Monoclonal Antibodies and Breast Cancer: Proceedings of the International Workshop on Monoclonal Antibodies and Breast Cancer San Francisco, California — November 8–9, 1984

326 Pages·1985·13.32 MB·English

by  L. Ozzello

MONOCLONAL ANTIBODIES AND
BREAST CANCER
DEVELOPMENTS IN ONCOLOGY
F.J. Cleton and J.W.I.M. Simons, eds.: Genetic Origins of Tumour Cells. 90-247-2272-1.
J. Aisner and P. Chang, eds.: Cancer Treatment and Research. 90-247-2358-2.
B.W. Ongerboer de Visser, D.A. Bosch and W.M.H. van Woerkom-Eykenboom, eds.: Neuro
oncology: Clinical and Experimental Aspects. 90-247-2421-X.
K. Hellmann, P. Hilgard and S. Eccles, eds.: Metastasis: Clinical and Experimental Aspects.
90-247-2424-4.
H.F. Seigler, ed.: Clinical Management of Melanoma. 90-247-2584-4.
P. Correa and W. Haenszel, eds.: Epidemiology of Cancer of the Digestive Tract. 90-247-2601-8.
L.A. Liotta and I.R. Hart, eds.: Tumour Invasion and Metastasis. 90-247-2611-5.
J. Banoczy, ed.: Oral Leukoplakia. 90-247-2655-7.
C. Tijssen, M. Halprin and L. Endtz, eds.: Familial Brain Tumours. 90-247-2691-3.
F.M. Muggia, C.W. Young and S.K. Carter, eds.: Anthracycline Antibiotics in Cancer. 90-247-2711-1.
B.W. Hancock, ed.: Assessment of Tumour Response. 9O-247-2712-X.
D.E. Peterson, ed.: Oral Complications of Cancer Chemotherapy. 0-89838-563-6.
R. Mastrangelo, D.G. Poplack and R. Riccardi, eds.: Central Nervous System Leukemia. Prevention
and Treatment. 0-89838-570-9.
A. Polliack, ed.: Human Leukemias. Cytochemical and Ultrastructural Techniques in Diagnosis and
Research. 0-89838-585-7.
W. Davis, C. Maltoni and S. Tanneberger, eds.: The Control of Tumor Growth and its Biological Bases.
0-89838-603-9.
A.P.M. Heintz, C. Th. Griffiths and J.B. Trimbos, eds.: Surgery in Gynecological Oncology.
0-89838-604-7.
M.P. Hacker, E.B. Double and I. Krakoff, eds.: Platinum Coordination Complexes in Cancer
Chemotherapy. 0-89838-619-5.
M.J. van Zwieten. The Rat as Animal Model in Breast Cancer Research: A Histopathological Study of
Radiation- and Hormone-Induced Rat Mammary Tumors. 0-89838-624-1.
B. Lowenberg and A. Hogenbeck, eds.: Minimal Residual Disease in Acute Leukemia. 0-89838-630-6.
I. van der Waal and O.B. Snow, eds.: Oral Oncology. 0-89838-631-4.
B.W. Hancock and A.M. Ward, eds.: Immunological Aspects of Cancer. 0-89838-664-0.
K.V. Honn and B.F. Sloane, eds.: Hemostatic Mechanisms and Metastasis. 0-89838-667-5.
K.R. Harrap, W. Davis and A.N. Calvert, eds.: Cancer Chemotherapy and Selective Drug
Development. 0-89838-673-X.
V.D. Velde, J.H. Cornelis and P.H. Sugarbaker, eds.: Liver Metastasis. 0-89838-648-5.
D.J. Ruiter, K. Welvaart and S. Ferrone, eds.: Cutaneous Melanoma and Precursor Lesions.
0-89838-689-6.
S.B. Howell, ed.: Intra-Arterial and Intracavitary Cancer Chemotherapy. 0-89838-691-8.
D.L. Kisner and J.F. Smyth, eds.: Interferon Alpha-2: Pre-Clinic'al and Clinical Evaluation.
0-89838-701-9.
P. Furmanski, J.e. Hager and M.A. Rich, eds.: RNA Tumor Viruses, Oncogenes, Human Cancer and
Aids: On the Frontiers of Understanding. 0-89838-703-5.
J.E. Talmadge, I.J. Fidler and R.K. Oldham: Screening for Biological Response Modifiers: Methods
and Rationale. 0-89838-712-4.
J.C. Bottino, R.W. Opfell and F.M. Muggia, eds.: Liver Cancer. 0-89838-713-2.
P.K. Pattengale, R.J. Lukes and C.R. Taylor, eds.: Lymphoproliferative Diseases: Pathogenesis,
Diagnosis, Therapy. 0-89838-725-6.
F. Cavalli, G. Bonadonna and M. Rozencweig, eds.: Malignant Lymphomas and Hodgkin's Disease.
0-89838-727-2.
L. Baker, F. Valeriote and V. Ratanatharathorn, eds.: Biology and Therapy of Acute Leukemia.
0-89838-728-0.
J. Russo, ed.: Immunocytochemistry in Tumor Diagnosis. 0-89838-737-X.
MONOCLONAL ANTIBODIES AND
BREAST CANCER
Proceedings of the
International Workshop on Monoclonal Antibodies
and Breast Cancer
San Francisco, California - November 8-9, 1984
edited by
Roberto L. Ceriani
John Muir Cancer and Aging Research Institute
Walnut Creek, California
~
"
Martinus Nijhoff Publishing
a member oj the Kluwer Academic Publishers Group
Boston/Dordrecht/Lancaster
Distributors for North America:
Kluwer Academic Publishers
190 Old Derby Street
Hingham, MA 02043
Distributors outside North America:
Kluwer Academic Publishers Group
Distribution Centre
P.O. Box 322
3300 AH Dordrecht
The Netherlands
Library of Congress Cataloging in Publication Data
International Workshop on Monoclonal Antibodies and
Breast Cancer (1984 : San Francisco, Calif.)
Monoclonal antibodies and breast cancer.
(Developments in oncology)
Includes bibliographies.
I. Breast-Cancer-Diagnosis-Congresses. 2. Anti
bodies, Monoclonal-Diagnostic use-Congresses.
3. Tumor antigens-Congresses. 4. Breast-Cancer
Immunological aspects-Congresses. I. Ceriani,
Roberto L. II. Title. III. Series. [DNLM:
I. Antibodies, Monoclonal-diagnostic use-congresses.
2. Breast Neoplasms-diagnosis-congresses.
WI DE998N/WP 870 1614m 1984]
RC280.B8I58 1984 616.99 '449 '075 85-11447
ISBN-13: 978-1-4612-9637-9 e-ISBN-13: 978-1-4613-2617-5
DOl: 10.1007/978-1-4613-2617-5
Copyright © 1985 by Martinus Nijhoff Publishing, Boston
Softcover reprint of the hardcover 1st edition 1985
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or
transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without
written permission of the publisher, Martinus Nijhoff Publishing, 190 Old Derby Street, Hingham,
Massachusetts 02043.
INTERNATIONAL WORKSHOP ON MONOCLONAL ANTIBODIES AND BREAST CANCER
San Francisco, Cal ifornia
November 8-9, 1984
(Organized by the John Muir Cancer and Aging Research Institute
and under the auspices of The International Association for
Breast Cancer Research)
CHAIRPERSON: Dr. Roberto L. Ceriani
John Muir Cancer and Aging Research Institute
ORGANIZING COMMITTEE:
Chairpersons: Dr. Jean Hager (AMC Cancer Center, Denver, CO)
Dr. Roberto L. Ceriani
Members: Dr. Daniel Ben-Zeev Dr. Robert Lowi tz
Dr. Bernard Larner Dr. Jerry Peterson
PROGRAM
COMMITTEE: Dr. Robert Cardi ff Dr. Jo Hi 1gers
Dr. Thomas Edgington Dr. RlcardoMesa-Tejada
Dr. Arthur Frankel Dr. Jeffrey Schlom
Dr. Ph i1 ip Furmanski Dr. Zenon Steplewski
Dr. Donald Henson
ACKNOWLEDGMENTS
The Organizing Committee for the International Workshop on
Monoclonal Antibodies and Breast Cancer, together with the
John Mui r Cancer and Aging Research Institute, gratefully
acknowledge the support of the following in making the
Workshop possible:
Board of Directors of John Muir Memorial Hospital,
Walnut Creek, California;
CETUS Corporation, Emeryville, California; and
Abbott Laboratories, North Chicago, Illinois.
CONTENTS
ACKNOWLEDGMENTS v
CONTRIBUTORS xi
PREFACE xix
SESSION t
1. IMMUNOSTAINING OF ESTROGEN RECEPTORS IN PARAFFIN SECTIONS OF
BREAST CANCERS USING ANTI-ESTROPHILIN MONOCLONAL ANTIBODIES 3
L. Ozzello, C. De Rosa, D.V. Habif and R. Lipton
2. CLINICAL STUDIES ON CELL SURFACE ESTROGEN-REGULATED
PROTEINS 13
F. Hendler, W. Kingsley, D. Burns, D. House,
K. Patrick and D. Yuan
3. MAM-6, A CARCINOMA ASSOCIATED MARKER: PRELIMINARY CHARAC-
TERISATION AND DETECTION IN SERA OF BREAST CANCER PATIENTS 28
J. Hilkens, V. Kroezen, F. Buijs, J. Hilgers,
M. van Vliet, W. de Voogd, J. Bonfrer and P.F. Bruning
4. MONOCLONAL ANTIBODIES IN THE STUDY OF MAMMARY DEVELOPMENT
AND NEOPLASIA 43
Renato Dulbecco, W. Ross Allen and Christine White
5. MONOCLONAL ANTIBODIES IN THE STUDY OF CELL LINEAGE,
DIFFERENTIATION AND MALIGNANCY IN THE HUMAN BREAST 60
J. TayIor-Papadimitriou, J. Bartek, E. Durban,
J. Burchell, R.C. Hal lowes , E.B. Lane and R. Millis
6. STUDIES WITH MONOCLONAL ANTIBODIES TO BREAST TUMORS 80
C.F. LeMaistre, D.P. Edwards, L.G. Dressler, B. Lathan,
R.E. Mansel and W.L. McGuire
SESSION II
7. SEROLOGICAL DISSECTION OF HUMAN BREAST CANCER WITH
MOUSE AND HUMAN MONOCLONAL ANTIBODIES 89
R.J. Cote, D. Morrissey, A.N. Houghton, T.M. Thomson,
C. Cordon-Carda, H.F. Oettgen and L.J. Old
8. POTENTIAL CLINICAL APPLICATION OF A MONOCLONAL ANTIBODY
TO A TUMOR ASSOCIATED GLYCOPROTEIN (TAG-72) 108
P. Horan Hand, M.O. Weeks, J. Greiner, A. Thor,
D. Colcher, C. Szpak, W. Johnston and J. Schlom
vii
viii
9. IMMUNOCYTOCHEMISTRY FOR THE SELECTION OF HYBRIDOMAS AND THE
CHARACTERIZATION OF MONOCLONAL ANTIBODIES: PROBLEMS,
SOLUTIONS AND SUGGESTIONS 119
R. Mesa-Tejada
10. EFFECTOR CELLS IN ADCC WITH ANTI-BREAST CANCER
MONOCLONAL ANTIBODIES 134
Z. Steplewski, M. Blaszczyk, D. Herlyn, M. Herlyn
and H. Koprowski
SESSION III
11. USE OF MONOCLONAL ANTIBODIES FOR BREAST CANCER DIAGNOSIS
AND PROGNOSIS 153
M.I. Colnaghi, S. Canevari, G. Della Torre,
R. Mariani-Costantini, S. Menard, S. Miotti and F. Rilke
12. INTRACELLULAR AND EXTRACELLULAR KERATINS OF HUMAN
MAMMARY EPITHELIAL CELLS 165
R. Chan. P.V. Rossitto, B.F. Edwards and R.D. Cardiff
13. BREAST CANCER ANTIGENS DETECTED WITH HUMAN MONOCLONAL
ANTIBODIES 179
K.G. Burnett, E. Oh and J. Hayden
14. MONOCLONAL ANTIBODIES AGAINST ESTROGEN RECEPTOR:
SPECIFICITY. SENSITIVITY AND POTENTIAL APPLICATIONS 190
K. McCarty, Jr., J. Snowhite, E. Cox, L. Miller
and K. McCarty, Sr.
SESSION IV
15. MONOCLONAL ANTIBODIES IN THE CHARACTERIZATION AND
IMAGING OF HUMAN BREAST CANCERS 205
P. Furmanski
16. USE OF MONOCLONAL ANTIBODIES TO DETECT METASTASES OF
SOLID TUMORS IN LYMPH NODES 218
J.N. Weinstein, A.M. Keenan, O.D. Holton, III,
Covell, S.M. Sieber, C.D.V. Black, J. Barbet.
D~G.
M.J. Talley and R.J. Parker
17. DETECTION OF BREAST CANCER USING THE MONOCLONAL
ANTIBODY 3E-l.2 233
S. Stacker. M.G. Lowe, K. McKatee, C.H. Thompson,
M. Lichtenstein, M. Leyden, N. Salehi. J. Andrews
and I.F.C. McKenzie
18. AN EXPERIMENTAL MODEL FOR THE IMMUNOLOGICAL TREATMENT
OF BREAST CANCER 248
R.L. Ceriani and E.W. Blank
ix
19. BREAST CANCER IMMUNOTOXINS 269
A. Frankel, D. Ring, M. Bjorn, W. Bloch, W. Laird,
K.T. Chong, K. Hwang and J. Winkelhake
20. DUCTAL CARCINOMA ANTIGEN: CHARACTERISTICS, TISSUE
DISTRIBUTION AND CAPACITY TO REPRESENT A TARGET FOR
MONOCLONAL ANTIBODY THERAPY 293
Lawrence D. Papsidero, Gary A. Croghan, Patrick M. Capone
and Edward A. Johnson
21. NON-IMMUNOLOGICAL FACTORS AFFECTING THE LOCALIZATION OF
MONOCLONAL ANTIBODIES IN XENOGRAFTS OF HUMAN BREAST AND
COLON TUMORS 303
H. Sands, S.A. Shah, P.L. Jones, W. Neacy and
B.M. Gallagher
CONTR I BUTORS
W. Ross Allen, The Salk Institute, 10010 North Torrey Pines Road, La
Jolla, California 92037.
J. Andrews, Research Centre for Cancer and Transplantation,
Department of Pathology, University of Melbourne and Departments of
Haemato-Oncology and Nuclear Medicine, Royal Melbourne Hospital,
Parkvi ne, Vi c. 3052 Australia.
J. Barbet, Laboratory of Mathematical Biology, National Cancer
Institute, (NCI), National Institutes of Health (NIH), Bethesda, MD
20205, USA.
J. Bartek, Res. Institute of Clinical & Exp. Oncology, Zluty Kopec
7, 600 00 BRNO, Czechoslovakia.
M. Bjorn, CETUS Corporation, 1400 Fifty-third Street, Emeryville,
California 9460B.
C.D.V. Black, Laboratory of Mathematical Biology, National Cancer
Institute, (NCI), National Institutes of Health (NIH), Bethesda, MD
20205, USA.
E.W. Blank, John Muir Cancer and Aging Research Institute, 2055 N.
Broadway, Walnut Creek, CA 94596
M. Blaszczyk, The Wistar Institute, 36th Street at Spruce,
Philadelphia, PA 19104.
W. Bloch, CETUS Corporation, 1400 Fifty-third Street, Emeryville,
California 94608.
J. Bonfrer, Depts. of Tumor Biology and Clinical Oncology, The
Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis),
Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
P.F. Bruning, Depts. of Tumor Biology and Clinical Oncology, The
Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis),
Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
F. Buijs, Depts. of Tumor Biology and Clinical Oncology, The
Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis),
Plesmanlaan 121,1066 CX Amsterdam, The Netherlands.
J. Burchell, Imperial Cancer Research Fund, P.O. Box 123, Lincoln's
Inn Fields, London WC2A 3PX, UK.
K.S. Burnett, Hybritech Incorporated, 11095 Torreyana Road, San
Diego, California 92121.
D. Burns, Department of Pathology, University of Texas Health
Science Center, Dallas Texas 75235.
xi
Di
S. Canevari. Istituto Nazionale per 10 Studio e la Cura dei Tumori,
Via G. Venezian 1, 20133 Milano, Italy.
Patrick M. Capone, Diagnostic Immunology Research and Biochemistry
Department, Roswell Park Memorial Institute, Buffalo, N.Y. 14263,
USA.
R.D. Cardiff, Department of Pathology. School of Medicine,
University of California, Davis, CA 95616.
R.L. Ceriani, John Muir Cancer and Aging Research Institute, 2055 N.
Broadway, Walnut Creek, CA 94596.
R. Chan, Department of Pathology, School of Medicine, University of
California, Davis, CA 95616.
K.T. Chong, CETUS Corporation, 1400 Fifty-third Street, Emeryville,
California 9460B.
D. Colcher, Laboratory of Tumor Immunology and Biology, National
Cancer Institute, National Institutes of Health, Bethesda, Maryland
20205, USA.
M.I. Colnaghi, Istituto Nazionale per 10 Studio e la Cura dei
Tumori, Via G. Venezian 1, 20133 Milano, Italy.
C. Cordon-Cardo, Laboratory of Human Cancer Immunology, Memorial
Sloan-Kettering Cancer Center, New York, New York.
R.J. Cote, Laboratory of Human Cancer Immunology, Memorial
Sloan-Kettering Cancer Center, New York, New York.
D.G. Covell, Laboratory of Mathematical Biology, National Cancer
Institute, (NCI), National Institutes of Health (NIH), Bethesda, MD
20205, USA.
E. Cox, Duke University, Durham, North Carolina.
Gary A. Croghan, Diagnostic Immunology Research and Biochemistry
Department, Roswell Park Memorial Institute, Buffalo, N.Y. 14263,
USA.
G. Della Torre, Istituto Nazionale per 10 Studio e la Cura dei
Tumori, Via G. Venezian 1, 20133 Milano, Italy.
C. De Rosa, Division of Surgical Pathology and Department of
Surgery, Columbia University, College of Physicians and Surgeons,
New York, N.Y. 10032.
L.G. Dressler, Department of Medicine, The University of Texas
Health Science Center, San Antonio, Texas 78284.