnryyyyyyyytsreMMMMssssMMMMssssttttttttessssssssiscffffffffeeeeeeeewuooooooootttttttthhhhhhhhddddddddolllllllllillllllllaaaaaaaatiiiiiiiitrooooooooscccccccchttttttttwwwwwwwwdaaaaaaaaoaaaaaaaaCettttttttnnnnnnnniiiiiiiifiiiiiiiinnnnnnnnYbttttttttIooooooooiiiiiiiiggggggggPNiccccccccnnnnnnnnl2iddddddddooooooooRtGGGGGGGGCaaiaiaiaiaiaiaiai.ssssssssgggggggg9tuuuuuuuuIcccccccceuuuuuuuun*ooooooooiiiiiiiidllllllll2ddddddddinnnnnnnnaaaaaaaatpeeeeeeeeittttttttnnnnnnnnaaiiiiiiiiannnnnnnnttttttttbbbbbbbbntteeeeeeeeeuuuuuuuueeeeeeeeideffffffffffffffffaaaaaaaat/ffffffffoooooooonheeeeeeeeottttttttiiiiiiiirrrrrrrrteccccccccoooooooorseeeeeeeerttttttttnnnnnnnnaossssssssmmmmmmmm........pttttttttraaaaaaaaAAAAAAAAaaaaaaaayirrrrrrrrddddddddyyyyyyyynttttttttw----------------ith
Conooooooootvvvvvvvvreeeeeeeearrrrrrrrddddddddioooooooonssssssssdeeeeeeeeioooooooocccccccccaccccccccuuuuuuuutirrrrrrrrossssssssnoooooooorrrrrrrrsaaaaaaaa/nnnnnnnnPttttttttiiiiiiiircccccccceoooooooocaaaaaaaaggggggggauuuuuuuuullllllllaaaaaaaatttttttttiiiiiiiiiooooooooonnnnnnnnnnnnnnnnnseeeeeeeeeeeeeeeeddddddddssssssssttttttttoooooooobbbbbbbbeeeeeeeeiiiiiiiimmmmmmmm-------- CYiiiiiiiiPnnnnnnnn2ggggggggCtttttttthhhhhhhh9eeeeeeee*rrrrrrrr3aaaaaaaaapppppppplyyyyyyyyleaaaaaaaalnnnnnnnneddddddddsowwwwwwwwriiiiiiiittttttttVhhhhhhhhKeeeeeeeeOaaaaaaaaccccccccRhhhhhhhhCRRRRRRRR1xxxxxxxxArrrrrrrrAeeeeeeeegfifififififififielllllllllllllllln........otype.
Conmmmmmmmmtreeeeeeeeaddddddddiiiiiiiiiaaaaaaaantttttttteeeeeeeedllllllllyyyyyyyyicrrrrrrrraeeeeeeeevvvvvvvvteeeeeeeeerrrrrrrrdsssssssseeeeeeeeiddddddddn,,,,,,,,:tttttttthhhhhhhhUeeeeeeeenaaaaaaaacnnnnnnnnottttttttniiiiiiiiddddddddtroooooooootttttttteeeeeeeelleiiiiiiiissssssssdvvvvvvvvbiiiiiiiittttttttlaaaaaaaaemmmmmmmmediiiiiiiinnnnnnnninKKKKKKKKg((((((((;ppppppppOhhhhhhhhpyyyyyyyye--------n ●●●●●●●●PORRRRRRRR,eeeeeeeeIvvvvvvvvViiiiiiiieeeeeeeewwwwwwww(Cffffffffhooooooooooooooooildddddddddssssssssrhhhhhhhheiiiiiiiingggggggghhhhhhhh(cid:30)iiiiiiiinnnnnnnn1vvvvvvvvmiiiiiiiittttttttaaaaaaaaommmmmmmm)iiiiiiii:nnnnnnnnInKKKKKKKKi((((((((tissssssssaeeeeeeeeleeeeeeeelAAAAAAAAoppppppppappppppppdeeeeeeeeinnnnnnnnnddddddddgiiiiiiiixxxxxxxxdoMMMMMMMMs))))))))e........—
wouttttttttnoooooooodnnnnnnnnsaaaaaaaa;ddddddddAiiiiiiiicooooooootnnnnnnnniveeeeeeeee,,,,,,,,AAAAAAAAuqqqqqqqqlcuuuuuuuueaaaaaaaarMMMMMMMMdEEEEEEEEisPPPPPPPPeHHHHHHHHaYYYYYYYYsTTTTTTTTeOOOOOOOO;RNNNNNNNNe))))))))c........eAAAAAAAAnddddddddtmmmmmmmmbiiiiiiiirnnnnnnnnaiiiiiiiiissssssssnttttttttrrrrrrrr,aaaaaaaaettttttttyiiiiiiiiooooooooennnnnnnn,ooooooooorffffffffspi- 0.2PPPPPPPPaaaaaaaamttttttttiiiiiiiigeeeeeeee/nnnnnnnnkttttttttgsssssssshhhhhhhh(oooooooomuuuuuuuuallllllllddddddddxihhhhhhhhmaaaaaaaauvvvvvvvveeeeeeeemccccccccdooooooooonnnnnnnnsssssssssiiiiiiiiessssssss:tttttttteeeeeeee1nnnnnnnn0ttttttttmlllllllliiiiiiiimmmmmmmmg)iiiiiiiitttttttteeeeeeeefoddddddddriiiiiiiinnnnnnnn2tttttttt–aaaaaaaakkkkkkkk4eeeeeeeedooooooooaffffffffysthen
nalcwwwwwwwwohhhhhhhhrdoooooooollllllllieeeeeeeenbbbbbbbbjulllllllloooooooorooooooooyddddddddoroooooooorrrrrrrrsupppppppprllllllllgaaaaaaaassssssssemmmmmmmmryaaaaaaaa;Saaaaaaaaellllllllssssssssvooooooooermmmmmmmmeaaaaaaaalyyyyyyyyivbbbbbbbbeeeeeeeeerorrrrrrrreeeeeeeerqqqqqqqqkuuuuuuuuiiiiiiiiidrrrrrrrrneeeeeeeeddddddddeyiiiiiiiinnnnnnnndissssssssseeeeeeee--------- adttttttttjhhhhhhhhueeeeeeeesssssssssteeeeeeeedffffffffaooooooooilooooooooydddddddddsssssssso,,,,,,,,aaaaaaaasessssssssvvvvvvvvbiiiiiiiiyttttttttaaaaaaaarmmmmmmmmesiiiiiiiinnnnnnnnulKKKKKKKKtsiiiiiiiissssssssoftttttttthhhhhhhhIeeeeeeeeNRaaaaaaaannnnnnnn,ttttttttuiiiiiiiiddddddddsooooooooetttttttt0eeeeeeee.ffffffff1oooooooorrrrrrrrmwwwwwwwwgaaaaaaaa/krrrrrrrrffffffffgaaaaaaaa--------if
easevvvvvvvv;eeeeeeeeUrrrrrrrrneeeeeeeecbbbbbbbbolllllllleeeeeeeeneeeeeeeetrddddddddoiiiiiiiinnnnnnnnllggggggggedbbbbbbbbeeeeeeeehccccccccyaaaaaaaapuuuuuuuuessssssssreeeeeeeeteoooooooonffffffffsttttttttihhhhhhhhoeeeeeeeendddddddd;eeeeeeeeOllllllllaaaaaaaaByyyyyyyy:eeeeeeeeCddddddddrooooooooonnnnnnnnsssssssssseeeeeeeeesttttttttoooooooopfffffffflavvvvvvvvciiiiiiiitttttttteaaaaaaaan--------ta liverrrrrrrriiiiiiiirnnnnnnnnd,,,,,,,,yaaaaaaaasnnnnnnnnfddddddddunaaaaaaaacllllllllttttttttteeeeeeeeiorrrrrrrrnnnnnnnnnaaaaaaaaittttttttsiiiiiiiinnnnnnnnpggggggggriiiiiiiiennnnnnnnstttttttteaaaaaaaankkkkkkkkteeeeeeee.ooooooooMffffffffatttttttthhhhhhhhineeeeeeeetsssssssseeeeeeeeenffffffffooooooooaoooooooonddddddddcssssssssewwwwwwwwdiiiiiiiiollllllllllllllllscccccccceaaaaaaaauuuuuuuusssssssseeeeeeee
andmmmmmmmmmiiiiiiiiannnnnnnnyKKKKKKKKc........ausefatalhemorrhageinthefetus.Mayalso raPPPPPPPPnTTTTTTTTgelllllllleeeeeeee—vvvvvvvveeeeeeeellllllll0ssssssss.tttttttt0oooooooo5flflflflflflflfl–uuuuuuuu0cccccccctttttttt.uuuuuuuu3aaaaaaaa4tttttttteeeeeeeem........gAAAAAAAA/ddddddddkvvvvvvvvgiiiiiiiissssssss/eeeeeeeedappppppppyaaaaaaaa.ttttttttiiiiiiiieeeeeeeennnnnnnnttttttttttttttttooooooooaaaaaaaavvvvvvvvooooooooiiiiiiiiddddddddccccccccrrrrrrrraaaaaaaannnnnnnn--------
UtcoaPIRPIRPIRPIRPIRPIRPIRPIRsrnnnnnnnnuiiiiiiiiyeooooooooesesesesesesesesskkkkkkkkoffffffffettttttttCffffffffeeeeeeeefeeeeeeeeffffffffcaooooooooccccccccunnnnnnnnottttttttrrrrrrrruliiiiiiiinttttttttcvvvvvvvviiiiiiiiiiiiiiiitgeeeeeeeeennnnnnnnaaaaaaaaierjjjjjjjjottttttttuuuuuuuullllllllniiiiiiiiossssssssurrrrrrrriNNNNNNNNssssssssrtyyyyyyyysauuuuuuuuluuuuuuuu((((((((lleeeeeeeeiSSSSSSSSvymrrrrrrrrppppppppeiiiiiiiissssssssddddddddireeeeeeeeaniiiiiiiieeeeeeeerrrrrrrrldnnnnnnnnfffffffff:EEEEEEEEouuuuuuuuiggggggggsffffffffMrssssssssffffffffemiiiiiiiieeeeeeeeDDDDDDDDaooooooooaccccccccsannnnnnnnlttttttttiiiiiiiiiesssssssstgaaaaaaaai(((((((())))))));onIIIIIIIIggggggggHnnnnnnnnnannnnnnnniddddddddn.siiiiiiiiooooooooctccccccccoyssssssssaaaaaaaa;rtttttttteeeeeeeeyPiiiiiiiioooooooossssssssaonnnnnnnntfissssssssep))))))))notosrwciothmhpilsi-- ●●●●●●●●ATavbClbbClbbClbbClbbClbbClbbClbbClbbeeeeeeeeaearearearearearearearearaaaaaaaaluuuuuuuuuuuuuuuurrrrrrrrieddddddddrrrrrrrrsssssssslttttttttiiiiiiiityiyiyiyiyiyiyiyihhhhhhhhannnnnnnnoooooooos,,,,,,,,jjjjjjjjgggggggg:nnnnnnnnbuuuuuuuunnnnnnnn1ttttttttiiiiiiiiippppppppooooooooccccccccoooooooolaaaaaaaameeeeeeeettttttttiiiiiiiiitttttttttttttttttnnnnnnnniiiiiiiioooooooooooooooogyeeeeeeeejjjjjjjjrrrrrrrr,uuuuuuuunnnnnnnnflflflflflflflfl2(pppppppprrrrrrrrttttttttoooooooogyyyyyyyyrrrrrrrrttttttttmsssssssso.o.o.o.o.o.o.o.ooooooooessssssssIIIIIIIIdddddddd,,,,,,,,gaaaaaaaannnnnnnnnuuuuuuuu,aaaaaaaavvvvvvvvssssssssoooooooonnnnnnnnecccccccc2ttttttttrrrrrrrriiiiiiiittttttttdddddddd.rddddddddsusususususususu5ittttccccctctctctddddddddIIIIIIIIoooooooocmttttttttMMMMMMMMuuuuuuuuppppppppssssssssrrrrrrrraghhhhhhhhaaaaaaaaiiiiiiiiiiiiiiii,nnnnnnnnnnnnnnnnvttttttttaaaaaaaa3iiiiiiiiggggggggjjjjjjjjvvvvvvvveeeeeeeeaeeeeeeeeeeeeeeeennnnnnnnmttttttttccccccccihhhhhhhhttttttttwwwwwwwwlttttttttgeeeeeeeeiiiiiiiiattttttttooooooooiiiiiiiioooooooo,rrrrrrrrttttttttnnnnnnnnbaaaaaaaahhhhhhhh4uuuuuuuuppppppppsssssssslaaaaaaaassssssssmyyyyyyyyeaaaaaaaaeeeeeeeennnnnnnn........nnnnnnnng)aaaaaaaaeeeeeeeedddddddd,llllllllssssssss5eeeeeeeeaaaaaaaaooooooooccccccccccccccccmffffffffttttttttttttttttttttttttrrrrrrrriiiiiiiivtvtvtvtvtvtvtvtiiiiiiiigoooooooocccccccciiiiiiii,ttttttttooooooooiiiiiiiirrrrrrrr6eeeeeeeettttttttaaaaaaaahhhhhhhhssssssssm----------------g, Msaofertey pinaftioernmt ation
anIIIIIIIImmmmmmmmce;ppppppppWlllllllleeeeeeeeommmmmmmmmeeeeeeeeennnnnnnnnwttttttttaaaaaaaaittttttttthiiiiiiiioooooooochnnnnnnnnildbearingpotential; Asianpa- 7.5zzzzzzzzoooooooomrrrrrrrrgdddddddd,uuuuuuuu1rrrrrrrriiiiiiii0nnnnnnnnmggggggggwwwwwwwwg.aaaaaaaaCrrrrrrrrffffffffoaaaaaaaarrrrrrrrsiiiiiiiitnnnnnnnn:ttttttttGhhhhhhhheeeeeeeeenrrrrrrrraaaaaaaaeppppppppryyyyyyyyi........cAAAAAAAA—ddddddddvvvvvvvviiiiiiii1sssssssseeeeeeeemppppppppgaaaaaaaatttttttt$iiiiiiiieeeeeeee1nnnnnnnn0tttttttt.8tttttttthhhhhhhh3aaaaaaaa/tttttttt100,
tie●●●●●●●●ntHHHHHHHHsoiiiiiiiiggggggggrhhhhhhhhthAAAAAAAAollllllllseeeeeeeeerrrrrrrrwtttttttt::::::::hMMMMMMMMoeeeeeeeecddddddddaiiiiiiiirccccccccraaaaaaaayttttttttiiiiiiiitoooooooohnnnnnnnneeeeeeeeeCrrrrrrrrYrrrrrrrrooooooooPrrrrrrrr2ssssssssCiiiiiiii9nnnnnnnn*vvvvvvvv2oooooooollllllllavvvvvvvviiiiiiiilnnnnnnnnleggggggggleaaaaaaaannnnnnnnattttttttniiiiiiiiccccccccdoooooooo/oaaaaaaaaggggggggr-------- 2mvvvvvvvveeeeeeeegnnnnnnnn$iiiiiiiipppppppp1uuuuuuuu0nnnnnnnn.cccccccc8tttttttt3uuuuuuuu/rrrrrrrr1eeeeeeee0ssssssss0aaaaaaaa,nnnnnnnn2dddddddd.5iiiiiiiinnnnnnnnmjjjjjjjjeeeeeeeeccccccccgttttttttiiiiiiii$oooooooo1nnnnnnnn0ssssssss.iiiiiiii8tttttttteeeeeeee3ssssssss/1rrrrrrrr0eeeeeeeeqqqqqqqq0uuuuuuuu,iiiiiiii3rrrrrrrreeeeeeeemaaaaaaaagpppppppppppppppp$llllllll1iiiiiiiicccccccc0aaaaaaaa.8--------3/ than any other
theCuuuuuuuuYllllllllaaaaaaaaPnnnnnnnn2ttttttttCssssssss9hhhhhhhh*aaaaaaaa3vvvvvvvveeeeeeeearrrrrrrrlleeeeeeeeessssssssluuuuuuuuellllllll,ttttttttoeeeeeeeeddddddddrwiiiiiiiinnnnnnnnitssssssssheeeeeeeerrrrrrrrthiiiiiiiiooooooooeuuuuuuuuVssssssssKhhhhhhhhOaaaaaaaarrrrrrrrRmmmmmmmmC1oooooooorrrrrrrrAddddddddAeeeeeeeegaaaaaaaaetttttttthhhhhhhhnoffffffffrrrrrrrrtyoooooooopmmmmmmmme 10tttttttt0iiiiiiiioooooooo,nnnnnnnn4oooooooomffffffffgpppppppprrrrrrrr$eeeeeeee1ssssssssssssssss0uuuuuuuu.8rrrrrrrreeeeeeee3/tttttttt1oooooooo0pppppppp0rrrrrrrr,eeeeeeee5vvvvvvvveeeeeeeemnnnnnnnnttttttttgbbbbbbbb$lllllllleeeeeeee8eeeeeeee.dddddddd5iiiiiiii2nnnnnnnn/gggggggg1oooooooo0rrrrrrrr0,hhhhhhhh6eeeeeeeemmmmmmmmmaaaaaaaagttttttttoooooooo$mmmmmmmm1aaaaaaaa0.64/
(qriiiiiiiiisnnnnnnnnktttttttteeeeeeeeorrrrrrrrnnnnnnnnfaaaaaaaabllllllllleooooooooerrrrrrrrdiiiiiiiinnnnnnnninttttttttrrrrrrrrgaaaaaaaawccccccccrrrrrrrriaaaaaaaathnnnnnnnniiiiiiiisaaaaaaaatllllllllabbbbbbbbnlllllllldeeeeeeeeaeeeeeeeerdddddddddiiiiiiiinnnnnnnndggggggggo........sBBBBBBBBineeeeeeeeffffffffgoooooooo;rrrrrrrrleeeeeeeeowaaaaaaaaddddddddemmmmmmmmriiiiiiiiinnnnnnnnniiiiiiiiissssssssti--------al 10ffffffff0oooooooo,rrrrrrrrmmmmmmmm7.aaaaaaaa5ttttttttiiiiiiiimoooooooonnnnnnnng........$10.83/100,10mg$10.83/100.Powder drug guide
dosesshouldbeconsidered);Pedi:Hasbeenused forinjection:5mg/vial.
(cid:31)Canadiandrugname. (cid:31)Geneticimplication.Strikethrough(cid:31)Discontinued.
*CAPITALSindicateslife-threatening;underlinesindicatemostfrequent.
Find enhanced Canadian content throughout—
in the monographs, appendices, and index.
DDG15E_FrontMatter_Section2_2015_revised.indd 1 1/28/16 11:30 AM
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Davis’s
DRUG GUIDE
FOR NURSES(cid:2)
FIFTHTEENTH EDITION
APRIL HAZARD VALLERAND, PhD, RN, FAAN
College of Nursing Alumni Endowed Professor of Nursing
Wayne State University
College of Nursing
Detroit, Michigan
CYNTHIA A. SANOSKI, BS, PharmD, FCCP, BCPS
Chair, Department of Pharmacy Practice
Thomas Jefferson University
Jefferson School of Pharmacy
Philadelphia, Pennsylvania
JUDITH HOPFER DEGLIN, PharmD
Consultant Pharmacist
Hospice of Southeastern Connecticut
Norwich, Connecticut
Contributing Editor:
HollyG.Mansell,BSP,PharmD
AssistantProfessorofPharmacy
CollegeofPharmacyandNutrition
UniversityofSaskatchewan
Saskatoon,SK,Canada
Name /bks_54412_deglins_dg/54412_fm_1 02/26/2016 01:54PM Plate # 0-Compositepg 4 # 1
F.A.DavisCompany
1915ArchStreet
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www.fadavis.com
Copyright(cid:2)2017byF.A.DavisCompany
Copyright(cid:2)1988,1991,1993,1995,1997,1999,2001,2003,2005,2007,2009,2011,2013,2015by
F.A.DavisCompany.Allrightsreserved.Thisbookisprotectedbycopyright.Nopartofitmaybe
reproduced,storedina retrievalsystem,ortransmittedinanyformorbyanymeans,electronic,
mechanical,photocopying,recording,orotherwise,withoutwrittenpermissionfromthepublisher.
PrintedinChina
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Editor-in-Chief,Nursing:JeanRodenberger
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NOTE: As new scientific information becomes available through basic and clinical research,
recommendedtreatmentsanddrugtherapiesundergochanges.Theauthorsandpublisherhavedone
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inserts)forchangesandnewinformationregardingdoseandcontraindicationsbeforeadministering
anydrug.Cautionisespeciallyurgedwhenusingneworinfrequentlyordereddrugs.
LibraryofCongressCataloging-in-PublicationData
Names:Vallerand,AprilHazard,author.|Sanoski,CynthiaA.,author.|
Deglin,JudithHopfer,1950,author.
Title:Davis’sdrugguidefornurses/AprilHazardVallerand,CynthiaA.
Sanoski,JudithHopferDeglin.
Othertitles:Drugguidefornurses
Description:Fifteenthedition.|Philadelphia:F.A.DavisCompany,[2017]|
Includesbibliographicalreferencesandindex.
Identifiers:LCCN2016001572|ISBN9780803657052(USpbk.)|ISBN
9780803657069(Canadianpbk.)
Subjects:|MESH:PharmaceuticalPreparations--administration&dosage|Drug
Therapy--nursing|Pharmacology,Clinical--methods|Handbooks|Nurses’
Instruction
Classification:LCCRM301.12|NLMQV735|DDC615.102/4613--dc23LCrecordavailableat
http://lccn.loc.gov/2016001572
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of payment has been arranged. The fee code for users of the Transactional Reporting Service is
978-0-8036-5705-2/170(US)and978-0-8036-5706-9/170(Canadian)(cid:2)$.25.
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DEDICATION
Tomyson,Ben,whosesensitivityandsenseofhumormakeeventhetoughestdayeasier.
Tomydaughter,Katharine,whosededicationandpassioninseekinghergoalsIadmire.
Watchingyoubothgrowtobecomewonderfulyoungadultsgivesmesuchprideandjoy.Yoursupport
ofmyworkinspiresme.Thankyouforsharingsomuchofyourliveswithme.Iloveyou.
AHV
Tomywonderfulmother,Geraldine,whohasprovidedhercontinuallove,support,andwisdomasI
continuetopursueallofmypersonalandprofessionalgoals.
CAS
Inlovingmemoryofmyolderchildren,SamanthaAnnandRandyEli,bothstruckandkilledbya
drinkingdriveronJanuary9,1997.Theyremainforeverinourhearts.Thewonderandjoytheybrought
toourlivescontinuestoinspireus.
ToStu,forhiscontinuedsupportandlove.
TomydaughterHanna,whosehardwork,talent,andgraceneverceasetoamazeme.
TomysonReuben,whosesmilewarmsmyheartandwhoseenergyisboundless.
Tomyparents,whoalwaysinspiredme.
JHD
ACKNOWLEDGMENTS
Weofferourthankstothestudentsandnurseswhohaveusedourbookforalmost30years.We
hopeourbookprovidesyouwiththecurrentknowledgeofpharmacotherapeuticsyouneedtocontinue
togivequalitycareinourrapidlychanginghealth-careenvironment.
April,Cindy,andJudi
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CONSULTANTS
MichelleFarkas,PMHNP-BC ThereseJamison,MSN,APRN-BC,ACNP
PrivatePractice AssociateProfessor
Dearborn,MI MadonnaUniversity
JamieCrawley,PhD,RN SchoolofNursing
AssistantProfessor Livonia,MI
UniversityofWindsor JaneenKidd,RN,BN
FacultyofNursing Instructor/SchoolPlacementProjectCoordinator
Windsor,ON,Canada UniversityofVictoria
LisaE.Davis,PharmD,FCCP,BCPS,BCOP SchoolofNursing
AssociateProfessorofClinicalPharmacy Victoria,BC,Canada
UniversityoftheSciencesinPhiladelphia NormaPerez,BSN,RN
PhiladelphiaCollegeofPharmacy NursingFaculty&ClinicalCoordinator
Philadelphia,PA IvyTechCommunityCollege
WandaEdwards,PMHCNS-BC,NP SchoolofNursing
Instructor(Clinical) Valparaiso,IN
WayneStateUniversity KimSubasic,MSN,RN
CollegeofNursing TheUniversityofScranton
Detroit,MI Scranton,PA
DeborahA.Ennis,RN,MSN,CCRN GladdiTomlinson,RN,MSN
HarrisburgAreaCommunityCollege ProfessorofNursing
Harrisburg,PA HarrisburgAreaCommunityCollege
LindaFelver,PhD,RN Harrisburg,PA
AssociateProfessor LindaS.Weglicki,PhD,RN,MSN
OregonHealth&ScienceUniversity ProgramDirector
SchoolofNursing NationalInstituteofNursingResearch
Portland,OR OfficeofExtramuralPrograms
CharleneC.Gyurko,PhD,RN,CNE Bethesda,MD
AssistantProfessor MarcellaWilliams,RN,MS,AOCN(cid:2)
PurdueUniversity,NorthCentral AdjunctFaculty
SchoolofNursing LansingCommunityHospital
Westville,IN StaffNurse,SparrowHealthSystem
AltheaDuBoseHayes,RD Lansing,MI
RenalDietitian
GreenfieldHealthSystem,
adivisionofHenryFordHealthSystem
Southfield,MI
vi
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F. A. DAVIS PHARMACOLOGIC
PUBLICATIONS ADVISORY BOARD
ShamimTejani, EmilyKarwacki-Sheff,
PharmD,CPHQ MS,CMSRN,FNP-BC
DirectorofQualityImprovement LecturerandClinicalInstructor
AdelanteHealthcare MassachusettsGeneralHospital
Phoenix,AZ InstituteofHealthProfessions
Charlestown,MA
DebraAbraham,
MSN,RN ClinicalInstructor
Lecturer
BostonCollege
UniversityofPennsylvania
ChestnutHill,MA
SchoolofNursing
LauraG.Leahy,
Philadelphia,PA MSN,PMH-CNS/FNP,BC
PsychiatricAdvancedPracticeNurseClinical
AngelaAnnBoggs,PharmD AssociateFaculty/Lecturer
ClinicalPharmacist UniversityofPennsylvania
UniversityofMarylandBaltimore SchoolofNursing
SpringfieldHospitalCenter Philadelphia,PA
Sykesville,MD StuartLevine,
PharmD
InformaticsSpecialist
DouglasLeeBoggs,
PharmD,MS,BCPP
InstituteforSafeMedicationPractices
ResearchAssociate
HuntingdonValley,PA
MarylandPsychiatricResearchCenter
UniversityofMarylandSchoolofMedicine GinetteA.Pepper,PhD,RN,FAAN
Baltimore,MD HelenLoweBambergerColbyPresidential
EndowedChairinGerontologicalNursing
HedyCohen,RN,BSN,MS AssociateDeanforResearch&PhDPrograms
ClinicalConsultingNurse SaltLakeCity,UT
InstituteforSafeMedicationPractices Director
HuntingdonValley,PA UniversityofUtahHartfordCenterofGeriatric
NursingExcellence
JaneVincentCorbett,
RN,Ed.D SaltLakeCity,UT
ProfessorEmerita
UniversityofSanFrancisco RosemaryC.Polomano,PhD,RN,FAAN
SchoolofNursing AssociateProfessorofPainPractice
SanFrancisco,CA UniversityofPennsylvania
SchoolofNursing
MargaretFalahee,APRN-BC Philadelphia,PA
ClinicalAssistantProfessor
DebbieRichmond,
NP-C,ACRN
WayneStateUniversity
WayneStateUniversity
CollegeofNursing
Detroit,MI
Detroit,MI
DorieSchwertz,
PhD,RN,FAAN,FAHA
SusanM.Hasenau,PhD,MSN,BSN AssociateProfessor
Professor UniversityofIllinois-ChicagoCollegeofNursing
MadonnaUniversity DepartmentofMedicalSurgicalNursingand
SchoolofNursing AdjunctProfessorofPharmacology
Livonia,MI Chicago,IL
vii
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F.A. Davis Canadian Advisory Board
AnanAhmed, WendyNeander,
BSP PhD(c),MN,BScN,BScv
Pharmacist,Shopper’sDrugMarket AssistantTeachingProfessor,SchoolofNursing
MSCCandidate,UniversityofSaskatchewan UniversityofVictoria
Saskatoon,Saskatchewan Nanaimo,BritishColumbia
AndreaM.Brandt, ArohaPage,
BScN,MS RN,BA,BScN,Grad.DipHealthSci,M.Phil(N),
PharmacologyInstructor,LeadFaculty,Nursing PhD(UCSF)FRCNA
GeorgianCollege AssociateProfessor,SchoolofNursing
Barrie,Ontario NipissingUniversity
MelanieDeveau, FacultyofApplied&ProfessionalStudies
MN-ANP,RN,NP
NursePractitioner,CardiovascularProgram NorthBay,Ontario
AdjunctLecturer VincentSalyers,Ed.D,MSN,BA
DalhousieUniversity-YarmouthSite AssociateDean,FacultyofHealth&Community
Yarmouth,NovaScotia Studies
LisaKeeping-Burke, MountRoyalUniversity
RN,PhD.(McGill)
AssistantProfessor,DepartmentofNursingand Calgary,Alberta
HealthSciences,UNB MichaelScarcello,RN,HBScN,MA
AdjunctAssistantProfessor,SchoolofNursing, ClinicalNurseSpecialistProgramCoordinator,
Queen’sUniversity PracticalNursingProgram
SaintJohn,NewBrunswick ConfederationCollege
Duncan(Stewart)MacLennan, ThunderBay,Ontario
MN,NP
FacultyLecturer,FacultyofNursing JeffTaylor,BSP,MSc,PhD
UniversityofAlberta ProfessorofPharmacy
Edmonton,Alberta UniversityofSaskatchewan
KerryMansell, Saskatoon,Saskatchewan
BSP,PharmD
AssistantDeanandAssociateProfessorof JimWohlgemuth,RN,MN,CTN-B
Pharmacy Instructor,NursingEducation&HealthStudies
UniversityofSaskatchewan GrandePrairieRegionalCollege
Saskatoon,Saskatchewan GrandePrairie,Alberta
CraigMiller
Instructor-PN
AssiniboineCommunityCollege
Brandon,Manitoba
viii
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CONTENTS
HOWTOUSEDAVIS’SDRUGGUIDEFORNURSES............................ 1
EVIDENCE-BASEDPRACTICEANDPHARMACOTHERAPEUTICS:
ImplicationsforNurses....................................................... 6
PHARMACOGENOMICS......................................................... 9
MEDICATIONERRORS:ImprovingPracticesandPatientSafety............ 12
DETECTINGANDMANAGINGADVERSEDRUGREACTIONS................. 18
OVERVIEWOFRISKEVALUATIONANDMITIGATIONSYSTEMS(REMS)... 22
SPECIALDOSINGCONSIDERATIONS.......................................... 23
ThePediatricPatient......................................................... 23
TheGeriatricPatient......................................................... 23
ThePatientofReproductiveAge.............................................. 24
RenalDisease................................................................ 24
LiverDisease................................................................ 24
HeartFailure................................................................ 24
BodySize.................................................................... 24
DrugInteractions............................................................ 25
THECYTOCHROMEP450SYSTEM............................................ 26
EDUCATINGPATIENTSABOUTSAFEMEDICATIONUSE..................... 29
CLASSIFICATIONS.............................................................. 31
Anti-Alzheimer’sagents...................................................... 31
Antianemics................................................................. 32
Antianginals................................................................. 33
Antianxietyagents............................................................ 34
Antiarrhythmics.............................................................. 35
Antiasthmatics............................................................... 36
Anticholinergics............................................................. 37
Anticoagulants............................................................... 38
Anticonvulsants.............................................................. 40
Antidepressants.............................................................. 41
Antidiabetics................................................................. 43
Antidiarrheals............................................................... 45
Antiemetics.................................................................. 46
Antifungals................................................................... 47
Antihistamines............................................................... 48
Antihypertensives............................................................ 49
Anti-infectives................................................................ 51
Antineoplastics............................................................... 52
Antiparkinsonagents......................................................... 54
Antiplateletagents........................................................... 55
Antipsychotics............................................................... 56
Antipyretics.................................................................. 58
Antiretrovirals............................................................... 59
Antirheumatics.............................................................. 60
Antituberculars.............................................................. 61
Antiulceragents.............................................................. 62
ix