Table Of ContentCARDIOPROTECTIVE
NATURAL PRODUCTS
Promises and Hopes
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CARDIOPROTECTIVE
NATURAL PRODUCTS
Promises and Hopes
Editor
Goutam Brahmachari
Visva-Bharati University, India
World Scientific
NEW JERSEY • LONDON • SINGAPORE • BEIJING • SHANGHAI • HONG KONG • TAIPEI • CHENNAI • TOKYO
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Published by
World Scientific Publishing Co. Pte. Ltd.
5 Toh Tuck Link, Singapore 596224
USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601
UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.
CARDIOPROTECTIVE NATURAL PRODUCTS
Promises and Hopes
Copyright © 2018 by World Scientific Publishing Co. Pte. Ltd.
All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means,
electronic or mechanical, including photocopying, recording or any information storage and retrieval
system now known or to be invented, without written permission from the publisher.
For photocopying of material in this volume, please pay a copying fee through the Copyright Clearance
Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to photocopy
is not required from the publisher.
ISBN 978-981-3231-15-3
Typeset by Stallion Press
Email: [email protected]
Printed in Singapore
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“9x6” b2989 Cardioprotective Natural Products: Promises and Hopes
Dedicated to Professor Kalisankar Mukherjee
(Visva-Bharati University, India)
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“9x6” b2989 Cardioprotective Natural Products: Promises and Hopes
Contents
Foreword ix
Preface xi
Editor Biography xv
List of Contributors xix
Chapter 1 Cardioprotective Natural Products: Promises
and Hopes — An Overview 1
Goutam Brahmachari
Chapter 2 Naturally Occurring Matrix Metalloproteinase
Inhibitors: A Group of Promising Cardioprotective
Agents 9
Tayebeh Anajafi, Abbas Sedigh and Sanku Mallik
Chapter 3 Promising Natural Cardioprotective Agents in Drug-
and Toxin-Induced Pathophysiology 47
Semantee Bhattacharya and Parames C. Sil
Chapter 4 Natural Products against Drug-Induced Cardiotoxicity 121
Meghana Koneru, Nasiruddin Nalban,
Bidya Dhar Sahu and Ramakrishna Sistla
Chapter 5 Cardioprotective Potential of Medicinal Plants in
Attenuating Doxorubicin-Induced Cardiotoxicity 149
Sameer N. Goyal, C.R. Patil, Nimisha Mishra,
Rajesh Mohanraj, Shreesh Ojha
vii
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b2989 Cardioprotective Natural Products: Promises and Hopes “9x6”
viii Cardioprotective Natural Products
Chapter 6 Role of Dietary Supplements in Cardiovascular
Diseases 193
Essam Abdel-Sattar, Soheir M. El Zalabani
and Manal M. Sabry
Chapter 7 Beneficial Role of Antioxidant Molecules with
Therapeutic Potential in Cardiac Disease 247
Jyotirmoy Ghosh, Krishnendu Sinha
and Parames C. Sil
Chapter 8 Small Molecule Phytocompounds as Promoters
of LDL-receptor and PCSK9 Inhibition: Potential
Role as Non-statin Based Cardio-protective Agents 277
Ajoy Basak, Paul O’Reilly, Bethel Ozed-Williams,
and Sarmistha Basak
Chapter 9 7,8-Dihydroxy-3-methylisochroman-4-one:
A Promising Anti-hypertensive Lead-Molecule
from Banana (Musa sapientun L.) Peel 319
Goutam Brahmachari
Index 331
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“9x6” b2989 Cardioprotective Natural Products: Promises and Hopes
Foreword
The quest of cardiovascular scientists is the discovery and development of
novel drug targets and drug compounds for the treatment of cardiovascular
diseases. Cardiovascular disease includes any condition that adversely
affects the structure or function of the heart and vasculature; such as, heart
failure, coronary heart disease, stroke, high blood pressure, diseases of the
arteries and many others. Standard pharmacological treatments of cardio-
vascular disease include angiotensin converting enzyme (ACE) inhibitors,
angiotensin II receptor blockers (ARBs), antiarrhythmic drugs, anticoa-
gulants, antiplatelet drugs, aspirin therapy, beta-blocker drugs, calcium
channel blockers, thrombolytic therapy, digoxin, diuretics and nitrates.
Natural product drug discovery is an important part of this quest to
develop new drug compounds for the treatment of cardiovascular
diseases.
This book on Cardioprotective Natural Products: Promises and Hopes,
edited by Professor Goutam Brahmachari, is a relevant and thorough book
that uniquely discusses recent research advances in the discovery and
development of cardiovascular natural products for the treatment of
cardiovascular diseases. Each of the eight technical chapters of this book
discusses recent advances of natural products with cardioprotective
promise. These advances include naturally occurring matrix metallo-
proteinase (MMPs) inhibitors, phytochemicals, antioxidants, dietary
supplements and other plant-based medicinal products. Also, examples of
promising cardioprotective lead compounds to treat specific types of
cardiovascular diseases are discussed.
Professor Brahmachari is an accomplished researcher, teacher,
mentor and author. His research interests include isolation, structural
ix
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