Table Of ContentCancer of the Liver,
Esophagus,
and Nasopharynx
Edited by Gustav Wagner and You-Hui Zhang
With 46 Figures and several Tables
Springer-Verlag Berlin Heidelberg NewY ork
London Paris Tokyo
Professor Dr. med. Gustav Wagner
Deutsches Krebsforschungszentrum
1m Neuenheimer Feld 280
D-6900 Heidelberg 1. FRG
Professor Zhang You-Hui
Director, Cancer Institute and Hospital
Chinese Academy of Medical Sciences
Pan Jia Yao
Zuo Anmen Wai
Beijing, P. R. China
Sponsored by the Federal Ministry for Science and Technology, Bonn, and
Behringwerke A. G., Marburg
ISBN-13 :978-3-540-16967-3 e-ISBN-13 :978-3-642-71510-5
DOl: 10.1007/978-3-642-71510-5
Library of Congress Cataloging in Publication Data.
Cancer of the liver, esophagus, and nasopharynx.
Proceedings of the Chinese-German Symposium on Cancer of the Liver, the Esophagus, and the
Nasopharynx, held in Heidelberg, July 3-5, 1985, and sponsored by the German Cancer Research
Center.
Includes index. 1. Liver-Cancer-Congresses. 2. Esophagus-Cancer-Congresses. 3. Nasopharynx
Cancer-Congresses. 4. Cancer-China-Congresses. I. Wagner, Gustav. II. Zhang, You-Hui.
Ill. Chinese-German Symposium on Cancer of the Liver, the Esophagus, and the Nasopharynx (1985:
Heidelberg, Germany)
IV. Deutsches Krebsforschungszentrum Heidelberg. [DNLM: 1. Esophageal Neoplasms-congresses.
2. Liver Neoplasms-congresses. 3. Nasopharyngeal Neoplasms-congresses. WI735 C215 1985]
RC280.L5C36 1986 616.99'436 86-26029
ISBN-13 :978-3-540-16967-3 (U. S.)
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is
concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting,
reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the
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"Verwertungsgesellschaft Wort", Munich.
© Springer-Verlag Berlin Heidelberg 1987
The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of
a specific statement, that such names are exempt from the relevant protective laws and regulations and
therefore free for general use.
Product liability: The publisher can give no guarantee for information about drug dosage and
application thereof contained in this book, in every individual case the respective user must check its
accuracy by consulting other pharmaceutical literature.
2119/3020-543210
List of Contributors
Bannasch, P.
Institut fUr Experimentelle Pathologie, Deutsches Krebsforschungszentrum,
D-6900 Heidelberg, FRG
Bomkamm, G. W.
Institut fUr Virologie, Zentrum fUr Hygiene der Universitiit,
D-7S00 Freiburg, FRG
Chen Ai-Mei
Cancer Institute, Sun Yat-Sen University of Medical Sciences,
Guangzhou, PRC
Chen Han
Changhai Hospital of the Second Military Medical College,
Shanghai, PRC
Chui Shao-Xing
Cancer Institute, Chinese Academy od Medical Sciences,
Beijing, PRC
De The, G.
Laboratoire d'epidemiologie et immunologie des tumeurs, Faculte de medecine Alexis Carrel
F-69372 Lyon, Cedex OS, France
Dhom, G.
Pathologisches Institut des Saarlandes,
D-6650 Homburg/Saar, FRG
Dong Zhic Wei
Beijing Institute of Cancer Research, Dept. of Biochemistry and Molecular Biology,
Beijing, PRC
Ebbers, J.
Hals-, Nasen-und Ohrenklinik der Universitiit,
D-4000 Dusseldorf, FRG
Fang Ru-Kang
Huatung Teschers University,
Shanghai, PRC
VI List of Contributors
Feng Luo
Cancer Institute, Chinese Academy of Medical Sciences,
Beijing, PRC
Freytag von Loringhoven, A.
HerwarthstraBe 25
D-5300 Bonn, FRO
de Villiers, E.-M.
Deutsches Krebsforschungszentrum,
D-6900 Heidelberg, FRO
Gao Ru-Nie
Shanghai Cancer Institute, Dept. of Epidemiology,
Shanghai 200032, PRC
Gu Biu-Chang
Shanghai Medical Laboratory,
Shanghai, PRC
Gu lian-Ren
Dept. of Biochemistry and Molecular Biology, Shanghai Cancer Institute,
Shanghai, 200032, PRC
Gu Xiang-Zhi
Cancer Institute and Hospital, Chinese Academy of Medical Sciences,
Beijing, PRC
He Li-li
Cancer Hospital, Yangcheng County, Shanxi Province,
Taiyuan, PRC
Hecker, E.
Biochemisches Institut am Deutschen Krebsforschungszentrum,
D-6900 Heidelberg, FRO
Hong ling-Xing
Shanghai Cancer Institute, Dept. of Immunology and Cell Biology,
Shanghai200032,PRC
Hu Li-Fu
Shanghai Cancer Institute, Dept. of Biochemistry and Molecular Biology,
Shanghai200032,PRC
Huang Guo-Chun
Cancer Institute and Hospital, Chinese Academy of Medical Sciences,
Beijing, PRC
Huang Yu-Long
Chongming County Center Hospital
Chongming Island, PRC
List of Contributors VII
Jiang Ji-Wen
Dept. of Hygiene Chemistry, Hunan Medical College,
Changsha, PRC
Li Chen-Chuan
Tumor Hospital and Cancer Institute, Sun Yat-Sen University of Medical Sciences,
Guangzhou, PRC
Li Guang-Weng
Vice President, Chinese Anti-Cancer Association,
Tianjin, PRC
Li Jun-Yao
Cancer Institute, Chinese Academy of Medical Sciences, Dept. of Epidemiology,
Beijing, PRC
Li Zhen-Pu
Beijing Institute of Cancer Research, Dept. of Biochemistry and Molecular Biology,
Beijing, PRC
Liang Hao-Cai
Wuhan Medical College, Unit of Cancer Epidemiology,
Wuhan 430033, PRC
Liang Yi-Ren
Cancer Institute, Sun Yat-Sen University of Medical Sciences,
Guangzhou, PRC
Liu Yu-Gu
Wuhan Medical College, Dept. of Environmental Toxicology,
Wuhan 430033, PRC
Lu Jiang-Bang
Dept. of Epidemiology, Henan Cancer Institute,
Zheng Zhou, PRC
Lu Shih-Hsin
Cancer Institute, Chinese Academy of Medical Sciences,
Beijing, PRC
Montesano, R.
International Agency for Research on Cancer,
F-69372 Lyon, France
Munoz, N.
International Agency for Research of Cancer,
F-69372 Lyon, France
Pan Jie-Ping
Shanghai Municipal Anti-epidemic Station,
Shanghai, PRC
VIII List of Contributors
Preuflmann, R.
Institut fUr Toxikologie und Chemotherapie, Deutsches Krebsforschungszentrum,
D-6900 Heidelberg, FRG
Rabes, H.M.
Pathologisches Institut der Universitat,
8000 Munchen, FRG
Rajewsky, M. F.
Institut fUr Zellbiologie, Universitat Essen,
D-4300 Essen, FRG
Rimkus, K.
Pathologisches Institut des Saarlandes,
D-6650 Homburg/Saar, FRG
Saffhill, R.
Paterson Laboratories, Christie Hospital and Holt Radium Institute,
Manchester M20 9BX, UK
Shanmugaratnam, K.
University Department of Pathology, General Hospital,
Singapore 0316
Tang Zhao-You
Shanghai First Medical College, Zhong Shan Hospital, Liver Cancer Research Unit,
Shanghai 200031, PRC
Tu Ji-Tao
Shanghai Cancer Institute, Dept. of Epidemiology,
Shanghai 200032, PRC
Umbenhauer, D.
Dept. of Biochemistry, Vanderbilt University School of Medicine,
Nashville, TN 37232, USA
Vosteen, K. H.
Hals-, Nasen-und Ohrenklinik der Universitat,
D-4000 Dusseldorf, FRG
Wagner, G.
Institut fUr Dokumentation, Information und Statistik des Deutschen
Krebsforschungszentrums,
D-6900 Heidelberg, FRG
Wahrendoif, J.
International Agency for Research on Cancer,
F-69372 Lyon, France
Wan Da-Feng
Shanghai Cancer Institute, Dept. of Biochemistry and Molecular Biology,
Shanghai 200032, PRC
List of Contributors IX
Wan Wen-Hui
Beijing Institute of Cancer Research, Dept. of Biochemistry and Molecular Biology,
Beijing, PRC
Wang Ru-Kuan
At present Deutsches Krebsforschungszentrum, Institut fUr Dokumentation,
Information und Statistik,
D-6900 Heidelberg, FRG
Wei Shu-Min
Beijing Institute of Cancer Research, Dept. of Biochemistry and Molecular Biology,
Beijing, PRC
Wolf, H.
Max von Pettenkofer Institut der Ludwig-Maximilians-Universitat, Molekulare und
Tumorbiologie,
D-8000 MUnchen, FRG
WuBo-Wen
Changhai Hospital of the Second Military Medical College,
Shanghai, PRC
Wu Meng-Chao
Changhai Hospital ofthe Second Military Medical College, Dept. of Hepatobiliary Surgery,
Shanghai, PRC
Wu Peng-Nian
Dept. of Epidemiology, Hunan Medical College,
Changsha, PRC
Xu Guang-Xiong
Shanghai Cancer Institute, Dept. of Epidemiology,
Shanghai 200032, PRC
Xu Guan-Nan
Changhai Hospital of the Second Military Medical College,
Shanghai, PRC
Xu Xiu-Lai
Beijing Institute of Cancer Research, Dept. of Biochemistry and Molecular Biology,
Beijing, PRC
Yang Bing-Hui
Shanghai First Medical College, Zhong Shan Hospital, Liver Cancer Research Unit,
Shanghai200031,PRC
Yang lia-Mei
Changhai Hospital of the Secondary Military Medical College,
Shanghai, PRC
x List of Contributors
Yao Kai-Tai
Cancer Research Laboratory, Hunan Medical College,
Changsha, PRC
Yao Xiao-Ping
Changhai Hospital of the Second Military Medical College,
Shanghai, PRC
YuHe
Shanghai Cancer Institute, Dept. of Epidemiology,
Shanghai 200032, PRC
Yu Song-Ling
Wuhan Medical College, Unit of Cancer Epidemiology,
Wuhan 430033, PRC
Yu Ye-Qiu
Shanghai First Medical College, Zhong Shan Hospital, Liver Cancer Research Unit,
Shanghai 200031, PRC
Zeng Yi
National Centre for Preventive Medicine, Institute of Virology,
Beijing 100052, PRC
Zerban, Heide
Institut fUr Experimentelle Pathologie am Deutschen Krebsforschungszentrum,
D-6900 Heidelberg, FRG
Zhang Dan-Hua
Chongming County Anti-epidemic Station,
Chongming Island, PRC
Zhang Ming-Shu
Cancer Institute, Chinese Academy of Medical Sciences,
Beijing, PRC
Zhang Yiao-Hua
Changhai Hospital of the Second Military Medical College,
Shanghai, PRC
Zhang You-Hui
Cancer Institute, Chinese Academy of Medical Sciences,
Beijing, PRC
Zhou Xiao-Han
Shanghai First Municipal Hospital,
Shanghai, PRC
zur Hausen, H.
Deutsches Krebsforschungszentrum,
D-6900 Heidelberg, FRG
Preface
To stimulate greater German-Chinese cooperation in the field of oncology, the Ger
man Cancer Research Center (DKFZ) carried through a "Chinese-German Sympo
sium on Cancer of the Liver, the Esophagus, and the Nasopharynx" in Heidelberg
from 3 to 5 July 1985. These three forms of cancer were chosen as they are extremely
rare in Europe but some of the most frequently found forms in China. Almost half
of the roughly 260000 cases of primary liver cancer occurring annually worldwide
are Chinese; of the roughly 300000 esophagus cancers occurring annually, more
than half are Chinese; nasopharyngeal cancer is roughly 100 times more frequent
among Chinese people than in Caucasians.
Under these circumstances, it is not surprising that the Chinese guest speakers of
the Heidelberg symposium - selected specialists in the three subsections of oncolo
gy mentioned - were able to report about extensive experiences with patient popu
lations of a size hardly imaginable in Europe. The great clinical experience of the
Chinese guests was supplemented by special contributions of European experts.
Thus, this volume permits a topical survey of the state of the art in these three can
cers, with subsections of epidemiology, pathology, and clinical treatment.
The editors wish to thank the Federal Ministry of Research and Technology
(BMFT) for their encouragement and direct help in preparing and carrying through
the symposium, the Management Board of the DKFZ for their generous assistance
and Springer-Verlag for the publication and excellent production of this volume.
Heidelberg, Peking, October 1986 Gustav Wagner
Zhang You-Hui
