Table Of ContentHandbook of
Clinical Nanomedicine
Vol. 2
Pan Stanford Series on Nanomedicine
Series Editor
Raj Bawa
Titles in the Series
Published Forthcoming
Vol. 1 Vol. 3
Handbook of Clinical Immune Effects of
Nanomedicine: Nanoparticles, Biopharmaceuticals and
Imaging, Therapy, and Clinical Nanomedicines
Applications Raj Bawa, János Szebeni,
Raj Bawa, Gerald F. Audette, and Thomas J. Webster, and
Israel Rubinstein, eds. Gerald F. Audette, eds.
2016 2017
978-981-4669-20-7 (Hardcover)
978-981-4669-21-4 (eBook)
Vol. 4
Impact of Nanobiotechnology
Vol. 2 on the Future of Medicine and
Handbook of Clinical Personalized Medicine
Nanomedicine: Law, Business, Shaker A. Mousa and
Regulation, Safety, and Risk Raj Bawa, eds.
Raj Bawa, ed., Gerald F. Audette 2017
and Brian E. Reese, asst. eds.
2016
978-981-4669-22-1 (Hardcover)
978-981-4669-23-8 (eBook)
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Pan Stanford Series on Nanomedicine Vol. 2
Handbook of
Clinical Nanomedicine
Law, Business, Regulation, Safety,
and Risk
Editor
Raj Bawa, MS, PhD
Patent Agent, Bawa Biotech LLC, Ashburn, Virginia, USA
Adjunct Professor, Department of Biological Sciences
editors
Rensselaer Polytechnic Institute, Troy, New York, USA
Preben Maegaard
Scientific Advisor, Teva Pharmaceutical Industries, Ltd., Israel
Anna Krenz
WAsoslifsgtaanntg EPdaitlzors
Gerald F. Audette, PhD
Associate Professor, Department of Chemistry
Acting Director, Centre for Research on Biomolecular Interactions
The Rise of Modern Wind Energy
York University, Toronto, Canada
WBrian Ei. Rneesed, Ph D,P JD, oMBAwer
Patent Attorney and Associate
Choate, Hall & Stewart LLP
Boston, Massachusetts, USA
for the World
CRC Press
Taylor & Francis Group
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Boca Raton, FL 33487-2742
© 2016 by Taylor & Francis Group, LLC
CRC Press is an imprint of Taylor & Francis Group, an Informa business
No claim to original U.S. Government works
Version Date: 20160419
International Standard Book Number-13: 978-981-4669-23-8 (eBook - PDF)
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This book is dedicated to my wife and parents for their
love and support, my students for their inspiration, and my
colleagues for their ethical professionalism.
This book is dedicated to my family for their— unRfalaj gBgaiwnga
support, and to my students who continually inspire me
with their curiosity.
This book is dedicated to my wife and b—abGye braolyd f oF.r A muadkeitntge
my life rich, to my parents for their unending support, and
to the nanotech innovators who strive to make the world
a better place.
—Brian E. Reese
TThhiiss ppaaggee iinntteennttiioonnaallllyy lleefftt bbllaannkk
About the Editor and Assistant Editors
The Editor
Raj Bawa, MS, PhD
, is president of Bawa Biotech
LLC, a biotech/pharma consultancy and patent law
firm based in Ashburn, Virginia that he founded in
2002. He is an inventor, entrepreneur, professor
and registered patent agent licensed to practice
before the US Patent & Trademark Office. Trained
as a biochemist and microbiologist, he has been an
active researcher for over two decades. He has extensive expertise
in the pharmaceutical sciences, biotechnology, nanomedicine,
drug delivery, biodefense, FDA regulatory issues, and patent law.
Since 1999, he has held various adjunct faculty positions at
Rensselaer Polytechnic Institute in Troy, NY, where he is currently
an adjunct professor of biological sciences and where he received
his doctoral degree in three years (biophysics/biochemistry). Since
2004, he has been an adjunct professor of natural and applied
sciences at NVCC in Annandale, VA. He is a scientific advisor to Teva
Pharmaceutical Industries, Ltd., Israel. He has served as a principal
investigator of National Cancer Institute SBIRs and reviewer for
both the National Institutes of Health and the National Science
Foundation. In the 1990s, Dr. Bawa held various positions at the
US Patent & Trademark Office, including primary examiner for
6 years. He is a life member of Sigma Xi, co-chair of the Nanotech
Committee of the American Bar Association and serves on
the Global Advisory Council of the World Future Society. He has
authored over 100 publications, co-edited four texts and serves
Nanomedicine
on the editorial boards of numerous peer-reviewed journals,
Journal of Interdisciplinary
including serving as a special associate editor of
Nanomedicine
(Elsevier) and an editor-in-chief of the
(Wiley). Some of Dr. Bawa’s awards include the
Innovations Prize from the Institution of Mechanical Engineers,
viii About the Editor and Assistant Editors
London, UK (2008), the Key Award from Rensselaer’s Office of
Alumni Relations (2005) and the Lifetime Achievement Award
fTrhome tAhses Aismtearnicta nE dSoitcoiertsy for Nanomedicine (2014).
Gerald F. Audette, PhD,
has been a faculty member
at York University in Toronto, Canada, since 2006.
Currently, he is an associate professor in the
Department of Chemistry and acting director of the
Centre for Research on Biomolecular Interactions
at York University. He received his doctorate in
2002 from the Department of Biochemistry at the
University of Saskatchewan in Saskatoon, Canada. Working with
Drs. Louis T. J. Delbaere and J. Wilson Quail (1995–2001),
Dr. Audette’s research focused on the elucidation of the protein–
carbohydrate interactions that occur during blood-group
recognition (in particular during the recognition of O blood
type) using high-resolution X-ray crystallography. Dr. Audette
conducted his postdoctoral research at the University of Alberta
(2001–2006) in Edmonton, Canada. Working with Drs. Bart
Hazes and Laura Frost; his research again utilized high-resolution
protein crystallography to examine the correlation between
protein structure and biological activity of type IV pilins that
are assembled into pili used by bacteria for multiple purposes,
including cellular adhesion during infection. It was during these
studies that Dr. Audette identified the generation of protein
nanotubes from engineered pilin monomers. Dr. Audette also
Escherichia coli
studied the process of bacterial conjugation (or lateral gene
transfer) using the F-plasmid conjugative system of .
Current research directions include: structure/function studies of
proteins involved in bacterial conjugation systems, the structural
and functional characterization of several type IV pilins (the
monomeric subunit of the pilus), their assembly systems, and
adapting these unique protein systems for applications in
Journal of Bionanoscience
bionanotechnology. Dr. Audette has previously served as co-editor-
in-chief of the (2007–2010), and is
FACETS
currently a subject editor of structural chemistry and crystallography
for the journal .
