Centre report Geissen

32 Pages·2015·0.41 MB·English

European Academy of Andrology – Centre Report 2014

EAA ANDROLOGY CENTRE GIESSEN

Directors:

Prof. Dr. med. Wolfgang Weidner
Department of Urology, Pediatric Urology and Andrology
Rudolf-Buchheim-Straße 7
D-35385 Giessen, Germany
Phone: [phone]
Fax: [phone]
E-Mail: [email protected]
URL: http://www.uniklinikum-giessen.de/urol

Prof. Dr. rer. physiol.Andreas Meinhardt
Department of Anatomy and Cell Biology
Division of Reproductive Biology
Justus-Liebig-University of Giessen
Aulweg 123
D-35385 Giessen, Germany
Phone: [phone]
Fax: [phone]
E-Mail: [email protected]
URL:http://www.uni-giessen.de/cms/fbz/fb11/institute/anatomie/forschung/ag-reproduktion

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European Academy of Andrology – Centre Report 2014

Structure of the centre
The EAA training centre Giessen consists of the following units:

- Department of Urology, Paediatric Urology and Andrology (Head: Prof. W. Weidner)
- Department of Anatomy and Cell Biology, Unit for Reproductive Biology (Head: Prof. A.
Meinhardt)
- Testicular Biopsy Repository, Department of Veterinary Anatomy, Histology and
Embryology (Head: Prof. Bergmann) (together with Prof. HC. Schuppe, Urological Clinic)
- Medical Department and Policlinic III –Endocrinology- (Head: Prof. Schäffler,
cooperating partner: Prof. T. Linn)

History of the centre
The history of andrology at the University of Giessen goes back to 1951, when a working group for the
study of male hypogonadism was founded by members of the Department of Internal Medicine, the
Outpatient Clinic of Internal Medicine, the Clinic of Dermatology, and the Institute of Anatomy.
A Department of Andrology at the Clinic of Dermatology at Giessen University was founded in 1968 and
was changed into a Chair of Andrology and Venereology in 1980. In 1989 a new Chair of Dermatology
and Andrology at the Clinic of Dermatology was taken over by W.-B. Schill. At the same time, a Study
Group for Reproductive Medicine was established, consisting of additional members of the Department
of Obstetrics and Gynaecology, a Working Group of Endocrinology, and the Veterinary Clinic. With the
appointment of W. Weidner as Chairman of the Clinic of Urology in 1993, the Department of Urology
joined the Study Group for Reproductive Medicine. In 1999, this network of collaborations was formally
established as Hessian Centre of Reproductive Medicine. Moreover, both research and training activities
were intensified in 1998, when the universities of Giessen and Marburg became hosts of a graduate
research training group of the Deutsche Forschungsgemeinschaft (DFG) entitled “Cell-Cell-Interaction in
Reproduction“. This programme was extended until 2005. In view of growing interest in clinical
andrology and related basic research, the Andrology Centre has been extended to include the Medical
Department and Policlinic III (Endocrinology), a certified European Training Centre for Endocrinology
(U.E.M.S.), headed by Prof. Schaeffler, and the Unit of Reproductive Biology in the Department of
Anatomy and Cell Biology, headed by Prof. A. Meinhardt. These structural changes of the centre were
part of the re-evaluation process in 2003. Beginning in 2009, the faculty of the Justus-Liebig-University
Giessen and the UKGM GmbH decided to transfer the whole scientific and clinical andrological activities
of the Department of Dermatology and Andrology to the Department of Urology, Pediatric Urology and
Andrology. With this consented decision, the new Department of Dermatology stopped the historical
tradition to diagnose and to treat andrological patients. In detail, the clinical andrological outpatient
department (Prof. Dr. H.-C. Schuppe), including the andrological laboratory, and the cryobanking
facilities have been transferred, histopatholgical work-up and the resp. collections of testicular biopsies
are now integrated in the Giessen testicular biopsy repository (Prof. M. Bergmann).

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European Academy of Andrology – Centre Report 2014

Name and address of Centre
Department of Urology, Paediatric Urology and Andrology

Rudolf-Buchheim-Str. 7, 35592 Giessen, Germany
Department of Anatomy and Cell Biology, Reproductive Biology
Aulweg 123, 35392 Giessen, Germany

Type of Centre
University
University Hospital X
Private Centre
Other (please specify)

1. Director Prof. Dr. Wolfgang Weidner (Co-chairs)

2. Director (if more Institutions in the Centre) Prof. Dr. Andreas Meinhardt (Co-chairs)

3. Present Staff (Senior Scientists)
1) Name Prof. Dr. W. Weidner
Degree MD
Speciality Urologist – Andrologist
Academician X Affiliated Member Clinical Andrologist X

2) Name Prof. Dr. H.C. Schuppe
Degree MD
Speciality Dermatologist - Andrologist
Academician X Affiliated Member Clinical Andrologist X

3) Name PD Dr. Th. Diemer
Degree MD
Speciality Urologist
Academician applied Affiliated Member Clinical Andrologist X
for

Insert any additional staff below (if required)
Prof. Dr. FM Wagenlehner (Specialist for urological infections)
Dr. A. Hauptmann (Specialist for Peyronie’s disease and sexual dysfunction)
Dr. A. Pilatz (Specialist for Prostatitis and urogenital infections, urosonography)
All mentioned colleagues are specialists for Urology and have the German
qualification - Andrological Urologist - .

MD/Biologists/Chemists
1) Name Prof. Dr. Klaus Steger
Degree Dr. rer. nat.
Speciality Biology
Full time/part time full time
Academician Affiliated Member Clinical Andrologist
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European Academy of Andrology – Centre Report 2014

2) Name Dr. Agnieszka Paradowska-Dogan
Degree Dr. rer. physiol.
Speciality Reproductive Biology
Full time/part time full time
Academician Affiliated Member X Clinical Andrologist

3) Name PD Dr. Undraga Schagdarsurengin
Degree Dr. rer. nat. habil., Dipl. Biol.
Speciality Biology, Genetics
Full time/part time full time
Academician Affiliated Member Clinical Andrologist

4) Name Dr. Temuujin Dansranjavin
Degree Dr. rer. nat., Dipl. Biol.
Speciality Biology
Full time/part time full time
Academician Affiliated Member Clinical Andrologist

5) Name Prof. Andreas Meinhardt (Co-chair of
the EAA Center)
Degree Dr. rer. nat.
Speciality Biology
Full time/part time full time
Head of the Department of
Anatomy and Cell Biology

PhD Students and andrological trainees 2009-2014

1 Marconi, Marcelo Santiago de Chile MIDLEPLAN, Chile Clinical Andrologist 2007-
2009
2 Steilmann, Cornelia Giessen DFG KFO 181/1 PhD 2007-
2010
3 Cavalcanti, Marcia Brasilien DFG KFO 181/1 Researcher 2009-
2010
4 Bärmann, Birte Giessen UKGM PhD 2009-
2013
5 Vieweg, Markus Giessen DFG KFO181/2 PhD 2010-
2012
6 Yang, Yang Shanghai Stipendium University PhD 2010-
Shanghai 2013
7 Steinfeld, Kai Tina Giessen DFG KFO 181/2 PhD 2010-
2014
8 Rusz, András EAA Center LOEWE- MIBIE, B1, B2 Urogenital infections for 2011-
Budapest PhD thesis 2012
9 Gaurav, Sarode India DFG KFO 181/2 PhD 2011-
2014
10 Günther, Katharina Giessen KFO 181/2 Researcher 2012
11 Lengemann, Björn Department of Klinikum German Subspeciality 2012-
Urology, Bad Bad Hersfeld Andrology in Urology 2013
Hersfeld
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European Academy of Andrology – Centre Report 2014

12 Alidjanov, Jakhongir Tashkent Center of Urology, Research assistant 2013
Tashkent
13 Hartley, Ricardo Temuco PhD program ORCHID PhD 2013-
Chile 2014
14 Menzel, Vivianna Giessen DFG KFO 181/2 Researcher 2013-
2014
15 Nessheim, Nils Giessen DFG KFO/2 PhD 2013-
2014
16 Velagala, Siva Reddy India IRTG (German PhD 2013-
Research Foundation) 2015
17 Benelli, Andrea Department of University of Genua Clinical Andrologist (EAA) 2014-
Urology, Genua 2015
18 Savadi-Shiraz, Elham Teheran IRTG (German PhD 2013-
Research Foundation) 2015
19 Ni, Kai Shanghai Grant University PhD 2013-
Shanghai 2016
20 Teubert, Lisa Giessen IRTG PhD 2014
21 Asmarinah, Draga Jakarta DAAD Project Researcher 2014

Nurses 7 nurses from the Dep. of Urology
1) Name are also integrated in the
2) Name andrological work-up, not
separated for Andrology
Laboratory Technicians (only
for Andrology)
1) Name G. Hecker
2) Name S. Pinkl
3) Name B. Schuster
4) Name F. Schmidt
5) Name T. Bloch

Administrative Personnel
1) Name Wolf, Julia (study nurse)
2) Name Conrad, Monika (chief secretary)
3) Name Oesterlein, Angelika
4) Name Endres, Katharina (DFG-research)
5) Name Buch-Heberling,Mareike(DFG-
research)
6) Name M. Blazevic (Testicular repository,
cryopreservation

Insert any additional staff below (if required)
Ottway, P. (lector, native english speaker)
Hess, M. (graphical assistant)

For each staff category please specify changes (increased or decreased since last EAA site visit

Physicians
Unchanged Increased X Decreased
Please specify: more financial support
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European Academy of Andrology – Centre Report 2014

Nurses
Unchanged X Increased Decreased

Please specify: more financial support Please specify
Laboratory Technicians
Unchanged Increased X Decreased

Please specify: more financial support (grants) Please specify

Administrative Personnel
Unchanged Increased X Decreased

Please specify: more financial support by the Please specify
clinical organization (UKGM)

Overall comment – is personnel staff enough for centres activities?

Yes X No Further comment

4. Clinical Activity

A. Outpatients: Consultations per year in the last 3 years

2012 2013 2014
New patients 1075 1218 1072 X
Controls 943 1054 931 X
X documented until 11/2014

Type of patients in the last years (%) 2012 2013 2014
Infertility not analysed not analysed 40%
Erectile dysfunction “ “ 20%
Hypogonadotropic Hypogonadism “ “ 5%
Klinefelter “ “ 1%
Gynaecomastia “ “ below 1%
Varicocele “ “ 8%
Cryptorchidism “ “ 5%
Male sex accessory gland infections “ “ 12%
Testicular tumours “ “ 2%
Disorders of gender identity “ “ below 1%
Other (e.g. ejaculatoy disorders, “ 5%
“
peyronies disease)

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European Academy of Andrology – Centre Report 2014

B. Ultrasound (testis, penile, prostate)

2012 2013 2014
total about 10.000 about 10.000 about 10.000
All patients coming to the Urological
Department are undergoing threemonthly
ultrasonography of the kindeys, bladder,
scrotal content, penis shaft and prostate
Controls (TRUS, if older than 50 years of age).
Furthermore about 1.000 duplex investigations
are done per year (erection test, varicocele
reflux) Certification by the German Society of
Ultrasonography, instructor Dr. B. Altiniklic)

C. Andrological surgery procedures

2012 2013 2014 X
116 (as TESE, per 138 120
Testicular biopsies
testicle)
Varicocele ligation 25 19 38
Prostate biopsies More than 300 More than 300 More than 300
BPH (TURP, laser TURP) More than 120 More than 130 More than 100
Prostate cancer (RRP) 42 35 39
Vasectomy 17 18 18
Vaso-vasostomy 12 38 40
Other (MESA) 16 22 10
Other microsurgery (e.g. nerv- 2 4
2
dissection)
Corporoplasty 44 40 39
Penile reconstruction and
penile implants 6 9 6

Testicular cancer operations 29 30 25
X documented until 11/2014

5. A. Andrology laboratory activity

2012 2013 2014
Semen analyses 1222 1314 1242 X
Sperm antibodies 390 632 590 X
Seminal markers 2693 3591 3088 X
X not finally documented

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European Academy of Andrology – Centre Report 2014

5. B. Andrology laboratory activity

Sperm banking donors Yes X No

Sperm banking cancer patients (90%) Yes X No

If yes:
2012 2013 2014
Number of samples 93 124 93 X
X not finally documented

5. C. Histopathologial evaluation of biopsies Yes X No
Biopsies: 2012: 986, 2013: 1164, 2014: 1010 (the testicular repository is run together with Prof. M.
Bergmann, University of Giessen)

5. D. Reproductive Hormones Assays Yes X No

If yes please specify type of assays and number of samples in the last year
All infertility patients : Testosterone, FSH, LH, Prolactin
All patients with sexual dysfunction: Testosterone, f-T, Estradiol, LH, Prolactin
Special indications: T3, T4, TSH, inhibin, cortisol
Are done in the Department of Endocrinology in cooperation (approx. 15.000 tests per year)

5. E. Y chromosome microdeletions according to Yes X No
EAA/EMQN guidelines

If yes number of tests in the past year 2012 not defined; 2013: 112; 2014: 108

Participation to the EAA quality control scheme? Yes No X

If no, specify if available in another lab of the same hospital Yes X No
- University Genetic Institute
Blood karyotyping - University Genetic Institute Yes X No

If no, specify if available in another lab of the same hospital Yes No

Other genetic tests (CBAVD screening) in all patients with CBAVD undergoing MESA
(University Genetic Institute)

6. Collaborations with other Clinical Units of the University/Hospital

IVF Unit Yes X No
University of Marburg, (Hospital Giessen-Marburg GmbH)

If yes please specify: Children, Endocrinology, IVF, Urology, Genetics, Pathology

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European Academy of Andrology – Centre Report 2014

Urology Clinic we are the Urology Clinic Yes No

Endocrine Clinic Yes X No

Genetics Lab/Unit Yes X No

Paediatric Unit we run the paediatric urology Yes X No

Central Hospital Laboratory Yes X No

Private Centres for IVF Wetzlar, Wiesbaden, Offenbach, Yes X No
Darmstadt, Frankfurt

If yes please specify:

7. Clinical teaching activity
Duration of training (years): 2

Number
A: Trainees in the last five years 8
B: Trainees who passed EAA-ESAU\exam for Clinical Andrologist in the last 5yrs 1
C: Trainees working in the centre preparing to pass the EAA-ESAU examination 2
D: Ph D Students 14
E: Medical Students 4
F: Other students 5
P.S.: Generally attendance from other centers in Germany are not interested in the EAA qualification but
mostly in the german subspeciality andrological urology.

8. Formal Andrology teaching program Yes X No

If yes: specify duration (years/months): Years Months 18

Professional training
Hours of formal teaching per year
(weeks/months)
Special program in english,
Urological Clinic: integrated into the section -
2 hours daily (not on Friday) impaired fertility in men and
- special consultation hours, operative animals - of the Giessen Graduate
Medical Students
theatre, ejaculate lab, cryobanking, School of the University of
testicular histology, sonocourses, IVF Giessen (theoretical and scientific
center, endocrinology background of Infertility) about 4-
6- hours per week
Ph D Students same procedure same procedure
Post Graduate students same procedure same procedure
Trainees same procedure same procedure
Other degrees (please specify)
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European Academy of Andrology – Centre Report 2014

Further Training and Congress activities

Reproductive medical Colloquium of the Hessian Centre of Reproductive Medicine (HZRM), the Clinical
Research Unit 181 (Mechanisms of male factor infertility) and the International Research Training Group
1871 ‚Molecular Pathogenesis of Male Reproductive Disorders’ (IRTG), monthly 2007

Laboratory practice of the Giessen Graduate Centre of the Life Sciences (GGL) „Reproduction at Human
and Animal“, since 2007 (Dr. A. Paradowska)

Lecture Reproductive Medicine Giessen Graduate Centre of the Life Sciences (GGL), section
„Reproduction at Human and Animal“: Operative Andrology, Sperm morphology – about old tales and
new tools, Obesity and male reproductive function, since 2007

Spermiogramm-Erstellung und Auswertung. Intensivkurs der Deutschen Gesellschaft für Andrologie,
(Prof. H.-C. Schuppe), Hamburg, 2009

Aufarbeitung von TESE-Material und Kryokonservierung. 52. Symposium der Deutschen Gesellschaft für
Endokrinologie, (Prof. H.-C. Schuppe), Giessen, 2009

Ejakulatanalyse nach WHO: Neue Richtlinien und praktische Übungen in der Beurteilung der
Morphologie. (Prof. H.-C. Schuppe), Fortbildungskurs Ejakulatanalyse, Bonn, 2009

Ejakulatdiagnostik nach WHO – Update 2009. DGRM School of Reproductive Medicine and
Endocrinology, "Störungen der Spermatogenese: aktuelle interdisziplinäre Strategien", (Prof. H.-C.
Schuppe), Regensburg, 2009

5th International Workshop "Molecular Andrology" – 1st Symposium of the Clinical Research Unit 181,
"Stem Cells - Somatic Cells - Germ Cells", Organisation: A. Meinhardt, H.-C. Schuppe, J. Klug, Giessen,
2009

Urogenitale Infektion und Infertilität. Urologisches Winterforum Großhadern der LMU München,
Großhadern am Tegernseee, (Prof. W. Weidner), 2010

EAA-Zentrum Giessen: Ejakulatdiagnostik nach WHO-Empfehlungen – Update 2010. Andrologische
Labordiagnostik – Spermiogramm-Kurs in Kooperation mit der Deutschen Gesellschaft für Andrologie
(Leitung: Prof. H.-C. Schuppe), Giessen, 2010

Andrologische Labordiagnostik – Spermiogramm-Kurs (in Kooperation mit der Deutschen Gesellschaft
für Andrologie); Giessen, Leitung: Prof. Dr. H.-C Schuppe, 2010

1st German DFG Reproductive Science Network Meeting (KFO 181 Giessen/FOR 1041 Münster), Giessen.
Organization: Prof. K. Steger (Giessen), 2010

DGRM School of Reproductive Medicine and Endocrinology / 16. Giessener Andrologisches Symposium
und Intensivkurs der Deutschen Gesellschaft für Andrologie: „Kritische Andrologie in der
interdisziplinären Reproduktionsmedizin“: Grenzen und Perspektiven, Leitung Prof. H.-C. Schuppe,
Giessen, 2011

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