Table Of ContentEXS 86
Fish Ecotoxicology
Edited by T. Braunbeck
D.E. Hinton
B. Streit
Springer Basel AG
Editors
Dr. Thomas Braunbeck Prof. Dr. David E. Hinton
Department of Zoology 1 Department of Anatomy, Physiology and Cell
University of Heidelberg Biology
Im Neuenheimer Feld 230 School ofVeterinary Medicine
D-69120 Heidelberg University of California
Germany Davis, CA 95616
USA
Prof. Dr. Bruno Streit
Department of Ecology and Evolution
University of Frankfurt
Siesmayerstr. 70
D-60054 Frankfurt
Germany
Library of Congress Cataloging-in-Publication Data
Fish ecotoxicology / edited by T. Braunbeck, D. E. Hinton, B. Streit.
p. cm. --(EXS ; 86)
Includes bibliographical references and index.
ISBN 978-3-0348-9802-7 ISBN 978-3-0348-8853-0 (eBook)
DOI 10.1007/978-3-0348-8853-0
(hardcover: alk. paper)
1. Fishes--Effect ofwater pollution ono 2. Water--Pollution
-Toxicology. 1. Braunbeck, T. (Thomas) II. Hinton, David E.
III. Streit, Bruno. IV. Series.
SH174.F558 1998
571.9'517--dc21
Deutsche Bibliothek Cataloging-in-Publication Data
Fish exotoxicology / ed. by T. Braunbeck ... -Basel ; Boston; Berlin
: Birkhiiuser, 1998
(EXS ; 86)
ISBN 978-3-0348-9802-7
86. Fish exotoxicology. - 1998
EXS. -Basel ; Boston; Berlin: Birkhiiuser
Friiher Schriftenreihe
Fortlaufende BeiI. zu: Experientia
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© 1998 Springer Basel AG
Originally published by Birkhiiuser Verlag in 1998
Softcover reprint ofthe hardcover 1s t edition 1998
Printed on acid-free paper produced from chlorine-free pulp. TCF
00
Cover illustration: Dipl.-Biol. Markus Islinger
ISBN 978-3-0348-9802-7
987654321
Contents
List of Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . VII
Helmut Segner
Fish cell lines as a tool in aquatic toxicology 1
Gilles Monod, Alain Devaux, Yves Valotaire and Jean-Pierre Cravedi
Primary cell cultures from fish in ecotoxicology . . . . . . . . . .. 39
Thomas Braunbeck
Cytological alterations in fish hepatocytes following in vivo
and in vitro sublethal exposure to xenobiotics - structural biomarkers
of environmental contamination. . . . . . . . . . . . . . . . . . .. 61
David E. Hinton and John A. Couch
Architectural pattern, tissue and cellular morphology in livers
offishes: Relationship to experimentally-induced neoplastic
responses ................ . ... 141
Anders GoksfJyr and Astrid-Mette HusfJY
Immunochemical approaches to studies ofCYPIA localization
and induction by xenobiotics in fish. . . . . . . . . . . . . . . . . . 165
Reinhard Lackner
"Oxidative stress" in fish by environmental pollutants ........ 203
GUnter Kock and RudolfH ofor
Origin of cadmium and lead in clear softwater lakes of high-altitude
and high-latitude, and their bioavailability and toxicity to fish . 225
Karl Fent
Effects of organotin compounds in fish: from the molecular
to the population level . . . . . . . . . . . . . . . . . . . . . . . . . 259
David E. Hinton
Multiple stressors in the Sacramento River watershed . . . . . . . . 303
Peter Matthiessen and John P. Sumpter
Effects of estrogenic substances in the aquatic environment . . . . . 319
VI Contents
Roland Nagel and Karla Isberner
Testing of chemicals with fish - a critical evaluation of tests
with special regard to zebrafish .................... 337
Bruno Streit
Bioaccumulation of contaminants in fish 353
Subject Index .............. . 389
List of Contributors
Thomas Braunbeck, Department of Zoology I, Morphology/Ecology,
University of Heidelberg, 1m Neuenheimer Feld 230,
D-69120 Heidelberg, Germany.
e-mail [email protected]
John Couch, 4703 Soule Place, Gulf Breeze, Florida 32561, USA.
Jean-Pierre Cravedi, Institut National de la Recherche Agronomique,
Laboratoire des Xenobiotiques, 180 chemin de Tournefeuille, BP 3,
F -31931 Toulouse Cedex, France.
e-mail [email protected]
Alain Devaux, Ecole Nationale des Travaux Publics de l'Etat,
Laboratoire des Sciences de l'Environnement, rue Maurice Audin,
F-69518 Vaulx-en Velin Cedex, France.
e-mail [email protected]
Karl Fent, EAWAG, Oberlandstrasse 133, CH-8699 Dubendorf.
e-mail [email protected]
Anders Goks0yr, Department of Molecular Biology, University of Bergen,
HIB, N-5020 Bergen, Norway.
e-mail [email protected]
Karla Isberner, Institute of Hydrobiology, Technical University of Dresden,
Zellerscher Weg 40, D-O 10 62 Dresden, Germany.
e-mail [email protected]
David Hinton, Department of Anatomy, Physiology and Cell Biology,
School of Veterinary Medicine, University of California, Davis,
CA 95616, USA.
e-mail [email protected]
Rudolf Hofer, Department of Zoology and Limnology,
University ofInnsbruck, Technikerstr. 25, A-6020 Innsbruck, Austria.
e-mail [email protected]
Astrid-Mette Hus0Y, Bergen College, N-5008 Bergen, Norway.
e-mail [email protected]
Gunter Kock, Department of Zoology and Limnology,
University ofInnsbruck, Technikerstr. 25, A-6020 Innsbruck, Austria.
e-mail [email protected]
VIII List of Contributors
Reinhard Lackner, Department of Zoology and Limnology,
University ofInnsbruck, Technikerstr. 25, A-6020 Innsbruck, Austria.
e-mail [email protected]
Peter Matthiessen, Centre for Environment, Fisheries and Aquaculture
Science, Remembrance Avenue, Burnham-on-Crouch,
Essex, CMO 8HA, UK.
e-mail [email protected]
Gilles Monod, Institut National de la Recherche Agronomique,
Unite d'Ecotoxicologie Aquatique, IFR 43, Campus de Beaulieu,
F-35042 Rennes Cedex, France.
e-mail [email protected]
Roland Nagel, Institute of Hydrobiology, Technical University of Dresden,
Zellerscher Weg 40, D-O 10 62 Dresden, Germany.
e-mail [email protected]
Helmut Segner, Centre for Environmental Research,
Department of Chemical Ecotoxicology, Permoserstr. 15,
D-04318 Leipzig, Germany.
e-mail [email protected]
Bruno Streit, Department of Ecology and Evolution, Biologie-Campus,
Siesmayerstrasse, D-60054 Frankfurt, Germany.
e-mail [email protected]
John P. Sumpter, Department of Biology and Biochemistry,
BruneI University, Uxbridge, Middlesex UB8 3PH, UK.
e-mail [email protected]
Yves Valotaire, Equipe d' Endocrinologie Moleculaire de la Reproduction,
UPRES-A CNRS 2026, IFR 43,
Campus de Beaulieu, F-35042 Rennes Cedex, France.
e-mail [email protected]
Preface
In the last twenty years, ecotoxicology has successfully established its
place as an interdisciplinary and multidisciplinary science concerned
with the effects of chemicals on populations and ecosystems, thus bridg
ing the gap between biological and environmental sciences, ecology,
chemistry and traditional toxicology. In modern ecotoxicology, fish have
become the major vertebrate model, and a tremendous body of informa
tion has been accumulated. A major challenge to ecotoxicology is the
integration of this vast amount of diverse knowledge from environmental
chemistry, toxicology, ecology and general environmental sciences.
Critical selection and compilation of the most important data has thus
received increasing importance. This volume of the EXS series is de
dicated to a selection of novel trends in fish ecotoxicology and makes an
attempt to summarize our present knowledge in a series of fields of
primary ecotoxicological interest ranging from the use of (ultra)structu
ral modifications of selected cell systems as sources of biomarkers for
environmental impact over novel approaches to monitor the impact of
xenobiotics with fish in vitro systems such as primary and permanent fish
cell cultures, the importance of early life-stage tests with fish, the bio
accumulation of xenobiotics in fish, the origin of liver neoplastic lesions
in fish related to the basic architectural patterns of fish liver, immuno
chemical approaches to monitor effects in cytochrome P450-related bio
transformation, the impact of heavy metals in soft water systems, the
environmental toxicology of organotin compounds, oxidative stress in
fish by environmental pollutants, and complex contamination in field
populations to effects by estrogenic substances in aquatic systems. As
editors, we are grateful to the colleagues, who made this volume possible
by their contributions from a specialized field in fish ecotoxicology. Part
of them also kindly served as reviewers for other contributions; in addi
tion, we express our gratitude to Drs. W Ahne, H. Babich, R. Baudo,
S. Baksi, P. Bannasch, N. DiGiulio, W Klein, P. Lemaire, J. Mosello,
P. Paert, H. J. Pluta, J. D. Reis, R. B. Spies, K. Steinhauser, R. Triebskorn,
P. Weis and P. W. Wester for their valuable comments and suggestions. In
the editorial phase, the tireless assistance ofM. Behncke-Braunbeck has
helped a lot to improve the formal standards of this volume. Finally, parti
cular thanks are due to Birkhauser Publishers, namely Janine Kern and
Dr. Petra Gerlach for the excellent cooperation and their constant support
during the entire publication process.
In the final analysis, however, the editors will have to bear the blame for
any errors and mistakes. This collection of reviews has been designed to
serve as a reference not only for specialists in fish ecotoxicology, but also
for scientists and students interested in related fields of environmental
x Preface
sciences; in case we should not have been able to meet the expectations by
this broad spectrum of readers, both contributors and editors will be happy
to receive any comments that might help to further improve our under
standing the various functions fish play in modem ecotoxicology.
Thomas Braunbeck
Bruno Streit
David E. Hinton
