European Congres Antiviral Antiviral Strategies Strategies Immune Nutrition Nutrition

156 Pages·2014·40.57 MB·English

by  Alex Vasquez

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10 January 2015 Brussels Belgium
Notes and compilation copyrighted © 2014 by Dr Alex Vasquez AntiviralNutrition.com
Event sponsored and hosted by EnergeticaNatura.com
EnergeticaAcademy ♦International College of Human Nutrition and Functional Medicine
Antiviral Strategies and Immune Nutrition ♦European Congres ♦In English, French, Dutch
Practical applications and “inside
information” on Dr Vasquez’s
recent book and other
publications
10 January 2015 ♦Van Der Valk Hotel, Brussels Airport ♦[email protected]
Notes and compilation copyrighted © 2014 by Dr Alex Vasquez AntiviralNutrition.com♦Event sponsored and hosted by
EnergeticaNatura.com♦EnergeticaAcademy ♦International College of Human Nutrition and Functional Medicine
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Notices
(cid:1) Copyright: Except for quotations and images obtained elsewhere, the material
and contents of these presentations are copyrighted by Dr Alex Vasquez and
have often been excerpted from his books which are also copyrighted. Any
unauthorized use of this material—including photocopying or any
distribution—is prohibited. No cameras. No recorders.
(cid:1) Copyright 2009-2015 by Dr Alex Vasquez. All rights
reserved and enforced.
(cid:1) Trademark: The “Functional Immunology/Inflammology
Protocol” discussed in this series of videos and notes is
Trademarked ® in association with Dr Vasquez’s book
Functional Immunology and Nutritional Immunomodulation
and other books and videos.
(cid:1) Intellectual integrity: Dr Vasquez’s views are his own.
(cid:1) Disclosures: Dr Vasquez authors books on several topics,
including viral infections and their treatments, and has
served as a researcher and lecturer for Biotics Research
Corporation.
Thank you, Biotics Research Corporation
(cid:1) Disclosures: Dr Vasquez authors books on several topics, including viral
infections and their treatments, and has served as a researcher and lecturer
for Biotics Research Corporation.
Notes and compilation copyrighted © 2014 by Dr Alex Vasquez AntiviralNutrition.com♦Event sponsored and hosted by
EnergeticaNatura.com♦EnergeticaAcademy ♦International College of Human Nutrition and Functional Medicine
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Digital “Antiviral Nutrition” published 2014.10 and updated regularly
1. Easy to implement: Anyone can do it
2. Concept-based: Provides a framework
for understanding a logical approach
3. Evidence-based:All treatments are based
on published peer-reviewed research,
prioritized and contextualized
throughout the discussion
4. Updates: the digital version of AntiViral
Nutrition(ASIN: B00OPDQG4W) is
updated regularly, and the updates can
be delivered directly to your phone,
computer, or iPad/tablet
5. Video tutorials, updates, and
explanations: The book (in paper and
digital versions) provides immediate
access to full-text articles and videos,
which provide explanations of the
concepts and treatments, as well as
important updates
6. Most doctors learnand haveno overall
strategy for treating viral infections—let
me show you how important a
structured strategy is, and how easy and
more effective this can be.
2014: Viral Infections in the news daily
Notes and compilation copyrighted © 2014 by Dr Alex Vasquez AntiviralNutrition.com♦Event sponsored and hosted by
EnergeticaNatura.com♦EnergeticaAcademy ♦International College of Human Nutrition and Functional Medicine
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What I noticed in all of this discussion is complete
chaos, a lack of organized thought, and –
resultantly–a complete lack of any effective
strategy –everything was just being piecemealed
together.
And by the way, we don’t have a drug or vaccine for
every virus and we never will (not in absolute terms
or in practical terms of affordability, safety,
effectiveness, and distribution)
The overall approach being used is submental,
incomplete, expensive, disempowering for doctors
and patients, overly influenced by profiteering, and
includes inappropriate use of military/political force
which raises legitimate suspicions of ulterior
motives; in sum, it is an ethical, scientific, political
and medical disaster.
Antiviral Strategies
(cid:1) Overview of Viral Illnesses, Vaccinations, and Antiviral Drugs
(cid:1) Antiviral Strategies
1. Antiviral—directly targeting the virus itself
1. Nutrients
2. Botanicals
2. Antireplication—blocking viral replication
1. NFKB
2. Methylation—not simply methylation, but the pattern of gene expression
3. ImmunoNutrition—optimizing immune responses with nutrition
1. Supporting immune responses
2. Maintaining mucosal surfaces, preventing secondary bacterial infections and
translocation
3. Modulating inflammation—addressing “counterinflammation”
4. Cellular and Systemic Support
1. Mitochondrial support, addressing ERS-UPR
2. Physical modalities
Notes and compilation copyrighted © 2014 by Dr Alex Vasquez AntiviralNutrition.com♦Event sponsored and hosted by
EnergeticaNatura.com♦EnergeticaAcademy ♦International College of Human Nutrition and Functional Medicine
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So, tell me doctor, “What is your strategy for
treating acute/chronic viral infections?”
(cid:1) 2009: First antiviral protocol published
(cid:1) 2014: Antiviral protocol updated in Rheumatology v3.5
(cid:1) 2014: Completely overhauled as Antiviral Strategies/Nutrition
“Having worked my way through three doctoral programs, dozens of
medical textbooks, and thousands of research articles, I've never seen
the clinical pathogenesis and treatment of viral infections explained in a
way that actually helps clinicians understand how to treat—in a
strategic manner—each of the core components of these common
conditions. The consequence of this confusion, obfuscation, and
phenomenalistic (ie, mostly or somewhat random) clinical approach has
left clinicians impaired in their ability to treat virally-infected patients,
which is all patients—everyone—at all times.”
Alex Vasquez DC ND DO FACN,
Antiviral Strategies, Antiviral Nutrition, 2014
How doctors are educated / how they treat
How we are taught about How we treat viral
viral infections: infections
Microbiology Sanitation—“cleanliness is
the best prevention”
Pathology Vaccination—“prime the
immune system for a potent
secondary response to
prevent illness”
Pharmacology Drugs—“use drugs to fight
the infection”
(cid:1) What gets ignored:
(cid:1) Nutritional modulation of viral replication and viral mutation
(cid:1) Nutrition for immune support; malnutrition is rampant
(cid:1) Support for cells and systems—a whole-body approach
Notes and compilation copyrighted © 2014 by Dr Alex Vasquez AntiviralNutrition.com♦Event sponsored and hosted by
EnergeticaNatura.com♦EnergeticaAcademy ♦International College of Human Nutrition and Functional Medicine
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Antiviral Strategies
(cid:1) Overview of Viral Illnesses, examples reviewed here
(cid:1) Patterns and Mechanisms
(cid:1) Viruses in the news: Common, Lethal, Interesting, …Pending
(cid:1) Vaccinations
(cid:1) In medical school, we are taught:
(cid:1) To always use vaccinations
(cid:1) That vaccinations always work, and
(cid:1) To never question them except—in the rare occasion that a specific patient
has a specific adverse effect.
(cid:1) The conversation on vaccination needs legitimate scientific balance,
(cid:1) 1) appreciation of the risks,
(cid:1) 2) appreciation of the inefficacies of vaccination.
(cid:1) Antiviral Drugs
(cid:1) Resources provided; a few points reviewed
The most interesting fact(s) about viral infections
(cid:1) You, me, everyone you know, everyone you see in your office—
we are all infected/colonized with multiple viruses all of the
time.
(cid:1) Therefore, the perspective of treating viral infections becomes
one of severity and relevance, not presence or absence.
(cid:1) How important and diverse is the *total viral load* in the situation
you are considering?
Notes and compilation copyrighted © 2014 by Dr Alex Vasquez AntiviralNutrition.com♦Event sponsored and hosted by
EnergeticaNatura.com♦EnergeticaAcademy ♦International College of Human Nutrition and Functional Medicine
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How viruses “infect” and cause disease
1. Cellular
attachment/entry
2. Nuclear entry
3. Integration into
DNA/RNA
machinery
4. Translation
5. Protein production
6. Envelopment and
assembly
7. Viral release
How viruses “infect” and cause disease
Genetic changes lead to:
(cid:1) Minor “Drift”—a slow and relatively minor
change, increases (re)infectivity by virtue of
new antigens
(cid:1) Drift = decay, damage,
(cid:1) Major “Shift”—a combinatorial change in the
virus—due to the merging of two previously
distinct viruses—that greatly increases
pathogenicity and behavior/transmissibility
https://en.wikipedia.org/wiki/Influenza
(cid:1) Shift = splicing of two viruses together
Notes and compilation copyrighted © 2014 by Dr Alex Vasquez AntiviralNutrition.com♦Event sponsored and hosted by
EnergeticaNatura.com♦EnergeticaAcademy ♦International College of Human Nutrition and Functional Medicine
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How viruses “infect” and cause disease
Antigenic Drift
(cid:1) After vaccination, your body produces
infection-fighting antibodies against the three
flu strains in the vaccine
(cid:1) If you are exposed to any of the three flu
strains during the flu season, the antibodies
will latch onto the virus’s HA antigens,
preventing the flu virus from attaching to
healthy cells and infecting them.
(cid:1) Influenza virus genes, made of RNA, are more
prone to mutations than genes made of DNA.
(cid:1) If the HA gene changes, so can the antigen that
it encodes, causing it to change shape
(cid:1) If the HA antigen changes shape, antibodies
that normally would match up to it no longer
can, allowing the newly mutated virus to infect
the body’s cells. This type of genetic mutation
is called “antigenic drift.”
http://www.niaid.nih.gov/topics/flu/research/basic/
Pages/AntigenicDriftIllustration.aspx
How viruses “infect” and cause disease
Antigenic Shift: The genetic change that enables a
flu strain to jump from one animal species to
another, including humans, is called antigenic shift.
Antigenic shift can happen in three ways:
(cid:1) Antigenic Shift 1
(cid:1) A duck or other aquatic bird passes a bird strain of
influenza A to an intermediate host such as a
chicken or pig.
(cid:1) A person passes a human strain of influenza A to
the same chicken or pig.
(cid:1) When the viruses infect the same cell, the genes
from the bird strain mix with genes from the
human strain to yield a new strain.
(cid:1) The new strain can spread from the intermediate
host to humans.
(cid:1) Antigenic Shift 2
(cid:1) Without undergoing genetic change, a bird strain of
influenza A can jump directly from a duck or other
aquatic bird to humans.
(cid:1) Antigenic Shift 3
(cid:1) Without undergoing genetic change, a bird strain of
influenza A can jump directly from a duck or other
aquatic bird to an intermediate animal host and
then to humans.
http://www.niaid.nih.gov/topics/flu/research/basic/
pages/antigenicshiftillustration.aspx
Notes and compilation copyrighted © 2014 by Dr Alex Vasquez AntiviralNutrition.com♦Event sponsored and hosted by
EnergeticaNatura.com♦EnergeticaAcademy ♦International College of Human Nutrition and Functional Medicine
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How viruses “infect” and cause disease
How do viruses cause disease?
(cid:1) Tissue/cellular specificity/tropism = pattern of disease
(cid:1) Virus have specificity for certain cells/tissues, based on:
(cid:1) Cellular receptors/proteins, allowing virus binding and entry
(cid:1)HIV with CD4 and the CXCR4 chemokine receptor on T cells
(cid:1) Cellular enzymes, allowing the viral binding/replication
(cid:1)Host protease activation of influenza virus hemagglutinin)
(cid:1) Cell-specific transcription factors
(cid:1)JC virus can only proliferate in oligodendroglia
Robbins & Cotran Pathologic Basis of Disease
Notes and compilation copyrighted © 2014 by Dr Alex Vasquez AntiviralNutrition.com♦Event sponsored and hosted by
EnergeticaNatura.com♦EnergeticaAcademy ♦International College of Human Nutrition and Functional Medicine
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How do viruses cause disease?
1. Tissue/cellular specificity/tropism = pattern of disease
2. Mechanism of disease = direct and indirect
Mechanismsof viral Examples
disease
Direct infection and triggering • Herpes encephalitis
of tissue destruction • Viralhepatitis, but here again, most of the damage
is done by the immune system (excess
inflammation)
Immunosuppression • Nearly all viral infections cause transient
immunosuppression, either via “cytokine
confusion” or overt leukopenia via bone marrow
suppression
Sustained cellular dysfunction • Alzheimer’s disease
Cytokine storm, shock, • Ebola
hemorrhage • Dengue
Autoimmunity • EBV, CMV, PvB19 with SLE,Sjogren’s, scleroderma
Viruses in Clinical Practice and in the News
(cid:1) Common
(cid:1) Viruses that we commonly consider
(cid:1) Viruses that we commonly consider but that we need to reconsider
in order to appreciate new therapeutic opportunities
(cid:1) Lethal
(cid:1) Just about any virus can be lethal if the infection overwhelms the host
(cid:1) Just about any virus can be survived and controlled if the host
defense overcomes the virus
(cid:1) Interesting
(cid:1) Brain infections
(cid:1) Bacteriophages
(cid:1) Pending
(cid:1) Consistent pattern of mishaps and “accidents” in the United States;
consistent errors in the NIH management of infectious agents.
Notes and compilation copyrighted © 2014 by Dr Alex Vasquez AntiviralNutrition.com♦Event sponsored and hosted by
EnergeticaNatura.com♦EnergeticaAcademy ♦International College of Human Nutrition and Functional Medicine
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