Table Of ContentVolume  24 Contents 
January 
Editorial 
Report  of Meeting on  Perceptions  of Biochemistry  by the Public,  the Press  and the Politicians.  J K Candlish 
N—_O  
Appropriate  Transfer  of Molecular  Technology  to Latin  America  for Public  Health  and Biomedical  Sciences. 
E Harris,  A Belli  and  N Agabian 
Peer  Tutoring:  Can  Medical  Students  Teach  Biochemistry?  M Carroll 
Teaching  the Urea  Cycle.  M B Patil  and  N V Shastri 
Erratum 
Stoichiometry  of the Water  Molecules  in Glucose  Oxidation  Revisited:  Inorganic  Phosphate  Plays a Unique 
Role  as  Water  in Substrate-Level  Phosphorylation.  K Horiike,  R Miura,  T Ishida  and  M Nozaki 
Learning  What it Means  to be a Biochemist:  Case  Study of a Tutorial  on  Glycolysis.  J Ryder and  J T Leach 
The Use of Michaelis-Menten  Kinetics in Cell Biology and Physiology Teaching Laboratories.  R Sorensen  and 
N Novak 
Proposal  for  a New  Regional  Organization  of Biochemists  in Africa.  The  Federation  of African  Biochemical 
Societies 
Book  Review  in Brief 
Straightening  Out  the Stereochemical  Numbering  System.  V A Mezl 
Features  Section 
Computer  Aided  Learning.  G R Parslow 
The  Old  Technology  Still  Works... 
Use  of Graphics  Workstations  to  Illustrate  Protein  and  Nucleic  Acid  Structure.  A  Description  of Three 
Modelling  Experiments  Carried  out  by  Second-year  Undergraduates.  C E  Sansom,  D  A  Waller  and 
A J Geddes 
Problem-based  Learning.  C A Smith 
Theoretical  Support  for  the  Existence  of  a  Sedoheptulose-1,7-bisphosphatase  Involved  in  Chloroplast 
Photosynthesis  Pathway.  F Cadet 
Announcement 
Book  Review 
Addressing  Content  in Problem-based  Courses:  The  Learning  Issue  Matrix.  H B White,  III 
Videotape  Review 
Biotechnology  Education.  R O Jenkins 
Book  Review 
The  Biotechnology  Internship  Programmes:  The  Role  of Industry  in Manpower  Training  in Hong  Kong. 
J C Tsang,  D C Cheung,  K Wong  and Y L Lo 
Experimental  Section 
Use  of  Monoclonal  Antibodies  in  ELISA  Assays.  J M  Johnston,  S K  Rathmell,  M  R  Wilson  and 
S B Easterbrook-Smith 
An  Experiment  on  the Denaturation  of «-Chymotrypsin  by an  Anionic  Surfactant,  Sodium  Dodecyl  Sulfate 
(SDS).  V H Mulimani  and J Lalitha 
A  Laboratory  Class  Experiment  Illustrating  Basic  Principles  of  DNA  cloning  and  Molecular  Biology 
Techniques.  J A Perez-Pons  and  E Querol 
An Assay Procedure  for Determining  the Rate of an  Enzyme Reaction  Lacking an Optical Signal: Validity of 
Coupled  Enzyme  Assays.  O P Malhotra,  P  K Ambasht,  P Prabhakar,  A K Lal  and  A M Kayastha 
The Role of Molecular Biology in Characterisation of «-Thalassaemia.  J Howarth,  H Waters,  K Hyde, S Heath, 
C Bottrill  and  J Richards 
Letters  to  the Editor 
Book  Reviews 
Obituary 
Lexicon 
Monitor 
April 
Editorial  77 
Features  Section 
Problem-based  Learning.  C A Smith  77 
Biochemistry  in Marine  Biotechnology.  C Alvarez  and  D Carillo  78 
How  Much  Biochemistry  should  a Good  Doctor  Know?  B H Moreland  79 
How  Much  Biochemistry  should  a  Medical  Student  be Taught?—The  Viewpoint  of the  General 
Medical  Council.  R D Cohen  80 
How  Much  Biochemistry  should  a  Good  Doctor  Know?  A  Biochemist’s  Viewpoint.  E  J Wood  82 
How Much Biochemistry should  a Good Doctor Know? An Educationalist’s  Perspective.  R Dennick 
ill
A New  Medical  Curriculum  at  Leicester.  T M  Harrison 
The  Manchester  Medical  Programme.  K Burdett  90 
The  New  Medical  Curriculum  at  Liverpool  University.  J Smith  91 
Current  Position  of UK  Medical  Schools  with  Respect  to  Curriculum  Changes.  B Moreland  92 
What  is Life?  An  Extended  Review  of a  Recent  Book  by L Morgulis  and  D Sagan.  F Vella  94 
A Different  Approach  to  the  Teaching  of Biological  Chemistry  to  Veterinary  Medicine  Students. 
V A Rivarola,  J R Bergesse  and  M  B Garcia  96 
The  Use  of False  Statement-type  Questions  in Biochemistry  Tests.  A S Gupthar  98 
Using  One’s  Hands  for Naming  Optical  Isomers  and  Other  Stereochemical  Positions.  V A Mezl  99 
The  Steady  State  Hypothesis  in Complex  Biological  Systems.  S Llesuy  and  E A Lissi  102 
Simple  and  Direct  Derivation  of Steady-state  Rate  Equations  for  Enzyme  Catalysed  Reactions 
Involving  Two  Substrates  and  Two  Products.  I  G Darvey  106 
Computer  Aided  Learning.  G R Parslow  109 
Respiratory  Control  Ratio:  A Computer  Simulation  of Oxidative  Phosphorylation.  J  D Morton, 
M F Barnes  and  R F Zyskowski  110 
Biotechnology  Education.  R O Jenkins  112 
Biotechnology  and  Environmental  Management.  T Hector  112 
Books  on  Biotechnology  114 
Experimental  Section 
Restriction  Mapping  and  Gene  Analysis.  M  Simsek  117 
Plastic  Atomic-Molecular  Models—A  Key to  Stereochemical  Structures.  R-H  Mikelsaar  120 
Letter  to  the Editor  124 
Videotape  Reviews  125 
Book  Reviews  126 
Lexicon  128 
Monitor  129 
July 
Editorial  131 
Laboratory  Work  in Biochemical  Education:  Purpose  and  Practice.  E J Wood  132 
Alternative  Modes  of Organising  Biochemical  Laboratory  Work.  G McKenzie  137 
Computer  Mediated  Learning in Laboratory  Classes.  F Pamula,  G J Wigmore  and J  F Wheldrake  141 
Students’  Bibliographic  Research:  .Competition  Enhances  Results.  N  Engel,  G  Stekolschik, 
F Mendive  and  S Baranzini  143 
The  Calvin  Cycle:  a Metabolic  Pathway  Still  Misunderstood.  J G Pereto  147 
The UFPE MSc Biochemistry Programme in Northeastern  Brazil.  LC B B Coelho and A M F Souza  149 
Minireview:  Genetic  and  Pathophysiological  Aspects  of Serum  Transferrin.  N Kilic¢,  A S Warsy 
and  M A F  El-Hazmi  151 
Report:  Second  International  Course  on  Molecular  Biology  Approaches  for  the  Study  of 
Plant—Microbe  Interactions  153 
Features  Section 
Problem-based  Learning.  C A Smith  154 
Thermal  Denaturation  of an  Enzyme—Choice  of a Model.  C Robert  and  F Cadet  154 
The  Inhibition  of Studies  on  Polyphenoloxidase  by Cysteine.  C Robert  and  F Cadet  157 
Computer  Aided  Learning.  G R Parslow  160 
RME/AGEE  a  Computer  Tool  for  Restriction  Enzyme  Mapping  Training.  G  lIazzetti  and 
R A Calogero  160 
Biotechnology  Education.  R O Jenkins  164 
Constraints  to the Implementation  of Distance  Learning Programmes in Biotechnology  and Related 
Disciplines  for Conventional  Universities.  C K Leach  and  R O Jenkins  165 
Lexicon  169 
Erratum  169 
Experimental  Section 
Zymography  of Extracellular  Matrix  Proteases.  A R Quesada,  I Fajardo,  D  Rodriguez-Agudo, 
J M Pachon  and  M A Medina  170 
The  Shapes  of  Scatchard  Plots  for  Systems  with  Two  Sets  of  Binding  Sites.  A K  Bordbar, 
A A Saboury  and  A A Moosavi-Movahedi
Immunological  Exercises  for  Beginners.  R B Ferreira,  G Esquivel  and  A R Teixeira 
Light-induced  Proton  Transport  through  Chloroplast  Membranes.  J W Ho  and  E S-M  Po 
Videotape  Reviews 
Book  Reviews 
Monitor 
October 
Editorial 
Beyond  Facilitation:  The  Active  Tutor  in  a  Problem-based  Course.  P  K  Rangachari  and 
D J Crankshaw 
Current  Statistical  Methods  for  Estimating  the  K,,  and  V,,,,  of  Michaelis-Menten  Kinetics. 
R J Ritchie  and  T.  Prvan 
Stoichiometry  of Glucose  Oxidation  when  Linked  to  ATP  Synthesis.  R A Mitchell 
How  Many  Water  Molecules  Produce  during  the  Complete  Oxidation  of  Glucose?  Reply  to 
Robert  A Mitchell.  K Horitike,  T Ishida  and  R Miura 
Electronic  Publishing  in Science.  Report  by D F Shaw 
Book  Review 
Perspectives  from  Conducting  a  Molecular  Biology  Workshop  in  Malaysia.  L  J Abraham  and 
J Whelan 
Denaturation  of Proteins—60  Years  On.  K Manchester 
Features  Section 
Problem-based  Learning.  C A Smith 
Environmental  Biochemistry—A  Problem-based  Approach.  L Jervis  and  P Morris 
Problem-solving  in molecular  biology.  J Szeberényi 
Computer  Aided  Learning.  G R Parslow 
Software  Review.  L Kirk 
Biotechnology  Education.  R O Jenkins 
Microbial  Cell  Culture—A  Basic  Teaching  Program.  A  H  Carvalho,  A  C Silva,  A  L Arnaud, 
E H M  Melo,  W M  Ledingham  and  J L Lima  Filho 
Videotape  Review.  F Lloyd 
Experimental  Section 
Molecular  Modeling  and  Experimental  Verification  of the  Relative  Stability  of DNA  Base  Pairs: 
a Biochemistry  Laboratory  Experiment.  S K Burgess,  N H Martin, T L Connelly,  W R Reynolds 
and  L D Spiro 
An  Experiment  on  the  Succinylation  of Wheat  Gluten  and  its  Consequences  for  pH-Solubility. 
D Fouques  and  M-C  Ralet 
A Rapid and Inexpensive  Procedure  for the Determination  of Amylase Activity.  VH Mulimani  and 
J Lalitha 
Spectrofluorimetric  Visualisation  of  the  Progress  of  an  Enzymatic  Reaction.  C  Saldanha  and 
J Martins-Silva 
Book  Reviews 
Monitor