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THERAPEUTIC MONOCLONAL ANTIBODIES THERAPEUTIC MONOCLONAL ANTIBODIES FROM BENCH TO CLINIC Editedby Zhiqiang An Copyright#2009byJohnWiley&Sons,Inc.Allrightsreserved PublishedbyJohnWiley&Sons,Inc.,Hoboken,NewJersey PublishedsimultaneouslyinCanada Nopartofthispublicationmaybereproduced,storedinaretrievalsystem,ortransmittedinanyformorbyany means,electronic,mechanical,photocopying,recording,scanning,orotherwise,exceptaspermittedunder Section107or108ofthe1976UnitedStatesCopyrightAct,withouteitherthepriorwrittenpermissionofthe Publisher,orauthorizationthroughpaymentoftheappropriateper-copyfeetotheCopyrightClearanceCenter, Inc.,222RosewoodDrive,Danvers,MA01923,(978)750-8400,fax(978)750-4470,oronthewebatwww. copyright.com.RequeststothePublisherforpermissionshouldbeaddressedtothePermissionsDepartment, JohnWiley&Sons,Inc.,111RiverStreet,Hoboken,NJ07030,(201)748-6011,fax(201)748-6008,oronline athttp://www.wiley.com/go/permission. LimitofLiability/DisclaimerofWarranty:Whilethepublisherandauthorhaveusedtheirbesteffortsin preparingthisbook,theymakenorepresentationsorwarrantieswithrespecttotheaccuracyorcompletenessof thecontentsofthisbookandspecificallydisclaimanyimpliedwarrantiesofmerchantabilityorfitnessfora particularpurpose.Nowarrantymaybecreatedorextendedbysalesrepresentativesorwrittensalesmaterials. Theadviceandstrategiescontainedhereinmaynotbesuitableforyoursituation.Youshouldconsultwitha professionalwhereappropriate.Neitherthepublishernorauthorshallbeliableforanylossofprofitoranyother commercialdamages,includingbutnotlimitedtospecial,incidental,consequential,orotherdamages. Forgeneralinformationonourotherproductsandservicesorfortechnicalsupport,pleasecontactour CustomerCareDepartmentwithintheUnitedStatesat(800)762-2974,outsidetheUnitedStatesat(317) 572-3993orfax(317)572-4002. Wileyalsopublishesitsbooksinavarietyofelectronicformats.Somecontentthatappearsinprintmaynotbe availableinelectronicformats.FormoreinformationaboutWileyproducts,visitourwebsiteatwww.wiley.com. LibraryofCongressCataloging-in-PublicationData: Therapeuticmonoclonalantibodies:fromthebenchtotheclinic/[editedby]ZhiqiangAn. p.; cm. Includesbibliographicalreferencesandindex. ISBN978-0-470-11791-0(cloth) 1. Monoclonalantibodies—Therapeuticuse. I.An,Zhiqiang,Dr. [DNLM: 1.Antibodies,Monoclonal—therapeuticuse. 2.DrugDiscovery. QW575.5.A6T3982009] RM282.M65T4952009 616.07098—dc22 2008053435 PrintedintheUnitedStatesofAmerica 10 9 8 7 6 5 4 3 2 1 & CONTENTS FOREWORD ix PREFACE xi CONTRIBUTORS xiii PART I ANTIBODY BASICS 1. TherapeuticMonoclonalAntibodies:Past,Present,andFuture 3 WilliamR.Strohl 2. AntibodyMolecularStructure 51 RobynL.StanfieldandIanA.Wilson 3. GlycosylationofTherapeuticIgGs 67 YusukeMimura,RoyJefferis,YukaMimura-Kimura,JodieAbrahams,andPaulineM.Rudd w 4. AntibodyDatabasesandTools:TheIMGT Experience 91 Marie-PauleLefranc PART II ANTIBODY SOURCES 5. HumanAntibodiesfromTransgenicMice 117 NilsLonberg 6. RabbitHybridoma 151 WeiminZhuandGuo-LiangYu 7. HumanAntibodyRepertoireLibraries 169 DavidLoweandTristanJ.Vaughan PART III IN VITRO DISPLAY TECHNOLOGY 8. AntibodyPhageDisplay 191 MichaelHust,HolgerThie,ThomasSchirrmann,andStefanDu¨bel v vi CONTENTS 9. YeastSurfaceDisplay 213 JenniferL.LahtiandJenniferR.Cochran 10. RibosomalDisplay 239 GeorgeThom 11. BacterialDisplayofAntibodies 255 ThomasJ.VanBlarcomandBarrettR.Harvey 12. AntibodySelectionfromImmunoglobulinLibraries ExpressedinMammalianCells 283 ErnestS.SmithandMauriceZauderer PART IV ANTIBODY ENGINEERING 13. AntibodyEngineering:Humanization,AffinityMaturation, andSelectionTechniques 311 JuanC.AlmagroandWilliamR.Strohl 14. ModulationofSerumProteinHomeostasisandTranscytosis bytheNeonatalFcReceptor 335 WilliamF.Dall’AcquaandHerrenWu 15. EngineeringtheAntibodyFcRegionforOptimal EffectorFunction 349 GregA.LazarandJohnR.Desjarlais PART V PHYSIOLOGY AND IN VIVO BIOLOGY 16. Antibody-ComplementInteraction 373 KileenL.MershonandSherieL.Morrison 17. BacteriaImmunoglobulin-BindingProteins:Biology andPracticalApplications 385 LeslieCopeandTessieMcNeely 18. ImmunogenicityScreeningUsinginSilicoMethods:Correlation betweenT-CellEpitopeContentandClinicalImmunogenicityof MonoclonalAntibodies 417 Si-HanHai,JulieA.McMurry,PaulM.Knopf,WilliamMartin,andAnneS.DeGroot 19. MonoclonalAntibodyPharmacokineticsandPharmacodynamics 439 ChristopherR.Gibson,PunamSandhu,andWilliamD.Hanley 20. BiodistributionandImaging 461 ToveOlafsenandAnnaM.Wu CONTENTS vii 21. AntibodiesandtheBlood-BrainBarrier 483 AngelaR.JonesandEricV.Shusta PART VI ANTIBODY CHARACTERIZATION 22. DeterminationofEquilibriumDissociationConstants 505 RobinE.Ernst,KatrinaN.High,TomR.Glass,andQinjianZhao 23. MolecularandFunctionalCharacterizationofMonoclonalAntibodies 525 QinjianZhao,TerranceA.Stadheim,LorenzoChen,andMichaelW.Washabaugh 24. CharacterizationofHeterogeneityinMonoclonalAntibodyProducts 541 YangWang,MichaelW.Washabaugh,andQinjianZhao PART VII ANTIBODY EXPRESSION 25. AntibodyExpressioninMammalianCells 557 FubaoWang,LorenzoChen,NealConnors,andHenrykMach 26. ProductionofAntibodiesinPichiapastoris 573 JuergenH.Nett 27. ProductionofAntibodyFab0 FragmentsinE.coli 589 DavidP.HumphreysandLeighBowering 28. ProductionofHumanTherapeuticMonoclonalAntibodies inChickenEggs 623 LeiZhuandRobertJ.Etches 29. ProductionofAntibodiesinPlants 651 KevinM.Cox,JeffreyT.Regan,JasonD.Sterling,VincentP.M.Wingate,andLynnF.Dickey PART VIII THERAPEUTIC ANTIBODIES 30. TheFormulationandDeliveryofMonoclonalAntibodies 675 VikasK.Sharma,Hung-WeiChih,RandallJ.Mrsny,andAnnL.Daugherty 31. TherapeuticAntibodiesinClinicalUseandLeading ClinicalCandidates 711 NingyanZhang,BrentR.Williams,PingLu,ZhiqiangAn,andChen-NiChin 32. Follow-OnProteinProducts:What,Where,When,How? 763 BrentR.WilliamsandWilliamR.Strohl 33. MonomericFcFusionMolecules 779 JenniferA.Dumont,SusanC.Low,RobertT.Peters,andAlanJ.Bitonti viii CONTENTS 34. Radioimmunotherapy:CurrentStatusandFutureDirections 797 NeetaPandit-TaskarandChaitanyaR.Divgi 35. Antibody-DrugConjugateTherapy 821 StephenC.Alley,DennisBenjamin,andChe-LeungLaw ABBREVIATIONS 857 INDEX 865

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70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies.  First book to address the discovery and development of antibody therapeutics in their entirety. Mos
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Therapeutic Monoclonal Antibodies: From Bench to Clinic PDF

924 Pages·2009·12.36 MB·English
by  Zhiqiang An
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70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies.  First book to address the discovery and development of antibody therapeutics in their entirety. Mos

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