Taurine 7

525 Pages·2009·9.46 MB·English

by  Takashi Ito

Taurine 7
Advances in Experimental Medicine and Biology
EditorialBoard:
NathanBack,StateUniversityofNewYorkatBuffalo
IrunR.Cohen,TheWeizmannInstituteofScience
AbelLajtha,N.S.,KlineInstituteforPsychiatricResearch
JohnD.Lambris,UniversityofPennsylvania
RodolfoPaoletti,UniversityofMilan
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· ·
Junichi Azuma Stephen W. Schaffer
Takashi Ito
Editors
Taurine 7
123
Editors
Dr.JunichiAzuma Dr.StephenW.Schaffer
OsakaUniversity CollegeofMedicine
DepartmentClinicalEvaluation UniversityofSouthAlabama
ofMedicinesandTherapeutics DepartmentofPharmacology
1–6YamadaOka,Suita 307Universityblvd.,Mobile,Alabama
Osaka 36688USA
565-0871Japan [email protected]
[email protected]
Dr.TakashiIto
CollegeofMedicine
UniversityofSouthAlabama
DepartmentofPharmacology
307Universityblvd.,Mobile,Alabama
36688USA
[email protected]
ISBN:978-0-387-75680-6 e-ISBN:978-0-387-75681-3
DOI:10.1007/978-0-387-75681-3
LibraryofCongressControlNumber:2008937801
(cid:2)c SpringerScience+BusinessMedia,LLC2009
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Preface
Taurine(2-ethanesulfonicacid)isauniqueandmysteriouscompound.Itispresent
in relatively high concentrations in a wide range of cells and tissues, but exists as
afreeaminoacidinthesecellswithoutbeingutilizedinproteinsynthesis.Taurine
wasfirstisolatedmorethan150yearsagofromox(Taurus)bile,whereitwasfound
inconjugationwithbileacidsthroughanamidelinkage.Sincethattime,ithasbeen
reported to exist in particularly high concentrations in the cytoplasm of excitable
tissues,suchascertainpartsofthebrain,retina,skeletalmuscle,myocardiumand
platelets. Some of its physiological functions have already been established, for
exampleitsroleasanessentialnutrientduringdevelopment,anosmolyteandaneu-
romodulator.Recently,taurinehasbeenadvancedasacytoprotectiveagentagainst
certain pathological perturbations, but the mechanisms underlying its actions are
stillmostlyamatterofspeculation.Moreover,itispossiblethatotherputativefunc-
tionsoftaurineremaintobediscovered.
The16thInternationalTaurineMeeting“TaurineforFutureHealthcare”washeld
onSeptember2–5,2007,inShimoda,Shizuoka,Japan,withthesiteofthemeeting
being the Shimoda Central Hotel. Approximately 80 individuals from 11 nations,
including newcomers as well as experts in taurine research, attended the scientific
meeting.Atotalof79paperswerepresentedaseitheroralorposterpresentations.
This meeting was multidisciplinary, with participants addressing multiple areas of
thebiologicalsciences.Typhoon“Fitow”,whichmeans“beautifulfragrantflower”
inaMicronesianlanguage,hittheShimodaregionwithfullforceattheendofthe
meeting, but we were able to finish the scientific sessions and enjoy an excursion
priortotheonslaught.ThemorningafterFitow’sfury,thelingeringscentofflowers
remindedusthatweareclearlyatthedawnofaneweraintaurineresearch.
TheorganizersofthetaurinemeetingwouldliketothankTaishoPharmaceutical
Co., Ltd., Tokyo, Japan, for their generous financial support and assistance in the
organization of the meeting. We would also like to thank Dong-A Pharmaceutical
Co,Korea,fortheirgenerousfinancialsupport.Inaddition,wewouldliketothank
all participants of the meeting, especially the participants from the Osaka Univer-
sity and Taisho Pharmaceutical Company. The staff of the Shimoda Central Hotel
wasextremelyhelpfulinmakingsurethatallparticipantswerecomfortableandfor
ensuringthesuccessoftheirplannedevents.Finally,wewouldliketoexpressour
v
vi Preface
appreciationfortheuntiringeffortbefore,duringandafterthescientificsessionsof
Dr.Abe,whohelpedensurethesuccessofthemeeting.
We are pleased to provide you with Taurine 7, which contains the proceedings
of the 16th International Taurine Meeting consisting, of 54 original papers. This
volume focuses on all aspects of taurine research, including topics of interest to
today’sscientistsaswellasfutureclinicalapplications.
PartI.CardiovascularandRenalEffectsofTaurine.
PartII.EffectofTaurineonBrainandRetina.
PartIII.EffectofTaurineonSkeletalMuscle.
PartIV.GastroentericandHepaticEffectsofTaurine.
PartV.EffectofTaurineonBone.
PartVI.EffectofTaurineonDiabetesandObesity.
PartVII.PotentialTherapeuticEffectsofTaurine.
PartVII.TaurineasanAntioxidant;RoleinImmuneSystemandOtherTissues.
PartIX.RegulationoftheTaurineTransporter.
Future interest in taurine will undoubtedly be robust. However, considerable
work remains to develop and uncover key new facts regarding taurine. This book
should provide insight into new avenues of investigation and help propel the field
intotheneweraoftaurineresearch.Finally,theorganizerswishtothankallofthe
participantsfortheirstimulatingdiscussions,probingquestionsandwrittencontri-
butionsthatmadetheShimodataurinemeetinganunmitigatedsuccess.
Wearedeeplythankfultoallscientistswhohaveaninterestintaurine,andare
lookingforwardtoseeingthetaurinefamilyatthenextTaurinemeetinginFlorida.
Alonewecandosolittle;togetherwecandosomuch.
HelenKeller
Osaka,Japan JunichiAzuma,MD
USA StephenW.Schaffer,PhD
Osaka,Japan TakashiIto,PhD
Meeting Participants
Dr.SatoshiAbe Dr.UdomChantharaksri
TaishoPharmaceuticalCo.Ltd. MahidolUniversity
JAPAN THAILAND
[email protected] [email protected]
Dr.ChangSoonAhn Dr.RussellW.Chesney
AnsanCollege UniversityofTennessee
KOREA USA
[email protected] [email protected]
Mr.TakaoAketo Dr.MiJaChoi
TaishoPharmaceuticalCo.Ltd. KeimyungUniversity
JAPAN KOREA
[email protected] [email protected]
Dr.MedeyaAkhalaya Dr.FiliFazzino
M.V.LomonosovMoscowState InstitutoVenezolanodeInvestigaciones
University Cient´ıficas
RUSSIA VENESUELA
[email protected] [email protected]
Dr.JunichiAzuma Mr.JunichiFukutome
OsakaUniversity TaishoPharmaceuticalCo.Ltd
JAPAN JAPAN
[email protected] [email protected]
Dr.KyungJaChang Dr.ShoichiroHamano
InhaUniversity HamanoInternationalCo.,Ltd.
KOREA JAPAN
[email protected] [email protected]
vii
viii MeetingParticipants
Dr.XiaobinHan Dr.KyoungSooKim
UniversityofTennessee KyungHeeUniversity
USA KOREA
[email protected] [email protected]
Dr.TakuzoHano Dr.AnKeunKim
WakayamaMedicalUniversity SookmyungWomen’sUniversity
JAPAN KOREA
[email protected] [email protected]
Dr.AbdeslemElIdrissi Dr.ChaekyunKim
CityUniversityofNewYork InhaUniversitySchoolofMedicine
USA KOREA
[email protected] [email protected]
Dr.KenichiImagawa Dr.YoungChulKim
PharmacogenomeTipTopInc. SeoulNationalUniversity
JAPAN KOREA
[email protected] [email protected]
Dr.TakashiIto Dr.MasayoshiKuwahara
OsakaUniversity TheUniversityofTokyo
JAPAN JAPAN
[email protected] [email protected]
Dr.JangmiKang Dr.CesarLau-Cam
HyogoNCCcollege St.John’sUniversity
JAPAN USA
[email protected] [email protected]
Dr.YoungSookKang Dr.Dong-HeeLee
SookmyungWomen’sUniversity UniversityofSeoul
KOREA KOREA
[email protected] [email protected]
Dr.ByongKakKim Dr.YuTehLi
SeoulNationalUniversity TulaneUniversitySchoolofMedicine
KOREA USA
[email protected] [email protected]
Dr.HaWonKim Dr.NingMa
UniversityofSeoul UniversityofTokushima
KOREA JAPAN
[email protected] [email protected]
MeetingParticipants ix
Dr.JanuszMarcinkiewicz Mr.HaruakiNobori
MedicalCollegeJagiellonianUniversity OsakaUniversity
POLAND JAPAN
[email protected] [email protected]
Dr.TadaomiAMiyamoto Dr.ConnyNordin
KokuraMemorialHospital LincopingUniversity
JAPAN SWEDEN
[email protected] [email protected]
Dr.TeruoMiyazaki Dr.SoniaNusetti
GeorgeWashingtonUniversity UniversidaddeOrienteCumana
USA VENESUELA
[email protected] [email protected]
Dr.MariMori Dr.TetsuyaOgino
MukogawaWomen’sUniversity OkayamaUniversity
JAPAN JAPAN
[email protected] [email protected]
Dr.ShigeruMurakami Dr.SimoS.Oja
TaishoPharmaceuticalCo.Ltd. UniversityofTampere
JAPAN FINLAND
[email protected] simo.oja@uta.fi
Dr.JunichiNakagawa Mr.YudhachaiRajatasereekul
TokyoUniversityofAgriculture OsotspaCoLtd
JAPAN THAILAND
[email protected] [email protected]
Dr.SeiichiroNishida Dr.SanyaRoysommuti
NaraMedicalUniversity KhonKaenUniversity
JAPAN THAILAND
s [email protected] [email protected]
Dr.HidekiNishimura Dr.MartinSamuelsson
TokyoWomensMedicalUniversity LincopingUniversity
JAPAN SWEDEN
[email protected] [email protected]
Dr.NaomichiNishimura Dr.ChaichanSangdee
NayoroCityUniversity ChaingMaiUniversity
JAPAN THAILAND
[email protected] [email protected]
x MeetingParticipants
Dr.PirjoSaransaari Ms.MikaTakai
UniversityofTampere OsakaUniversity
FINLAND JAPAN
pirjo.saransaari@uta.fi [email protected]
Dr.HemantaK.Sarkar Ms.AtcharapornThaeomor
BBTech KhonKaenUniversity
USA THAILAND
[email protected] [email protected]
Mr.NoppadolTunglukmongkol
Dr.HiroyasuSatoh
OsotspaCoLtd
NaraMedicalUniversity
THAILAND
JAPAN
[email protected]
[email protected]
Mr.ShuichiUmeda
Dr.StephenW.Schaffer
TaishoPharmaceuticalCo.Ltd
UniversityofSouthAlabama
JAPAN
USA
[email protected]
[email protected]
Ms.YorikoUozumi
Dr.YukioSeki
TaishoPharmaceuticalCo.Ltd
ChubuRosaiHospital
JAPAN
JAPAN
[email protected]
[email protected]
Ms.GaofengWu
Dr.MakotoShimizu ShenYangAgriculturalUniversity
TheUniversityofTokyo CHINA
JAPAN [email protected]
[email protected]
Dr.JangYenWu
Dr.KyokoTakahashi FloridaAtlanticUniversity
OsakaUniversity USA
JAPAN [email protected]
[email protected]
Dr.YukioYamori
Mr.ToshioTakahashi InternationalCenterforResearchon
TaishoPharmaceuticalCo.Ltd PrimaryPreventionofCardiovascular
JAPAN DiseasesWHOExpertAdvisoryPanel
[email protected] JAPAN
[email protected]
Dr.MasaruTakahashi
TaishoPharmaceuticalCo.Ltd Dr.YoshihisaYatabe
JAPAN MoriyaDaiichiHospital
[email protected] JAPAN
[email protected]