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About Critical Reviews in Oral Biology & Medicine: The Role of Human Papillomavirus in Oral Carcinogenesis
The document discusses the role of human papillomavirus (HPV) in oral carcinogenesis. Specifically, it summarizes that: 1) HPV infection with high-risk types 16 and 18 has been linked to oral cancer development, though the association is less established than for cervical cancer. 2) HPV's oncogenic potential comes from its E6 and E7 proteins inactivating the tumor suppressor proteins p53 and Rb, respectively, which disrupts cell cycle regulation and allows cells to proliferate even in the presence of DNA damage. 3) While HPV likely plays a role in some oral cancers, its contribution remains incompletely understood and requires further study.
Detailed Information
| Author: | ['BimalKrishna'] |
|---|---|
| Publication Year: | 2018 |
| Pages: | 10 |
| Language: | English |
| Format: | |
| Price: | FREE |
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