Table Of ContentAPS
Advances in Pharmacological Sciences
Animal Models in
Psychopharmacology
Edited by
B.Olivier
J.Mos
J. L. Slangen
Springer Basel AG
Editors' addresses:
Dr. B. Olivier Prof. Dr. J. L. Slangen
Dr. J. Mos Department of Psychopharmacology
CNS-Pharmacology Faculty of Pharmacy
DupharB.Y. University of Utrecht
P.O. Box 900 Sorbonnelaan 16
1380 DA Weesp 3584 CA Utrecht
The Netherlands The Netherlands
Deutsche Bibliothek Cataloging-in-Publication Data
Animal models in psychopharmacology / ed. by B. Olivier ... -
Basel ; Boston ; Berlin : Birkhäuser, 1991
(Advances in pharmacological sciences)
ISBN 978-3-0348-6421-3 ISBN 978-3-0348-6419-0 (eBook)
DOI 10.1007/978-3-0348-6419-0
NE: Olivier, Berend [Hrsg.]
Product Liability: The publisher can give no guarantee for information about drug dosage
and application thereof contained in this book. In every individual case the respective user
must check its accuracy by consulting other pharmaceuticalliterature.
The use of registered names, trademarks, etc. in this publication does not imply, even in the
absence of a specific statement, that such names are exempt from the relevant protective
laws and regulations and therefore free for general use.
This work is subject to copyright. All rights are reserved, whether the whole or part
of the material is concerned, specifically those of translation, reprinting, re-use of
illustrations, broadcasting, reproduction by photocopying machine or similar means,
and storage in data banks. Under § 54 of the German Copyright Law, where copies are
made for other than private use a fee is payable to >>Verwertungsgesellschaft Wort«, Munich.
© 1991 Springer Basel AG
Originally published by Birkbäuser Verlag in 1991.
Softcover reprint of tbe hardcover 1s t edition 1991
v
Preface
As part of the XIth International Congress of Phannacology, a post-congress
Satellite Meeting entitled ANIMAL MODELS IN PSYCHOPHARMACOLOGY was
held on July 7 and 8, 1990 in Amsterdam. The organizers (B.Olivier, J.Mos and
J.L.Slangen) thought it a very convenient time to deal with various new developments
in the field of drug treatment and phannacological prevention of abnormal human
behaviour.
The emergence of better classifications of psychiatric disorders, e.g. in anxiety, has
created realistic opportunities for developing new psychoactive agents for separate
diagnostic categories such as panic disorders or obsessive-compulsive disorder . It
appeared that drugs with new mechanisms of action were active in a therapeutic area,
like in anxiety, where the existing and effective treatment was dominated by the use of
benzodiazepines. Such findings led to an explosion of preclinical research aiming for
detecting new drugs, with new mechanisms of action. A fascinating example is the
serotonergic field, where the serendipitous finding of the anxiolytic activities of
buspirone steered research into the role of 5-HT agonists in anxiety, which has been
1A
very successful.
However, these new drugs appeared not easily detectable with the classical animal
models in use for the particular area. In the case of the anxiolytics, animal models of
anxiety appeared biased towards detecting benzodiazepines. Consequently, new animal
models had to be developed which are sensitive towards other mechanisms involved in
anxiety, like serotonin or NMDA.
The central aim of the present volume is the description and explanation of the
developments in the various fields exploiting animal models for psychiatric disorders.
The emphasis of this research focusses on three methodological disciplines, viz.
phannacological, psychological and ethological models. Because of the broadness of the
fields, we restricted ourselves to animal models of anxiety, depression, psychosis,
aggression and sexual behaviour. Moreover, drug-discrimination was chosen as a topic
of interest because this technique appears of value for every therapeutic area.
We invited for every discipline leading experts in their respective fields. For anxiety,
Sanger (phannacological models), Barrett (psychological models) and Insel (ethological
models) cover the new developments in this field. These main contributions are
complemented with several interesting papers from invited poster contributions. For
depression Porsolt (phannacological models), Willner (psychological models) and
Panksepp (ethological models) set the scene, complemented by interesting poster
VI
contributions and one invited commentary (Archer). For psychosis Costall
(pharmacological models) and Ellenbroek (ethological models) present intriguing
thoughts on animal models of psychosis. Aggression (Mos and Olivier) and sexual
behaviour (Everitt) are covered by single chapters, primarily because the clinical fields
are not yet so weIl exploited and understood as the preceding ones. PreclinicaIly,
however, recent developments promise exciting avenues for treatment of human
disorders (e.g. the serenics). Drug-discrimination has emerged during the last decade as
a very promising and helpful technique in the search for the in vivo mechanism of
action of psychoactive drugs. The technique can be used for every discipline and
directly complements in vitro studies on the mechanism of action of psychotropic drugs.
In the miscellaneous section a very interesting chapter was contributed by Miczek on
ultrasonic vocalizations and the possible application in animal models for various
therapeutic areas.
We think that the broadness and scope of this volume describing animal models in
psychopharmacology, will be of help for students of behaviour and pharmacology as
weIl as for clinicians involved in drug studies in humans. It is hoped that the enormous
gaps between the preclinical and clinical understanding of psychiatric diseases and
animal analogues of those, can be narrowed by this contribution.
The editors wish to thank an the scientists for their excellent contributions. Many
people have contributed to the success of this symposium and the present volume. We
want to thank Duphar B.V. for their generous support, especially Dr.H.Roseboom and
Dr.A. de Jonge.
This book would not have appeared without the excellent technical assistance of
Marijke Mulder, who assisted in all the "invisible" work behind the production of this
volume.
Berend Olivier Jef Slangen
Jan Mos Laboratory of Psychopharmacology
CNS-pharmacology Faculty of Pharmacy
Department of Pharmacology State University of Utrecht
Duphar B.V. Utrecht
Weesp.
VII
CONTRIBUTORS
Alberto, A.
Department of Physiology, Pharmacology and Biophysics, Institute of Biological
Sciences, Federal University of Rio Grande do SuI, Porto Alegre, RS, 90.049,
Brazil
Archer, T.
Department of Psychology, University of Göteborg, P.O.Box 14158, S-4OO 20
Göteborg, Sweden
Awouters, F.H.L.
Janssen Research Foundation, B-2340 Beerse, Beigium
Barrett, J.E.
Department of Psychiatry, Uniformed Services University of the Hea1th Sciences,
4301 Jones Bridge Road, Bethesda, Maryland 20889, U.S.A.
Berendsen, H.H.G.
CNS-Pharmacology Department, Organon, P.O.Box 20, Oss, The Netherlands
Blanchard, D.C.
Bekesy Laboratory of Neurobiology and John A. Bums School of Medicine,
University of Hawaii, HonoIuIu, HI 96822, U.S.A.
Blanchard, R.J.
Department of Psychology, University of Hawaii, HonoIuIu, HI 96822, U.S.A.
Bohus, B.
Department of Animal Physiology, University of Groningen, Biological Centre,
9750 AA Haren, The Netherlands
Bouws, G.A.
Department of Animal Physiology, University of Groningen, Biological Centre,
9750 AA Haren, The Netherlands
Brand, T.
Department of Endocrinology and Reproduction, Faculty of Medicine and Health
Sciences, Erasmus University, P.O.Box 1738, 3000 DR Rotterdam, The
Netherlands
Brandao, M.L.
Department of Physiology, University of Wales College of Cardiff, Cardiff, CFl
ISS, United Kingdom
Broekkamp, C.L.
CNS-Pharmacology Department, Organon, P.O.Box 20, Oss, The Netherlands
Broersen, L. M.
Department of Psychopharmacology, Faculty of Pharmacy, University of Utrecht,
Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
BruinveIs, J.
Department of Pharmacology, Workgroup Biological Psychiatry, Erasmus
University Rotterdam, P.O.Box 1738, 3000 DR Rotterdam, The Netherlands
VIII
Casas, J.
Department of Neurosciences, School of Medicine, Cadiz, Spain
Christensen, A.V.
St. Hans Hospital Department P, DK-4000 Roskilde, Denmark
Colin, C.
Laboratoire de Biologie du Comportement, URA C.N.R.S. 1293, B.P. 239, 54506
Vandoeuvre les Nancy CEDEX, France
Commissaris, R.L.
Department of Pharmaceutical Sciences, College of Pharmacy, Wayne State
University, Detroit, Michigan 48202, U.S.A.
Costall, B.
Postgraduate Studies in Pharmacology, The School of Pharmacy, Un iversity of
Bradford, Bmdford, BD7 lDP, United Kingdom
de Almeida, R.M.M.
Department of Physiology, Pharmacology and Biophysics, Institute of Biological
Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, 90.049,
Brazil
de Boer, S.F.
Department of Psychopharmacology, Faculty of Pharmacy, University of Utrecht,
Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands
de Haes, P.L.A.J.
Janssen Research Foundation, B-2340 Beerse, Belgium
Desor, D.
Laboratoire de Biologie du Comportement, URA C.N.R.S. 1293, B.P. 239, 54506
Vandoeuvre les Nancy CEDEX, France
Domeney, A.M.
Postgraduate Studies in Pharmacology, The School of Pharmacy, University of
Bradford, Bradford, BD7 IDP, United Kingdom
Dortmans, C.
CNS-Pharmacology Department, Organon, P.O.Box 20, Oss, The Netherlands
Ellenbroek, B.A.
Psychoneuropharmacological Research Unit, Department of Pharmacology,
University of Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
Elorza, J.
Department of Neurosciences, School of Medicine, Cadiz, Spain
Enginar, N.
Department of Pharmacology, Istanbul Medical Faculty, University of lstanbul,
Istanbul, Turkey
Eroglu, L.
Department of Pharmacology, Istanbul Medical Faculty, University of Istanbul,
Istanbul, Turkey
IX
Everitt, B.J.
Department of Anatomy, University of Cambridge, Downing Street, Cambridge
CB2 3DY, United Kingdom
Filho, R.
Department of Physiology, Pharmacology and Biophysics, Institute of Biological
Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, 90.049,
Brazil
Fontana, D.J.
Department of Pharmaceutical Sciences, College of Pharmacy, Wayne State
University, Detroit, Michigan 48202, U.S.A.
Gamble, E.E.
Department of Psychiatry, Uniformed Services University of the Health Sciences,
4301 Jones Bridge Road, Bethesda, Maryland 20889-4799, U.S.A.
Geoffroy, M.
St. Hans Hospital Department P, DK-4000 Roskilde, Denmark
Gibert-Rahola, J.
Departments of Neurosciences and Toxicology, Neuropsycho-pharmacology Unit,
University of Clidiz, Spain
Gleeson, S.
Department of Psychiatry, Uniformed Services University of the Health Sciences,
4301 Jones Bridge Road, Bethesda, Maryland 20889-4799, U.S.A.
Gomez-Cama, M.C.
Department of Neurosciences, School of Medicine, cadiz, Spain
Ikemoto, S.
Department of Psychology, Bowling Green State University, Bowling Green,
Ohio 43403, U.S.A.
Insel, T.R.
Laboratory of Clinical Science, National Institute of Mental Health, P.O. Box 289,
Poolesville, MD 20837, U .S.A.
Jenck, F.
CNS-Pharmacology Department, Organon, P.O.Box 20, Oss, The Netherlands
Joly, D.
Synthelabo Recherche (L.E.R.S), 31 ave P.V. Couturier, 92220 - Bagneux, France
Kelly, M.E.
Postgraduate Studies in Pharmacology, The School of Pharmacy, University of
Bradford, Bradford, BD7 lDP, United Kingdom
Ketelaars, C.E.J.
Polikliniek Kinder- en Jeugdpsychiatrie A.Z.G., P.O.Box 30001, 9700 RB
Groningen, The Netherlands
