Table Of ContentA
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“This book provides a broad look at autism spectrum disorders,
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ranging from etiology to treatment. An excellent choice for
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students or practitioners who want a comprehensive review of the complex
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topic of autism from leaders in the field.”
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Geraldine Dawson, Ph.D., FAPA, FAPS, Professor of Psychia-
try and Behavioral Sciences, Professor of Pediatrics, Professor S
AUTISM
of Psychology and Neuroscience; Director, Duke Center for P
Autism and Brain Development; Director, Duke Autism Clinic, E
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Duke Institute for Brain Sciences
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SPECTRUM
Autism Spectrum Disorders serves as an essential guide and R
concise, focused introduction to the progress and U
promise of autism research and evidence-based and targeted treatments.
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Since the initial descriptions by Kanner and Asperger more than 75 years ago
DISORDERS
of what are now recognized as the autism spectrum disorders, understand-
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ing of the neurobiological, psychosocial, and genetic aspects of these disor-
ders has changed radically. The editors have assembled a formidable roster I
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of experts on autism spectrum disorders, as well as on genetics, epidemiol-
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ogy, environmental toxicity, occupational therapy, and other fields that con-
tribute to our understanding of the etiology and treatment of these complex R
disorders, to create a book that is cutting edge, yet accessible enough to be D
suitable for families as well as for clinicians. The book’s emphasis on types
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of assessment, genetic testing and counseling, and medical and psycholog-
R
ical treatment will be exceedingly useful to health care providers navigating
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the new diagnostic criteria introduced in DSM-5® and to parents plotting a
course for their child’s care. Well-written, authoritative, and evidence-based,
Autism Spectrum Disorders fills a void in the literature and meets the needs
of a growing audience.
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ao Edited by
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Autism Spectrum
Disorders
Autism Spectrum
Disorders
Edited by
Eric Hollander, M.D.
Randi Hagerman, M.D.
Deborah Fein, Ph.D.
Note: The authors have worked to ensure that all information in this book is accurate
at the time of publication and consistent with general psychiatric and medical standards,
and that information concerning drug dosages, schedules, and routes of administration
is accurate at the time of publication and consistent with standards set by the U.S. Food
and Drug Administration and the general medical community. As medical research and
practice continue to advance, however, therapeutic standards may change. Moreover,
specific situations may require a specific therapeutic response not included in this book.
For these reasons and because human and mechanical errors sometimes occur, we rec
ommend that readers follow the advice of physicians directly involved in their care or
the care of a member of their family.
Books published by American Psychiatric Association Publishing represent the find
ings, conclusions, and views of the individual authors and do not necessarily represent
the policies and opinions of American Psychiatric Association Publishing or the Amer
ican Psychiatric Association.
If you wish to buy 50 or more copies of the same title, please go to www.appi.org/speciald
iscounts for more information.
Copyright © 2018 American Psychiatric Association Publishing
ALL RIGHTS RESERVED
First Edition
Manufactured in the United States of America on acid-free paper
22 21 20 19 18 5 4 3 2 1
American Psychiatric Association Publishing
800 Maine Ave., S.W.
Suite 900
Washington, DC 20024
www.appi.org
Library of Congress Cataloging-in-Publication Data
Names: Hollander, Eric, editor. | Hagerman, Randi Jenssen, editor. | Fein, Deborah,
editor. | American Psychiatric Association Publishing, issuing body.
Title: Autism spectrum disorders / edited by Eric Hollander, Randi Hagerman,
Deborah Fein.
Other titles: Autism spectrum disorders (Hollander)
Description: First edition. | Washington, DC : American Psychiatric Association
Publishing, [2018] | Includes bibliographical references and index.
Identifiers: LCCN 2018004289 (print) | LCCN 2018005532 (ebook) | ISBN
9781615371921 (ebook) | ISBN 9781615370528 (pbk. : alk. paper)
Subjects: | MESH: Autism Spectrum Disorder
Classification: LCC RC553.A88 (ebook) | LCC RC553.A88 (print) | NLM WS
350.8.P4 | DDC 616.85/882—dc23
LC record available at https://lccn.loc.gov/2018004289
British Library Cataloguing in Publication Data
A CIP record is available from the British Library.
Contents
Contributors . . . . . . . . . . . . . . . . . . . . . . ix
Foreword . . . . . . . . . . . . . . . . . . . . . . . . .xv
1
Epidemiology. . . . . . . . . . . . . . . . . . . . . . .1
Julianne Myers, B.A.
Alison Presmanes Hill, Ph.D.
Katharine Zuckerman, M.D., M.P.H.
Eric Fombonne, M.D.
2
Genomics and Epigenomics. . . . . . . . . .49
Fereydoun Hormozdiari, Ph.D.
Megan Y. Dennis, Ph.D.
Janine M. LaSalle, Ph.D.
3
Environmental Toxicity and
Immune Dysregulation. . . . . . . . . . . . . .77
Judy Van de Water, Ph.D.
Isaac N. Pessah, Ph.D.
4
Psychiatric Assessment and
Pharmacological Treatment. . . . . . . . . 111
Casara Jean Ferretti, M.S.
Bonnie P. Taylor, Ph.D.
Jacqueline Shinall, M.S.
Eric Hollander, M.D.
5
Pediatric and Neurological
Assessment and
Targeted Treatments. . . . . . . . . . . . . . . 143
Andrew Ligsay, M.D.
Jennifer M. Bain, M.D., Ph.D.
Jeremy Veenstra-VanderWeele, M.D.
Randi Hagerman, M.D.
6
Cognitive Assessment . . . . . . . . . . . . . 175
Marianne Barton, Ph.D.
Julia Chen, M.S.
Cara Cordeaux, B.S.
Deborah Fein, Ph.D., ABPP
7
Behavioral Treatments . . . . . . . . . . . . . 195
Rebecca P.F. MacDonald, Ph.D., BCBA-D
Diana Parry-Cruwys, Ph.D., BCBA-D
Pamela Peterson, M.S., BCBA
8
The DIR® (Developmental, Individual
Difference, Relationship-Based) Model
A P -M A
ARENT EDIATED PPROACH TO
I A
NTERDISCIPLINARY SSESSMENT AND
C I . . . . . . . . . . 231
OMPREHENSIVE NTERVENTION
Serena Wieder, Ph.D.
Gilbert M. Foley, Ed.D., IMH-E
9
Autism Interventions in Schools . . . . .253
Christina Kang Toolan, M.A.
Connie Kasari, Ph.D.
10
Language, Communication, and
Occupational Therapy
Interventions . . . . . . . . . . . . . . . . . . . . .277
Leonard Abbeduto, Ph.D.
Laura Greiss Hess, Ph.D., OTR/L
Julia Wilbarger, Ph.D., OTR/L
Andrea McDuffie, Ph.D., CCC-SLP
11
Complementary and
Integrative Approaches. . . . . . . . . . . . .307
Robert L. Hendren, D.O.
Felicia Widjaja, M.P.H.
Brittany Lawton, B.S.
12
Transcranial Magnetic Stimulation
and Noninvasive Brain Stimulation . . .329
Peter G. Enticott, Ph.D.
Stefano Pallanti, M.D., Ph.D.
Eric Hollander, M.D.
Index. . . . . . . . . . . . . . . . . . . . . . . . . . . .343
Contributors
Leonard Abbeduto, Ph.D.
Director, MIND Institute and Tsakopoulos-Vismara Endowed Chair, and
Professor, Department of Psychiatry and Behavioral Sciences, University of
California, Davis
Jennifer M. Bain, M.D., Ph.D.
Assistant Professor, Division of Child Neurology, Department of Neurology,
Columbia University, New York, New York
Marianne Barton, Ph.D.
Clinical Professor and Director of Clinical Training, Department of Psycho
logical Sciences, University of Connecticut, Storrs, Connecticut
Julia Chen, M.S.
Graduate Student, Division of Clinical Psychology, University of Connecticut,
Storrs, Connecticut
Cara Cordeaux, B.S.
Graduate Student, Division of Clinical Psychology, University of Connecticut,
Storrs, Connecticut
Megan Y. Dennis, Ph.D.
Member, Genome Center; Member, MIND Institute; Assistant Professor,
Department of Biochemistry and Molecular Medicine, University of Califor
nia, Davis
Peter G. Enticott, Ph.D.
Professor of Psychology (Cognitive Neuroscience), School of Psychology,
Deakin University, Melbourne, Victoria, Australia
Deborah Fein, Ph.D., ABPP
Board of Trustees Distinguished Professor and Division Head, Clinical Divi
sion, Department of Psychological Sciences, University of Connecticut, Storrs,
Connecticut
Casara Jean Ferretti, M.S.
Research Associate, Autism and Obsessive-Compulsive Spectrum Program,
Department of Psychiatry and Behavioral Sciences, Montefiore Medical Cen
ter, Albert Einstein College of Medicine, Bronx, New York
ix
