Table Of ContentStem Cells in Clinical Applications
Phuc Van Pham Editor
Bone and
Cartilage
Regeneration
Stem Cells in Clinical Applications
Series Editor
Phuc Van Pham
Laboratory of Stem Cell Research and Application
University of Science
Vietnam National University
Ho Chi Minh City, Vietnam
More information about this series at http://www.springer.com/series/14002
Phuc Van Pham
Editor
Bone and Cartilage
Regeneration
Editor
Phuc Van Pham
Laboratory of Stem Cell Research and Application
University of Science
Vietnam National University
Ho Chi Minh City, Vietnam
ISSN 2365-4198 ISSN 2365-4201 (electronic)
Stem Cells in Clinical Applications
ISBN 978-3-319-40143-0 ISBN 978-3-319-40144-7 (eBook)
DOI 10.1007/978-3-319-40144-7
Library of Congress Control Number: 2016948211
© Springer International Publishing Switzerland 2016
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Preface
Bone- and cartilage-related diseases are the most popular diseases in human beings.
They affect millions of people worldwide. It is estimated that an osteoporotic frac-
ture occurs every three seconds, with one in three women – and one in five men –
over fifty being affected by the condition. Similarly, up to one in five women and
one in ten men over the age of sixty will be affected by osteoarthritis.
The current treatments for these disorders aim at pain reduction and replacement
surgery. Stem cells can be used to replace and regenerate injured tissues. The first clini-
cal stem cell applications for cartilage and bone regeneration were first attempted more
than thirty years ago. To date, there are more than 100 clinical trials using stem cells in
bone and cartilage regeneration that registered in clinicaltrials.gov. Compared to the
clinical applications of stem cells in other diseases, the different uses of stem cells for
bone and cartilage regeneration are being developed at a higher rate. There are at least
four mesenchymal stem cell-based products that were prepared and approved in some
countries for orthopedics such as CARTISTEM (Korea), AlloStem (USA), Osteocel
Plus (USA), and Trinity Evolution (USA). These products significantly contributed to
the development of stem cells in bone and cartilage regeneration.
This volume of the Stem Cells in Clinical Applications series, Bone and Cartilage
Regeneration provides an updated, invaluable resource for advanced undergraduate
students, graduate students, researchers, and clinicians in stem cell applications for
bone and cartilage regeneration.
In fifteen chapters, the book covers almost all of the present applications of stem
cells in orthopedics including bone repair, cartilage defect treatment, osteoarthritis
treatment, temporomandibular joint regeneration, tendon regeneration, femoral
head necrosis treatment, rotator cuff repair, sports injuries treatment, and dentistry
treatment.
We are indebted to our authors who graciously accepted their assignments and who
have infused the text with their energetic contributions. We are extremely thankful to
our responsible editor Aleta Kalkstein and the staff of Springer Science+Business
Media who published this book.
Ho Chi Minh City, Vietnam Phuc Van Pham
v
Contents
1 Clinical Applications of Stem Cells for Bone Repair ........................... 1
Wasim S. Khan, Philip Pastides, and David Marsh
2 Stem Cell Therapy for the Treatment of Cartilage Defects
and Osteoarthritis ................................................................................... 11
Luminita Labusca and Florin Zugun-Eloae
3 Repair and Regeneration of Temporomandibular Joint:
The Future of Stem Cell-Based Therapies ............................................ 47
Adrian U. Jin Yap and Wei Seong Toh
4 Clinical Application of Stem Cells to Include Muscle,
Bone and Tendon Pathology ................................................................... 77
Taimur Khan, Tahir Khan, Wasim S. Khan, and Atif A. Malik
5 Stem Cell Therapy for Avascular Femoral Head Necrosis:
From Preclinical to Clinical Study ........................................................ 89
Phuc Van Pham and Ngoc Bich Vu
6 Mesenchymal Stem Cells: Are They the Magic Bullet
for Skeletal Tissue Regeneration? ......................................................... 107
Amir Ardakani and Wasim S. Khan
7 Stem Cells for Articular Cartilage Repair and Regeneration ............ 119
Dinesh A. Parate, Shipin Zhang, James Hoi Po Hui,
and Wei Seong Toh
8 Mesenchymal Stem Cell Therapy in Rheumatoid Arthritis ............... 149
Alasdair G. Kay, Jim Middleton, and Oksana Kehoe
9 Stem Cells in Bone and Articular Cartilage Tissue Regeneration ..... 177
Christopher R. Fellows, Kalamegam Gauthaman, Peter N. Pushparaj,
Mohammed Abbas, Csaba Matta, Rebecca Lewis,
Constanze Buhrmann, Mehdi Shakibaei, and Ali Mobasheri
vii
viii Contents
10 Mesenchymal Stem Cells: An Optimistic Cell Source
in Tissue Engineering for Bone Regeneration ...................................... 205
Samaneh Hosseini and Mohamadreza Baghaban Eslaminejad
11 Dental-Derived Mesenchymal Stem Cells as a Promising
Source for Regenerative Medicine ......................................................... 245
Marco Tatullo, Massimo Marrelli, Francesco Paduano,
and Roberto Gatto
12 Bone Formation in Osteoporosis, In Vitro Mechanical
Stimulation as Compared with Biochemical Stimuli ........................... 255
Martin H. Pham, Zori Buser, and Frank L. Acosta
13 Tissue Engineering Approaches for Rotator Cuff Repair ................... 265
Nick Aresti, Wasim S. Khan, and Atif A. Malik
14 The Role of Bone Marrow-Derived Mesenchymal Stem
Cells in Sports Injuries ........................................................................... 277
Alex Vris, Nick Aresti, Wasim S. Khan, and Atif A. Malik
15 Stem Cells in Dentistry: Potential Applications
and Perspectives in Clinical Research ................................................... 293
Thekkeparambil Chandrabose Srijaya, Sandhya Sriram,
Shigeki Sugii, and Noor Hayaty Abu Kasim
Index ................................................................................................................. 309
Contributors
Mohammed Abbas Sheikh Salem Bin Mahfouz Scientific Chair for Treatment of
Osteoarthritis by Stem Cells, King Abdulaziz University, Jeddah, Saudi Arabia
Frank L. Acosta Department of Neurosurgery, Keck School of Medicine, University
of Southern California, Los Angeles, CA, USA
Amir Ardakani Royal National Orthopaedic Hospital, University College London
Institute for Orthopaedics and Musculoskeletal Sciences, Stanmore, UK
Nick Aresti Department of Trauma & Orthopaedics, Barts Health NHS Trust, The
Royal London Hospital, London, UK
Constanze Buhrmann Institute of Anatomy, Ludwig-Maximilians-University Munich,
Munich, Germany
Zori Buser Department of Neurosurgery, Keck School of Medicine, University of
Southern California, Los Angeles, CA, USA
Mohamadreza Baghaban Eslaminejad Department of Stem Cell and Developmental
Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and
Technology, ACECR, Tehran, Iran
Christopher R. Fellows Department of Veterinary Preclinical Sciences, School of
Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey,
Guildford, UK
Roberto Gatto Faculty of Medicine, School of Dentistry, University of L’Aquila,
L’Aquila, Italy
Kalamegam Gauthaman Center of Excellence in Genomic Medicine Research
(CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia
Sheikh Salem Bin Mahfouz Scientific Chair for Treatment of Osteoarthritis by Stem
Cells, King Abdulaziz University, Jeddah, Saudi Arabia
ix
x Contributors
Samaneh Hosseini Department of Stem Cell and Developmental Biology, Cell
Science Research Center, Royan Institute for Stem Cell Biology and Technology,
ACECR, Tehran, Iran
James Hoi Po Hui Department of Orthopaedic Surgery, Yong Loo Lin School of
Medicine, National University of Singapore, Singapore, Singapore
Tissue Engineering Program, Life Sciences Institute, National University of
Singapore, Singapore, Singapore
Cartilage Repair Program, Therapeutic Tissue Engineering Laboratory, National
University Health System, Singapore, Singapore
Noor Hayaty Abu Kasim Department of Restorative Dentistry, Faculty of Dentistry,
University of Malaya, Kuala Lumpur, Malaysia
Alasdair G. Kay Keele University, ISTM at RJAH Orthopaedic Hospital, Oswestry,
Shropshire, UK
Oksana Kehoe Keele University, ISTM at RJAH Orthopaedic Hospital, Oswestry,
Shropshire, UK
Tahir Khan Cattarrel Unit, Royal National Orthopaedic Hospital, Stanmore, UK
Taimur Khan Faculty of Medical Sciences, University College London, London,
UK
Wasim S. Khan Royal National Orthopaedic Hospital, University College London
Institute for Orthopaedics and Musculoskeletal Sciences, Stanmore, UK
Division of Trauma & Orthopaedics, University of Cambridge, Addenbrooke’s
Hospital, Cambridge, UK
Luminita Labusca Faculty of Health and Medical Sciences, Department of Veterinary
Clinical and Animal Sciences, Section for Anatomy, Biochemistry, University of
Copenhagen, Frederiksberg C, Denmark
Orthopedic and Traumatology Clinic, Emergency University Hospital Saint
Spiridon, Iasi, Romania
National Institute of Research and Development for Technical Physics, Iasi, Romania
Department of Molecular Genetics and Immunology, Gr.T.Popa: University of
Medicine and Pharmacy, Iasi, Romania
Rebecca Lewis Department of Veterinary Preclinical Sciences, School of Veterinary
Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford,
UK
Atif A. Malik Department of Trauma & Orthopaedics, Buckinghamshire NHS Trust,
Stoke Mandeville Hospital, Aylesbury, UK
Massimo Marrelli Tecnologica Research Institute, Crotone, Italy
Calabrodental Healthcare Center, Crotone, Italy
Contributors xi
David Marsh Royal National Orthopaedic Hospital, University College London
Institute for Orthopaedics and Musculoskeletal Sciences, Stanmore, UK
Csaba Matta Department of Anatomy, Histology and Embryology, Faculty of
Medicine, University of Debrecen, Debrecen, Hungary
Department of Veterinary Preclinical Sciences, School of Veterinary Medicine,
Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
Jim Middleton Faculty of Medicine and Dentistry, University of Bristol, Bristol,
UK
Ali Mobasheri Department of Veterinary Preclinical Sciences, School of Veterinary
Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford,
UK
Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz
University, Jeddah, Saudi Arabia
Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis, Arthritis
Research UK Pain Centre, Medical Research Council and Arthritis Research UK
Centre for Musculoskeletal Ageing Research, Queen’s Medical Centre, Nottingham,
UK
Francesco Paduano Tecnolovgica Research Institute, Crotone, Italy
Dinesh A. Parate Department of Orthopaedic Surgery, Yong Loo Lin School of
Medicine, National University of Singapore, Singapore, Singapore
Philip Pastides Royal National Orthopaedic Hospital, University College London
Institute for Orthopaedics and Musculoskeletal Sciences, Stanmore, UK
Martin H. Pham Department of Neurosurgery, Keck School of Medicine, University
of Southern California, Los Angeles, CA, USA
Peter N. Pushparaj Center of Excellence in Genomic Medicine Research (CEGMR),
King Abdulaziz University, Jeddah, Saudi Arabia
Mehdi Shakibaei Institute of Anatomy, Ludwig-Maximilians-University Munich,
Munich, Germany
Thekkeparambil Chandrabose Srijaya Department of Restorative Dentistry,
Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
Sandhya Sriram Fat Metabolism and Stem Cell Group (FMSCG), Laboratory of
Metabolic Medicine (LMM), Singapore Bioimaging Consortium (SBIC), A*STAR,
Singapore, Singapore
Shigeki Sugii Fat Metabolism and Stem Cell Group, Laboratory of Metabolic
Medicine, Singapore Bioimaging Consortium (SBIC), A*STAR, Singapore, Singapore
Cardiovascular and Metabolic Disorders Program, Duke-NUS Graduate Medical
School, Singapore, Singapore
