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Allgemeine Tumorlehre IV. Tumorprogression, Metastasenbildung Andras Kiss dr. med., Ph.D. Semmelweis Universität, Budapest II. Institut für Pathologie Was ist Karzinogenese ? Entstehungsweg der Tumoren Entartung einer normalen Zelle zu bösartigem Phenotyp. Definition der Neoplasie • „Neoplasia = New growth „ • Greenlee et al.: CA Cancer J. Clin, 51: 15-36, 2001 • 1 268 000 neue Fälle in der USA, ~ 553 400 Leute sind im Krebs gesstorben. Grosse Unterschiede in Krebs Inzidenz und Mortalität ! • In Ungarn: 60 000 neue berichtete Fälle, 35 000 Krebstod pro Jahr. • Nur Kardiovaskuläre Krankheiten verursachen mehrere Todesfälle ! Karzinogenese • Initiation • Promotion - von initiierten onkogeneen Potenz der Zelle zur vollstandigen Entartung • Progression - Proliferation veränderter Zellklone Initiation Progression Promotion Zell Zyklus Proliferation Apoptosie Genalterationen: deletio, amplificatio; cis-activatio (HBV); demethylatio genetische genetische genetische genetische Veränderung Veränderung Veränderung Veränderung Normal Zell sejt Iniziierte Zell Preneoplastische Bösartiger klinisch Invasion, Lasion Metastase Tumor det. HCC klonale Expansion HCV HBV core, E2, NS3, NS5A HBx,HBsAg; PreS2; Integration Hepatokarzinogenese proto Onkogene Cytokine c-myc, N-ras, c-fos a aaa TGF- , HGF ! HCC IGF-I, IGF-II., b, bb,,b, TGF- Tumor Suppressoren gene - p53, p16, RB Adhesions - molekuls LOH 1p,1q, Ampl. Integrine, 2q, 4q, 5q, 6q, 9p, 9q, Chromo- E-cadherin, 10q, 11p, 13q, 16p, som. b bbb -catenin ! 16q, 17p, 22/APC Regionen 1q, 8q Hepatokarzinogenese etiologische Faktoren Alkohol Metabolische Krankh. HCC Mutagene Androgene Einwirkungen Cirrhosis ! Schistosoma Aflatoxin HBV, HCV (Toxin eines Schimmelpilzes) Fusarium toxin NEOPLASIA Krebs ist eine GENETISCHE Krankheit !! Die Wirkung eines kranken Gen oder eine Kooperation mehreren Gene !

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Initiation. • Promotion - von initiierten onkogeneen. Potenz der Zelle zur vollstandigen Entartung. • Progression - Proliferation veränderter. Zellklone

Allgemeine Tumorlehre IV. Andras Kiss dr. med., Ph.D. PDF

76 Pages·2015·5 MB·German

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Initiation. • Promotion - von initiierten onkogeneen. Potenz der Zelle zur vollstandigen Entartung. • Progression - Proliferation veränderter. Zellklone

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Publication Year:	2015
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