Organelle-Specific Pharmaceutical Nanotechnology

638 Pages·2010·8.561 MB·English

by  Volkmar Weissig, Gerard G. D'Souza

ORGANELLE-SPECIFIC
PHARMACEUTICAL
NANOTECHNOLOGY
Edited by
Volkmar Weissig
Gerard G. M. D’Souza
A JOHN WILEY & SONS, INC., PUBLICATION
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ORGANELLE-SPECIFIC
PHARMACEUTICAL
NANOTECHNOLOGY
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ORGANELLE-SPECIFIC
PHARMACEUTICAL
NANOTECHNOLOGY
Edited by
Volkmar Weissig
Gerard G. M. D’Souza
A JOHN WILEY & SONS, INC., PUBLICATION
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Copyright © 2010 by John Wiley & Sons, Inc. All rights reserved
Published by John Wiley & Sons, Inc., Hoboken, New Jersey
Published simultaneously in Canada
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ISBN 978-0-470-63165-2
Library of Congress Cataloging-in-Publication Data is available.
Printed in the United States of America
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CONTENTS
Preface ix
Contributors xi
1. An Introduction to Subcellular Nanomedicine: Current Trends
and Future Developments 1
Gerard G. M. D’Souza and Volkmar Weissig
2. Delivery of Nanonsensors to Measure
the Intracellular Environment 15
Paul G. Coupland and Jonathan W. Aylott
3. Cytoplasmic Diffi usion of Dendrimers and Dendriplexes 35
Alexander T. Florence and Pakatip Ruenraroengsak
4. Endocytosis and Intracellular Traffi cking of Quantum Dot–
Ligand Bioconjugates 55
Tore-Geir Iversen, Nadine Frerker, and Kirsten Sandvig
5. Synthesis of Metal Nanoparticle-Based Intracellular Biosensors
and Therapeutic Agents 73
Neil Bricklebank
6. Subcellular Fate of Nanodelivery Systems 93
Dusica Maysinger, Sebastien Boridy, and Eliza Hutter
7. Intracellular Fate of Plasmid DNA Polyplexes 123
Kevin Maier and Ernst Wagner
8. Intracellular Traffi cking of Membrane Receptor-Mediated
Uptake of Carbon Nanotubes 143
Bin Kang and Yaodong Dai
9. Real-Time Particle Tracking for Studying Intracellular Transport
of Nanotherapeutics 161
Clive Chen and Junghae Suh
10. Tracking Intracellular Polymer Localization Via Fluorescence
Microscopy 177
Simon C. W. Richardson
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vi CONTENTS
11. Can QSAR Models Describing Small-Molecule Xenobiotics
Give Useful Tips for Predicting Uptake and Localization of
Nanoparticles in Living Cells? And If Not, Why Not? 193
Richard W. Horobin
12. Self-Unpacking Gene Delivery Scaffolds 207
Millicent O. Sullivan
13. Cellular Traffi cking of Dendrimers 231
Yunus Emre Kurtoglu and Rangaramanujam M. Kannan
14. Endolysosomolytically Active pH-Sensitive
Polymeric Nanotechnology 247
Han Chang Kang and You Han Bae
15. Uptake and Intracellular Dynamics of Proteins Internalized
by Cell-Penetrating Peptides 263
Arwyn T. Jones
16. Cargo Transport by Teams of Molecular Motors: Basic
Mechanisms for Intracellular Drug Delivery 289
Melanie J. I. Müller, Florian Berger, Stegan Klumpp, and
Reinhard Lipowsky
17. The Potential of Photochemical Internalization (PCI) for the
Cytosolic Delivery of Nanomedicines 311
Kristian Berg, Anette Weyergang, Anders Høgset, and Pål Kristian Selbo
18. Peptide-Based Nanocarriers for Intracellular Delivery of
Biologically Active Proteins 323
Seong Loong Lo and Shu Wang
19. Organelle-Specifi c Pharmaceutical Nanotechnology: Active
Cellular Transport of Submicro- and Nanoscale Particles 337
Galya Orr
20. Subcellular Targeting of Virus-Envelope-Coated Nanoparticles 357
Jia Wang, Mohammad F. Saeed, Andrey A. Kolokoltsov, and
Robert A. Davey
21. Mitochondria-Targeted Pharmaceutical Nanocarriers 385
Volkmar Weissig and Gerard G.M. D’Souza
22. Cell-Penetrating Peptides for Cytosolic Delivery
of Biomacromolecules 403
Camilla Foged, Xiaona Jing, and Hanne Moerck Nielsen
23. Therapeutic Nano-object Delivery to Subdomains of
Cardiac Myocytes 433
Valeriy Lukyanenko
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CONTENTS vii
24. Design Parameters Modulating Intracellular Drug Delivery:
Anchoring to Specifi c Cellular Epitopes, Carrier Geometry,
and Use of Auxiliary Pharmacological Agents 449
Silvia Muro and Vladimir R. Muzykantov
25. Uptake Pathways Dependent Intracellular Traffi cking of
DNA Carrying Nanodelivery Systems 475
Ikramy A. Khalil, Yuma Yamada, Hidetaka Akita, and
Hideyoshi Harashima
26. Cellular Interactions of Plasmon-Resonant Gold Nanorods 507
Qingshan Wei and Alexander Wei
27. Quantum Dot Labeling for Assessment of Intracellular
Traffi cking of Therapeutically Active Molecules 535
Diane J. Burgess and Mamta Kapoor
Index 569
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