Apoptosis in Cardiac Biology

346 Pages·2000·11.295 MB·English

by  Jürgen Holtz M.D., Dorothea Darmer Ph.D. (auth.), Heribert Schunkert, G. A. J. Riegger (eds.)

Erratum
The publisher regrets the incomplete address of the editors of this book.
APOPTOSIS IN CARDIAC BIOLOGY
Edited by:
Heribert Schunkert
G.A.J . Riegger
University of Regensburg
Germany
Kluwer Academic Publishers
Boston-Dordrecht-London
APOPTOSIS IN CARDIAC BIOLOGY
Edited by:
Heribert Schunkert
Klinik und bliklinik fur Innere
Germany
Kluwer Academic Publishers
Boston-Doredrecht-London
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Copyright 2000 by Kluwer Academic Publishers
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Contents
List of Contributors ................................................................................ vii
...
Introduction.. .........................,...........................,...... ..... .............................X M
PART ONE: BASIC MECHANISMS OF APOPTOSlS
The initiation of apoptosis
Death receptors and their ligands ................................................................5.
Jurgen Holh, Dorothea Darner
Regulation of apoptosis by CD 137 ...........................................................2 9
Henbert Schwan
Reactive oxygen species and apoptosis ................................ .. ...............3 9
Riidiger von Harsdorf
The mediators of apoptosis
Oncogenes and p53 .................................................................... ...............6 1
Franz Kohlhuber, Dirk Eick
BCL-2 family members and mitochondria. .................................................7. 1
Klaus Schloltmann, Jiirgen Schdlmerich
Inhibition of cardiac myocyte apoptosis by gpl30-dependent cytokines .... 91
Kai C. Wollert
Cell cycle regulation and apoptotic cell death .........................................I.0. 1
Lothar Jahn, Hamid Bar
The execution of apoptosis
Caspase cascades and caspase targets .................................................1. 11
Thomas Rude/
Apoptosis: a distinctive form of cell death ...............................................1..2 3
L.B. Jordan, D.J . Harrison
PART TWO: CELLULAR TARGETS IN THE CARDIOVASCULAR
SYSTEM
Blood vessels
Apoptosis and cell cycle in endothelial cells ........................................... 141
loakim Spyridopoulos
APOPTOSIS IN CARDIAC BIOLOGY
11.2 Myocardium
11.2.1 Endurance under stress and cardioprotective functions by
cardiac fibroblasts .................................................................................I..5. 9
Mahboubeh Eghbali- Webb
11.2.2 Cardiac myocytes ............................ .. ...................................................I.7. 5
Armin Haunstetter, Markus Haass, Seigo lzurno
11.2.3 Cardiac myocytes and fibroblasts exhibit differential sensitivity
to apoptosis-inducing stimuli .................... . ......................................... 189
Edward G. Lakatta, Xilin Long, Alan Chesley, Michael Crow
PART THREE: APOPTOSIS IN CARDIAC DISORDERS
111.1 Vascular disease
Ill.1 . I Hypertension as a cardiovascular proliverative disorder .........................2. 1 3
Denis deBlois, Sergei Orlov, Pave1 Hamet
111.1.2 Apoptosis in human atherosclerosis... ....................................................2..2 3
Gerhard Bauriedel, Randolph Hutter, Ulrich Welsch, Bemdt Luderitz
111.2 Cardiac disease
111.2.1 Apoptosis in myocardial infarction ........................................................ 239
Andreas V. Sigel, Gunter A. J. Riegger
111.2.2 Pro-inflammatory and pro-apoptotic factors in heart failure ....................2..6 1
Laura Agnoletti, Laura Comini, Guiseppina Gaia, Salvatore Curello,
Roberto Ferari
111.2.3 Molecular mechanisms of cardiac myocardial remodeling during
aging. Role of apoptosis .........................................................................2..7 3
Ziad MaNat, Bernard Swynghedauw
111.2.4 Apoptosis during cardiac surgery ...................................... .... ....................2. 87
Hemann Aebert, Joachim P. Schmitt, Heribert Schunkert
PART FOUR: THERAPEUTICAL OPTIONS
IV.1 New opportunities for heart disease therapeutics. ...................................2. 99
Giora Z. Feuerstein
1V.2 Beta blocker therapy and prevention of apoptosis ............... .. .............3 09
Andreas V. Sigel, Heribert Schunkert
lV.3 Apoptosis in cardiac myocytes - Role of the renin-angiotensin-system ... 317
Daniela Grimm, Gilbert Schonfelder, Martin Paul
IV.4 Estrogens and the prevention of cardiac apoptosis .................................3. 29
Christian Grohe, Rainer Meyer, Hans Vetter
IV.5 Open questions on apoptosis in cardiac biology .................................. 337
Heriben' Schunkert
Index ........................................................................................................-. 343
List of Contributors
Privatdozent Dr. rned. Hermann Aebert Laura Comini, M.D.
Klinik und Poliklinik fur Herz-, Thorax- Cardiovascular Research Center
und herznahe Gefilnchirurgie ,,Salvatore Maugeri" Foundation
University of Regensburg Via Pinidolo, 23
Franz-Josef-Straui3-Allee 11 1-25064 Gussago (Brescia)
0-93053 Regensburg ltaly
Germany
Laura Agnoletti, M.D. Michael T. Crow, Ph.D.
Cardiovascular Research Center Laboratory of Cardiovascular Sciences
,,Salvatore Maugeri" Foundation Gerontology Research Center
Via Pinidolo, 23 National Institute on Aging, National Institutes
1-25064 Gussago (Brescia) of Health
Italy 5600 Nathan Shock Drive
Baltimore, MD 21 224
USA
Dr. med. Harald Bar Salvatore Curello, M.D.
Department of Internal Medicine Chair of Cardiology
University of Heidelberg Spedali Civili
Bergheimer Strafie 58 P.le Spedali Civili
D-69115 Heidelberg 1-2512 3 Brescia
Germany ltaly
Prof. Dr. med. Gerhard Bauriedel, Dr. rer. nat. Dorothea Darmer
FACC, FESC Martin-Luther Universitat Halle-Wittenberg
Associate Professor, Department of Internal lnstitut fur Pathophysiologie
Medicine II/Cardiology Magdeburger Strafie 18
University of Bonn D-06097 Halle
Sigmund-Freud-Strai3e2 5 Germany
D-53105 Bonn
Germany
Alan Chesley, Ph.D. Denis deBlois, Ph.D.
Laboratory of Cardiovascular Sciences CHUM Research Center
Gerontology Research Center 3840 St-Urbain
National lnstitute on Aging, National Institutes Montreal, Quebec
of Health H2W IT8
5600 Nathan Shock Drive Canada
Baltimore, MD 21 224
USA
APOPTOSIS IN CARDIAC BIOLOGY
Mahboubeh Eghbali-Webb, Ph.D. Privatdozent Dr. med. Christian Grohb
Department of Anesthesiology Rheinische Friedrich-Wilhelms-UniversitPt
Yale School of Medicine Medizinische Univ.-Poliklinik
333 Cedar Street Wilhelmstral3e 35-37
New Haven, CT 065/0 D-53111 Bonn
USA Germany
Dr. rer. nat. Dirk Eick Dr. med. Markus Haass
lnstitut fur Klinische Molekularbiologie Department of Cardiology
und Tumorgenetik University of Heidelberg
GSF-Forschungszentrum fur Umwelt und Bergheimer StraRe 58
Gesundheit D-69115 Heidelberg
MarchioninistraRe 25 Germany
0-813 77 Munchen
Germany
Roberto Ferrari, M.D. Pave! Hamet, M.D., Ph.D.
Chair of Cardiology Professor of Internal Medicine
University of Ferrara CHUM Research Center
"Salvatore Maugeri" Foundation 3840 St-Urbain
Via Pinidolo, 23 Montreal, Quebec
1-25064 Gussago (Brescia) H2W IT8
ltaly Canada
Giora 2. Feuerstein, M.D. David J. Harrison, M.D.
Senior Director, Cardiovascular Sciences Professor of Pathology
DuPont Pharmaceuticals Corporation Department of Pathology
E40013255 The University of Edinburgh
Route 141 & Henry Clay Road Medical School
Wilmington, DE 19880-0400 Teviot Place
USA Edinburgh EH8 9AG.
United Kingdom
Guiseppina Gaia, M.D. Dr. med. RSjdiger von Harsdorf
Cardiovascular Research Center Franz-Valhard-Klinik
,,Salvatore Maugeri" Foundation Humboldt-UniversitPt
Via Pinidolo, 23 UniversitiitsklinikumC harit4
1-25064 Gussago (Brescia) Wiltbergstral3e 50
ltaly 0-13 12 5 Berllin
Germany
Dr. med. Daniela Grimm Dr. med. Armin Haunstetter
Institute of Clinical Pharmacology and Department of Cardiology
Toxicology University of Heidelberg
Benjamin Franklin Medical Center Bergheimer StraQe 58
FU-Berlin 0-6911 5 Heidelberg
GarystralSe 5 Germany
D-14195 Berlin
Germany
viii
LIST OF CONTRIBUTORS
Prof. Dr. rned. Jiirgen Holtz Edward G. Lakatta, M.D., Ph.D.
Professor of Physiology Laboratory of Cardiovascular Sciences
Martin-Luther Universitlt Halte-Wittenberg Gerontology Research Center
Institut fur Pathophysiologie National Institute on Aging, National Institutes
Magdeburger Strafie 18 af Health
D-06097 Halle 5600 Nathan Shock Drive
Germany Baltimore, MD 21 224
USA
Dr. med. Randolph Hutter Xilin Long, M.D.
Department of Internal Medicine IIICardiology Laboratory of Cardiovascular Sciences
University of Bonn Gerontology Research Center
Sigmund-Freud-StralJe 25 National lnstitute on Aging, National lnstitutes
D-53105 Bonn of Health
Germany 5600 Nathan Shock Drive
Baltimore, MD 21224
USA
Seigo Izumo, M.D. Prof. Dr. med. Berndt LUderik,
Cardiovascular Division FACC, FESC
Beth Israel Deaconess Medical Center Professor of lnternal Medicine
Harvard Medical School Department of Internal Medicine ll/Cardiology
330 Brookline Ave. University of Bonn
Boston, MA 0221 5 Sigmund-Freud-Srafie 25
USA 0-53105 Bonn
Germany
Privatdozent Dr. med. Lothar Jahn Ziad Mallat, M.D.
Department of Internal Medicine U141-INSERM-Hospital tariboisiere
University of Heidelberg 41 Bd de la Chapelle
Bergheimer Straf3e 58 F-75475 Paris Cedex
0-691 15 Heidelberg France
Germany
Lee Baines Jordan, S.Sc.(Hons), Privatdozent Dr. rer. nat. Rainer Meyer
M.B., Ch.B. Rheinische Friedrich-Wiihelms-Universitiit
Department of Pathology Physiologisches lnstitut
The University of Edinburgh Wilhelmstral3e 31
Medical School D-53111 Bonn
Teviot Place Germany
Edinburgh EH8 9AG.
United Kingdom
Dr. rer. nat. Franz Kohlhuber Sergei Qrlov, Ph.D.
lnstitut for Kiinische Molekularbiologie CHUM Research Center
und Tumorgenetik 3840 St-Urbain
GSF-Forschungszentrum fiir Umwelt und Montreal, Quebec
Gesundheit H2W IT8
Marchioninistraae2 5 Canada
D-81377 Mtinchen
Germany
APOPTOSIS IN CARDIAC BIOLOGY
Prof. Dr. med. Martin Paul Dr. med. Gilbert Schiinfelder
Professor of Pharmacology and Toxicology Institute of Clinical Pharmacology and
Institute of Clinical Pharmacology and Toxicology
Toxicology Benjamin Franklin Medical Center
Benjamin Franklin Medical Center FU-Berlin
FU-Berlin Garystral3e 5
Garystraae 5 D-14195 Berlin
D-14195 Berlin Germany
Germany
Prof. Dr. med. Giinter A.J. Riegger Prof. Dr. med. Heribert Schunkert
Professor of lnternal Medicine Professor of Clinical and Molecular Cardiology
University of Regensburg University of Regensburg
Franz-Josef-Straul3-Atlee 11 Franz-Josef-Straun-Allee 11
D-93053 Regensburg D-93053 Regensburg
Germany Germany
Dr. rer. nat. Thomas Rudei Dr. rer. nat. Herbert Schwarz
Max-Planck-Institutef or Infection Biology Department of Pathology
Department of Molecular Biology University of Regensburg
Monbijoustraae 2 Franz-Josef-StraulJ-Allee 11
D-10117 Berlin D-93053 Regensburg
Germany Germany
Dr. med. Klaus Schlottmann Dr. med. Andreas V. Sigel
Department of lnternal Medicine Department of lnternal Medicine
University of Regensburg University of Regensburg
Franz-Josef-StrauO-Allee 11 Franz-Josef-Straul3-AIlee 11
D-93053 Regensburg D-93053 Regensburg
Germany Germany
Dr. med. Joachim P. Schmitt loakim Spyridopoulos, M.D.
Klinik und Poliklinik fur Herz-, Thorax- Department of Cardiology and Cardiovascular
und herznahe GefPGchirurgie Research
University of Regensburg Medizinische Klinik Tubingen
Franz-Josef-StraulJ-Allee 11 Otfried-MLiller-Stra13e 10
D-93053 Regensburg D-72076 Tubingen
Germany Germany
Prof. Dr. med. JQrgen Schiilmerich Bernard Swynghedauw, M.D.
Professor of lnternal Medicine Professor of Physiology
University of Regensburg U127-INSERM-Hospital Lariboisierf
Franz-Josef-StrauO-Allee 1 1 41 Bd de la Chapelle
0-93053 Regensburg F-75475 Paris Cedex
Germany France
LIST OF CONTRIBUTORS
Prof. Dr. med. Hans Vetter
Rheinische Friedrich-Wilhelms-Universitat
Medizinische Univ.-Poliklinik
Wilhelmstrafie 35-37
D-53111 Bonn
Germany
Dr. med. Ulrich Welsch
Department of Anatomy Ill
University of Munich
Pettenkoferstrafie 11
D-80336 Miinchen
Germany
Dr. med. Kai C. Wollert
Department of Cardiology and Angiology
Medizinische Hochschule Hannover
Carl-Neuberg-Straae 1
D-30625 Hannover
Germany