Table Of ContentAcademic Press Rapid Manuscript Reproduction
Proceedings of the
1980 ICN-UCLA Symposia on Animal Virus Genetics
Held in Keystone, Colorado
March 9-14, 1980
ICN—UCLA Symposia on Molecular and CeUufar Biology,
Volume XVIII, 1980
ANIMAL VIRUS GENETICS
edited by
BERNARD N. FIELDS
Department of Microbiology and Molecular Genetics
Harvard Medical School
Boston, Massachusetts
RUDOLF JAENISCH
Department of Tumor Virology
Heinrich —Pette Institut
Hamburg, West Germany
Series Editor
C. FRED FOX
Department of Microbiology and Molecular Biology
University of California, Los Angeles
Los Angeles, Cahfornia
Managing Editor
Frances J. Stusser
ICN—UCLA Symposia
University of California, Los Angeles
Los Angeles, California
ACADEMIC PRESS 1980
A Subsidiary of Harcourt Brace Jovanovich, Publishers
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United Kingdom Edition published by
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Library of Congress Cataloging in Publication Data
ICN-UCLA Symposia on Animal Virus Genetics, Keystone,
Colo., 1980.
Animal virus genetics.
(ICN-UCLA symposia on molecular and cellular biology;
v. 18)
Includes bibliographical references and index.
1. Viral genetics—Congresses. I. Fields,
Bernard N. II. Jaenisch, Rudolf. III. Fox, C. Fred.
IV. ICN Pharmaceuticals, inc. V. California.
University. University at Los Angeles. VI. Title.
VII. Series.
QH434.I14 1980 576'.64 80-21830
ISBN 0-12-255850-2
PRINTED IN THE UNITED STATES OF AMERICA
80 81 82 83 9 8 7 6 5 4 3 2 1
CONTRIBUTORS
Numbers in parentheses refer to chapter numbers.
Cheryl Adler (9), Department of Microbiology, State University of New York,
Stony Brook, New York 11794
R. Ahmed (56), Department of Microbiology and Molecular Genetics, Harvard
Medical School, Boston, Massachusetts 02115
S. M. Anderson (42), The Rockefeller University, New York, New York 10021
Ralph B. Arlinghaus (54), Department of Tumor Virology, M.D. Anderson Hospi-
tal and Tumor Institute, Houston, Texas 77030
Lome A. Babiuk (61), Department of Veterinary Microbiology, Western College
of Veterinary Medicine, University of Saskatchewan, Saskatoon, S7N OWO
Canada
Lee T. Bacheler (16), Tumor Virlogy Laboratory, The Salk Institute, San Diego,
California 92138
David Baltimore (55, 72), Center for Cancer Research, El 7-517, Massachusetts
Institute of Technology, Cambridge, Massachusetts 02139
Ralph S. Baric (58), Department of Microbiology, North Carolina State Univer-
sity, Raleigh, North Carolina 27650
Renato Baserga (28), Department of Pathology, Fels Research Institute, Temple
University School of Medicine, Philadelphia, Pennsylvania 19140
William Batterson (32), Kovler Viral Oncology Laboratories, University of Chi-
cago, Chicago, Illinois 60637
Karen Beemon (43), Tumor Virology Laboratory, The Salk Institute, San Diego,
California 92138
T. L. Benjamin (26, 27), Pathology Department, Harvard Medical School, Bos-
ton, Massachusetts 02115
Eric J. Berman (20), Laboratory of Viral Carcinogenesis, National Cancer Insti-
tute, N1H, Bethesda, Maryland 20205
xiii
XIV CONTRIBUTORS
Anton Berns (40), Laboratory of Biochemistry, University of Nijmegen, Nijmegen,
The Netherlands
Hartmut Beug (47), Institut für Virusforschung, Deutsches Krebsforschungszen-
trum, Im Neuenheimer Feld 280, 6900 Heidelberg, Federal Republic of Ger-
many
John Billelo (36), Department of Molecular Biology, University of Hamburg, D-
2000, Hamburg 13, West Germany
E. Birkenmeier (17), National Cancer Institute, NIH, Bethesda, Maryland 20205
Klaus Bister (45), Department of Molecular Biology, University of California,
Berkeley, California 94720
D. G. Blair (39), Laboratory of Viral Carcino gene sis, National Cancer Institute,
NIH, Bethesda, Maryland 20205
Barry Bloom (59), Departments of Microbiology and Immunology, Albert Einstein
College of Medicine, Bronx, New York 10461
Robert A. Bosselman (40), Tumor Virology Laboratory, The Salk Institute, San
Diego, California 92138
David Botstein (2), Department of Biology, Massachusetts Institute of Technology,
Cambridge, Massachusetts 02139
Michael A. Bratt (57), Department of Microbiology, University of Massachusetts
Medical School, Worcester, Massachusetts
Martin L. Breitman (44), University of Southern California Medical School, Los
Angeles, California 90033
Trudy Breznik (35), Department of Microbiology, Tulane Medical Center, New
Orleans, Louisiana 70112
S. Burstin (56), Department of Medicine, Peter Brent Hospital, Boston, Massa-
chusetts 02115
R. Callahan (17), Laboratory of Viral Carcinogenesis, National Cancer Institute,
NIH, Bethesda, Maryland 20205
G. G. Carmichael (26), Department of Pathology, Harvard Medical School, Bos-
ton, Massachusetts 02115
Donald R. Carrigan (64), Neurology Research Laboratory, V.A. Medical Center,
San Francisco, California 94121
Suzie Chen (18), Department of Biological Sciences, Columbia University, New
York, New York 10027
J. E. Clements (60), Department of Neurology, The Johns Hopkins School of Med-
icine, Baltimore, Maryland 21205
Donald M. Coen (49), Sidney Färber Cancer Institute, Boston, Massachusetts
02115
John M. Coffin (38), Department of Microbiology and Molecular Biology, Tufts
University School of Medicine, Boston, Massachusetts 02111
J. Craig Cohen (35), Department of Microbiology, Tulane University Medical
Center, New Orleans, Louisiana 70112
Giulia Colletta (36), The Beatson Institute for Cancer Research, Garscube Estate,
Glasgow, G61 1BD, Scotland
CONTRIBUTORS xv
Robert J. Crouch (8), Laboratory of Molecular Genetics, National Institute of
Child Health and Human Development, NIH, Bethesda, Maryland 20205
N. D'Antonio (60), Tufts University School of Medicine, Boston, Massachusetts
02111
Edward Darzynkiewicz (10), Roche Institute of Molecular Biology, Nutley, New
Jersey 07110
T. M. Dexter (37), Pater son Laboratories, Manchester, England
Dino Dina (48), Department of Genetics, Albert Einstein College of Medicine,
Bronx, New York 10461
Richard A. F. Dixon (49), Sidney Färber Cancer Institute, Boston, Massachusetts
02115
Walter Doerfler (30), Institute of Genetics, University of Cologne, Weyertal 121,
5000 Cologne 41, West Germany
David Dolberg (16), Department of Biology, University of California at San
Diego, La Jolla, California 92093
Lawrence A. Donehower (23), Tumor Virus Genetics Laboratory, National Can-
cer Institute, NIH, Bethesda, Maryland 20205
H. Donis-Keller (56), Department of Microbiology and Molecular Genetics, Har-
vard Medical School, Boston, Massachusetts 02115
Ludvik Donner (46), Department of Viral Carcinogenesis, National Cancer Insti-
tute, NIH, Bethesda, Maryland 20205
D. T. Drayna (56), Department of Microbiology and Molecular Genetics, Har-
vard Medical School, Boston, Massachusetts 02115
W. Drohan (15), National Cancer Institute, NIH, Bethesda, Maryland 20205
Peter H. Duesberg (45), Department of Molecular Biology, Stanley Hall, Univer-
sity of California, Berkeley, California 94720
Jeffrey C. Edman (25), Department of Biochemistry and Biophysics, University of
California, San Francisco, California 94143
Melanie Ehrlich (35), Department of Biochemistry, Tulane Medical Center, New
Orleans, Louisiana 70112
John D. Estes (20), Department of Pathology, University of Southern California
School of Medicine, Los Angeles, California 90033
Hung Fan (16), Tumor Virology Laboratory, The Salk Institute, San Diego, Cali-
fornia 92138
B. N. Fields (56, 69), Department of Microbiology and Molecular Genetics, Har-
vard Medical School, Boston, Massachusetts 02115
Robert Z. Florkiewicz (63), Department of Cellular and Developmental Biology,
University of Arizona, Tucson, Arizona 85721
Michèle M. Fluck (27), Microbiology Department, Michigan State University,
East Lansing, Michigan 48824
Jeffrey A. Frelinger (21), Departments of Neurology and Microbiology, University
of Southern California School of Medicine, Los Angeles, California 90033
David Frisby (36), The Beatson Institute for Cancer Research, Garscube Estate,
Switchback Road, Bearsden, Glasgow G61 1BD, Scotland
XVI CONTRIBUTORS
Robert S. Fujinami (65), Scripps Clinic and Research Foundation, La Jolla, Cali-
fornia 92037
Yasuhiro Furuichi (34), Department of Cell Biology, Roche Institute of Molecular
Biology, Nutley, New Jersey 07110
Murray B. Gardner (20), University of Southern California School of Medicine,
Los Angeles, California 90032
Malcolm L. Gefter (31), Department of Biology, Massachusetts Institute of Tech-
nology, Cambridge, Massachusetts 02139
Charles W. Gehrke (35), Experimental Station, Chemical Laboratories, University
of Missouri, Columbia, Missouri 65211
J. Gentsch (56), Department of Microbiology and Molecular Genetics, Harvard
Medical School, Boston, Massachusetts 02115
Walter Gerhard (50), The Wistar Institute, Philadelphia, Pennsylvania 19104
Elizabeth Grabau (59), Department of Biology, University of California at San
Diego, La Jolla, California 92093
Thomas Graf (47), Institut für Virusforschung, Deutsche Krebsforschungszentrum,
Im Neuenheimer Feld 280, 6900 Heidelberg Federal Republic of Germany
Michael Graiser (48), Department of Genetics, Albert Einstein College of Medi-
cine, Bronx, New York 10461
Patrick Gray (5, 25), Departments of Biochemistry and Biophysics, University of
California, San Francisco, California 94143
Doris Grotkopp (24), Heinrich-Pette-Institute, Martinistrasse 52, 2000 Hamburg
20, Federal Republic of Germany
David J. Grunwald (19), McArdle Laboratory for Cancer Research, University of
Wisconsin, Madison, Wisconsin 53706
Gordon L. Hager (23), Tumor Virus Genetics Laboratory, National Cancer Insti-
tute, N1H, Bethesda, Maryland 20205
H. Hanafusa (42), The Rockefeller University, New York, New York 10021
T. Hanafusa (42), The Rockefeller University, New York, New York 10021
Douglas Hanahan (13), Cold Spring Harbor Laboratories, Cold Spring Harbor,
New York 11724
W. S. Haseltine (60), Harvard Medical School, Boston, Massachusetts 02115
Michael J. Hay man (47), Imperial Cancer Research Fund Laboratories, Lincoln's
Inn Fields, P.O. Box 123, London WC2A3PX, England
Gary S. Hay ward (4), Department of Pharmacology and Experimental Therapeu-
tics, Physiology 314, The Johns Hopkins University School of Medicine, Bal-
timore, Maryland 21205
W. S. Hayward (42), The Rockefeller University, New York, New York 10021
Martinez J. Hewlett (63), Department of Cellular and Developmental Biology,
Bioscience West, University of Arizona, Tucson, Arizona 85721
Lawrence E. Hightower (52), Microbiology Section, University of Connecticut,
Storrs, Connecticut 06268
John Holland (59), Department of Biology, University of California at San Diego,
La Jolla, California 92093
CONTRIBUTORS XVll
Frans V.d. Hoorn (40), Laboratory of Biochemistry, University of Nijmegen, Nij-
megen, The Netherlands
J. Peltier Horn (54), Department of Tumor Virology, M.D. Anderson Hospital and
Tumor Institute, Houston, Texas 77030
Frank Horodyski (59), Department of Biology, University of California at San
Diego, La Jolla, California 92093
D. Hrdy (56), Department of Microbiology and Molecular Genetics, Harvard
Medical School, Boston, Massachusetts 02115
Chung-H. Hsu (51), Division of Virology, St. Jude Children's Research Hospital,
Memphis, Tennessee 38101
Shiu-Lok Hu (31), Cold Spring Harbor Laboratories, Cold Spring Harbor, New
York 11724
Alice S. Huang (70), Division of Infectious Diseases, Children's Hospital Medical
Center, Boston, Massachusetts 02115
Tony Hunter (43), The Salk Institute, San Diego, California 92138
Linda E. Iverson (7), Tumor Virology Laboratory, The Salk Institute, San Diego,
California 92138
Rudolf Jaenisch (24), Heinrich-Pette-Institut, Martinistrasse 52, 2000 Hamburg
20, Federal Republic of Germany
Detlev Jahner (24), Heinrich-Pette-Institut, Martinistrasse 52, 2000 Hamburg 20,
Federal Republic of Germany
Burton Janis (59), Department of Medicine and Microbiology, University of Utah
Medical School, Salt Lake City, Utah 84132
Patricia Jelen (19), McArdle Laboratory for Cancer Research, University of Wis-
consin, Madison, Wisconsin 53706
Kenneth P. Johnson (64), Department of Neurology, University of California, San
Francisco, California 94143
Robert E. Johnston (58), Department of Microbiology, North Carolina State Uni-
versity, Raleigh, North Carolina 27650
Wolfgang K. Joklik (11, 71), Department of Microbiology and Immunology, Duke
University Medical Center, Durham, North Carolina 27710
Gerald J. Jonak (28), Department of Pathology, Fels Research Institute, Temple
University School of Medicine, Philadelphia, Pennsylvania 19104
Charlotte Jones (59), Tumor Virology Laboratory, The Salk Institute, San Diego,
California 92138
Matt Jones (40), Department of Biology, University of California at San Diego, La
Jolla, California 92093
R. E. Karess (42), The Rockefeller University, New York, New York 10021
Jack D. Keene (11), Department of Microbiology and Immunology, Duke Univer-
sity Medical Center, Durham, North Carolina 27710
David W. Kingsbury (51), Division of Virology, St. Jude Children's Research
Hospital, Memphis, Tennessee 38101
Naomi Kitamura (9), Department of Microbiology, State University of New York,
Stony Brook, New York 11794
Will CONTRIBUTORS
David M. Knipe (32), Department of Microbiology and Molecular Genetics, Har-
vard Medical School, Boston, Massachusetts 02115
Gebhard Koch (36), Department of Molecular Biology, University of Hamburg,
D-2000 Hamburg 13, Federal Republic of Germany
M. Koga (62), Institute for Virology, University of Wurzburg, D-8700 Wurzburg,
Federal Republic of Germany
Hilary Koprowski (50), The Wistar Institute, Philadelphia, Pennsylvania 19104
Christine A. Kozak (14), Laboratory of Viral Diseases, National Institute of Al-
lergy and Infectious Diseases, NIH, Bethesda, Maryland 20205
E. L. Kuff (17), National Cancer Institute, NIH, Bethesda, Maryland 20205
Ingrid Kuhlman (30), Institute of Genetics, University of Cologne, Cologne, Fed-
eral Republic of Germany
Robert L. LaFemina (4), Department of Pharmacology and Experimental Thera-
peutics, The Johns Hopkins University School of Medicine, Baltimore, Mary-
land 21205
Jeri L. Lane (33), Department of Microbiology and Immunology, Washington
University School of Medicine, St. Louis, Missouri 63110
Wen-Hwa Lee (45), Department of Molecular Biology, University of California,
Berkeley, California 94720
Arnold J. Levine (67), Department of Microbiology, State University of New York,
Stony Brook, New York 11794
James B. Lewis (29), Cold Spring Harbor Laboratory, Cold Spring Harbor, New
York 11724
Joseph K.-K. Li (11), Department of Microbiology and Immunology, Duke Uni-
versity Medical Center, Durham, North Carolina 27710
Frank Lilly (18), Department of Genetics, Albert Einstein College of Medicine,
Bronx, New York 10461
D. Linemeyer (37, 41), National Cancer Institute, NIH, Bethesda, Maryland
20205
K. K. Lueders (17), National Cancer Institute, NIH, Bethesda, Maryland 20205
Deidre D. Lyons (54), Department of Tumor Virology, M. D. Anderson Hospital
and Tumor Institute, Houston, Texas 77030
Charles H. Madansky (57), Department of Microbiology, University of Massachu-
setts Medical School, Worcester, Massachusetts
Jacob V. Maizel (8), Laboratory of Molecular Genetics, National Institute of
Child Health and Human Development, NIH, Bethesda, Maryland 20205
John E. Majors (22), Department of Microbiology and Immunology, University of
California, San Francisco, California 94143
James L. Manley (31), Department of Biology, Massachusetts Institute of Technol-
ogy, Cambridge, Massachusetts 02139
Michael B. Mathews (29), Cold Spring Harbor Laboratories, Cold Spring Harbor,
New York 11724
Kenneth McClain (8), Box 356, Mayo Memorial Hospital, Minneapolis, Minne-
sota 55455
CONTRIBUTORS XIX
W. L. McClements (39), Laboratory of Molecular Virology, National Cancer
Institute, NIH, Bethesda, Maryland 20205
Marcella A. McClure (33), Department of Microbiology and Immunology, Wash-
ington University School of Medicine, St. Louis, Missouri 63110
John G. Menke (41), National Cancer Institute, NIH, Bethesda, Maryland
20205
Marnin Merrick (12), Department of Biology, Center for Cancer Research, Mas-
sachusetts Institute of Technology, Cambridge, Massachusetts 02139
V. ter Meulen (62), Institute for Virology, University of Wurzburg, D-8700, Würz-
burg, West Germany
Lois K. Miller (6), Department of Bacteriology and Biochemistry, The University
of Idaho, Moscow, Idaho 83843
Nagahiro Minato (59), Department of Microbiology and Immunology, Albert Ein-
stein College of Medicine, Bronx, New York 10461
Vikram Misra (61), Department of Veterinary Microbiology, Western College of
Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan
S7N OWO, Canada
S.-M. Mong (54), Department of Tumor Virology, M.D. Anderson Hospital and
Tumor Institute, Houston, Texas 77030
D. B. Moore (58), Department of Microbiology, North Carolina State University,
Raleigh, North Carolina 27650
Edwin C. Murphy (54), Department of Tumor Virology, M.D. Anderson Hospital
and Tumor Institute, Houston, Texas 77030
O. Narayan (60), The Johns Hopkins School of Medicine, Baltimore, Maryland
21205
James C. Neil (44), University of Southern California Medical School, Los
Angeles, California 90033
Rainer Neumann (30), Institute of Genetics, University of Cologne, Cologne, Fed-
eral Republic of Germany
Stephen J. O'Brien (20), Laboratory of Viral Carcinogenesis, National Cancer
Institute, NIH, Bethesda, Maryland 20205
Michael B. A. Oldstone (65),Department of Immunology, Scripps Clinic and Re-
search Foundation, La Jolla, California 92037
A. Oliff (37), Laboratory of Tumor Virus Genetics, National Cancer Institute,
NIH, Bethesda, Maryland 20205
M. Oskarsson (39), Laboratory of Molecular Virology, National Cancer Institute,
NIH, Bethesda, Maryland 20205
Wolfram Ostertag (36), The Beatson Institute for Cancer Research, Garscube Es-
tate, Glasgow G61 1BD, Scotland
L. C. Padhy (12), Department of Biology, Center for Cancer Research, Massa-
chusetts Institute for Technology, Cambridge, Massachusetts 02139
Bijay K. Pal (20), Department of Pathology, University of Southern California
School of Medicine, Los Angeles, California 90033
F. S. Pederson (60), Harvard Medical School, Boston, Massachusetts 02115
