Table Of ContentCancer and Pregnancy
Springer
London
Berlin
Heidelberg
New York
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Hong Kong
Milan
Paris
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Tokyo
Eytan R. Barnea, Eric Ja uniaux
and Peter E. Schwartz (Eds)
Cancer and
Pregnancy
Springer
Eytan R. Barnea, MD, FACOG
Society for the Investigation of Early Pregnancy, 1697 Lark Lane, Cherry Hill,
NJ 08003-3157, USA
Eric Ja uniaux, MD, PhD
Department of Obstetric and Gynaecology, University College London Medical
School, 86-96 Chenies Mews, London, WC1E 6HX
Peter E. Schwartz, MD, FA COG
Department of Obstetrics and Gynaecology, Yale University School of Medicine,
333 Cedar Street, New Haven, CT 06510, USA
British Library Cataloguing in Publication Data
Cancer and pregnancy
1. Cancer in pregnancy
I. Barnea, E. R. II. Jauniaux, E. III. Schwartz, Peter E.
618.3
ISBN-13:978-1-4471-1184-9
Library of Congress Cataloging-in-Publication Data
Cancer and pregnancy
Cancer in pregnancy 1 Eytan R. Barnea, Eric Jauniaux and Peter E. Schwartz (eds.).
p.;cm
Includes bibliographical references and index.
ISBN-13:978-1-4471-1184-9 e-ISBN -i3: 978-1-4471-0707-1
DOI:I 0.1007/978-1-4471-0707-1
1. Cancer in pregnancy. 2. Pregnancy-Complications. I. Barnea, E. R. II. Jauniaux, E.
III. Schwartz, Peter E.
[DNLM: 1. Pregnancy Complications, Neoplastic. WQ 240 C2147 2001]
RG580.C3 C35 2001
618.3-dc21 00-049240
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ISBN-13:978-1-4471-1184-9 Springer-Verlag London Berlin Heidelberg
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© Springer-Verlag London Limited 2001
Softcover reprint of the hardcover 1st edition 2001
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Contents
PART I: CLINICAL ASPECTS: DIAGNOSIS AND MANAGEMENT
1 The Epidemiology of Cancer in Pregnancy
T. Dinh and D. Warshal ......................................... .
2 Placental and Fetal Cancers
E. /auniaux, Y. Gillerot and /. Hustin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6
3 Breast Cancer and Pregnancy
E. Shah and C. Saunders. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21
4 Gynaecologic Malignancies in Pregnancy
M.L. Anderson, G. Mari and P.E. Schwartz. . . . . . . . . . . . . . . . . . . . . . . . . . 33
5 Hematologic Malignancies in Pregnancy
T. Pejovic, P.E. Schwartz and G. Mari. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50
6 Melanoma in Pregnancy
S.P. Harlow..................................................... 54
7 Rare Tumours in Pregnancy
T. Pejovic, G. Mari and P.E. Schwartz. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
8 Coloredal-(ancer in Pregnancy
S.M. Stemmer................................................... 76
9 Radiologic Diagnosis of Cancer in Pregnancy
K. Odunsi, P.E. Schwartz and G. Mari. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
10 Pregnancy Derived Tumor Marker
T. Maruo and T. Otani . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93
11 Chemo and Radiation Therapy During Pregnancy
M. Muslim, /. Goldberg and A. Hageboutros . . . . . . . . . . . . . . . . . . . . . . . . . 108
12 Management of Cancer in Pregnancy (Case Reports)
M.L. Anderson and G. Mari, P.E. Schwartz. . . . . . . . . . . . . . . . . . . . . . . . .. 119
13 Transplacental Carcinogenesis: Role of Chemicals, Radiation and Viruses
o.
Diav-Citrin, A. Ornoy and R. K. Miller. . . . . . . . . . . . . . . . . . . . . . . . . . .. 131
PART II COMPARATIVE ASPECTS OF PREGNANCY
DEVELOPMENT AND TUMOUR BIOLOGY
14 Metabolism of Chemotherapeutic Drugs by Maternal and Conceptus Tissues
M.K. Sanyal . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 149
15 Adverse Reproductive Outcome Potential of Cancer Therapies During Pregnancy
M.K. Sanyal.................................................... 174
16 Immunomodulatory Analogies Between Trophoblastic and Cancer Cells
and Their Hosts
e.B. Coulam and D. Rukavina. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 190
17 Protective Role of Human Chorionic Gonadotrophin and Luteinizing Hormone
Against Breast Cancer
Z.M. Lei and Ch. V. Rao . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 209
18 Proliferation, Differentiation and Apoptosis in Pregnancy and Cancer
R.G. Lea. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 216
19 Controlled vs Uncontrolled Angiogenesis: Color Doppler Studies
A. Kurjak, S. Kupesic and T. Zodan. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 229
20 Angiogenesis and Vasculogenesis in Pregnancy and in Tumor Development
M.Zygmunt.................................................... 251
21 Trophoblast Implantation Versus Tumor Invasion
o.
R. Foulk and Genbacev. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 267
22 Pregnancy Derived Compounds that Control Proliferation
E.R. Barnea, G. Aboagye-Mathiesen, W.e. Hatch and P.e. Leavis . . . . . . . .. 277
23 Cancer and Pregnancy: Bioethical and Legal Dilemmas
F.A. Chervenak and I.B. McCullough. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 287
Epilogue
Cancer and Pregnancy: a Reason for Hope
E.R. Barnea .................................................... 298
Index 303
Contributors
George Aboagye-Mathiesen, PhD Tuan A Dinh, MD
Institute of Medical Biochemistry Departmenet of Obstetrics and Gynecology
University of Aarhus Cooper Hospital! University Medical Center
Ole Worms Alle, Building 170 1 Cooper Plaza, suite 623
8000 Aarhus C, Denmark Camden NJ 08103, USA
Matthew L. Anderson, MD, PhD Russell Foulk, MD, FACOG
Department of Obstetrics and Gynecology University of Nevada School of Medicine
and Divisions of Maternal-Fetal Medicine Medical Director
Yale University School of Medicine The Nevada and Idaho Center for
New Haven, Connecticut USA Reproductive Medicine
6630 S. McCarran Blvd, Suite 9
Eytan R. Barnea, MD, FACOG Reno, NV 89509, USA
Chairman
The Society for the Investigation of Early Olga Genbacev, PhD
Pregnancy (SIEP) Department of Stomatology
1697 Lark Lane University of California, San Francisco
Cherry Hill, NJ 08003-3157, USA 513 Parnassus Avenue HSW 604
San Francisco, CA 94143-0512, USA
Frank A. Chervenak, MD
Professor and Acting Chairman Yves Gillerot, MD, PhD
Department of Obstetrics and Gynecology Institut de Morphologie
New York Weill Cornell Medical Center Pathologique Loverval (IMPL)
525 East 68th Street, Room J130 Allee des Templiers 41
New York, NY 10021, USA 6280 Gerpinnes (Loveral), Belgium
Carolyn B. Coulam, MD Jack Goldberg, MD
Sher Institute for Reproductive Medicine of Department of Medicine
Chicago Division of Hematology/Medical Oncology
233 E Erie, Suite 500 Cooper Hospital/University Medical Center
Chicago, IL 60611, USA 3 Cooper Plaza, Suite 220
Camden, NJ 08103, USA
Orna Diav-Citrin, MD
Department of Pediatrics
The Hebrew University
Hadassah Medical School
P.O. Box 12272
Jerusalem 91120, Israel
vii
viii Cancer and Pregnancy
Alexandre Hageboutros, MD Paul C. Leavis, PhD
Department of Medicine Boston Biomedical Research Institute
Division of Hematology/Medical Oncology 64 Grove Street
Cooper Hospital/University Medical Center Watertown, MA 02472-2829, USA
3 Cooper Plaza, Suite 220
Camden, NJ 08103, USA Z. M. Lei, PhD
Division of Basic Science Research
Seth P. Harlow, MD Department of Obstetrics and Gynecology
Assistant Professor of Surgery University of Louisville Health Sciences
Division of Surgical Oncology Center
University of Vermont Louisville, Kentucky, USA
Given Building, Room 309
Burlington, VT 05405, USA Giancarlo Mari, MD
Department of Obstetrics and Gynecology
William C. Hatch, PhD and Divisions of Maternal-Fetal Medicine
Boston Biomedical Research Institute Yale University School of Medicine
64 Grove Street New Haven, Connecticut, USA
Watertown, MA 02472-2829, USA
Takeshi Maruo, MD
Jean Hustin, MD, PhD Department of Obstetrics and Gynecology
Institut de Morphologie Kobe University School of Medicine
Pathologique Loverval (IMPL) Kusunoki-Cho, Chuo-Ku
Allee des Templiers 41 Kobe 650-0017, Japan
6280 Gerpinnes (Loveral), Belgium
Laurence B. McCullough, PhD
Eric Jauniaux, MD, PhD Professor of Medicine and Medical Ethics
Reader in Obstetrics and Maternofoetal Center for Medical Ethics and Health Policy
Medicine Baylor College of Medicine
Academic Departments of Obstetrics and 1 Baylor Plaza
Gynaecology Houston, TX 77030, USA
University College London Medical School
86-96 Chenies Mews Richard K. Miller, PhD
London WClE 6HX, UK Professor and Director
Department of Obstetrics and Gynecology
Sanja Kupesic, MD, PhD Division of Research/PEDECS
Department of Obstetrics and Gynecology University of Rochester Medical Center
Medical School University of Zagreb 601 Elmwood Avenue, Box 668
Sveti Duh Jospital Rochester, NY 14642-8668, USA
SvetiDuh 64
10000 Zagreb, Croatia Muhammad Muslim, MD
Department of Medicine
Asim Kurjak, MD, PhD Division of Hematology/Medical Oncology
Department of Obstetrics and Gynecology Cooper Hospital, University Medical Center
Medical School University of Zagreb 3 Cooper Plaza, Suite 220
Sveti Duh Jospital Camden NJ 08103, USA
Sveti Duh 64
10000 Zagreb, Croatia Kunle Odunsi, MD, PhD
Department of Gynecological Oncology
Richard G. Lea, PhD Roswell Park Cancer Institute
Senior Research Scientist Elm and Carlton Streets
Division of Nutrition and Development Buffalo, NY 14263, USA
The Rowett Research Institute
Greenburn Road, Bucksburn
Aberdeen AB21 9SB, UK
Contributors ix
Asher Ornoy, MD Christobel Saunders, FRCS
Department of Anatomy and Cell Biology Department of Surgery
The Hebrew University Charles Bell House
Hadassah Medical School Riding House Street
P.O. Box 12272 London, UK
Jerusalem 91120, Israel
Elizabeth F. Shah, MSc, FRCS
Tetsuo Otani, MD Department of Surgery
Department of Obstetrics and Gynecology Charles Bell House
Kobe University School of Medicine Riding House Street
Kusunoki-Cho, Chuo-Ku London, UK
Kobe 650-0017, Japan
Peter E. Schwartz, MD, FACOG
Tanja Pejovic, MD, PhD Vice Chair/Director of Gynecologic
Department of Obstetrics and Gynecology Oncology
Yale University School of Medicine Department of Obstetrics and Gynecology
333 Cedar Street Yale University School of Medicine
New Haven, CT 06520, USA 333 Cedar Street
New Haven, CT 06510, USA
Ch. V. Rao, PhD
Division of Basic Science Research Shlomo Marc Stemmer, MD, MS, FACOG
Department of Obstetrics and Gynecology Crispin Square
University of Louisville Health Sciences 230 N Maple Ave
Center Marlton, NJ 08053, USA
438 Medical-Dental Building
511 South Floyd Street David P. Warshal, MD
Louisville, KY 40292, USA Department of Obstetrics and Gynecology
Cooper Hospital! University Medical Center
Daniel Rukavina, MD, DSc 3 Cooper Plaza, suite 221
Professor and Chairman Camden, NJ 08103, USA
Department of Physiology and Immunology
Medical Faculty, University of Rijeka Tina Zodan, MD
B. Branchetta 20 Opca Bolnica
51000 Rijeka, Croatia SvetiDuh64
10000 Zagreb, Croatia
Mrinal K. Sanyal, PhD
Departments of Obstetrics and Gynecology and Marek Zygmunt, MD
Molecular, Cellular and Developmental Biology Department of Obstetrics and Gynecology
Yale University School of Medicine University of Giessen
333 Cedar Street Klinikstr.32
New Haven, CT 06510, USA Giessen, 35385, Germany
Part I
Clinical Aspects: Diagnosis and Management
