Innovative Rheumatology

316 Pages·2013·17.79 MB·English

by  Hiroaki Matsuno

INNOVATIVE
RHEUMATOLOGY
Edited by Hiroaki Matsuno
INNOVATIVE
RHEUMATOLOGY
Edited by Hiroaki Matsuno
Innovative Rheumatology
http://dx.doi.org/10.5772/55641
Edited by Hiroaki Matsuno
Contributors
Wahid Ali Khan, Mohd. Wajid Ali Khan, Mohd Wajid Khan, Andrew B Lemmey, Stevan Stojanović, Branislav Predrag
Belić, Rafael Burgos, María A. Hidalgo, Juan L. Hancke, Juan C. Bertoglio, Giovanni Ciancio, Uta Schurigt, Michał
Gajewski, Przemyslaw Rzodkiewicz, Koichiro Komiya, Maria Das Graças Henriques, Hiroaki Matsuno, Katarzyna
Romanowska-Prochnicka, Marzena Olesinska, Chenqi Zhao
Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia
Copyright © 2012 InTech
All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to
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Notice
Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those
of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published
chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the
use of any materials, instructions, methods or ideas contained in the book.
Publishing Process Manager Danijela Duric
Technical Editor InTech DTP team
Cover InTech Design team
First published December, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from [email protected]
Innovative Rheumatology, Edited by Hiroaki Matsuno
p. cm.
ISBN 978-953-51-0916-7

Contents
Preface VII
Section 1 Basic Science 1
Chapter 1 Sphingosine-1-Phosphate and Rheumatoid Arthritis:
Pathological Implications and Potential
Therapeutic Targets 3
Zhiyi Zhang and Chenqi Zhao
Chapter 2 New Therapeutic Targets for the Control of Inflammatory
Arthritis: A Pivotal Role for Endothelins 29
Maria das Graças Muller de Oliveira Henriques
Chapter 3 The Role of Micro-RNAs in Rheumatic Diseases:
An Update 51
Giovanni Ciancio, Manuela Ferracin, Massimo Negrini and Marcello
Govoni
Chapter 4 Catecholestrogens in Rheumatoid Arthritis (RA):
Hidden Role 71
Wahid Ali Khan and Mohd. Wajid Ali Khan
Section 2 Clinical Science 93
Chapter 5 Treatment of Rheumatoid Arthritis with Biological Agents 95
Hiroaki Matsuno
Chapter 6 Perioperative Surgical Site Infections and Complications in
Elective Orthopedic Surgery in Patients with Rheumatoid
Arthritis Treated with Anti-Tumor Necrosis Factor-Alpha
Agents − Discontinue or Not, Clinical Dilemma 109
Koichiro Komiya and Nobuki Terada
VI Contents
Chapter 7 Extraskeletal Manifestations in Rheumatoid Arthritis -
Clinical Cases 131
Katarzyna Romanowska-Próchnicka, Przemysław Rzodkiewicz,
Marzena Olesińska, Dariusz Szukiewicz and Sławomir Maśliński
Chapter 8 Small Molecule DMARD Therapy and Its Position in RA
Treatment 165
Hiroaki Matsuno
Chapter 9 Gas-Therapy in Rheumatoid Arthritis Treatment: When West
Meets East – Actual Medical Concepts with Ancient
World Ideas 189
Michal Gajewski, Slawomir Maslinski, Przemyslaw Rzodkiewicz and
Elzbieta Wojtecka-Lukasik
Chapter 10 Laryngeal Manifestations of Rheumatoid Arthritis 215
Stevan Stojanović and Branislav Belić
Chapter 11 Andrographolide a New Potential Drug for the Long Term
Treatment of Rheumatoid Arthritis Disease 247
María A. Hidalgo, Juan L. Hancke, Juan C. Bertoglio and Rafael A.
Burgos
Chapter 12 Efficacy of Nandrolone Decanoate in Treating Rheumatoid
Cachexia in Male Rheumatoid Arthritis Patients 271
Andrew B. Lemmey, Srinivasa Rao Elamanchi, Samuele M. Marcora,
Francesco Casanova and Peter J. Maddison
Chapter 13 Role of Cysteine Cathepsins in Joint Inflammation and
Destruction in Human Rheumatoid Arthritis and Associated
Animal Models 287
Uta Schurigt
Preface
First of all, we are delighted to be able to provide the "Innovative Rheumatology" to
everyone involved in the treatment and research of rheumatoid arthritis. In recent years, the
treatment of Rheumatoid Arthritis has undergone tremendous changes due to methotrexate
and biologics in large part. Until a decade ago, avoiding joint destruction in rheumatoid
arthritis was not realistic for rheumatologist. However, prevention of joint deterioration is
now possible, and the quality of life of patients with rheumatoid arthritis in long-term has
been able to improve by advances in treatment. However, there are still many problems to
be overcome before achieving the treatment of rheumatoid arthritis. All of review articles
presented on this book are explaining treatment, basic research, and patient care of
rheumatoid arthritis with innovative perspective and ideas. I hope that the ideas that have
been described in these articles help the reader to resolve the outstanding issues in
rheumatoid arthritis. Finally, the editor would like to thank the wonderful authors for their
contribution to this book. Furthermore, I would like to thank Mr. Danijela Duric and Ms.
Silvia Valsa of InTech's for their unfailing help.
Hiroaki Matsuno
Director,
Matsuno Clinic for Rheumatic Diseases,
Toyama, Japan

Section 1
Basic Science